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Solonex Tablet is used to treat and prevent tuberculosis (TB). It contains isoniazid, an antibiotic that works by preventing bacteria from producing mycolic acids, an enzyme required for cell wall formation (protective coating). As a result of the disturbance in their metabolism, bacteria that lack a cell wall die and burst. Thus, it inhibits the spread of infection by acting against the bacteria Mycobacterium tuberculosis, which causes tuberculosis.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Solonex Tablet
  • If you have excess nerve pain and numbness, soak in Epsom salt and warm water. This can help ease the pain and associated discomfort.
  • Use compression socks and make sure to rest for a while to get relief from pain.
  • Avoid smoking and intake of alcohol or fluids that aggravate the pain.
  • Massage your feet or affected area often to get relief from pain. Take the medication prescribed by your doctor without fail.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

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Drug-Drug Interactions

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IsoniazidLomitapide
Critical

Drug-Drug Interactions

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IsoniazidLomitapide
Critical
How does the drug interact with Solonex Tablet:
When Lomitapide is taken with Solonex Tablet, Solonex Tablet may increase the blood levels of lomitapide which leads to side effects.

How to manage the interaction:
Taking Solonex Tablet with Lomitapide is not recommended but can be taken if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, exhaustion, nausea, vomiting, dark urine, light stools, and skin or eye yellowing, decreased hunger, consult the doctor.
How does the drug interact with Solonex Tablet:
When Lovastatin is taken with Solonex Tablet, can increase the risk of myopathy (muscles problems), including rhabdomyolysis (a condition that causes your muscles to break down, which leads to muscle death).

How to manage the interaction:
Taking Solonex Tablet with Lovastatin is not recommended but can be taken if a doctor has prescribed it.
How does the drug interact with Solonex Tablet:
When Solonex Tablet is taken with Regorafenib, it can increase the levels of Regorafenib leading to side effects.

How to manage the interaction:
Taking Regorafenib with Solonex Tablet is not recommended, it taken can be taken if prescribed by the doctor.
IsoniazidMipomersen
Severe
How does the drug interact with Solonex Tablet:
Taking Solonex Tablet and Mipomersen can increase the risk and severity of side effects of liver.

How to manage the interaction:
Although taking Solonex Tablet and Mipomersen together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms -fatigue, decreased hunger, nausea, vomiting, abdominal discomfort, dark urine, pale feces, yellowing of the skin or eyes, joint pain or swelling, fever, chills, unusual bleeding or bruises, skin rash, itching, and/or skin itchiness, please contact a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Solonex Tablet:
Using Solonex Tablet with Teriflunomide can increase the risk and severity of the side effects of the liver.

How to manage the interaction:
Taking Solonex Tablet with Teriflunomide together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to consult a doctor: Fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, nausea, vomiting, abdominal pain, dark urine, light colored stool, and/or yellowing of the skin or eyes. Do not stop using any medications without talking to a doctor.
How does the drug interact with Solonex Tablet:
The combined use of Solonex Tablet and Simvastatin will enhance the levels of Simvastatin, which increases the risk of side effects.

How to manage the interaction:
Co-administration of Simvastatin and Solonex Tablet can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any unusual symptoms, consult the doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Solonex Tablet:
Co-administration of Glimepiride with Solonex Tablet may interfere with blood glucose control and reduce the effectiveness of Glimepiride.

How to manage the interaction:
Although there is a possible interaction, Glimepiride can be taken with Solonex Tablet if prescribed by the doctor. Regular monitoring of blood glucose levels is advised. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Solonex Tablet:
Co-administration of Rifabutin with Solonex Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Rifabutin and Solonex Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, a skin rash or itching, appetite loss, nausea, vomiting, or yellowing of the skin or the whites of your eyes, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Solonex Tablet:
Using Phenytoin together with Solonex Tablet may increase the effects of Phenytoin, which may increase the risk of side effects.

How to manage the interaction:
Although taking Phenytoin and Solonex Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience jerky eye movements, slurred speech, loss of balance, shaking, muscle stiffness or weakness, nausea, vomiting, feeling dizzy, fainting, and slow or shallow breathing, consult a doctor immediately. Do not discontinue the medications without consulting a doctor.
IsoniazidCholera, live attenuated
Severe
How does the drug interact with Solonex Tablet:
Taking Solonex Tablet and Cholera, live attenuated together may reduce the effectiveness of the vaccine.

How to manage the interaction:
Although taking Solonex Tablet and Cholera, live attenuated together can cause an interaction, it can be taken if a doctor has suggested it. You shouldn't receive the cholera vaccination until at least 14 days after finishing your Solonex Tablet therapy in order to ensure an appropriate immune response. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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ISONIAZID-300MGCaffeine containing foods/drinks

Drug-Food Interactions

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ISONIAZID-300MGCaffeine containing foods/drinks
Common Foods to Avoid:
Dark Chocolate, Cocoa, Coffee, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Taking caffeine containing products including chocolates(which contains caffeine) during Solonex Tablet treatment may lead to an interaction. Avoid caffiene and its products during treatment with Solonex Tablet.

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