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  1. Home
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  3. Advamab 400 Injection 16 ml

Prescription drug
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Advamab 400 Injection 16 ml, Pack of 1 INJECTION
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Extra 15% Off with Bank Offers

Composition :

BEVACIZUMAB-400MG

Manufacturer/Marketer :

Alkem Laboratories Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Advamab 400 Injection

Advamab 400 Injection is a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. Cancer is a condition where cells in a specific part of the body grow and reproduce uncontrollably. Cancer can start in one region of the body and spread to other parts. This is referred to as metastasis.

Advamab 400 Injection contains 'Bevacizumab' that works against vascular endothelial growth factor (VEGF) which is found on the lining of lymph and blood vessels. VEGF causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Inhibition of vascular endothelial growth factor limits the flow of oxygen and nutrients to the tumour, causing it to shrink or cease developing. Thus, it helps treat cancers.

Advamab 400 Injection will be administered by a healthcare professional; do not self-administer. Based on your medical condition, your doctor will decide the dose and duration. In some cases, Advamab 400 Injection may cause loss of appetite, constipation, fever, nosebleeds, change in speech, and taste. The majority of these side effects do not require medical treatment and fade away with time. However, consult your doctor if the side effects persist or worsen

Avoid taking Advamab 400 Injection if you are pregnant. Use effective contraception during the treatment and for 6months after the last dose. Advamab 400 Injection may cause sleepiness and fainting, so avoid driving while on treatment with Advamab 400 Injection. Do not breastfeed during the treatment and for 6months after the last dose of Advamab 400 Injection. Keep your doctor informed about your health condition and all the medicines you take to rule out any side effects.

Uses of Advamab 400 Injection

Advamab 400 Injection is used in the treatment of Metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, and cancer of the colon and rectum. The detailed uses of Advamab 400 Injection are as follows:

  • Colorectal Cancer: Advamab 400 Injection is used in combination with chemotherapy for metastatic cases.
  • Non-Small Cell Lung Cancer (NSCLC): Advamab 400 Injection helps slow tumor growth and spread when combined with carboplatin and paclitaxel.
  • Ovarian, Cervical, and Peritoneal Cancer: Advamab 400 Injection is often used post-surgery or with chemotherapy to improve outcomes.
  • Renal Cell Carcinoma (Kidney Cancer): Advamab 400 Injection enhances treatment efficacy when paired with other agents.
  • Glioblastoma (Brain Tumor): Advamab 400 Injection is approved for recurrent cases to reduce tumor vascularization.
  • Hepatocellular Carcinoma (Liver Cancer): Advamab 400 Injection is used in combination with other drugs for advanced stages.

Have a query?

Directions for Use

  • Follow your doctor's instructions regarding doses and timing of Advamab 400 Injection for optimal results.
  • Advamab 400 Injection will be administered by a healthcare professional in a medical setting.
  • Kindly do not self-administer.

Medicinal Benefits

Advamab 400 Injection contains Bevacizumab, a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum. Advamab 400 Injection works against a protein called vascular endothelial growth factor (VEGF). Vascular endothelial growth factor (VEGF) inhibition limits the flow of oxygen and nutrients to the tumour cells, causing them to shrink or cease developing. Thus, it helps treat cancer.

How Advamab 400 Injection Works

Advamab 400 Injection contains 'Bevacizumab' that works against vascular endothelial growth factor (VEGF) which is found on the lining of lymph and blood vessels. VEGF causes blood vessels to grow within tumours which provide oxygen and nutrients to the tumour. Inhibition of vascular endothelial growth factor limits the flow of oxygen and nutrients to the tumour, causing it to shrink or cease developing. Thus, it helps treat cancers.

