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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Arbitus 500Mg Tablet is used in combination with prednisone or prednisolone to treat prostate cancer in adult men that has spread to other body parts. It contains Abiraterone, which works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer. It is not for use in women, children, and adolescents. In some cases, Arbitus 500Mg Tablet may cause common side effects such as diarrhoea, urinary tract infection, high blood pressure, low blood potassium, and oedema. If any of the side effects persist or worsen, consult your doctor.

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Whats That

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Synonym :

ABIRATERONE ACETATE

Composition :

ABIRATERONE-500MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Arbitus 500Mg Tablet

Arbitus 500Mg Tablet belongs to the group of medicines called androgen biosynthesis inhibitors that is indicated in combination with prednisone or prednisolone to treat prostate cancer in adult men that have spread to other body parts.

Arbitus 500Mg Tablet contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

In some cases, Arbitus 500Mg Tablet may cause common side effects such as diarrhoea, urinary tract infection, high blood pressure, low blood potassium, and oedema. If any of the side effects persist or worsen, consult your doctor.

Arbitus 500Mg Tablet is not for use in women, children, and adolescents. Arbitus 500Mg Tablet should not be given in combination with Ra-233 (a radioactive isotope used to treat prostate cancer) due to the increased risk of bone fracture or death. Inform your doctor about your health condition and medications to rule out any side effects/interactions.

Uses of Arbitus 500Mg Tablet

Treatment of Prostate cancer

Directions for Use

Take this medicine on an empty stomach, i.e., 1 hour before or 2 hours after food. Swallow Arbitus 500Mg Tablet as a whole with a glass of water; do not chew or break it.

Medicinal Benefits

Arbitus 500Mg Tablet belongs to the group of medicines called androgen biosynthesis inhibitors, indicated in combination with prednisone or prednisolone to treat prostate cancer in adult men that have spread to other body parts. Arbitus 500Mg Tablet contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer. It is indicated in patients with metastatic castration-resistant prostate cancer (CRPC) who have received prior chemotherapy containing docetaxel and metastatic high-risk castration-sensitive prostate cancer (CSPC). Arbitus 500Mg Tablet is prescribed in the early stages of the disease, where it is still responding to hormone therapy. It is used with androgen deprivation therapy (a treatment that lowers testosterone).

How Arbitus 500Mg Tablet Works

Arbitus 500Mg Tablet contains ‘Abiraterone’ that works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

Storage

Store in a cool and dry place away from sunlight
Side effects of Arbitus 500Mg Tablet
  • If you have discomfort, illness, or unease after taking medication, seek medical attention.
  • Your treatment plan may be modified, including adjusting the dosage, substituting with an alternative medication, or discontinuing the medication. Additionally, certain lifestyle changes may be recommended to help manage symptoms.
  • To manage discomfort, follow your doctor's advice, like getting plenty of rest, or staying hydrated, and practising stress-reducing techniques.
  • Track your symptoms regularly and report any changes or concerns to your healthcare provider to manage the discomfort effectively.
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.

What if I have taken an overdose of Arbitus 500Mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Arbitus 500Mg Tablet may include fast or irregular heartbeat, lightheadedness, dizziness, or fainting, shortness of breath or difficulty breathing, swelling of the feet, ankles, or lower legs, and unexplained weight gain. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Do not take Arbitus 500Mg Tablet if you are allergic to any of its components, if you have severe liver damage, or in combination with Ra-233 (used to treat prostate cancer). Inform your doctor if you have liver problems, high blood pressure, low blood potassium, heart failure, heart or blood vessel problems, irregular or rapid heartbeat, heart rhythm problems, shortness of breath, rapid weight gain, swelling in the legs, ankles, or feet, high blood sugar, bone problems, or if you have taken ketoconazole in the past for prostate cancer. Arbitus 500Mg Tablet may cause libido (decreased sex drive), muscle weakness, decreased red blood cells, and/or muscle pain. Arbitus 500Mg Tablet should not be given in combination with Ra-233 due to an increased risk of bone fracture or death.

Drug-Drug Interactions

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AbirateroneThioridazine
Critical
AbirateroneEliglustat
Critical

Drug-Drug Interactions

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AbirateroneThioridazine
Critical
How does the drug interact with Arbitus 500Mg Tablet:
Taking Arbitus 500Mg Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Arbitus 500Mg Tablet and Thioridazine together is not recommended and can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneEliglustat
Critical
How does the drug interact with Arbitus 500Mg Tablet:
Coadministration of Arbitus 500Mg Tablet with Eliglustat can increase the levels of Eliglustat in the body. This increases the risk or severity of side effects.

