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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Aprovel 300mg Tablet is used for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults. It contains Irbesartan, which widens and relaxes blood vessels. Thus, lowers high blood pressure. In some cases, you may experience nausea, vomiting, fatigue, and orthostatic hypotension. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Whats That

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Composition :

IRBESARTAN-300MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Aprovel 300mg Tablet

Aprovel 300mg Tablet belongs to a group of medicines known as angiotensin II receptor blockers indicated for the treatment of hypertension (high blood pressure) in adults. Additionally, Aprovel 300mg Tablet is used to reduce the risk of heart attack or stroke in adults. Hypertension is a medical condition in which the blood pressure is elevated persistently in the arteries without any known cause. On the other hand, heart attack or stroke occurs due to blocked blood flow to the heart or brain, respectively.

Aprovel 300mg Tablet works by blocking the action of a hormone called angiotensin II in the body, which causes the narrowing of blood vessels, leading to high blood pressure. Thereby, Aprovel 300mg Tablet widens and relaxes blood vessels, lowering high blood pressure.

You can take Aprovel 300mg Tablet irrespective of food and swallow it whole with a glass of water. Do not crush, chew, or break it. Your doctor will let you how often you should take your tablets based on your medical condition. In some cases, you may experience nausea, vomiting, fatigue, and orthostatic hypotension. Most of these side effects of Aprovel 300mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor.

Aprovel 300mg Tablet is not for pregnant women as its use during your pregnancy can cause injury and even death to your unborn baby. It is not known whether Aprovel 300mg Tablet passes into your breast milk or not. Your doctor will decide if you will take Aprovel 300mg Tablet while using Aprovel 300mg Tablet and breastfeeding together. Prolonged intake of Aprovel 300mg Tablet may cause high potassium in the blood (hyperkalemia). Avoid intake of potassium supplements with Aprovel 300mg Tablet as it may lead to high potassium levels in the blood, so the doctor may ask you to have a regular check of your potassium level. Do not consume alcohol with Aprovel 300mg Tablet as it may increase the risk of low blood pressure. Taking Aprovel 300mg Tablet with painkillers (like aspirin and ibuprofen) can increase the risk of kidney problems and reduce the efficiency of Aprovel 300mg Tablet.

Uses of Aprovel 300mg Tablet

Treatment of Hypertension, Heart failure, Prevents heart attack & heart stroke.

Directions for Use

Swallow Aprovel 300mg Tablet as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Aprovel 300mg Tablet is used to treat high blood pressure and reduce the risk of heart attack or stroke. Aprovel 300mg Tablet is an angiotensin II receptor blocker that decreases high blood pressure by widening and relaxing the blood vessels by blocks the action of a hormone called angiotensin II in the body which causes the narrowing of blood vessels leading to high blood pressure.

How Aprovel 300mg Tablet Works

Aprovel 300mg Tablet works by blocking the action of a hormone called angiotensin II in the body, which causes the narrowing of blood vessels, leading to high blood pressure. Thereby, Aprovel 300mg Tablet widens and relaxes blood vessels, lowering high blood pressure.

Storage

Store in a cool and dry place away from sunlight
Side effects of Aprovel 300mg Tablet
  • Limit fruit intake to two servings a day, choose a low-potassium options like apples and strawberries.
  • Restrict starchy vegetables like potatoes and pumpkin to half a cup daily.
  • Avoid or limit foods like tomato products, high-bran cereals, and salty or sugary snacks.
  • Limit dairy products to 200g of yoghurt or 300ml of milk per day.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Aprovel 300mg Tablet

Do not take more than the prescribed dose of Aprovel 300mg Tablet as it may cause overdose. The symptoms of overdose include low blood pressure, fast or slow heart rate. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Aprovel 300mg Tablet is not recommended for people with impaired kidney function, diabetes or severe liver problems. Aprovel 300mg Tablet may increase the risk of low blood pressure when taken with alcohol. Aprovel 300mg Tablet may cause tiredness or dizziness in some people. Make sure you are not affected before driving. Breastfeeding women are advised to consult a doctor before taking Aprovel 300mg Tablet. Avoid intake of potassium supplements with Aprovel 300mg Tablet as it may lead to high potassium levels in the blood, so the doctor may ask you to have a regular check of your potassium level. Do not consume alcohol with Aprovel 300mg Tablet as it may increase the risk of low blood pressure. Taking Aprovel 300mg Tablet with painkillers (like aspirin and ibuprofen) can increase the risk of kidney problems and reduce the efficiency of Aprovel 300mg Tablet.

