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  3. Actrapid Hm Penfill 40I.U Injection 10 ml

Actrapid Hm Penfill 40I.U Injection 10 ml, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus. It contains Regular human insulin, which replaces the deficient hormone insulin in patients with diabetes. It increases the uptake of glucose by cells, thereby improving glucose metabolism. This effect helps in decreasing glucose levels in the blood. It can cause some side effects such as low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin at the injection site. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

REGULAR HUMAN INSULIN-100IU

Manufacturer/Marketer :

Boots Knoll Pharma

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Actrapid Hm Penfill 40I.U Injection 10 ml

Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus. Diabetes mellitus (DM) is a condition in which glucose levels are elevated in the body. In type 1 diabetes, the body does not make enough insulin (a hormone essential for the metabolism of glucose). On the other hand, in type 2 diabetes, the body cells do not respond to insulin, or in later stages, your body may not produce enough insulin. Symptoms of DM include excessive thirst, excessive hunger, fatigue, increased appetite, and dry mouth. This condition may worsen over time and cause toxic effects if not properly treated.

Actrapid Hm Penfill 40I.U Injection 10 ml contains ‘regular human insulin’, which is a short-acting insulin. It starts to work within 30 minutes after injection, and its action lasts up to 8 hours. It replaces the deficient hormone 'insulin' in patients with diabetes. It increases the uptake of glucose by cells, thereby improving glucose metabolism. This effect helps in decreasing glucose levels in the blood.

Actrapid Hm Penfill 40I.U Injection 10 ml is to be taken subcutaneously (under the skin). You should take this medicine as prescribed by your doctor. A healthcare professional will teach you how to take the injection. It can cause some side effects such as low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin where you injected the medicine. Consult your doctor if any of these effects persist or get worse.

Do not take Actrapid Hm Penfill 40I.U Injection 10 ml if you are allergic to ‘insulin’ or if you have an episode of hypoglycemia (low blood sugar). Talk to your doctor if you have a history of liver disease or kidney disease and if you are pregnant or breastfeeding. Also, inform your doctor if you are taking any other antidiabetic medications. If you experience an episode of hypoglycemia, seek medical attention immediately.

Uses of Actrapid Hm Penfill 40I.U Injection 10 ml

Treatment of Type 1 diabetes, Type 2 diabetes.

Directions for Use

• Actrapid Hm Penfill 40I.U Injection 10 ml should be administered 30 to 40 minutes before a meal as prescribed by the doctor. • Administer Actrapid Hm Penfill 40I.U Injection 10 ml subcutaneously as instructed by the doctor. Your doctor will train you on how to use Actrapid Hm Penfill 40I.U Injection 10 ml at home. Check the label for directions and use it as advised by the doctor. Actrapid Hm Penfill 40I.U Injection 10 ml should be administered subcutaneously (under the skin) in the thighs, abdomen, buttocks, or upper arm.• Rotate the injection site each time. Do not inject into the areas where the skin is tender, red, bruised, hard, scarred or has stretch marks.

Medicinal Benefits

Actrapid Hm Penfill 40I.U Injection 10 ml is a short-acting form of insulin that helps lower blood sugar levels in both adults and children. It stimulates the recovery of sugar in muscle and fat cells and thus suppresses the production of sugar in the liver. Actrapid Hm Penfill 40I.U Injection 10 ml helps in improving glycemic control, which in turn decreases the risk of progression of complications of diabetes like damage to the retina (retinopathy), damage of kidney (nephropathy), damage of nerve cells (neuropathy), delayed wound healing, diabetic foot ulcer, and others. 

How Actrapid Hm Penfill 40I.U Injection 10 ml Works

Actrapid Hm Penfill 40I.U Injection 10 ml contains ‘regular human insulin’, which is a short-acting insulin. It starts to work within 30 minutes after injection, and its action lasts up to 8 hours. It replaces the deficient hormone 'insulin' in patients with diabetes. It increases the uptake of glucose by cells, thereby improving glucose metabolism. This effect helps in decreasing glucose levels in the blood.

