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compositionComposition:AZATHIOPRINE-50MG
prescriptionPrescription Medicine
ATZ 50 Tablet 15's
ATZ 50 Tablet 15's
ATZ 50 Tablet 15's
ATZ 50 Tablet 15's
ATZ 50 Tablet 15's
ATZ 50 Tablet 15's

ATZ 50 Tablet is an immunosuppressant primarily used to prevent kidney transplant rejection and manage the symptoms of active rheumatoid arthritis (a condition in which the immune system attacks the joints). It suppresses the overactive immune system by inhibiting the proliferation of certain white blood cells, thereby helping to prevent the body from rejecting newly transplanted organs. It also helps relieve joint pain and inflammation and slows disease progression in patients with rheumatoid arthritis.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

AZATHIOPRINE-50MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About ATZ 50 Tablet

ATZ 50 Tablet is used to prevent rejection of kidney transplants. It is also used to treat symptoms of active rheumatoid arthritis (a condition in which the immune system attacks the joints, causing pain and inflammation).

ATZ 50 Tablet contains Azathioprine (an immunosuppressant), which works by calming the immune system. It prevents certain white blood cells (especially T and B cells that attack foreign invaders and defend the body against harmful cells) from proliferating excessively. As a result, ATZ 50 Tablet helps prevent the body from attacking a transplanted organ and reduces inflammation in joint tissues.

Take ATZ 50 Tablet exactly as prescribed by your doctor. Swallow it whole with a glass of water, and do not crush or chew it. ATZ 50 Tablet may cause common side effects, including nausea, headache, vomiting, diarrhoea, dizziness, loss of appetite, increased liver enzymes, reduced resistance to infections, and leukopenia (decreased white blood cell count). Please consult your doctor if these side effects persist or worsen.

Do not take ATZ 50 Tablet if you are allergic to any of its ingredients or if you are pregnant, planning to become pregnant, or breastfeeding. ATZ 50 Tablet should not be given to children, as its safety and efficacy have not been established. Inform your doctor before taking ATZ 50 Tablet if you have any bacterial, fungal, or viral infections, liver or kidney problems, or are taking other immunosuppressant or chemotherapy medications.

Uses of ATZ 50 Tablet

ATZ 50 Tablet is used to prevent kidney transplant rejection and manage rheumatoid arthritis. The detailed uses of ATZ 50 Tablet are as follows:

  • Prevention of organ rejection in kidney transplantation: ATZ 50 Tablet is used along with other medications to help prevent the body from rejecting a transplanted kidney.
  • Treatment of severe active rheumatoid arthritis: ATZ 50 Tablet is also prescribed to reduce signs and symptoms in patients with rheumatoid arthritis that have not improved with standard treatments, such as disease-modifying antirheumatic drugs (DMARDs) or nonsteroidal anti-inflammatory drugs (NSAIDs).

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Directions for Use

  • ATZ 50 Tablet can be taken with or without food. However, if you experience stomach upset, take it with food. Avoid taking it with milk or dairy products, as they may reduce its effectiveness.
  • Your doctor will determine the dosage and timing of this medication based on your medical condition. If taken regularly, it is typically recommended 1-2 times daily.
  • Swallow ATZ 50 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Key Benefits

ATZ 50 Tablet offers the following medicinal benefits:

  • Suppresses the immune system to help prevent rejection of newly transplanted organs, such as kidneys.
  • Relieves joint pain and inflammation while slowing joint damage and disease progression in patients with rheumatoid arthritis.
  • May help control an overactive immune system in various autoimmune conditions (such as ulcerative colitis, lupus, and autoimmune hepatitis)
  • May decrease the need for long-term steroid use in patients with severe inflammatory skin disorders.

How ATZ 50 Tablet Works

ATZ 50 Tablet contains Azathioprine (an immunosuppressant) that works by modulating the immune system. It prevents certain white blood cells (especially T and B cells that attack foreign invaders and defend the body against harmful cells) from proliferating excessively. As a result, ATZ 50 Tablet helps prevent the body from attacking a transplanted organ and reduces inflammation in joint tissues.

