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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Ampholip 100 mg Injection is used to treat severe fungal infections. It contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. In some cases, this medicine may cause side effects such as fever, chills, nausea, vomiting, headache, muscle cramps or pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Whats That

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Synonym :

LIPOSOMAL AMPHOTERICIN B

Manufacturer/Marketer :

Bharat Serums and Vaccines Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Ampholip 100 mg Injection

Ampholip 100 mg Injection belongs to a class of medication called 'antifungal' used to treat severe fungal infections like leishmaniasis. A fungal infection is a disease in which fungi attack the tissue and cause infection. Fungi are commonly present in nature but do not cause infections normally. However, if the person has a weak immune system, certain types of fungi may infect them. 

Ampholip 100 mg Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Ampholip 100 mg Injection is given by a doctor or nurse. In some cases, you may experience fever, chills, irregular heartbeat, high or low blood pressure, breathing problems, nausea, vomiting, headache, shaking, muscle cramps or pain. Most of these side effects of Ampholip 100 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Ampholip 100 mg Injection or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Ampholip 100 mg Injection. Ampholip 100 mg Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Ampholip 100 mg Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain or difficulty in breathing, or encephalopathy (a brain disease which may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help.

Uses of Ampholip 100 mg Injection

Treatment of Severe fungal infections

Directions for Use

Ampholip 100 mg Injection will be administered by a healthcare professional; do not self-administer.

Medicinal Benefits

Ampholip 100 mg Injection contains Amphotericin B, an antifungal used to treat severe fungal infections. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents. Ampholip 100 mg Injection damages fungal cell membranes and kills fungi. Ampholip 100 mg Injection is used to treat infections such as blood infection with candida, cryptococcus, fusarium, zygomycetes, aspergillus, coccidiodes or blastomycetes, or cryptococcal meningitis (inflammation of the brain).

How Ampholip 100 mg Injection Works

Ampholip 100 mg Injection contains Amphotericin B, which kills fungi by destroying the fungal outer cell membrane. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stop the leakage of cell contents.

Storage

Store in a cool and dry place away from sunlight
Side effects of Ampholip 100 mg Injection 20 ml
  • Eat potassium-rich foods like avocados, bananas, spinach, and potatoes.
  • Stay hydrated by drinking plenty of water.
  • Exercise regularly and maintain healthy weight.
  • Manage stress.
  • Prioritize 7-9 hours of sleep each night to help your body and mind recharge.
  • Avoid smoking and limit intake of caffeine.
  • Practice stress-reducing activities like meditation, yoga, or deep breathing to help calm your mind and body.
  • Avoid stimulants and illegal drugs.
  • Call your doctor if it worsens.
  • Muscle cramps can be treated with regular exercise or yoga, which includes mild stretching, which helps strengthen the lower body.
  • Warm baths and gentle massage of the affected parts can help relieve cramps.
  • Avoid strenuous activity and take frequent breaks, as rest is critical.
  • Intake of nutritious food can help strengthen body and mind. A trained nutritionist can help design a balanced diet for strengthening muscles.
  • Speak to your doctor if the pain lasts an extended period. Medical help can be practical in finding a cure for cramps.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Take pain reliever medicines such as ibuprofen or paracetamol.
  • Apply an ice pack for 15 minutes multiple times a day during the first 48 hours. Then, use a heating pad or take warm shower.
  • Gently stretch the neck and massage to relieve pain.
  • Good posture and gentle exercise may help to prevent it.
  • Maintain proper sleep hygiene.

What if I have taken an overdose of Ampholip 100 mg Injection

Since Ampholip 100 mg Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

If you are allergic to Amphotericin B or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Ampholip 100 mg Injection. Ampholip 100 mg Injection is not recommended for children below one month as the safety and effectiveness were not established. Avoid driving after taking Ampholip 100 mg Injection as it may affect your ability to drive. If you experience severe adverse effects such as chest pain, difficulty breathing, or encephalopathy (a brain disease that may cause you to behave strangely, be confused or feel drowsy), seek immediate medical help. If you have diabetes, electrolyte imbalance (low magnesium or potassium levels in the blood), kidney, liver or heart problems, inform your doctor before taking Ampholip 100 mg Injection.