Storage

Keep this medicine out of the sight and reach of children.
Side effects of Actrapid Hm Penfill 40I.U Injection 10 ml
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Actrapid Hm Penfill 40I.U Injection 10 ml

Do not use more than the prescribed dose of Actrapid Hm Penfill 40I.U Injection 10 ml as it may cause overdose. The symptoms of overdose include hypoglycemia (low blood sugar), seizures (fits) or loss of consciousness. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

Actrapid Hm Penfill 40I.U Injection 10 ml is for subcutaneous (under the skin) use only. However, in rare cases, it can be given via infusion intravenously under medical supervision. If you are changing the insulin brand or injecting your insulin by another method, it should be done under strict medical supervision. Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. The first hyperglycemia symptoms (high blood sugar level) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and acetone odour of the breath. You should closely monitor these symptoms. Symptoms like heart failure, weight gain, and oedema (fluid deposition in tissue) should not be overruled. It is advisable not to consume alcohol as it may either increase or decrease your blood glucose level. Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. Actrapid Hm Penfill 40I.U Injection 10 ml may decrease the level of potassium, leading to a state of hypokalaemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death. Do not take Actrapid Hm Penfill 40I.U Injection 10 ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription recreational drugs. 

Drug-Drug Interactions

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INSULIN HUMANGatifloxacin
Critical
INSULIN HUMANCiprofloxacin
Severe

Drug-Drug Interactions

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INSULIN HUMANGatifloxacin
Critical
How does the drug interact with Actrapid Hm Penfill 40I.U Injection 10 ml:
Coadministration of Gatifloxacin with Actrapid Hm Penfill 40I.U Injection 10 ml may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Actrapid Hm Penfill 40I.U Injection 10 ml can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised.
INSULIN HUMANCiprofloxacin
Severe
How does the drug interact with Actrapid Hm Penfill 40I.U Injection 10 ml:
Taking Actrapid Hm Penfill 40I.U Injection 10 ml with ciprofloxacin effects blood glucose levels, which may cause hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking ciprofloxacin and Actrapid Hm Penfill 40I.U Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor if you experience headaches, dizziness, sleepiness, anxiety, disorientation, tremors, nausea, hunger, weakness, increased sweating, and a rapid heartbeat, increased hunger, increased thirst. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Do exercise as it may lower your body’s need for insulin during and for some time after the physical activity. It may also speed up the effect of an insulin dose, especially if the exercise involves the area of the injection site (for example, the leg should not be used for injection just prior to running).

  • Discuss with your doctor how you should adjust your insulin regimen to accommodate exercise.

  • Avoid eating sugar food and prefer cooked food that is low in calories.

  • Talk to your doctor concerning adjustments in your insulin schedule when traveling across more than 2 time zones.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS
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Alcohol

Caution

Consumption of alcohol may alter glucose levels and increase the risk of side-effects.

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Pregnancy

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used in pregnant women only if clinically needed.

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Breast Feeding

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used in breastfeeding mothers only if clinically needed.

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Driving

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml may decrease glucose levels. So, avoid driving or operating heavy machinery while using this medicine.

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Liver

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used with caution in patients with liver diseases. Your doctor may adjust the dose of this medicine before prescribing.

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Kidney

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml should be used with caution in patients with kidney diseases. Your doctor may adjust the dose of this medicine before prescribing.

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Children

Caution

Actrapid Hm Penfill 40I.U Injection 10 ml is not recommended for use in children below 2 years of age. However, it can be used for the treatment of diabetes in children above 2 years of age.

Have a query?

FAQs

Actrapid Hm Penfill 40I.U Injection 10 ml is used in the treatment of type 1 and type 2 diabetes mellitus.

Actrapid Hm Penfill 40I.U Injection 10 ml works by increasing the glucose uptake by fats and muscles, suppresses the production of glucose in the liver, and also the formation of glycogen from glucose. These effects help in reducing the glucose levels in the blood.

In hypoglycemia, blood sugar levels decrease significantly. It causes symptoms such as dizziness, headache, sweating, hunger, loss of consciousness, rapid breathing, or seizure (fits). In such cases, seek medical attention immediately.

If you experience low blood sugar, eat glucose tablets, chocolate, or another high sugar snack such as sweet or biscuit. Use a blood glucose monitor to test your blood sugar levels after 15 minutes if possible. Eat a snack or have proper meals if the blood glucose returns to normal.

You should not change the brand of medicine or syringe without informing your doctor. It decreases blood sugar levels, so avoid driving or operating heavy machinery if you have any signs of low sugar levels. Do not take alcohol as it may worsen the health condition.

Actrapid Hm Penfill 40I.U Injection 10 ml is a short-acting human insulin used to control blood sugar levels in people with diabetes mellitus.