How to manage the interaction:
Taking Arbitus 500Mg Tablet with Eliglustat is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, slow heart rate, weak pulse, or heart palpitations. Do not discontinue any medications without consulting a doctor.
AbirateroneSaquinavir
Critical
How does the drug interact with Arbitus 500Mg Tablet:
Taking Arbitus 500Mg Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Arbitus 500Mg Tablet and Saquinavir together is not recommended as it can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
AbirateroneMesoridazine
Critical
How does the drug interact with Arbitus 500Mg Tablet:
Taking Arbitus 500Mg Tablet with Mesoridazine can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Arbitus 500Mg Tablet and Mesoridazine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneZiprasidone
Critical
How does the drug interact with Arbitus 500Mg Tablet:
Taking Arbitus 500Mg Tablet with ziprasidone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Although there is an interaction between Arbitus 500Mg Tablet and ziprasidone, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
AbirateroneOsimertinib
Severe
How does the drug interact with Arbitus 500Mg Tablet:
Taking Arbitus 500Mg Tablet with Osimertinib can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Arbitus 500Mg Tablet with Osimertinib together can result in an interaction; it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat. Do not discontinue any medications without consulting a doctor.
AbirateroneLoperamide
Severe
How does the drug interact with Arbitus 500Mg Tablet:
When taken in combination, Arbitus 500Mg Tablet may considerably raise loperamide levels in the blood and cause irregular heart rhythm.

How to manage the interaction:
Although taking loperamide with Arbitus 500Mg Tablet together can result in an interaction, they can be taken if a doctor has prescribed it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations while taking these drugs, consult the doctor. Do not discontinue any medication without consulting a doctor.
AbirateroneCarbamazepine
Severe
How does the drug interact with Arbitus 500Mg Tablet:
Taking carbamazepine and Arbitus 500Mg Tablet together may reduce the blood level of Arbitus 500Mg Tablet.

How to manage the interaction:
Taking carbamazepine and Arbitus 500Mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. Without consulting a doctor, never stop taking any medication.
AbirateroneLeflunomide
Severe
How does the drug interact with Arbitus 500Mg Tablet:
Coadministration of Arbitus 500Mg Tablet with leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Arbitus 500Mg Tablet and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience ever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
AbirateroneVenetoclax
Severe
How does the drug interact with Arbitus 500Mg Tablet:
Coadministration of Arbitus 500Mg Tablet with Venetoclax can increase the levels of Venetoclax in the body. This increases the risk or severity of side effects like bleeding problems, kidney injury, and the risk of developing serious infections.

How to manage the interaction:
Taking Arbitus 500Mg Tablet with Venetoclax together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugar.
  • Get optimal sleep; rest well.

Habit Forming

No

Therapeutic Class

MISCELLANEOUS

Arbitus 500Mg Tablet Substitute

Substitutes safety advice
  • Samtica 500 mg Tablet 60's

    by Others

    423.67per tablet
  • Abiratred Tablet 60's

    by Others

    191.33per tablet
  • Avirat Tablet 60's

    by Others

    650.00per tablet
  • Alkeprost 500 mg Tablet 60's

    by Others

    191.32per tablet
  • Abione-500Mg Tablet 60'S

    by AYUR

    378.57per tablet
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Alcohol

Consult your doctor

It is unknown if alcohol affects Arbitus 500Mg Tablet . Please consult your doctor.

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Pregnancy

Unsafe

Arbitus 500Mg Tablet is not for use in women.

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Breast Feeding

Not applicable

Arbitus 500Mg Tablet is not for use in women.

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Driving

Safe if prescribed

Arbitus 500Mg Tablet is not likely to affect your ability to drive or operate machinery.

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Liver

Caution

Do not take Arbitus 500Mg Tablet if you have severe liver damage. Please consult your doctor if you have a liver impairment or any concerns.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns.

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Children

Not applicable

Arbitus 500Mg Tablet is not for use in children and adolescents.

FAQs

Arbitus 500Mg Tablet is used to treat Prostate cancer.

Arbitus 500Mg Tablet works by stopping the body from making testosterone, thereby slowing the growth of prostate cancer.

Prednisolone/prednisone is prescribed along with Arbitus 500Mg Tablet to lower the chances of getting high blood pressure, fluid retention (having too much water in the body), or low blood potassium levels.

Arbitus 500Mg Tablet should not be given along with Ra-233 (a radioactive isotope used to treat prostate cancer) due to the increased risk of bone fracture or death. If you are prescribed to take Ra-233 following treatment with Arbitus 500Mg Tablet and prednisolone/prednisone, you must wait five days before starting treatment with Ra-233.

No, Arbitus 500Mg Tablet cannot cure prostate cancer. However, it is used to manage advanced or metastatic prostate cancer that works by inhibiting the production of testosterone, thereby preventing the growth and spread of cancer.

No, Arbitus 500Mg Tablet is not a chemotherapy drug. It is a hormone therapy medication, which reduces testosterone levels to help manage prostate cancer.

Yes, Arbitus 500Mg Tablet may affect the liver. Therefore, the doctor may advise regular blood tests to monitor its effects on the liver.

For patients taking Arbitus 500Mg Tablet liver investigations are recommended. However, the frequency may differ for each individual and can be determined by the doctor based on your medical condition.

Arbitus 500Mg Tablet can be taken orally on an empty stomach, either 1 hour before a meal or 2 hours after the meal. Swallow it as a whole with a glass of water. Do not chew or break it.

The side effects of Arbitus 500Mg Tablet include oedema, urinary tract infection, high blood pressure, low blood potassium, and diarrhoea. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - ARB0053

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