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Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Topcid 40 Tablet is used to reduce acid production in the stomach. It treats stomach ulcers (gastric and duodenal ulcers), reflux oesophagitis, and Zollinger-Ellison syndrome. It contains Famotidine, which reduces the production of acid and the volume of gastric secretions. In some cases, it may cause side effects such as headaches, dizziness, constipation, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Drug-Drug Interactions

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FamotidineRisedronic acid
Severe
FamotidineNicotine
Severe

Drug-Drug Interactions

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FamotidineRisedronic acid
Severe
How does the drug interact with Topcid 40 Tablet:
Taking Topcid 40 Tablet with Risedronic acid can increase the blood levels of Risedronic acid.

How to manage the interaction:
There may be a possibility of interaction between Risedronic acid and Topcid 40 Tablet, but it can be taken if prescribed by a doctor. In case you experience any unusual side effects, consult a doctor. Do not stop using any medications without talking to a doctor.
FamotidineNicotine
Severe
How does the drug interact with Topcid 40 Tablet:
Combining Nicotine with Topcid 40 Tablet may reduce the clearance of nicotine.

How to manage the interaction:
Although taking Topcid 40 Tablet and Nicotine together can cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without a doctor's advice.
FamotidinePazopanib
Severe
How does the drug interact with Topcid 40 Tablet:
Topcid 40 Tablet can make Pazopanib less effective by reducing its absorption in the body.

How to manage the interaction:
There may be a possibility of interaction between Topcid 40 Tablet and Pazopanib, but it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
FamotidineDigoxin
Severe
How does the drug interact with Topcid 40 Tablet:
Co-administration of Digoxin and Topcid 40 Tablet may increase the level or effect of Digoxin.

How to manage the interaction:
Although there is a possible interaction between Digoxin and Topcid 40 Tablet, you can take these medicines together if prescribed by a doctor. Do not discontinue the medication without consulting a doctor.
FamotidineGefitinib
Severe
How does the drug interact with Topcid 40 Tablet:
Topcid 40 Tablet can make Gefitinib less effective by reducing its absorption in the body. This can lead to low treatment outcomes.

How to manage the interaction:
Co-administration of Topcid 40 Tablet with Gefitinib can result in an interaction, but it can be taken if a doctor has advised it. It is advised you to take gefitinib 6 hours before or 6 hours after Topcid 40 Tablet, to reduce the effects of the interaction. Do not stop using any medications without a doctor's advice.
FamotidineAtazanavir
Severe
How does the drug interact with Topcid 40 Tablet:
Using Topcid 40 Tablet with atazanavir may interfere with atazanavir and decrease its effectiveness.

How to manage the interaction:
Co-administration of Topcid 40 Tablet with Atazanavir can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
FamotidineIndinavir
Severe
How does the drug interact with Topcid 40 Tablet:
Using Topcid 40 Tablet with indinavir can impair Indinavir absorption, resulting in lower levels in the blood and, potentially, lower effectiveness.

How to manage the interaction:
Co-administration of Topcid 40 Tablet with Indinavir can result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
FamotidineSecretin
Severe
How does the drug interact with Topcid 40 Tablet:
Co-administration of Topcid 40 Tablet with secretin may generate a hyperresponse in gastrin(hormone) secretion in reaction to secretin stimulation tests, erroneously indicating gastrinoma (tumor usually found in the pancreas or duodenum).

How to manage the interaction:
Although taking Topcid 40 Tablet and Secretin together can cause an interaction, it can be taken if a doctor has suggested it. To assist in the identification of gastrinoma(tumor usually found in the pancreas or duodenum), discontinue Topcid 40 Tablet at least 2 days before using secretin. Do not stop using any medications without a doctor's advice.
FamotidineTizanidine
Severe
How does the drug interact with Topcid 40 Tablet:
When Tizanidine with Topcid 40 Tablet, Topcid 40 Tablet can considerably raise the blood levels and effects of Tizanidine. This could result in a sudden decrease in blood pressure.

How to manage the interaction:
Taking Topcid 40 Tablet with Tizanidine together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience dizziness, fainting, and irregular heart rhythm, consult your doctor immediately. Do not stop using any medications without talking to a doctor.
FamotidineKetoconazole
Severe
How does the drug interact with Topcid 40 Tablet:
Coadministration of ketoconazole and Topcid 40 Tablet may reduce the effectiveness of ketoconazole.

How to manage the interaction:
Although taking Ketoconazole and Topcid 40 Tablet together can result in an interaction, it can be taken if a doctor has prescribed it. Without consulting a doctor, never stop taking any drugs.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Topcid 40 Tablet Substitute

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