Actrapid Hm Penfill 40I.U Injection 10 ml typically starts working within 30 minutes to 1 hour after injection. It reaches its peak effect within 2-4 hours and has a duration of action of approximately 6-8 hours. However, please consult your doctor for personalized guidance on using Actrapid Hm Penfill 40I.U Injection 10 ml and managing your blood glucose levels.

Typically, yes, if you have diabetes and are prescribed Actrapid Hm Penfill 40I.U Injection 10 ml, you will likely need to continue taking insulin for the rest of your life to manage your condition. However, following your healthcare provider's guidance and treatment plan is essential, as individual needs may vary.

Yes, Actrapid Hm Penfill 40I.U Injection 10 ml can be used with other diabetes medications. It is often prescribed alongside long-acting insulin or other diabetes medicines to help control blood sugar levels more effectively. However, follow your doctor's advice and treatment plan, as they will determine the best combination of medications for your specific needs.

A healthcare professional should administer Actrapid Hm Penfill 40I.U Injection 10 ml. For self-administration, inject subcutaneously 30 minutes before a meal into the thigh, upper arm, abdomen, or buttocks, rotating between these typical injection sites to reduce the risk of lipodystrophy and localized cutaneous amyloidosis. Be sure to follow your doctor's instructions regarding dosage and frequency.

Actrapid Hm Penfill 40I.U Injection 10 ml is generally considered safe to use during pregnancy. In fact, insulin is often essential for managing blood sugar levels in pregnant women with diabetes. However, it's crucial to consult with your healthcare provider to discuss the safe use of Actrapid Hm Penfill 40I.U Injection 10 ml and any potential risks or benefits during pregnancy.

Yes, Actrapid Hm Penfill 40I.U Injection 10 ml is safe to use in type 2 diabetes if used in the dose and duration your doctor advises. Keep monitoring your blood sugar levels regularly, as advised. Your dosage may need to be adjusted according to your needs. Follow the lifestyle changes advised by your doctor. Talk to your doctor about the side effects and ways to prevent and manage them.

The side effects of Actrapid Hm Penfill 40I.U Injection 10 ml may include redness, itching, pain, and swelling at the injection site. Rarely, repeated injections in the same area can lead to lipodystrophy, causing abnormal changes in fat tissue, such as lipohypertrophy (thickened skin) or lipoatrophy (thinned skin). To prevent these side effects, rotate injection sites within the same region to minimize the risk of lipodystrophy and ensure consistent insulin absorption.

Yes, Actrapid Hm Penfill 40I.U Injection 10 ml can cause hypoglycemia (low blood sugar), a common side effect of insulin therapy. To prevent hypoglycaemia, regularly check your blood sugar levels to detect any drops early. Keep a record of your readings and inform your doctor. Ensure you have regular meals and snacks to maintain stable blood sugar levels. Avoid skipping meals. Follow your doctor's instructions on insulin dosage. Never adjust your dose without consulting your healthcare provider.

Actrapid Hm Penfill 40I.U Injection 10 ml is typically administered subcutaneously (under the skin) in areas such as the abdomen, thigh, buttocks, or upper arm. However, it can also be given intravenously (into a vein) in specific situations like diabetic ketoacidosis or severe hyperglycaemia, but only by a healthcare professional in a hospital setting.

The dosage of Actrapid Hm Penfill 40I.U Injection 10 ml may need to be changed in various situations. This includes changes in meal patterns or physical activity, fluctuations in blood sugar levels or insulin sensitivity, or during illness or stress. Dosage adjustments may also be necessary when switching from another insulin product, during pregnancy or after delivery. It's essential to consult with your healthcare provider to determine if a dosage adjustment is necessary.

Yes, Actrapid Hm Penfill 40I.U Injection 10 ml needs to be refrigerated. It should be stored between 2°C and 8°C, but do not freeze it.

Country of origin

INDIA

Manufacturer/Marketer address

M-17, Pharma Tower, Basement & Ground Floor, Badli Industrial Area, New Delhi 110 042.
Other Info - ACT0037

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Keep Refrigerated. Do not freeze.Prepaid payment required.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:40 AM IST

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Reference

  1. https://www.drugs.com/sfx/insulin-regular-side-effects.html
  2. https://www.healthline.com/health/regular-insulin-injectable-solution#take-as-directed

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