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  3. Arpimune-O 50 mg Softgel Capsule 5's

Arpimune-O 50 mg Softgel Capsule 5's, Pack of 5 SoftgelsS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Arpimune-O 50 mg Softgel Capsule is used to prevent organ transplant rejection. It is also used to treat inflammation and pain associated with psoriasis and rheumatoid arthritis. This medicine contains cyclosporine, which works by suppressing the immune system. It also helps reduce rapid skin cell growth, pain, and inflammation. It may sometimes cause common side effects such as headaches, vomiting, nausea, high blood pressure, increased hair growth, loss of appetite, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Synonym :

CYCLOSPORIN

Composition :

CYCLOSPORINE-50MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Arpimune-O 50 mg Softgel Capsule

Arpimune-O 50 mg Softgel Capsule belongs to a group of medications called 'immunosuppressants,' primarily used to prevent organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants. It is also used to treat symptoms associated with psoriasis and rheumatoid arthritis. Organ transplant rejection occurs when the immune system attacks a transplanted organ. Psoriasis is a long-lasting, inflammatory skin illness.  Rheumatoid arthritis is an autoimmune disease, where the body's immune system attacks its own tissue, leading to joint pain and damage.

Arpimune-O 50 mg Softgel Capsule contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and the production of interleukins (molecules involved in inflammation), which are needed for T cells to activate and attack the body. Additionally, it also reduces pain and inflammation in the joints and slows down the joint damage caused by an overactive immune system.

You are advised to take Arpimune-O 50 mg Softgel Capsule for as long as your doctor has prescribed it, depending on your medical condition. You may experience headaches, vomiting, nausea, high blood pressure, increased hair growth, loss of appetite (feeling unwell and upset stomach), kidney disease, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

To treat your condition effectually, continue taking Arpimune-O 50 mg Softgel Capsule for as long as your doctor has prescribed. To avoid recurring symptoms, do not stop it midway. Before taking Arpimune-O 50 mg Softgel Capsule, inform your doctor if you have any allergies, kidney disease, uncontrolled high blood pressure, or any type of cancer. Arpimune-O 50 mg Softgel Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and any medications you are taking to help rule out any potential unpleasant side effects.

Uses of Arpimune-O 50 mg Softgel Capsule

Treatment of Organ Transplant Rejection: Arpimune-O 50 mg Softgel Capsule is used in the prevention of organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants. It helps prevent organ rejection by suppressing the immune system.
Treatment of Psoriasis: Arpimune-O 50 mg Softgel Capsule is used in the treatment of psoriasis. It helps reduce rapid skin cell growth and inflammation caused by psoriasis.
Treatment of Rheumatoid Arthritis: Arpimune-O 50 mg Softgel Capsule is used in the treatment of rheumatoid arthritis. It helps reduce pain and inflammation in the joints and slows down joint damage.

Directions for Use

  • Arpimune-O 50 mg Softgel Capsule ideally should be given 12 hours apart. It should be taken with water and swallowed whole.
  • Grapefruit and grapefruit juice should be avoided as they can raise ciclosporin levels in the blood. 

Medicinal Benefits

Arpimune-O 50 mg Softgel Capsule is an immunosuppressant medication used to prevent organ transplant rejection. It contains cyclosporine, which suppresses the immune system and prevents your body from rejecting a new organ. It helps reduce rapid skin cell growth and inflammation caused by psoriasis. Additionally, it helps reduce pain and inflammation in the joints and slows down joint damage caused by an overactive immune system in people with rheumatoid arthritis.

How Arpimune-O 50 mg Softgel Capsule Works

Arpimune-O 50 mg Softgel Capsule contains 'cyclosporine,' which works by suppressing the immune system, thereby stopping your body from rejecting a new organ. It also reduces rapid skin cell growth and the production of interleukins (molecules involved in inflammation), which are needed for T cells to activate and attack the body. Additionally, it also reduces pain and inflammation in the joints and slows down the joint damage caused by an overactive immune system.

