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Sysron-N Tablet is used to treat heavy, painful, or irregular periods, premenstrual syndrome (PMS), and endometriosis. Additionally, it may be used in the treatment of breast cancer. It contains Norethisterone, which works by restoring the hormone levels in the body. In some cases, this medicine may cause side effects such as unusual vaginal bleeding or spotting, dizziness, dry mouth, constipation, nausea, and diarrhoea. Let the doctor know if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Sysron-N Tablet:
Coadministration of Phenytoin and Sysron-N Tablet may decrease the blood levels of Sysron-N Tablet, which may make Sysron-N Tablet less effective.

How to manage the interaction:
Although taking Phenytoin and Sysron-N Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. If you experience any symptoms, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Sysron-N Tablet:
Taking carbamazepine and Sysron-N Tablet may possibly reduce the effects of Sysron-N Tablet which may result in higher risk of breakthrough bleeding and unexpected pregnancy.

How to manage the interaction:
Although taking carbamazepine and Sysron-N Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. Contact your doctor if you experience hot flashes, vaginal dryness, or uncontrolled bleeding. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Coadministration of Sysron-N Tablet with Rifabutin can reduce the blood levels and effects of norethindrone.This increases the risk of severe bleeding and unintended pregnancy.

How to manage the interaction:
Taking Sysron-N Tablet with Rifabutin together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of abnormal bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Sysron-N Tablet:
Using Felbamate and Sysron-N Tablet together can reduce the blood levels and effects of norethindrone.

How to manage the interaction:
There may be a possibility of interaction between Sysron-N Tablet and Felbamate, but it can be taken if prescribed by a doctor. If you notice any unusual symptoms like changes in your menstrual cycle, excessive bleeding, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
NorethisteroneTelaprevir
Severe
How does the drug interact with Sysron-N Tablet:
Using Telaprevir and Sysron-N Tablet together can increase risk of unintended pregnancy and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Telaprevir with Sysron-N Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneBexarotene
Severe
How does the drug interact with Sysron-N Tablet:
Coadministration of Bexarotene and Sysron-N Tablet together can decrease the effectiveness of norethindrone and increase the risk of unintended pregnancy.

How to manage the interaction:
Combining Bexarotene with Sysron-N Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
NorethisteroneBoceprevir
Severe
How does the drug interact with Sysron-N Tablet:
Using Boceprevir and Sysron-N Tablet together can reduce the blood levels and decrease the effectiveness of norethindrone.

How to manage the interaction:
Combining Boceprevir with Sysron-N Tablet can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms like increased hot flashes, vaginal dryness, or menstrual abnormalities, abnormal bleeding, contact the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Eslicarbazepine may reduce the effects of Sysron-N Tablet and its blood levels.

How to manage the interaction:
Although taking Eslicarbazepine and Sysron-N Tablet results in an interaction, they can be taken together if prescribed by your doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Using tranexamic acid together with norethindrone may increase the risk of blood clots.

How to manage the interaction:
Taking Sysron-N Tablet with tranexamic acid can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg, contact a doctor immediately .Do not discontinue any medications without consulting a doctor.
How does the drug interact with Sysron-N Tablet:
Coadministration of Acitretin with Sysron-N Tablet may interfere with the contraceptive effect of Sysron-N Tablet.

How to manage the interaction:
Acitretin and Sysron-N Tablet should be used together only if prescribed by your doctor. Use of at least two methods of effective contraception is mandatory during acitretin therapy and for at least 3 years after stopping therapy.

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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NORETHISTERONE-5MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice

How to manage the interaction:
Consuming Grapefruit juice may increase the blood levels of Sysron-N Tablet. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Sysron-N Tablet dose. Avoid or limit the consumption of grapefruit and grapefruit juice while taking the Sysron-N Tablet dose.

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