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
Amphotericin bDeferasirox
Severe

Drug-Drug Interactions

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Amphotericin bStreptozocin
Critical
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Taking Ampholip 100 mg Injection 20 ml and streptozocin together can enhance kidney injury and can cause damage to the ear.

How to manage the interaction:
Taking Streptozocin with Ampholip 100 mg Injection 20 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it.
Amphotericin bDeferasirox
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Deferasirox can cause kidney issues, and mixing it with Ampholip 100 mg Injection 20 ml, can enhance that risk.

How to manage the interaction:
Taking Ampholip 100 mg Injection 20 ml with Deferasirox together can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Drink plenty of water if you experience diarrhea or vomiting while taking these medications, as dehydration can potentially affect the kidneys. Do not stop using any medications without talking to a doctor.
Amphotericin bZiprasidone
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Co-administration of Ziprasidone with Ampholip 100 mg Injection 20 ml may raise the chance of a significantly abnormal heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Ampholip 100 mg Injection 20 ml and Ziprasidone, but it can be taken if prescribed by a doctor. However, if you experience abrupt dizziness, lightheadedness, fainting, or rapid or pounding heartbeats, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting, contact a doctor immediately. You may need regular monitoring of your electrolyte (magnesium, potassium) levels. Do not stop using any medications without talking to a doctor.
Amphotericin bIoxilan
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Coadministration of Ampholip 100 mg Injection 20 ml and Ioxilan may increase the risk of kidney problem.

How to manage the interaction:
Taking Ampholip 100 mg Injection 20 ml with Ioxilan together can result in an interaction, but it can be taken if a doctor has advised it. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm let the doctor know right away. Do not stop using any medications without a doctor's advice.
Amphotericin bIoversol
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Coadministration of Ampholip 100 mg Injection 20 ml and Ioversol may increase the risk of kidney damage.

How to manage the interaction:
There may be a possibility of interaction between Ampholip 100 mg Injection 20 ml and Ioversol, but it can be taken if prescribed by a doctor. If you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not stop using any medications without talking to a doctor.
Amphotericin bEverolimus
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Coadministration of Ampholip 100 mg Injection 20 ml and Everolimus can increase the risk of kidney problems.

How to manage the interaction:
Taking Ampholip 100 mg Injection 20 ml with Everolimus together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bTenofovir alafenamide
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Tenofovir alafenamide can cause kidney problems and taking it with amikacin, can enhance the risk.

How to manage the interaction:
There may be a possibility of interaction between Ampholip 100 mg Injection 20 ml and Tenofovir alafenamide, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm. Do not discontinue any medications without a doctor's advice.
Amphotericin bAdefovir dipivoxil
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Combining Ampholip 100 mg Injection 20 ml with Adefovir dipivoxil can increase the risk of kidney damage.

How to manage the interaction:
Although taking Ampholip 100 mg Injection 20 ml and Adefovir dipivoxil together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm, seek immediate medical attention. Do not stop using any medications without talking to a doctor.
Amphotericin bFoscarnet
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Using foscarnet together with Ampholip 100 mg Injection 20 ml can cause serious side effects to the kidneys. Using these drugs together can also increase the risks of seizures (fits) and an irregular heart rhythm.

How to manage the interaction:
There may be a possibility of interaction between Ampholip 100 mg Injection 20 ml and Foscarnet, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact a doctor right away: seizures, an irregular heart rhythm, feeling sick, swelling, sudden weight gain or loss, severe pain in your upper stomach that spreads, strong heartbeats, feeling dizzy, or chest pain. Do not discontinue any medications without consulting a doctor.
Amphotericin bDroperidol
Severe
How does the drug interact with Ampholip 100 mg Injection 20 ml:
Using droperidol together with Ampholip 100 mg Injection 20 ml can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Although taking Ampholip 100 mg Injection 20 ml and Droperidol together can cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these symptoms - an irregular heart rhythm, a heart condition, a condition called congenital long qt syndrome, problems with your heart's conduction, severe or long-lasting diarrhea, vomiting, complications, sudden dizziness, feeling lightheaded, fainting, difficulty breathing, heart palpitations, feeling weak, feeling sleepy, feeling confused, muscle pain, feeling nauseous or vomiting - make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Wash your hands regularly and keep your hands clean to prevent the spread of germs.

