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compositionComposition:AMPHOTERICIN B-50MG
prescription
Prescription Medicine
info
Ambisome Injection 1's
Ambisome Injection is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AMPHOTERICIN B-50MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Ambisome Injection

Ambisome Injection belongs to a class of medication called 'antifungal' used to treat severe fungal infections like leishmaniasis. A fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. 

Ambisome Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Ambisome Injection is given by a doctor or nurse. In some cases, you may experience fever, chills, irregular heartbeat, high or low blood pressure, breathing problems, nausea, vomiting, headache, shaking, muscle cramps or pain. Most of these side effects of Ambisome Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Ambisome Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Ambisome Injection. Ambisome Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Ambisome Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain or difficulty in breathing, or encephalopathy (a brain disease which may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help.

Uses of Ambisome Injection

Ambisome Injection is used in the treatment of Severe fungal infections. The detailed uses of Ambisome Injection are as follows:

  • Systemic fungal infections: Ambisome Injection is used to treat fungal infections including cryptococcosis (especially cryptococcal meningitis), histoplasmosis, blastomycosis, candidiasis (disseminated or invasive), coccidioidomycosis, aspergillosis, sporotrichosis.
  • Treatment of mucormycosis: Ambisome Injection is used in the treatment of mucormycosis and other rare fungal infections.

Key Benefits

Ambisome Injection contains Amphotericin B, an antifungal used to treat severe fungal infections. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Ambisome Injection damages fungal cell membranes and kills fungi. Ambisome Injection is used to treat infections such as blood infection with candida, cryptococcus, fusarium, zygomycetes, aspergillus, coccidiodes or blastomycetes, or cryptococcal meningitis (inflammation of the brain).

Side effects of Ambisome Injection
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • Prefer liquid food like juices and soups when you are not likely to eat.
  • Avoid spicy, fatty and fried foods as they cause stomach upset.
  • Eat small and frequent meals, avoiding large meals at a time.
  • Add healthy foods in your diet like fruits and vegetables.
  • Take starchy food like cereals, bread and potatoes etc.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

  • Your doctor will determine the dosage and timing of Ambisome Injection based on the severity of your infection. Typically, it is administered once daily.
  • Ambisome Injection is administered by a healthcare professional in the hospital.
  • Do not self-administer it.

How Ambisome Injection Works

Ambisome Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.
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Alcohol

Caution

The interaction of Ambisome Injection with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Ambisome Injection is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Consult your doctor

It is unknown whether Ambisome Injection is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

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Driving

Caution

Avoid driving after taking Ambisome Injection as it may affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving Ambisome Injection.

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Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving Ambisome Injection.

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Children

Caution

Ambisome Injection is not recommended for children below one month as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please inform your doctor if you have a history of heart disease before using Ambisome Injection. Your doctor will prescribe it only if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Limited information available for use of Ambisome Injection in elderly patients. Please consult your doctor.

What if I have taken an overdose of Ambisome Injection

Since Ambisome Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Diet & Lifestyle Advise

  • Wash your hands regularly and keep your hands clean to prevent the spread of germs.

  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt and long pants while doing outdoor activities such as yard work, gardening or visiting wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Have a query?

How Soon It Starts Working

The time required for Ambisome Injection to start to work: Ambisome Injection ideally shows its action within 1 to 3 hours after administration The time for which the effects of Ambisome Injection last: The duration of action for Ambisome Injection is clinically unknown.

What if you forget to take Ambisome Injection

As this medicine is administered by a healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Ambisome Injection out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
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Keep Refrigerated. Do not freeze.Prepaid payment required.

Drug Warnings

If you are allergic to Amphotericin B or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Ambisome Injection. Ambisome Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Ambisome Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain, difficulty breathing, or encephalopathy (a brain disease that may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help. If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Ambisome Injection.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Ambisome Injection may interact with an anti-HIV drug (zidovudine), immunosuppressant (ciclosporin), antifungal (flucytosine), water pills (furosemide), anticancer drug (methotrexate).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Ambisome Injection.

Amphotericin bStreptozocin
Critical
Amphotericin bDroperidol
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Ambisome Injection:
Taking Ambisome Injection and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Ambisome Injection is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bDroperidol
Severe
How does the drug interact with Ambisome Injection:
Using droperidol together with Ambisome Injection can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Ambisome Injection and Droperidol together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - an irregular heart rhythm, a heart condition, a condition called congenital long qt syndrome, problems with your heart's conduction, severe or long-lasting diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, heart palpitations, feeling weak, feeling sleepy, feeling confused, muscle pain, feeling nauseous or vomiting - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
Amphotericin bAciclovir
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Aciclovir with Ambisome Injection can increase the risk or severity of kidney disorder.

