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compositionComposition:OFATUMUMAB-1000MG
prescriptionPrescription Medicine

Arzerra 1000mg Solution for Infusion is used to treat Chronic Lymphocytic Leukemia and Multiple sclerosis. It contains Ofatumumab, which works by inhibiting the B-cell lymphocytes that are responsible for the multiplication of cancer cells; this causes shrinkage of tumour cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. Arzerra 1000mg Solution for Infusion may cause certain side effects, such as nausea, vomiting, diarrhoea, fever, decreased platelet count, fatigue, cough, insomnia, injection site reactions and pain at the site of injection.

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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

OFATUMUMAB-1000MG

Consume Type :

Parenteral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Arzerra 1000mg Solution for Infusion

Arzerra 1000mg Solution for Infusion is an anti-cancer medicine used in the treatment of cancer. The intravenous route of this medicine is used in combination with chlorambucil for the treatment of CLL in patients for whom fludarabine-based therapy is considered inappropriate and as an extended treatment in patients who have a partial response after at least two lines of therapy. Chronic lymphocytic leukaemia is a cancer that occurs in the bone marrow and blood. The subcutaneous route of the medicine is used in treating relapsing forms of multiple sclerosis. It is a condition in which the immune system attacks the protective covering of the nerves called myelin.

Arzerra 1000mg Solution for Infusion contains Ofatumumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the B-cell lymphocytes that are responsible for the multiplication of cancer cells.

Arzerra 1000mg Solution for Infusion may cause certain side effects, such as nausea, vomiting, diarrhoea, fever, decreased platelet count, fatigue, cough, insomnia, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Arzerra 1000mg Solution for Infusion. Hence, do not self-administer.

While taking Arzerra 1000mg Solution for Infusion if you experience any allergic reaction, inform your doctor. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, active infections, skin problems, or any allergic conditions. Arzerra 1000mg Solution for Infusion is known to cause fetal B-cell depletion in neonates. Hence, inform your physician if you are pregnant beforehand. Breastfeeding mothers should avoid taking Arzerra 1000mg Solution for Infusion.

Uses of Arzerra 1000mg Solution for Infusion

Arzerra 1000mg Solution for Infusion used in the treatment of Chronic Lymphocytic Leukemia, and Multiple sclerosis. The detailed uses of Arzerra 1000mg Solution for Infusion are as follows:

  • Relapsing forms of multiple sclerosis (MS): Arzerra 1000mg Solution for Infusion is used to treat adults with relapsing forms of MS, including clinically isolated syndrome, relapsing-remitting MS, and active secondary progressive MS. It works by targeting CD20-positive B cells, which play a key role in the autoimmune process that damages the nervous system.
  • Chronic lymphocytic leukemia (CLL): Arzerra 1000mg Solution for Infusion is used in combination with other chemotherapy agents such as chlorambucil, fludarabine, or cyclophosphamide to treat CLL, a cancer of the white blood cells. It helps reduce the number of malignant B cells and slow disease progression.

Key Benefits

Arzerra 1000mg Solution for Infusion contains Ofatumumab, which belongs to the class of CD20-directed cytolytic antibodies. It is used in the treatment of chronic lymphocytic leukaemia. This medicine works by binding to the CD20 antibody and causes lysis of B-cell lymphocytes responsible for the multiplication of cancer cells. This causes shrinkage of tumour cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Arzerra 1000mg Solution for Infusion will be administered by a healthcare professional.
  • Do not self-administer.

How Arzerra 1000mg Solution for Infusion Works

Arzerra 1000mg Solution for Infusion contains Ofatumumab, which belongs to the class of monoclonal antibodies. It works by inhibiting the B-cell lymphocytes that are responsible for the multiplication of cancer cells.
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Alcohol

Consult your doctor

It is unknown whether Arzerra 1000mg Solution for Infusion interacts with alcohol. Consult your doctor.

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Pregnancy

Unsafe

Arzerra 1000mg Solution for Infusion is not recommended for use in pregnancy as it may cause fatal B-lymphocyte depletion in your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Arzerra 1000mg Solution for Infusion.

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Breast Feeding

Caution

If you are breastfeeding, inform your doctor before receiving Arzerra 1000mg Solution for Infusion. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Arzerra 1000mg Solution for Infusion will be administered in the hospital setting. Hence, driving is not recommended.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Arzerra 1000mg Solution for Infusion. Arzerra 1000mg Solution for Infusion may cause increased bilirubin levels and liver failure. Hence, inform your doctor if you observe any symptoms such as fatigue, yellow discolouration of eyes, and dark coloured urine. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Arzerra 1000mg Solution for Infusion. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

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Children

Unsafe

Arzerra 1000mg Solution for Infusion is not recommended for use in children as the safety and efficacy are not established.

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Heart

Consult your doctor

Please consult your doctor before receiving Arzerra 1000mg Solution for Infusion if you have pre-existing heart problems. Your doctor will prescribe Arzerra 1000mg Solution for Infusion if the benefits outweigh the risks.

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Geriatrics

Safe if prescribed

Arzerra 1000mg Solution for Infusion is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Arzerra 1000mg Solution for Infusion

Since Arzerra 1000mg Solution for Infusion is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Have a query?

How Soon It Starts Working

The time required for Arzerra 1000mg Solution for Infusion to start to work: The time required for Arzerra 1000mg Solution for Infusion to show its action is not clinically established. The time for which the effects of Arzerra 1000mg Solution for Infusion last: The duration of action for Arzerra 1000mg Solution for Infusion is not clinically established.

What if you forget to take Arzerra 1000mg Solution for Infusion

As this medicine is administered in a hospital by your healthcare professional, the chances of missing a dose are less. However, if you have any concerns, contact your doctor.

Storage

• Store in a cool and dry place away from sunlight. • Keep Arzerra 1000mg Solution for Infusion out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.

Drug Warnings

Arzerra 1000mg Solution for Infusion should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, active infections, skin problems, or any allergic conditions. Arzerra 1000mg Solution for Infusion may cause remission of active infections, severe skin reactions, tumour lysis syndrome (tumour cells release their contents into the bloodstream), hepatitis B virus reactivation, progressive multifocal leukoencephalopathy, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Arzerra 1000mg Solution for Infusion may cause fetal B-cell depletion in infants. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Arzerra 1000mg Solution for Infusion is not recommended for use in children as the safety and efficacy are not established.

verifiedApollotooltip

Drug-Drug Interactions: No interactions found.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, skin diseases, and infections before receiving Arzerra 1000mg Solution for Infusion.

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

Arzerra 1000mg Solution for Infusion is used to treat chronic lymphocytic leukemia and multiple sclerosis.

Arzerra 1000mg Solution for Infusion contains Ofatumumab, which works by inhibiting the B-cell lymphocytes that are responsible for the multiplication of cancer cells.

Arzerra 1000mg Solution for Infusion may cause reactivation of serious infections, tumour lysis syndrome, hepatitis B virus reactivation, progressive multifocal leukoencephalopathy, and anaphylactic reactions in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

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Author Details

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Country of origin

United kingdom
Other Info - AR77893
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