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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Xylocaine 10% Spray is used to reduce/relieve pain and discomfort associated with skin irritation, burns, scratches, insect bites, skin abrasions, or sunburn. It is also used to treat post-herpetic neuralgia (lasting pain after a shingles infection). It may also be used to treat premature ejaculation. It is also indicated for the prevention and control of pain in urethritis (inflammation of the urethra). It may also be used as an adjunct for endotracheal intubation. It contains Lidocaine, which blocks the influx (entry) of sodium ions into the membrane that surrounds the nerves, thereby preventing initiation and conduction of impulses. It produces local numbness by blocking the nerve signal in the affected area. Hence, it produces an anaesthetic effect and helps decrease the sensation of pain. In some cases, it may cause application site reactions such as burning sensation, itching, redness, and irritation.

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Drug-Drug Interactions

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LidocaineSaquinavir
Critical
LidocaineArbutamine
Critical

Drug-Drug Interactions

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LidocaineSaquinavir
Critical
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with Saquinavir can increase the blood levels of Xylocaine 10% Spray 50 ml and cause an irregular heart rhythm.

How to manage the interaction:
Taking Xylocaine 10% Spray 50 ml with Saquinavir is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting and rapid heartbeat. Do not discontinue any medications without consulting a doctor.
LidocaineArbutamine
Critical
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml and Arbutamine together can affect the rhythm of your heart.

How to manage the interaction:
Taking Xylocaine 10% Spray 50 ml with arbutamine is not recommended, but can be taken together if prescribed by a doctor. However, consult your doctor if you experience irregular heartbeat, chest tightness, blurred vision and nausea. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Coadministration of Ifosfamide with Xylocaine 10% Spray 50 ml can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
There may be a possibility of interaction between Ifosfamide and Xylocaine 10% Spray 50 ml, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with bupropion can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of bupropion along with Xylocaine 10% Spray 50 ml can lead to an interaction, it can be taken if recommended by a doctor. In case you experience any unusual side effects, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with Atazanavir can increase the effects of Xylocaine 10% Spray 50 ml.

How to manage the interaction:
There may be a possibility of interaction between Xylocaine 10% Spray 50 ml and Atazanavir, but it can be taken if prescribed by a doctor. If you notice any of these symptoms - irregular heartbeat, chest tightness, blurred vision or nausea. - it's important to contact a doctor. Do not stop using any medications without talking to a doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with Phenytoin may increase the risk of methemoglobinemia (a blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Xylocaine 10% Spray 50 ml with Phenytoin together can result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
LidocaineConivaptan
Severe
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Conivaptan with Xylocaine 10% Spray 50 ml may increase the blood levels of Xylocaine 10% Spray 50 ml which increase the risk of serious side effects such as irregular heart rhythm and other cardiovascular problems.

How to manage the interaction:
Although taking Xylocaine 10% Spray 50 ml and Conivaptan together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking phenazopyridine with Xylocaine 10% Spray 50 ml can increase the risk of methemoglobinemia(a blood disorder in which too little oxygen is delivered to the cells).

How to manage the interaction:
Co-administration of Phenazopyridine with Xylocaine 10% Spray 50 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with Trimethoprim may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Trimethoprim with Xylocaine 10% Spray 50 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience, gray skin color, feeling sick, having a headache, feeling dizzy or lightheaded, feeling tired, having trouble breathing, a fast or irregular heartbeat, feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.
How does the drug interact with Xylocaine 10% Spray 50 ml:
Taking Xylocaine 10% Spray 50 ml with Nitrofurantoin may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Taking Nitrofurantoin with Xylocaine 10% Spray 50 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any symptoms of gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, weakness, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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