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  1. Home
  2. Medicine

  3. Primox Tablet 10's

Primox Tablet 10's, Pack of 10 TABLETS
Primox Tablet 10's, Pack of 10 TABLETS
Primox Tablet 10's, Pack of 10 TABLETS
Primox Tablet 10's, Pack of 10 TABLETS
Primox Tablet 10's, Pack of 10 TABLETS
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Composition :

NORTRIPTYLINE-25MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Primox Tablet

Primox Tablet is used to treat depression. Additionally, it is also used to treat neuropathic pain and bedwetting at night. Depression is a mental illness or disorder characterized by persistently depressed mood or loss of interest in activities, causing significant impairment in daily life.

Primox Tablet contains Nortriptyline, which works by affecting certain chemical messengers (serotonin, norepinephrine) in the brain. These messengers communicate with brain cells, thereby regulating mood and preventing depression. Besides this, Primox Tablet also transmits pain signals. Thus, it provides relief from neuropathic pain.

Take Primox Tablet as prescribed by your doctor. In some cases, you may experience certain common side effects such as increased heart rate, flushing, drowsiness, weight gain, difficulty in urination, orthostatic hypotension (sudden lowering of blood pressure on standing), dryness in the mouth, tingling in the arms or legs, blurred vision (dilated pupils). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Primox Tablet for as long as your doctor has prescribed. Inform your doctor if you have suicidal ideation or behaviour symptoms, heart disease, seizure disorders, glaucoma, thyroid problems, or kidney and liver problems. Do not take Primox Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. The safety and effectiveness in children less than 18 years of age have not been established, so Primox Tablet should not be given to them. Avoid consuming alcohol along with Primox Tablet as it could lead to increased drowsiness and dizziness. Consult your doctor immediately if you have suicidal thoughts, such as killing or harming yourself. Rise slowly from sitting or lying position as Primox Tablet causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing). Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Primox Tablet

Treatment of Depression

Directions for Use

Take Primox Tablet with or without food as advised by your doctor, and swallow it as a whole with a glass of water. Do not crush, chew or break it.

Medicinal Benefits

Primox Tablet belongs to a group of medicines called tricyclic antidepressants used to prevent depression. It works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain, which communicate between brain cells, thereby helping regulate mood and treat depression. Primox Tablet prevents the transmission of pain signals, thereby providing relief from neuropathic pain.

How Primox Tablet Works

Primox Tablet contains Nortriptyline, which works by affecting certain chemical messengers (serotonin, norepinephrine) in the brain. These messengers communicate with brain cells, thereby regulating mood and preventing depression. Besides this, Primox Tablet also transmits pain signals. Thus, it provides relief from neuropathic pain.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Primox Tablet

Do not take more than the prescribed dose of Primox Tablet as it may cause overdose. The symptoms of overdose include vision problems, irregular heartbeats, confusion, severe drowsiness, agitation, hallucinations, overactive reflexes, stiff muscles, feeling hot or cold, vomiting, seizures (fits), feeling like you might pass out, or coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Primox Tablet if you are known to be allergic to Primox Tablet . Inform your doctor if you have suicidal ideation or behaviour symptoms, have heart rhythm problems or hypotension, heart disease, seizure disorders, bone marrow suppression, diabetes, schizophrenia, bipolar disorder, acute alcohol intoxication, glaucoma, thyroid problems, kidney and liver problems. Do not take Primox Tablet if you are pregnant or breastfeeding unless prescribed by the doctor. Primox Tablet should not be given to children less than 18 years of age, as its safety and efficacy have not been established. Avoid consuming alcohol along with Primox Tablet as it could lead to increased drowsiness and dizziness. Rise slowly from sitting or lying position as Primox Tablet causes orthostatic hypotension (sudden lowering in blood pressure leading to dizziness on standing).