Storage

Store in a cool and dry place away from sunlight
Side effects of ATZ 50 Tablet
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

What if I have taken an overdose of ATZ 50 Tablet

Do not take more than the prescribed dose of ATZ 50 Tablet , as it may cause serious side effects. If you suspect you have taken an overdose or notice any unusual symptoms, please consult a doctor immediately.

Drug Warnings

  • Do not take ATZ 50 Tablet if you are allergic to any of its ingredients or other immunosuppressant medications.
  • Let your doctor know before taking ATZ 50 Tablet if you have liver or kidney problems, serious blood disorders, immune system problems, bone marrow problems, serious infections, or immunodeficiency syndrome.
  • Do not take ATZ 50 Tablet if you are pregnant or planning to become pregnant, as it may cause serious congenital disabilities in the unborn baby.
  • Avoid taking ATZ 50 Tablet while breastfeeding, as it can pass into breast milk.
  • ATZ 50 Tablet should not be given to children, as its safety and effectiveness have not been established.
  • ATZ 50 Tablet may cause dizziness and drowsiness, so drive with caution.
  • Using ATZ 50 Tablet for a long time may increase your chance of getting certain types of cancer, such as lymphoma (cancer of the spleen, thymus gland, and bone marrow), leukaemia (blood cancer), and skin cancer.
  • Avoid excessive exposure to sunlight; wear protective clothing; and apply a high-SPF sunscreen while using ATZ 50 Tablet .

Drug-Drug Interactions

verifiedApollotooltip
AzathioprineFebuxostat
Critical
AzathioprineClozapine
Severe

Drug-Drug Interactions

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AzathioprineFebuxostat
Critical
How does the drug interact with ATZ 50 Tablet:
Taking ATZ 50 Tablet and Febuxostat together can increase the blood levels of ATZ 50 Tablet

How to manage the interaction:
Taking ATZ 50 Tablet with Febuxostat is not recommended, but it can be taken together if prescribed by a doctor. However, if you experience any unusual symptoms contact a doctor immediately. Do not stop using any medications without talking to a doctor.
AzathioprineClozapine
Severe
How does the drug interact with ATZ 50 Tablet:
When ATZ 50 Tablet and Clozapine are taken together can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of ATZ 50 Tablet with Clozapine can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you have a fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
AzathioprineCladribine
Severe
How does the drug interact with ATZ 50 Tablet:
The use of cladribine with ATZ 50 Tablet can increase the risk of serious infections.

How to manage the interaction:
Although taking ATZ 50 Tablet and Cladribine together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain during urination, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineMercaptopurine
Severe
How does the drug interact with ATZ 50 Tablet:
The combined use of ATZ 50 Tablet with Mercaptopurine together can increase the risk of side effects.

How to manage the interaction:
Co-administration of ATZ 50 Tablet with Mercaptopurine can possibly result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor immediately, if you experience any symptoms such as bruising or bleeding, fever, chills, sore throat, flu symptoms, mouth sores, black urine, severe stomach pain, jaundice (yellowing of the skin or eyes), or severe nausea, vomiting, or diarrhea. Do not stop using any medications without a doctor's advice.
AzathioprineTofacitinib
Severe
How does the drug interact with ATZ 50 Tablet:
The use of tofacitinib with ATZ 50 Tablet may raise the risk of severe infections.

How to manage the interaction:
Co-administration of ATZ 50 Tablet with Tofacitinib can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
AzathioprineGolimumab
Severe
How does the drug interact with ATZ 50 Tablet:
When ATZ 50 Tablet and Golimumab are taken together, they may raise the risk of severe infections

How to manage the interaction:
There may be a possibility of interaction between ATZ 50 Tablet and Golimumab, but it can be taken if prescribed by a doctor. However, if you have any of these symptoms- fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, blood in phlegm (a thick secretion in the airway during disease and inflammation), losing weight, or pain while peeing, make sure to contact a doctor immediately. Do not stop using any medications without a doctor's advice.
AzathioprineVoclosporin
Severe
How does the drug interact with ATZ 50 Tablet:
Taking ATZ 50 Tablet with Voclosporin may lead to a higher chance of severe infections and certain cancers, such as skin cancer and lymph gland cancer (lymphoma).