Drug-Drug Interactions

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IrbesartanTriamterene
Severe
IrbesartanPotassium citrate
Severe

Drug-Drug Interactions

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IrbesartanTriamterene
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Triamterene may increase potassium levels in the blood. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis and heart problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Triamterene together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanPotassium citrate
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Potassium citrate may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Potassium citrate together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. It is advised to reduce the intake of potassium-rich foods. Do not discontinue any medications without a doctor's advice.
IrbesartanBenazepril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Benazepril may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Aprovel 300mg Tablet and Benazepril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanTizanidine
Severe
How does the drug interact with Aprovel 300mg Tablet:
Combining Tizanidine with Aprovel 300mg Tablet can increase the risk of low blood pressure.

How to manage the interaction:
Taking Aprovel 300mg Tablet with Tizanidine together can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - headache, dizziness, feeling lightheaded, or fainting, make sure to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
IrbesartanEnalapril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Due to additive or synergistic effects, coadministration of enalapril with Aprovel 300mg Tablet may raise the risk of hyperkalemia, hypotension, syncope, and renal failure. In severe cases, hyperkalemia can lead to muscle paralysis,kidney damage, and cardiac problems. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although taking Enalapril together with Aprovel 300mg Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of hyperkalemia, such as nausea, vomiting, confusion, numbness, tingling in hands and feet, and irregular heartbeat. It is advised to limit the intake of potassium-rich foods like tomatoes, bananas, mangoes, beans, and potassium-containing supplements. Do not discontinue any medication without consulting your doctor.
IrbesartanTrimethoprim
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Trimethoprim may increase potassium levels in the blood and kidney problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Trimethoprim together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult your doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanNaproxen
Severe
How does the drug interact with Aprovel 300mg Tablet:
Co-administration of Aprovel 300mg Tablet along with naproxen may result in side effects including low blood pressure, impaired kidney function.

How to manage the interaction:
There may be a possible interaction between Naproxen and Aprovel 300mg Tablet, but they can be taken together if they are prescribed by a doctor. However, if you experience any symptoms such as nausea, vomiting, decreased hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, breathing difficulty, muscle pains, dizziness, confusion, and irregular heart rhythm, consult the doctor. Do not discontinue any medication without a doctor's advice.
IrbesartanAmiloride
Severe
How does the drug interact with Aprovel 300mg Tablet:
When used with Aprovel 300mg Tablet, Amiloride may raise potassium levels in the blood. High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm, and heart problems in extreme cases.

How to manage the interaction:
Although taking Amiloride and Aprovel 300mg Tablet together may lead to an interaction it can be taken if prescribed by the doctor. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
IrbesartanPerindopril
Severe
How does the drug interact with Aprovel 300mg Tablet:
Taking Aprovel 300mg Tablet with Perindopril may cause low blood pressure and kidney problems.

How to manage the interaction:
Although taking Aprovel 300mg Tablet with Perindopril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in the legs, or a slow or irregular heartbeat. Do not discontinue any medications without consulting a doctor.
IrbesartanLofexidine
Severe
How does the drug interact with Aprovel 300mg Tablet:
Co-administration of Aprovel 300mg Tablet with Lofexidine can decrease the low blood pressure, which may lead to side effects.

