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Zisavel 100 mg Capsule 7's
Zisavel 100 mg Capsule is used to treat fungal infections such as invasive aspergillosis and mucormycosis. It contains Isavuconazole which works by killing or inhibiting the growth of the fungus. In some cases, this medicine may cause side effects such as headache, decreased appetite, drowsiness, nausea, vomiting, stomach pain, diarrhoea or chest pain. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Zisavel 100 mg Capsule
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

Drug-Drug Interactions

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IsavuconazoleRitonavir
Critical
IsavuconazoleKetoconazole
Critical

Drug-Drug Interactions

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IsavuconazoleRitonavir
Critical
How does the drug interact with Zisavel 100 mg Capsule:
Taking Zisavel 100 mg Capsule with Ritonavir may significantly increase the blood levels of Zisavel 100 mg Capsule, which may increase the risk of side effects.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Ritonavir is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. If you notice any of these symptoms like nausea, vomiting, loose stools, light color stools or dark urine, consult a doctor. Do not discontinue any medications without consulting a doctor.
IsavuconazoleKetoconazole
Critical
How does the drug interact with Zisavel 100 mg Capsule:
Co-administration of Ketoconazole and Zisavel 100 mg Capsule can significantly increase the blood levels of Zisavel 100 mg Capsule, which may increase the risk of side effects.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Ketoconazole is not recommended as it can cause an interaction, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, stomach pain, headache while on therapy with these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
IsavuconazoleSaquinavir
Critical
How does the drug interact with Zisavel 100 mg Capsule:
When Zisavel 100 mg Capsule is taken with Saquinavir, it can increase the risk of liver damage.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Saquinavir is not recommended, it can be taken if prescribed by the doctor. However, if you experience symptoms like nausea, vomiting, diarrhea while on therapy with these drugs, consult the doctor.
IsavuconazoleClarithromycin
Critical
How does the drug interact with Zisavel 100 mg Capsule:
When Zisavel 100 mg Capsule is taken with Clarithromycin, it can increase the risk of side effects.

How to manage the interaction:
Co-administration of Clarithromycin and Zisavel 100 mg Capsule can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like nausea, vomiting, or diarrhoea, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazolePhenobarbital
Critical
How does the drug interact with Zisavel 100 mg Capsule:
When Zisavel 100 mg Capsule is taken with Phenobarbital, may decrease the blood levels of Zisavel 100 mg Capsule, which may make Zisavel 100 mg Capsule less effective.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Phenobarbital is not recommended it can be taken if prescribed by the doctor. Do not stop using any medications without talking to a doctor.
IsavuconazolePhenytoin
Critical
How does the drug interact with Zisavel 100 mg Capsule:
Co-administration of phenytoin and Zisavel 100 mg Capsule may significantly reduce the blood levels of Zisavel 100 mg Capsule, which may make Zisavel 100 mg Capsule less effective in treating your condition.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Phenytoin is not recommended as it can cause an interaction, consult a doctor before taking it. Do not discontinue any medication without consulting a doctor.
IsavuconazoleCeritinib
Critical
How does the drug interact with Zisavel 100 mg Capsule:
Taking ceritinib with Zisavel 100 mg Capsule may significantly increase the blood levels of Zisavel 100 mg Capsule.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Ceritinib is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loose stools, yellow discoloration of skin and eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
IsavuconazoleCisapride
Critical
How does the drug interact with Zisavel 100 mg Capsule:
When Zisavel 100 mg Capsule is taken with Cisapride, it can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Cisapride is not recommended, it can be taken if prescribed by the doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.
IsavuconazoleCarbamazepine
Critical
How does the drug interact with Zisavel 100 mg Capsule:
When Carbamazepine and Zisavel 100 mg Capsule are taken together, carbamazepine will reduce the effectiveness of the Zisavel 100 mg Capsule.

How to manage the interaction:
Taking Zisavel 100 mg Capsule with Carbamazepine is not recommended, it can be taken if prescribed by the doctor. Do not discontinue any medications without doctor's advice.
IsavuconazolePosaconazole
Critical
How does the drug interact with Zisavel 100 mg Capsule:
When Zisavel 100 mg Capsule is taken with Posaconazole, it can increase the levels of Zisavel 100 mg Capsule in the blood.

How to manage the interaction:
Although there is an interaction between Zisavel 100 mg Capsule and posaconazole, it can be taken if prescribed by the doctor. However, if you experience nausea, vomiting, diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ISAVUCONAZOLE-100MGGrapefruit and Grapefruit Juice

Drug-Food Interactions

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ISAVUCONAZOLE-100MGGrapefruit and Grapefruit Juice
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Taking grapefruit and grapefruit juice during Zisavel 100 mg Capsule treatment may cause an interaction. Avoid grapefruit products during treatment with Zisavel 100 mg Capsule

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 18, 2025 | 7:27 AM IST

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