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compositionComposition:DILOXANIDE-500MG+METRONIDAZOLE-400MG
prescription
Prescription Medicine
info
Ameebee DF 400mg/500mg Tablet

Ameebee DF 400mg/500mg Tablet is used to treat infections caused by bacteria and parasites (amoeba). It contains Metronidazole and Diloxanide, which work by killing the infection-causing bacteria and amoeba. This medicine may occasionally cause side effects, such as nausea, vomiting, upset stomach, loss of appetite, dry mouth, and a metallic taste. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DILOXANIDE-500MG+METRONIDAZOLE-400MG

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Ameebee DF 400mg/500mg Tablet

Ameebee DF 400mg/500mg Tablet belongs to a group of medicines known as antibiotics used to treat various infections caused by bacteria and parasites (amoeba). It is prescribed for the treatment of diarrhea caused by microorganisms Clostridium difficile, Entamoeba histolytica and Giardia lamblia. Additionally, it also treats vaginal and other bacterial infections. Infections caused by amoeba usually happen due to drinking contaminated water or eating food that contains contaminated water. Diarrhea is defined as loose, watery stools or frequent movement of the bowel.

Ameebee DF 400mg/500mg Tablet contains two medicines namely: Metronidazole and Diloxanide. Ameebee DF 400mg/500mg Tablet contains Metronidazole, which is an antibiotic, it treats the infection by damaging the DNA of the organism and kills the bacteria. Diloxanide is an amoebicide. It works inside the large intestine to kill the infection-causing amoeba (parasites). Altogether, Ameebee DF 400mg/500mg Tablet kills the bacteria and parasites. Ameebee DF 400mg/500mg Tablet does not treat a viral infection like the flu or a common cold.

Take Ameebee DF 400mg/500mg Tablet as prescribed by your doctor. You are advised to take Ameebee DF 400mg/500mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. Some common side effects of Ameebee DF 400mg/500mg Tablet are nausea, vomiting, upset stomach, loss of appetite, dry mouth and metallic taste. If these effects appear and are bothersome, call your doctor or pharmacist.

Use of Ameebee DF 400mg/500mg Tablet is contraindicated in patients suffering from central nervous system (CNS) diseases like seizures (fits). Ameebee DF 400mg/500mg Tablet should not be used during pregnancy, especially during the first trimester. So, let your doctor know if you are pregnant or planning to get pregnant. You should not breastfeed while taking Ameebee DF 400mg/500mg Tablet as it passes into the breastmilk, and can affect the baby. Do not drive or operate heavy machinery after taking Ameebee DF 400mg/500mg Tablet as it may cause dizziness, drowsiness and make you less alert.

Uses of Ameebee DF 400mg/500mg Tablet

Ameebee DF 400mg/500mg Tablet is used in the treatment of Bacterial Infections, Diarrhea due to Entamoeba histolytica, Giardia lamblia or Clostridium difficile, Vaginal bacterial infections, Dental infections, Post-surgery infections, and Skin bacterial infections.

  • Bacterial Infections: Ameebee DF 400mg/500mg Tablet is effective against a wide range of bacterial infections by inhibiting the growth of harmful bacteria.
  • Diarrhea Due to Parasites or Bacteria: Ameebee DF 400mg/500mg Tablet helps to treat diarrhea caused by Entamoeba histolytica, Giardia lamblia, and Clostridium difficile.
  • Vaginal Infections: Ameebee DF 400mg/500mg Tablet is used to treat bacterial vaginosis and other vaginal infections caused by anaerobic bacteria.
  • Dental Infections: Ameebee DF 400mg/500mg Tablet helps in treating dental abscesses and gum infections by targeting oral anaerobic bacteria.
  • Post-Surgery Infections: Ameebee DF 400mg/500mg Tablet is prescribed to prevent or treat infections that may occur after surgical procedures.
  • Bacterial Skin Infections: Ameebee DF 400mg/500mg Tablet is also effective in treating skin and soft tissue infections caused by susceptible bacteria.
  • Prevents Recurrence: Ameebee DF 400mg/500mg Tablet helps in preventing relapse or recurrence by eliminating the parasite from the intestine and the tissues.

Key Benefits

Ameebee DF 400mg/500mg Tablet is a broad-spectrum antibiotic that is effective against a wide range of gram-positive and gram-negative bacteria. kills the harmful bacteria and amoeba (Entamoeba histolytica, Giardia lamblia, Clostridium difficile), causing diarrhoea. Ameebee DF 400mg/500mg Tablet contains Metronidazole, which is an antibiotic, it treats the infection by damaging the DNA of the organism and kills the bacteria. Diloxanide is an amoebicide. It works inside the large intestine to kill the infection-causing amoeba (parasites). Altogether, Ameebee DF 400mg/500mg Tablet kills the bacteria and parasites. Ameebee DF 400mg/500mg Tablet does not treat a viral infection like the flu or a common cold.

Side effects of Ameebee DF 400mg/500mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Inflammation of Vagina needs immediate attention and cannot be ignored.
  • Get a physical examination and prevent wearing clothes that can hold heat and moisture.
  • Avoid using vaginal sprays or perfumed soaps that increase itching and irritation.
  • Follow your doctor's instructions, and rest well with proper medication.
  • Take a balanced diet and get regular screenings to reduce inflammation.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.

Directions for Use

  • Tablet: Swallow it as a whole with water; do not crush, break, or chew it.
  • Syrup/suspension: Shake the bottle well before use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.