How to manage the interaction:
Taking Aprovel 300mg Tablet with Lofexidine can possibly result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any of these signs - slow heart rate, headache, feeling dizzy or lightheaded, or fainting - make sure to contact a doctor right away. Avoid activities requiring mental focus like driving, operating dangerous equipment. Be careful while getting up from a sitting or lying position. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate

Drug-Food Interactions

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IRBESARTAN-300MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Consuming potassium-containing substances during treatment with Aprovel 300mg Tablet can lead to high potassium levels which may result in side effects like weakness, irregular heartbeat, confusion, tingling of the extremities, or feelings of heaviness in the legs. Avoid potassium-containing salt substitutes and over-the-counter potassium supplements during Aprovel 300mg Tablet therapy.

Diet & Lifestyle Advise

  • Maintain a low-salt diet and minimize eating processed foods, as they contain more sodium. Try to replace salt with spices or herbs to add flavour to the food.
  • Regular exercise, such as cycling, walking, jogging, dancing, or swimming, should be done for a minimum of 30 minutes daily.
  • Chronic stress may also cause high blood pressure. Therefore, avoid stress by changing your expectations, readjusting your reactions to certain situations, and making time for yourself to do activities that you enjoy.
  • Maintain a diet that is rich in fruits, vegetables, whole grains and low-fat dairy products.
  • Avoid smoking and alcohol intake.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Aprovel 300mg Tablet Substitute

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Alcohol

Caution

Not recommended. Aprovel 300mg Tablet and alcohol together result in an abnormal decrease in blood pressure levels, thus strictly not to be taken together.

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Pregnancy

Unsafe

Not recommended in pregnant patients. Aprovel 300mg Tablet is harmful to an unborn baby, especially in the first 3 months of pregnancy. Aprovel 300mg Tablet is to be replaced with any other blood pressure-lowering drug on doctor consultation.

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Breast Feeding

Caution

Not recommended in breastfeeding patients. Enough data is not available on the usage of Aprovel 300mg Tablet in breastfeeding mothers; thus, it is replaced with any alternative blood pressure-lowering agents in doctors' consultations.

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Driving

Safe if prescribed

Aprovel 300mg Tablet is unlikely to affect your ability to drive or use heavy machines. However, occasionally, dizziness or slowness of movements may occur during the treatment of high blood pressure. If you experience these, talk to your doctor before attempting such activities.

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Liver

Caution

Aprovel 300mg Tablet has been found to affect liver function in certain cases; thus, patients with liver problems should discuss with their doctor for proper guidance regarding treatment with this medication.

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Kidney

Caution

Aprovel 300mg Tablet is not advised for patients with kidney disease as there have been cases of harmful interactions between kidney patients and Aprovel 300mg Tablet. Patients are strictly advised to consult and discuss this medication with their doctors before taking it.

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Children

Safe if prescribed

It is safe to give to children under 12 years of age. No harmful interaction has been reported in patients under 12 years of age, yet doctor's consultation is advised.

Have a query?

FAQs

Aprovel 300mg Tablet is indicated for the treatment of hypertension (high blood pressure) in adults. Additionally, it is used to reduce the risk of heart attack or stroke in adults.

Aprovel 300mg Tablet may increase potassium levels in the blood (hyperkalemia). Therefore, it is recommended to avoid intake of potassium supplements and foods that are rich in potassium like coconut water, bananas and broccoli.

Only on doctors consultation, a patient can take Aprovel 300mg Tablet with metformin which has been found to have a beneficial effect on kidneys in a diabetic patient with hypertension.

Not recommended in overweight patients as per studies conducted by researchers,Aprovel 300mg Tablet causes weight gain in normal individuals and thus contraindicated in overweight patients.

Take the missed dose as soon as possible. if it has been too late then a patient is advised to jump to the next dose without attempting double dose to make up for the missed dose.

Absolutely safe to be used in patients with stomach ulcers as there has been no harmful interaction between Aprovel 300mg Tablet and peptic ulcers except occasional nausea. Recently it has been found to have a protective role against stomach ulcers yet not approved for stomach diseases yet.

Country of origin

India
Other Info - AP76648

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