  • Avoid dusty activities and digging in the soil.
  • Wear shoes, a long-sleeved t-shirt and long pants while doing outdoor activities such as yard work, gardening or visiting wooded areas to protect from fungus commonly present in the environment.
  • Maintain a diet that is low in sugar, refined carbohydrates, mould-containing foods and yeast.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Ampholip 100 mg Injection Substitute

Substitutes safety advice
  • Amphocil 100mg Injection

    by Others

    9020.00per tablet
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Alcohol

Caution

The interaction of Ampholip 100 mg Injection with alcohol is unknown. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Consult your doctor

Ampholip 100 mg Injection is a Category B pregnancy drug and is given to a pregnant woman if the doctor thinks the benefits outweigh the risks. Please consult your doctor if you are pregnant or planning pregnancy.

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Breast Feeding

Consult your doctor

It is unknown whether Ampholip 100 mg Injection is excreted in human milk. If you are breastfeeding, inform your doctor before receiving this injection.

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Driving

Caution

Avoid driving after taking Ampholip 100 mg Injection as it may affect your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor if you have a history of liver diseases/conditions before receiving Ampholip 100 mg Injection.

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Kidney

Consult your doctor

Inform your doctor if you have a history of kidney diseases/conditions before receiving Ampholip 100 mg Injection.

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Children

Caution

Ampholip 100 mg Injection is not recommended for children below one month as the safety and effectiveness were not established.

FAQs

Ampholip 100 mg Injection is used to treat severe fungal infections like leishmaniasis.

Ampholip 100 mg Injection contains Amphotericin B, an antifungal that works by damaging fungal cell membranes, thereby killing fungi.

You are not recommended to take Ampholip 100 mg Injection with furosemide as co-administration of these medicines may increase the risk of hypokalaemia (low potassium levels in the blood), and in severe cases, it may lead to paralysis, muscle weakness, irregular heart rhythm, difficulty in breathing or swallowing. However, please consult your doctor before taking Ampholip 100 mg Injection with other medicines.

Ampholip 100 mg Injection may cause blue lips and skin, probably during infusion or in the initial 2 days of treatment. However, your doctor or nurse may arrange certain simple treatments to control such adverse effects.

Yes, a test dose of Ampholip 100 mg Injection may be given in smaller amounts before starting the treatment to check if you are sensitive to any of the ingredients.

You are recommended to use Ampholip 100 mg Injection for as long as your doctor has prescribed it. However, the usual treatment is for a minimum of 14 days. Please consult a doctor if you experience any difficulty while taking Ampholip 100 mg Injection.

Ampholip 100 mg Injection is not used to treat viral infections. Ampholip 100 mg Injection is an antifungal that kills fungi and is used to treat severe fungal infections.

Ampholip 100 mg Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis. It kills fungi by destroying the fungal outer cell membrane.

Ampholip 100 mg Injection will be administered intravenously by a healthcare professional; do not self-administer.

Ampholip 100 mg Injection is fungicidal in nature, it works by killing the infection-causing fungus.

Inform the doctor if you are allergic to any of the components in Ampholip 100 mg Injection or if you experience allergic reactions during treatment with Ampholip 100 mg Injection. Let the doctor know if you have kidney problems, diabetes, or if you are taking any other medicines.

Ampholip 100 mg Injection is an antifungal medication used to treat severe fungal infections like leishmaniasis

Ampholip 100 mg Injection may cause side effects like fever, chills, nausea, vomiting, headache, muscle cramps or pain. Most of these side effects of Ampholip 100 mg Injection do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

3rd Floor, Liberty Tower, Plot No. K-10, Behind Reliable Plaza Kalwa Industrial Estate, Airoli, Navi Mumbai, Thane 400 708
Other Info - AMP0081

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