Storage

Store in a cool and dry place away from sunlight
Side effects of Arpimune-O 50 mg Softgel Capsule
  • Get plenty of fresh air.
  • Take regular sips of a cold drink.
  • Take ginger containing foods like ginger tea and ginger biscuits.
  • Do not take heavy meals at a time, take small and frequent meals.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Increase protein intake by eating protein-rich foods like eggs, fish, lean meat, beans, and nuts to support nail strength.
  • Include biotin-rich foods like salmon, avocado, bananas, almonds, and whole grains in your diet to promote nail health.
  • Boost iron intake by consuming iron-rich foods like spinach, red meat, lentils, and fortified cereals to prevent iron deficiency.
  • Moisturize your nails and cuticles regularly by applying cuticle oil or hand cream multiple times a day.
  • Keep your nails short to reduce the risk of breakage and snagging.
  • Avoid biting your nails, as it can cause significant damage to your nails and cuticles.
  • Consider taking biotin supplements after consulting your doctor, as they may help strengthen brittle nails.

What if I have taken an overdose of Arpimune-O 50 mg Softgel Capsule

Take Arpimune-O 50 mg Softgel Capsule only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. Symptoms of overdose may include headache, drowsiness, vomiting, increased heart rate, liver and kidney toxicity. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take Arpimune-O 50 mg Softgel Capsule if you are allergic to any immunosuppressant medicines or Cyclosporine. Let your doctor know if you have liver or kidney problems, high blood pressure, low magnesium levels, or high potassium levels. Your Arpimune-O 50 mg Softgel Capsule may make you more susceptible to infections. Consult your doctor if you develop any signs of severe conditions, such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising. Before taking Arpimune-O 50 mg Softgel Capsule inform your doctor if you have any type of cancer. Arpimune-O 50 mg Softgel Capsule should not be taken by breastfeeding mothers as it passes into breast milk. Inform your doctor about your health condition and any medications you are taking to help rule out any potential unpleasant side effects.

Drug-Drug Interactions

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CiclosporinCidofovir
Critical
CiclosporinPitavastatin
Critical

Drug-Drug Interactions

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CiclosporinCidofovir
Critical
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Arpimune-O 50 mg Softgel Capsule with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinPitavastatin
Critical
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Coadministration of pitavastatin with Arpimune-O 50 mg Softgel Capsule may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Arpimune-O 50 mg Softgel Capsule is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinBaricitinib
Critical
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Arpimune-O 50 mg Softgel Capsule with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinSimvastatin
Critical
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Combining Arpimune-O 50 mg Softgel Capsule and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Arpimune-O 50 mg Softgel Capsule and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinBosentan
Critical
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Arpimune-O 50 mg Softgel Capsule with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinCeritinib
Severe
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Using ceritinib and Arpimune-O 50 mg Softgel Capsule may increase the blood levels of Arpimune-O 50 mg Softgel Capsule.

How to manage the interaction:
There may be a possibility of interaction between ceritinib and Arpimune-O 50 mg Softgel Capsule, but it can be taken if prescribed by a doctor. However, contact a doctor immediately if you experience any symptoms such as diarrhea or stomach pain, feeling dizzy or tired, having a headache or fits, having a fever or sore throat, or bleeding or bruising. Do not stop using any medications without a doctor's advice.
CiclosporinRilonacept
Severe
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Co-administration of rilonacept with Arpimune-O 50 mg Softgel Capsule can increase the risk of infections.

