Votrient 200 mg Tablet का उपयोग, फायदे ,साइड इफेक्ट,कीमत in Hindi

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Votrient 200 mg Tablet is an anti-cancer drug used in the treatment of kidney and soft tissue cancer. It contains Pazopanib, which works by stopping the action of an abnormal protein that causes the multiplication of cancerous cells. Thus, it stops the spread of cancerous cells. It may cause common side effects such as itching or skin rash, acne, dry skin, vomiting, diarrhea and loss of appetite.

Written By Bayyarapu Mahesh Kumar , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

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Side effects of Votrient 200 mg Tablet

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Hair Color Changes

Consult your doctor for dose adjustment or alternative medicine if you notice hair color changes.
To avoid further scalp irritation, use a mild shampoo and conditioner.
Avoid harsh styling techniques such as tight hairstyles and excessive heat styling.
Discuss your concerns with a professional hairstylist who can recommend color techniques to manage the look of hair color changes.

Nausea

Overcome Medication-Induced Nausea: A 9-Step Plan

Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
Divide your daily food intake into smaller, more frequent meals to reduce nausea.
Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
Use ginger (tea, ale, or candies) to help relieve nausea.
Get adequate rest and also avoid strenuous activities that can worsen nausea.
Talk to your doctor about taking anti-nausea medication if your nausea is severe.
Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Loss of appetite

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Stomach Pain

Drink water or other clear fluids.
To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
Include bland foods like rice, toast, crackers, and rice in your diet.
Avoid lying down immediately after eating as it may cause indigestion or heartburn.
Avoid acidic and spicy food as it may cause indigestion.

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Drug-Drug Interactions

Drug-Drug Interaction: Votrient 200 mg Tablet may have interaction with anti-cancer medicine (Sorafenib and Paclitaxel), antibiotics (Neomycin), anti-seizure medicine (carbamazepine, phenytoin), an antacid (Omeprazole).

Drug-Food Interaction: The absorption of Votrient 200 mg Tablet gets reduced in presence of food. This is why it is suggested to take Votrient 200 mg Tablet on an empty stomach or 1 or 2 hours after a meal. Additionally, an individual should avoid grapefruit juice as it may increase the amount of drug in the bloodstream.

Drug-Disease Interaction: Do not take Votrient 200 mg Tablet if you have squamous cell lung cancer.

PazopanibChloroquine

Critical

PazopanibHalofantrine

Critical

Drug-Drug Interactions

PazopanibChloroquine

Critical

How does the drug interact with Votrient 200 mg Tablet:
Taking Votrient 200 mg Tablet with chloroquine can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Votrient 200 mg Tablet with Chloroquine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

PazopanibHalofantrine

Critical

How does the drug interact with Votrient 200 mg Tablet:
Using Votrient 200 mg Tablet together with halofantrine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Votrient 200 mg Tablet with Halofantrine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

PazopanibPimozide

Critical

How does the drug interact with Votrient 200 mg Tablet:
Taking Pimozide with Votrient 200 mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Votrient 200 mg Tablet with Pimozide is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

PazopanibAluminium hydroxide

Critical

How does the drug interact with Votrient 200 mg Tablet:
Co-administration of Votrient 200 mg Tablet with aluminium hydroxide can reduce the blood levels and effects of Votrient 200 mg Tablet.

How to manage the interaction:
Although there is an interaction between Votrient 200 mg Tablet and Aluminium hydroxide, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

PazopanibYellow fever vaccine

Critical

How does the drug interact with Votrient 200 mg Tablet:
Coadministration of Yellow fever vaccine with Votrient 200 mg Tablet can increase the risk of infection.

How to manage the interaction:
Taking Votrient 200 mg Tablet with Yellow fever vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

PazopanibMesoridazine

Critical

How does the drug interact with Votrient 200 mg Tablet:
Co-administration of Votrient 200 mg Tablet with mesoridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Mesoridazine with Votrient 200 mg Tablet is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

PazopanibBCG vaccine

Critical

How does the drug interact with Votrient 200 mg Tablet:
Taking BCG vaccine with Votrient 200 mg Tablet can increase the risk of infection.

How to manage the interaction:
Taking Votrient 200 mg Tablet with BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

PazopanibDronedarone

Critical

How does the drug interact with Votrient 200 mg Tablet:
Taking dronedarone together with Votrient 200 mg Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Votrient 200 mg Tablet with Dronedarone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

PazopanibThioridazine

Critical

How does the drug interact with Votrient 200 mg Tablet:
Taking Votrient 200 mg Tablet with Thioridazine can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Votrient 200 mg Tablet with Thioridazine is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

PazopanibCisapride

Critical

How does the drug interact with Votrient 200 mg Tablet:
Using cisapride together with Votrient 200 mg Tablet can increase the risk of an irregular heart rhythm

How to manage the interaction:
Taking Votrient 200 mg Tablet with Cisapride is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

PAZOPANIB-200MGGrapefruit and Grapefruit Juice

Severe

Drug-Food Interactions

PAZOPANIB-200MGGrapefruit and Grapefruit Juice

Severe

Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Coadministration of Votrient 200 mg Tablet with grapefruit juice can increase the blood levels of Votrient 200 mg Tablet, which may lead to an increased risk of serious side effects such as liver problems, irregular heart rhythm, bleeding, and high blood pressure. Avoid taking grapefruit juice along with Votrient 200 mg Tablet, as it can lead to an interaction.

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