How Ameebee DF 400mg/500mg Tablet Works

Ameebee DF 400mg/500mg Tablet contains two medicines namely: Metronidazole and Diloxanide. Ameebee DF 400mg/500mg Tablet contains Metronidazole which is an antibiotic , it treats the infection by damaging the DNA of the organism and does killing the bacteria. Diloxanide is an amoebicide. It works inside the large intestine to kill the infection causing amoeba (parasites). Altogether Ameebee DF 400mg/500mg Tablet kills the bacteria and parasites. Ameebee DF 400mg/500mg Tablet does not treat a viral infection like flu or a common cold.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Ameebee DF 400mg/500mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Ameebee DF 400mg/500mg Tablet should not be used during pregnancy, especially during the first trimester.

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Breast Feeding

Caution

Take Ameebee DF 400mg/500mg Tablet only when prescribed, it is known to pass on in a limited quantity via breast milk to the child.

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Driving

Caution

Ameebee DF 400mg/500mg Tablet may affect driving as it causes dizziness, so it is advised to avoid driving.

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Liver

Caution

Ameebee DF 400mg/500mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Ameebee DF 400mg/500mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.

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Children

Caution

Dose to be adjusted and recommended by a child specialist only.

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Heart

Unsafe

Ameebee DF 400mg/500mg Tablet is contraindicated in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Ameebee DF 400mg/500mg Tablet can be given in elderly patients with extreme caution, due to the cause of adverse effects.

What if I have taken an overdose of Ameebee DF 400mg/500mg Tablet

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Diet & Lifestyle Advise

  • If you have diarrhea try to drink appropriate amounts of fluids to avoid dehydration.
  • If you have minor diarrhea (less than four stools daily) drinking caffeine-free soft drinks, juices or sport rehydration drinks can be sufficient.
  • If the diarrhoea is more severe, specially formulated rehydration drinks should be taken. Consult your doctor immediately.

Have a query?

How Soon It Starts Working

  • The time required for Ameebee DF 400mg/500mg Tablet to start to work: Ameebee DF 400mg/500mg Tablet starts to show its action within 1 to 2 hour of administration. 
  • The time for which the effects of Ameebee DF 400mg/500mg Tablet last: Ameebee DF 400mg/500mg Tablet effect lasts for 6 to 8 hours.

Storage

• Store in a cool and dry place away from sunlight.• Keep Ameebee DF 400mg/500mg Tablet out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

You should immediately report to the doctor in case you have symptoms of dehydration like dehydration dry mouth, excessive thirst, wrinkled skin, little or no urination, dizziness and lightheadedness. In some cases, prolonged intake of Ameebee DF 400mg/500mg Tablet has been associated with leukopenia (low count of white blood cells). Intake of probiotics, prebiotics and plenty of fluids is recommended if you are suffering from dysentery and diarrhea. If you are feeling sick or vomiting, then it is advised to eat simple foods or avoid spicy foods. If a person experiences skin rash or itching after taking Ameebee DF 400mg/500mg Tablet then they should consult with their doctor.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interaction: Ameebee DF 400mg/500mg Tablet have interactions with medicines to stop your blood clotting (coumarins, warfarin), to treat epilepsy (phenobarbital, phenytoin, primidone), to treat depression (lithium), to treat cancer (busulfan, fluorouracil or mycophenolate), to treat alcohol addiction (disulfiram), to treat stomach ulcers (cimetidine). 

Drug-Food Interaction: The consumption of alcoholic beverages should be avoided as it may lead to flushing, drowsiness and dizziness.

Drug-Disease Interaction: Ameebee DF 400mg/500mg Tablet should not be given to people with liver problems, muscle problems (myasthenia gravis), heart rhythm disorder (arrhythmia), seizures (fits), alcoholism, cancer, electrolyte imbalance (low potassium or magnesium level), colitis (inflammation of the intestine) porphyria (rare genetic blood disorder) and neuro-related diseases.

No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Ameebee DF 400mg/500mg Tablet is used to treat infections caused by bacteria and parasites (amoeba). It is prescribed for the treatment of diarrhoea caused by Clostridium difficile, Entamoeba histolytica and Giardia lamblia. Additionally, it also treats vaginal infections.
Ameebee DF 400mg/500mg Tablet is an antibiotic medication so it is advised to complete the full course even if you start to feel better to prevent the return of the infection.
Yes, it could be due to jaundice as in rare cases Ameebee DF 400mg/500mg Tablet can lead to it. Please consult your doctor immediately if the yellowing of the skin persists and does not subside.
You should complete the full course of Ameebee DF 400mg/500mg Tablet as prescribed by your doctor. After completing the full course of Ameebee DF 400mg/500mg Tablet will work. You must take Ameebee DF 400mg/500mg Tablet at the right dose, right times and for the right numbers of days.
Ameebee DF 400mg/500mg Tablet is an antibacterial medicine that acts only against bacterial infections and not viral infections like common cold and flu. You should not take Ameebee DF 400mg/500mg Tablet without prior consulting your doctor. Self-medication is dangerous and can lower the efficacy of Ameebee DF 400mg/500mg Tablet, leading to antibiotic resistance.
If you miss a dose of Ameebee DF 400mg/500mg Tablet, take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.
The side effects of Ameebee DF 400mg/500mg Tablet include stomach upset, nausea, vomiting, loss of appetite, dry mouth and metallic taste. Consult the doctor if any of these side effects persist or worsen.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.11318 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Metronidazole 400Mgs Bp Leaflet Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. National Health Service (NHS). Metronidazole - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026] Check here
  4. Electronic Medicines Compendium (EMC). Pil.9238 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  5. Metronidazole Metronidazole. 2013. [Accessed on 08 Apr. 2019] Check here
  6. ScienceDirect ScienceDirect. [Accessed on 08 Apr. 2019] Check here
  7. Diloxanide. Diloxanide tablets and side effects at Patient. [Accessed on 02 Jun. 2026]Check here

Country of origin

India
Other Info - AMEE997
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