How to manage the interaction:
Taking rilonacept with Arpimune-O 50 mg Softgel Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinDeferasirox
Severe
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Coadministration of deferasirox with Arpimune-O 50 mg Softgel Capsule may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between deferasirox and Arpimune-O 50 mg Softgel Capsule, they can be taken together if your doctor has prescribed them. However, contact your doctor immediately if experience nausea, vomiting, loss of hunger, increased or decreased urination, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or irregular heart rhythm. Do not stop using any medications without talking to a doctor.
CiclosporinMorphine
Severe
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Co-administration of morphine with Arpimune-O 50 mg Softgel Capsule can increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking morphine with Arpimune-O 50 mg Softgel Capsule together can result in an interaction, it can be taken if a doctor has advised it. However, if you notice any symptoms of dizziness, drowsiness, difficulty concentrating, and impairment in judgment contact a doctor immediately. Do not stop using any medications without consulting a doctor.
CiclosporinHuman immunoglobulin
Severe
How does the drug interact with Arpimune-O 50 mg Softgel Capsule:
Coadministration of Human immunoglobulin with Arpimune-O 50 mg Softgel Capsule, may raise the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Human immunoglobulin and Arpimune-O 50 mg Softgel Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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CYCLOSPORINE-50MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Consuming grapefruit and grapefruit juice while taking Arpimune-O 50 mg Softgel Capsule can increase the effects of Arpimune-O 50 mg Softgel Capsule. Avoid consuming grapefruit and grapefruit juice while taking Arpimune-O 50 mg Softgel Capsule.

Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities, such as 20-30 minutes of walking or swimming, would be helpful.
  • Practising yoga may also help improve joint flexibility and manage pain.
  • Maintain a healthy weight by engaging in regular low-impact exercises and eating a balanced diet.
  • Get adequate sleep, as rest can help reduce inflammation and swelling.
  • Follow heat or cold therapy by applying a cold or hot compress to the joints for 15-20 minutes regularly.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.
  • Eat foods rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
  • Foods containing flavonoids can help reduce inflammation. These include soy, berries, broccoli, grapes, and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

IMMUNOSUPPRESSANTS

Arpimune-O 50 mg Softgel Capsule Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Arpimune-O 50 mg Softgel Capsule. It could lead to increased dizziness and drowsiness.

bannner image

Pregnancy

Caution

It is not known whether Arpimune-O 50 mg Softgel Capsule will harm an unborn baby. Inform your doctor if you are pregnant or plan to become pregnant.

bannner image

Breast Feeding

Unsafe

It is not recommended to take Arpimune-O 50 mg Softgel Capsule while you are breastfeeding. Arpimune-O 50 mg Softgel Capsule passes into breast milk.

bannner image

Driving

Caution

Drive or operate machinery only if you are alert.

bannner image

Liver

Caution

Take Arpimune-O 50 mg Softgel Capsule only if prescribed by the doctor, especially if you are dealing with Liver diseases/conditions, as your doctor may adjust the dose as required.

bannner image

Kidney

Caution

Please consult your doctor if you have kidney impairment before taking Arpimune-O 50 mg Softgel Capsule.

bannner image

Children

Unsafe

Arpimune-O 50 mg Softgel Capsule should not be given to children, as the efficacy and safety have not been established.

Have a query?

FAQs

Arpimune-O 50 mg Softgel Capsule belongs to a group of medications called 'immunosuppressants,' primarily used to prevent organ transplant rejection after liver, kidney, pancreas, lungs, heart, skin, and bone marrow transplants. It is also used to treat symptoms associated with psoriasis and rheumatoid arthritis.

Arpimune-O 50 mg Softgel Capsule acts as an immunosuppressant, which helps reduce pain and inflammation in the joints and prevent joint stiffness, thereby relieving rheumatoid arthritis.

If you miss a dose of Arpimune-O 50 mg Softgel Capsule, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take the scheduled dose. Do not take a double dose to make up for a missed one.

Diarrhoea might be a side-effect of Arpimune-O 50 mg Softgel Capsule. Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea consult your doctor. Do not take anti-diarrheal medicine on your own.

Yes, using Arpimune-O 50 mg Softgel Capsule may cause abnormal hair growth, although it does not affect everybody. Consult your doctor if you have any concerns.