Drug-Drug Interactions

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NortriptylineTranylcypromine
Critical
NortriptylineLinezolid
Critical

Drug-Drug Interactions

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NortriptylineTranylcypromine
Critical
How does the drug interact with Primox Tablet:
Coadministration of Primox Tablet with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Primox Tablet with Tranylcypromine together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
NortriptylineLinezolid
Critical
How does the drug interact with Primox Tablet:
Coadministration of Primox Tablet with Linezolid might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Primox Tablet with Linezolid together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineSelegiline
Critical
How does the drug interact with Primox Tablet:
Co-administration of Primox Tablet with Selegiline might raise serotonin hormone levels in the body (A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Primox Tablet with Selegiline together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience confusion, hallucination, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylinePotassium citrate
Critical
How does the drug interact with Primox Tablet:
Coadministration of Primox Tablet with Potassium citrate can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Primox Tablet with Potassium citrate together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, dizziness, lightheadedness, abdominal pain, bloating, decreased hunger, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
NortriptylineIsocarboxazid
Critical
How does the drug interact with Primox Tablet:
Using Primox Tablet together with Isocarboxazid can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Isocarboxazid with Primox Tablet is not recommended, please consult your doctor before taking it. However, if you experience increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea call a doctor. Do not discontinue any medications without consulting a doctor.
NortriptylineZiprasidone
Critical
How does the drug interact with Primox Tablet:
Coadministration of Primox Tablet with Ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Primox Tablet with Ziprasidone together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, severe or prolonged diarrhea, or vomiting. Do not discontinue any medications without consulting a doctor.
NortriptylineSafinamide
Critical
How does the drug interact with Primox Tablet:
Coadministration of Primox Tablet with Safinamide may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Primox Tablet with Safinamide together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
NortriptylineChloroquine
Severe
How does the drug interact with Primox Tablet:
Coadministration of Primox Tablet with Chloroquine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Primox Tablet with Chloroquine together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
NortriptylineGranisetron
Severe
How does the drug interact with Primox Tablet:
Using Primox Tablet together with Granisetron can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Taking Granisetron with Primox Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any of the following symptoms -confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, blurred vision, muscle spasm, stomach cramp, nausea, vomiting, diarrhea, dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations it is recommended to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
NortriptylineNorepinephrine
Severe
How does the drug interact with Primox Tablet:
Primox Tablet can enhance the effects of Norepinephrine on blood pressure.

How to manage the interaction:
Although taking Norepinephrine and Primox Tablet together can cause an interaction, it can be taken if your doctor has suggested it. It's important to keep an eye on your blood pressure regularly. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintaining a healthy diet and exercising regularly helps improve overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help maintain neurotransmitters properly.
  • Complex carbohydrates help stimulate serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges, and pears.
  • Exercising helps produce the body’s natural antidepressants. It also relieves stress, improves mood, boosts self-esteem, and provides restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

ANTIDEPRESSANT

Primox Tablet Substitute

Substitutes safety advice

  • Sensival 25 Tablet 10's

    by Others

    ₹5.27per tablet

  • Nortimer 25 Tablet 10's

    by AYUR

    ₹5.49per tablet

  • Daventyl Tablet 10's

    by Others

    ₹3.47per tablet

  • Nortin 25 mg Tablet 10's

    by Others

    ₹4.54per tablet

  • Nordep 25mg Tablet

    by Others

    ₹8.55per tablet

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Primox Tablet as it may cause an increased sedative effect. Please consult a doctor before consuming alcohol with Primox Tablet .

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Pregnancy

Unsafe

Avoid taking Primox Tablet if you are pregnant unless prescribed by a doctor. Please consult your doctor if you have any concerns regarding this. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Consult your doctor before taking Primox Tablet ; your doctor will decide whether breastfeeding mothers can take Primox Tablet or not.

bannner image

Driving

Caution

Primox Tablet may affect your ability to drive or operate machinery safely. Therefore, drive only if you are alerted after taking the Primox Tablet .

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Liver

Caution

Take Primox Tablet with caution, especially if you have a history of liver disease/conditions. Your doctor may adjust the dose as required.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Unsafe

Primox Tablet is not recommended for children under 18. Its safety and efficacy have not been established.

FAQs

Primox Tablet is used to treat depression. Additionally, it is also used to treat neuropathic pain and bedwetting at night.

Primox Tablet contains Nortryptaline, which works by affecting certain chemical messengers (serotonin and/or norepinephrine) in the brain that communicate between brain cells. Thus, it helps regulate mood and treats depression.

Do not take Primox Tablet if you are allergic to antidepressants (like nortriptyline, amitriptyline, amoxapine, clomipramine, desipramine, doxepin, imipramine, protriptyline, trimipramine), antiallergic (like carbamazepine, eslicarbazepine, oxcarbazepine and rufinamide), and MAO inhibitors (like isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others). Besides this, if you have used an SSRI antidepressant in the last 5 weeks like escitalopram, fluoxetine, citalopram, fluvoxamine, paroxetine, sertraline, trazodone, or vilazodone let your doctor know about this.