Storage

• Store in a cool and dry place away from sunlight. • Keep Advamab 400 Injection out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Advamab 400 Injection 16 ml
Managing Medication-Triggered Epistaxis (Nosebleed): A Step-by-Step Guide:
  • If you experience nosebleeds or unusual bleeding after taking medication, seek medical attention right away and schedule an appointment to discuss your symptoms with your doctor.
  • Your doctor may adjust your treatment plan by changing the dosage, switching to a different medication, or stopping the medication.
  • If your doctor advises, take steps to manage bleeding and promote healing, such as applying pressure, using saline nasal sprays, or applying a cold compress, using humidifiers, avoiding blowing or picking your nose, and applying petroleum jelly to the nostrils.
  • Schedule follow-up appointments with your doctor to monitor progress, adjust treatment plans, and prevent future episodes.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Increased protein levels indicate the body is dehydrated and when blood plasma is concentrated.
  • Consume water and stay hydrated. Talk to your doctor and take an oral rehydrating salt (ORS).
  • Sleep for 7-8 hours per night to assist your body in repairing and rebuilding hydration.
  • Manage your blood pressure by implementing changes in lifestyle like losing weight, reducing stress and exercising regularly.
  • Regularly brush and floss your teeth.
  • Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
  • Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
  • Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
  • Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
  • Apply warm compresses to the affected eye to help loosen blockages.
  • Gently massage the eyelids to promote tear drainage.
  • Avoid rubbing the eyes, as this can exacerbate the condition.
  • Use artificial tears to help lubricate the eyes.
  • Keep the eyes clean and free of irritants.
  • Avoid exposure to wind, dust, and other environmental irritants.
  • Consider using humidifiers to add moisture to the air and reduce tear evaporation.

What if I have taken an overdose of Advamab 400 Injection

An overdose of Advamab 400 Injection does not have a recommended course of action or counteragent. Because infusion reactions can be quite severe, treatment for hypersensitivity reactions must be started as soon as possible. Your doctor may take necessary action if an overdose is suspected.

Drug Warnings

Advamab 400 Injection should only be taken under medical supervision. While taking Advamab 400 Injection, the doctor will monitor your condition on a regular basis. If you have a history of allergic reactions to Advamab 400 Injection or other medications, inform your doctor before taking it. Avoid taking Advamab 400 Injection if you are pregnant. Use effective contraception during the treatment and for 6months after the last dose. Advamab 400 Injection may cause sleepiness and fainting, so avoid driving while on treatment with Advamab 400 Injection. Inform your doctor if you have/had high blood pressure, heart attack, stroke, bleeding problems, stomach/intestinal bleeding, perforation; if you had surgery in the past 28days/are due to have surgery. Do not breastfeed during the treatment and for 6months after the last dose of Advamab 400 Injection. While taking Advamab 400 Injection, please do not get any immunizations or vaccinations unless your doctor has approved it. Advamab 400 Injection may increase the risk of bleeding, so be cautious and consult your doctor if you notice any bleeding or bruising.

Drug-Drug Interactions

verifiedApollotooltip
BevacizumabIdarubicin
Severe
BevacizumabThalidomide
Severe

Drug-Drug Interactions

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BevacizumabIdarubicin
Severe
How does the drug interact with Advamab 400 Injection 16 ml:
Taking Advamab 400 Injection 16 ml with Idarubicin can increase the risk of heart problems.

How to manage the interaction:
There may be a possibility of interaction between Advamab 400 Injection 16 ml and Idarubicin, but it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
BevacizumabThalidomide
Severe
How does the drug interact with Advamab 400 Injection 16 ml:
Taking thalidomide together with Advamab 400 Injection 16 ml may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Advamab 400 Injection 16 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
BevacizumabClozapine
Severe
How does the drug interact with Advamab 400 Injection 16 ml:
Taking Advamab 400 Injection 16 ml and clozapine may increase the risk of infection.

How to manage the interaction:
Although taking Advamab 400 Injection 16 ml and Clozapine together can cause an interaction, it can be taken if your doctor has suggested it. If you notice fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, losing weight, or feeling pain, make sure to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditating, reading novels, taking a nice bubble bath, or listening to calming music can all help you relax.
  • Yoga can also aid in the improvement of both physical and mental health.
  • Maintain a healthy weight by engaging in low-strain workouts on a regular basis and consuming nutritious foods.
  • To maintain a healthy weight, eat a portion of nutritious food and exercise on a regular basis.
  • Leafy greens, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs should all be part of your daily diet.
  • Rest well and get a good night's sleep.
  • Avoid smoking and consuming alcoholic beverages.
  • Fast food, fried foods, processed meats, refined carbohydrates, and added sugars should be avoided.

Habit Forming

No

Therapeutic Class

MONOCLONAL ANTIBODIES

Advamab 400 Injection Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended to avoid alcohol consumption while taking Advamab 400 Injection. It could lead to unpleasant side effects.