Arpimune-O 50 mg Softgel Capsule is known to decrease the immune system. As a result, it increases your risk of developing certain types of cancer, especially skin cancer. You should reduce your contact with sunlight and UV light by wearing suitable protective clothing. Sunscreen should be used regularly.

No, Arpimune-O 50 mg Softgel Capsule is not a steroid. It is an immunosuppressant.

Yes, cyclosporine can cause weight gain. However, this is not a common side effect, and the amount of weight gain varies from person to person.

Yes, fatigue is a common side effect of cyclosporine. Many people who take cyclosporine report feeling tired or fatigued.

Arpimune-O 50 mg Softgel Capsule is an immunosuppressant medication, meaning it weakens your immune system. This can make you more susceptible to infections and other health problems. Your doctor will likely order regular blood tests to monitor your health and ensure the medication is working effectively.

Arpimune-O 50 mg Softgel Capsule has not been definitively linked to causing cancer. However, discussing any concerns you may have with your doctor is essential. They can provide personalized information about your health situation and why you take cyclosporine.

Common side effects of Arpimune-O 50 mg Softgel Capsule may include headaches, vomiting, nausea, high blood pressure, increased hair growth, loss of appetite (feeling unwell and upset stomach), kidney disease, and diarrhoea. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Arpimune-O 50 mg Softgel Capsule ideally should be given 12 hours apart. The capsules should be taken with water and swallowed whole. Grapefruit and grapefruit juice should be avoided, as they can increase ciclosporin levels in the blood.

The duration of Arpimune-O 50 mg Softgel Capsule treatment varies depending on the underlying condition and individual response.

Always consult with your doctor or pharmacist before starting any new medications or supplements while taking Arpimune-O 50 mg Softgel Capsule. They can help you identify potential interactions and recommend safe alternatives if necessary.

Yes, you can travel while taking cyclosporine. However, it's essential to plan and take necessary precautions. Ensure you have a sufficient supply of your medication, and be aware of any potential customs regulations or travel restrictions.

Generally, moderate exercise is safe while taking Arpimune-O 50 mg Softgel Capsule. However, listening to your body and avoiding overexertion is essential, especially if you have any underlying health conditions.

Excessive alcohol consumption can increase the risk of side effects and interact with cyclosporine. It's best to limit alcohol intake or avoid it altogether while taking this medication.

Your doctor will determine the frequency of your blood tests based on your situation. However, regular monitoring is essential to ensure that cyclosporine works effectively and detects potential side effects.

If you miss a dose of Arpimune-O 50 mg Softgel Capsule, take it as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose.

Some people may experience mood changes or anxiety while taking Arpimune-O 50 mg Softgel Capsule. If you notice any changes in your mental health, it's important to talk to your doctor.

Arpimune-O 50 mg Softgel Capsule occasionally causes blurred vision or eye irritation. If you experience any vision problems, contact your doctor.

Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimize side effects.

Taking more than the recommended dosage does not provide additional benefit and can increase the risk of adverse effects.

Arpimune-O 50 mg Softgel Capsule contains cyclosporine, an immunosuppressant.

Arpimune-O 50 mg Softgel Capsule should not be given to children, as the efficacy and safety have not been established.

Country of origin

India

Manufacturer/Marketer address

463, 4 Th Floor, Rpg House, Dr. Annie Besant Road, Worli, Mumbai €“ 400 030. Maharashtra, India
Other Info - ARP0044

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Apr 22, 2025 | 1:53 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/050715s035,050716s038lbl.pdf
  2. https://www.mayoclinic.org/drugs-supplements/cyclosporine-oral-route/description/drg-20075815
  3. https://medlineplus.gov/druginfo/meds/a601207.html
  4. https://www.drugs.com/disease-interactions/cyclosporine.html
  5. https://www.medicines.org.uk/emc/files/pil.5300.pdf
  6. https://www.webmd.com/drugs/2/drug-5645-9108/cyclosporine-oral/cyclosporine-oral/details
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