No, you should not take Primox Tablet if you have had a recent heart attack or stroke. Taking Primox Tablet after a heart attack can worsen your present health conditions Unless your doctor thinks the benefits outweigh the risks.

In some cases, Primox Tablet could make your skin sensitive and sunburn more easily. So, it is advisable to avoid sunlight or tanning beds. You can also wear protective clothing and use sunscreen (SPF 30 or more) when outside.

The common side effects of Primox Tablet include dizziness, blurred vision, headache, trouble with eye focusing, vision problems, constipation, dry mouth, high heartbeat (heart palpitation), tiredness, low blood pressure (especially on standing). Prolonged intake of Primox Tablet may increase the risk of eye pressure and heart attack. So, if you experience any of these symptoms immediately contact a doctor.

Primox Tablet could increase the pressure in your eyes. If you have a history of glaucoma or increased eye pressure, your doctor will monitor you more closely while you take nortriptyline.

No, If you have bipolar disorder that is not being treated, taking nortriptyline can make your condition worse.

Take the Primox Tablet as prescribed by your doctor. You can take it with or without food. Primox Tablet can make you feel sleepy. So it’s best to take it in the evening or before you go to bed. Swallow it whole with water. Do not crush, chew, or break it.

No, you should not stop taking Primox Tablet even if your pain is relieved, as it can lead to withdrawal symptoms such as nausea, headache, and weakness. It's important to consult your doctor before stopping Primox Tablet .

Maintain a healthy weight by focusing on a diet rich in fruits, vegetables, whole grains, and lean proteins, avoiding sugary foods, and by engaging in regular exercise. If you still have any concerns, discuss with your doctor.

The serious side effects of Primox Tablet include fast and irregular heartbeat, yellowing of eyes or skin, persistent headaches, confusion, muscle cramps, eye pain, eye swelling, and persistent constipation. If you experience any of these side effects, please consult your doctor immediately.

The onset of action for Primox Tablet can vary depending on the condition being treated. For depression, it typically takes 4 to 6 weeks to show full effect and for nerve pain, you may start to notice improvement within 1 to 3 weeks. Do not stop taking Primox Tablet after 1 or 2 weeks if you feel it’s not helping your symptoms. Give it at least 6 weeks to work. However consult your doctor if you have any concerns.

Take the Primox Tablet as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dose. Do not take a double dose to make up for a missed one.

Taking too much nortriptyline can cause overdose and result in symptoms such as irregular heartbeat, hallucinations, widened pupils, drowsiness, fever, vomiting, confusion, muscle stiffness, or seizures (fits). If these side effects persist or worsen, please consult your doctor immediately.

Avoid drinking alcohol while taking Primox Tablet as it may increase sleepiness or affect your alertness or concentration. Some medications should not be taken with Primox Tablet , discuss with your doctor before taking Primox Tablet and you should also avoid foods high in tyramine. These include aged cheeses, cured meats (like salami and pepperoni), and fermented foods.

While taking Primox Tablet , you should follow your doctor's advice regarding follow-up appointments. However consult your doctor immediately, if you experience any side effects.

Yes, Primox Tablet can cause sleepiness or drowsiness as a side effect, especially when you first start taking the medication. This side effect may decreases as your body adjusts to the medication, but if it persists or worsens, please consult your doctor.

No, taking Primox Tablet more than recommended will not increase its effectiveness. Instead, it can lead to severe side effects and toxicity, such as confusion, seizures, rapid heart rate, and potentially life-threatening conditions. It's important to take Primox Tablet in dosage prescribed by your doctor if you feel your current dose is not working effectively, consult your doctor.

Store Primox Tablet at room temperature in a dark and dry place. Keep it out of reach of children.

Country of origin

India

Manufacturer/Marketer address

90, Delhi - Jaipur Road, Sector 32, Gurugram, Haryana 122001
Other Info - PRI0013

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Author Details

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Written By

Bayyarapu Mahesh Kumar

M Pharmacy

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Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10915.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/018013s58lbl.pdf
  3. https://www.drugs.com/nortriptyline.html
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