How to manage the interaction:
Taking Aciclovir with Ambisome Injection together can result in an interaction, it can be taken if a doctor has advised it. Consult a doctor if you experience irregular urination, muscle ache, shortness if breath, or palpitations. Do not discontinue any medications without consulting a doctor.
Amphotericin bPimozide
Severe
How does the drug interact with Ambisome Injection:
Pimozide used with Ambisome Injection may raise the chance of a significantly abnormal heart rhythm, although it is a rare side effect.

How to manage the interaction:
Although taking Ambisome Injection and Pimozide together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
Amphotericin bTacrolimus
Severe
How does the drug interact with Ambisome Injection:
Taking tacrolimus with Ambisome Injection can increase the risk of kidney problems.

How to manage the interaction:
Although taking tacrolimus and Ambisome Injection together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
Amphotericin bFoscarnet
Severe
How does the drug interact with Ambisome Injection:
Using foscarnet together with Ambisome Injection can cause serious side effects to the kidneys. Using these drugs together can also increase the risks of seizures (fits) and an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Ambisome Injection and Foscarnet, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: seizures, an irregular heart rhythm, feeling sick, swelling, sudden weight gain or loss, severe pain in your upper stomach that spreads, strong heartbeats, feeling dizzy, or chest pain. Do not discontinue any medications without consulting a doctor.
Amphotericin bAdefovir dipivoxil
Severe
How does the drug interact with Ambisome Injection:
Combining Ambisome Injection with Adefovir dipivoxil can increase the risk of kidney damage.

How to manage the interaction:
Although taking Ambisome Injection and Adefovir dipivoxil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Do not stop using any medications without talking to a doctor.
Amphotericin bEverolimus
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Ambisome Injection and Everolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Ambisome Injection with Everolimus together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bIoxilan
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Ambisome Injection and Ioxilan may increase the risk of kidney problem.

How to manage the interaction:
Taking Ambisome Injection with Ioxilan together can result in an interaction, but it can be taken if a doctor has advised it. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not stop using any medications without a doctor's advice.
Amphotericin bIodixanol
Severe
How does the drug interact with Ambisome Injection:
Coadministration of Ambisome Injection and Iodixanol can cause higher levels of Iodixanol in the blood by reducing its excretion rate.

How to manage the interaction:
There may be a possibility of interaction between Ambisome Injection and Iodixanol, but it can be taken if prescribed by a doctor. It's important to keep an eye on how much you pee. If you notice any changes, like peeing more or less than usual, it's a good idea to let the doctor know right away. These changes could be a sign of different health issues, like problems with your kidneys, diabetes, or dehydration. Other symptoms to watch out for include feeling sick, throwing up, not wanting to eat, gaining or losing weight suddenly, or having trouble breathing. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIFUNGALS]

FAQs

Ambisome Injection is used to treat severe fungal infections like leishmaniasis.
Ambisome Injection contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.
You are not recommended to take Ambisome Injection with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Ambisome Injection with other medicines.
Ambisome Injection may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.
Yes, a test dose of Ambisome Injection may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.
You are recommended to use Ambisome Injection for as long as your doctor has prescribed it. However, the usual treatment is for a minimum of 14 days. Please consult a doctor if you experience any difficulty while taking Ambisome Injection.
Ambisome Injection is not used to treat viral infections. Ambisome Injection is an antifungal that kills fungi and is used to treat severe fungal infections.
Ambisome Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis. It kills fungi by destroying the fungal outer cell membrane.
Ambisome Injection will be administered intravenously by a healthcare professional; do not self-administer.
Ambisome Injection is fungicidal in nature, it works by killing the infection-causing fungus.
Inform the doctor if you are allergic to any of the components in Ambisome Injection or if you experience allergic reactions during treatment with Ambisome Injection. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.
Ambisome Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis
Ambisome Injection may cause side effects like fever, chills, nausea, vomiting, headache, muscle cramps or pain. Most of these side effects of Ambisome Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Disclaimer

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Country of origin

INDIA

Manufacturer/Marketer address

401, LSC, C-Block, Mohan Place Saraswati Vihar Delhi DL 110034 In
Other Info - AMB0029

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