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Pregnancy

Unsafe

Advamab 400 Injection should not be used during pregnancy because it causes harm to the fetus. Women of childbearing potential must use an effective contraception method while taking Advamab 400 Injection and at least six months after the last dose. Please consult your doctor about any concerns regarding this.

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Breast Feeding

Unsafe

Avoid breastfeeding during treatment and for 6months after the last dose. This is due to the possibility of the medication being passed on to the infant through breast milk.

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Driving

Caution

Caution should be exercised when driving or operating machinery because in some cases, Advamab 400 Injection may cause sleepiness and fainting.

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Liver

Caution

If you have/had a history of any liver-related diseases, please inform the doctor before taking Advamab 400 Injection. Your doctor will weigh the benefits and potential risks before prescribing Advamab 400 Injection.

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Kidney

Caution

If you have/had a history of any kidney-related diseases, please inform the doctor before taking Advamab 400 Injection. Your doctor will weigh the benefits and potential risks before prescribing Advamab 400 Injection.

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Children

Unsafe

Advamab 400 Injection is not recommended for children below 18years as the safety and effectiveness have not been established.

FAQs

Advamab 400 Injection is a monoclonal antibody used to treat metastatic breast cancer, non-small cell lung cancer, kidney cancer, cervical cancer, epithelial ovarian, fallopian tube, or primary peritoneal cancer, cancer of colon and rectum.

Advamab 400 Injection works against a protein called vascular endothelial growth factor (VEGF). Inhibition of vascular endothelial growth factor (VEGF) limits the flow of oxygen and nutrients to the tumour cells, causing them to shrink or cease developing. Thereby, Advamab 400 Injection helps treat cancer.

Advamab 400 Injection may reduce the number of red blood cells leading to anaemia. Its symptoms include pale skin, lack of energy, feeling breathless, feeling dizzy and lightheadedness.

Chemotherapy remains necessary. Advamab 400 Injection is given along with chemotherapy for treating cancer.

Advamab 400 Injection may increase the risk of bleeding and problems with wound healing. If you have had major surgery in the past 28days or if the wound hasn't healed, you should not take Advamab 400 Injection. Talk to your doctor for more information.

Cancer can affect anyone, though the risk increases with age. Individual risk is determined by factors such as smoking and drinking habits, lifestyle choices such as what you eat and exercise; a family history of cancer, and factors in your workplace and environment.

Advamab 400 Injection may increase the incidence of hypertension. Therefore, consult your doctor before taking Advamab 400 Injection if you have high blood pressure.

Advamab 400 Injection is given intravenously (into a vein) infusion by a healthcare professional. Advamab 400 Injection should never be given as an intravenous push or bolus. Do not self-administer.

The duration of treatment with Advamab 400 Injection depends on your condition and response to the treatment. Your doctor will decide the length of time, based on its effectiveness and your tolerance. Regular monitoring will guide ongoing treatment.

Chemotherapy targets and destroys rapidly dividing cells, including cancer cells, to stop their growth and spread. While, Advamab 400 Injection works by inhibiting the formation of new blood vessels that supply oxygen and nutrients to tumors. Cutting off this blood supply helps shrink the tumor or prevent it from growing further.

A person taking Advamab 400 Injection may still require chemotherapy. Advamab 400 Injection is often used in combination with chemotherapy to treat certain cancers, as it helps prevent tumor growth by blocking blood vessel formation and improves the effectiveness of chemotherapy.

Advamab 400 Injection causes side effects such as constipation, loss of appetite, fever, nose bleeds, change in speech, voice changes/hoarseness, and loss of body weight. Most of these side effects do not require any medical requirements as they will gradually reduce over time. Contact a doctor if these side effects persist for longer durations.

Country of origin

India

Manufacturer/Marketer address

Alkem Laboratories Limited, Devashish Building, Alkem House, Senapati Bapat Road, Lower Parel, Mumbai - 400 013.
Other Info - ADV0080

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Sep 3, 2025 | 5:22 PM IST

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Reference

  1. https://www.ema.europa.eu/en/documents/product-information/avastin-epar-product-information_en.pdf
  2. https://www.avastin.com/hcp.html
  3. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/bevacizumab
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/125085s332lbl.pdf
  5. https://www.drugs.com/drug-interactions/bevacizumab.html
  6. https://www.medicines.org.uk/emc/files/pil.3885.pdf

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