How to manage the interaction:
Although taking ATZ 50 Tablet and Voclosporin together can cause an interaction, it can be taken if a doctor has suggested it. However, if you notice any symptoms like fever, chills, sore throat, muscle aches, blood in coughing fluid, red or inflamed skin, or body sores it is recommended to contact a doctor right away. Other symptoms such as weight loss, pain during urination, or difficulty breathing should also be reported promptly. Do not discontinue any medications without consulting a doctor.
AzathioprineEtanercept
Severe
How does the drug interact with ATZ 50 Tablet:
When Etanercept is used with ATZ 50 Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although there is a possible interaction between ATZ 50 Tablet and Etanercept, you can take these medicines together if prescribed by a doctor. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AzathioprineBCG vaccine
Severe
How does the drug interact with ATZ 50 Tablet:
Taking the BCG vaccine with ATZ 50 Tablet can increase the risk of infection.

How to manage the interaction:
Co-administration of ATZ 50 Tablet with BCG vaccine can result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
AzathioprineInfliximab
Severe
How does the drug interact with ATZ 50 Tablet:
Coadministration of ATZ 50 Tablet and Infliximab can increase the risk or severity of developing infections.

How to manage the interaction:
Although taking Infliximab and ATZ 50 Tablet together can cause an interaction, it can be taken if a doctor has suggested it. If you have any symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Healthy diet:

  • Eat foods rich in antioxidants, such as berries, spinach, kidney beans, and dark chocolate.
  • Consume foods containing flavonoids to help reduce inflammation, such as soy, berries, broccoli, grapes, and green tea.
  • Avoid alcohol consumption.

Physical activity and exercise:

  • Maintain a healthy weight by engaging in regular low-impact exercise and eating a healthy diet.
  • Physical activity helps strengthen muscles and relieve joint stiffness. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Practising yoga may also help improve joint flexibility and manage pain.

Rest and recovery:

  • Get adequate sleep, as rest can help reduce inflammation and swelling.
  • Apply cold or hot compresses to the joints for 15-20 minutes regularly to reduce swelling.

Stress management and therapies:

  • De-stress by meditating, reading, taking a warm bubble bath, or listening to soothing music.
  • Acupuncture, massage, and physical therapy may also be helpful.

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

All Substitutes & Brand Comparisons

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking ATZ 50 Tablet . It could lead to increased dizziness and drowsiness.

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Pregnancy

Caution

ATZ 50 Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only under the strict guidance of the doctor, as there is no clinical data available on use in pregnant women.

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Breast Feeding

Caution

It is not recommended to take ATZ 50 Tablet while you are breastfeeding. ATZ 50 Tablet passes into breast milk.

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Driving

Caution

ATZ 50 Tablet may cause dizziness, drowsiness, and tiredness; do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Take ATZ 50 Tablet only as prescribed by your doctor, especially if you are dealing with Liver diseases/conditions, as your doctor may adjust the dose as required.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment before taking ATZ 50 Tablet .

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Children

Unsafe

ATZ 50 Tablet should not be used by children below 18 years of age, as its efficacy and safety have not been established.

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Heart

Consult your doctor

Please consult your physician if you have any heart-related problems before taking ATZ 50 Tablet .

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Geriatrics

Caution

Exercise caution when administering ATZ 50 Tablet to geriatric patients; close monitoring is required.

FAQs

ATZ 50 Tablet is used to prevent kidney transplant rejection. It is also used to treat symptoms of active rheumatoid arthritis (a condition in which the immune system attacks the joints, causing pain and inflammation).

ATZ 50 Tablet causes leukopenia (decreased number of white blood cells) and hence may make you more susceptible to infections. Consult your doctor if you develop any signs of infections such as fever, sore throat, breathlessness, jaundice, unexplained bleeding, or bruising.

ATZ 50 Tablet acts as an immunosuppressant, which helps in reducing inflammation and preventing joint stiffness, thereby providing relief from rheumatoid arthritis.

If you miss a dose of ATZ 50 Tablet , take the missed dose as soon as you remember it. However, if it's almost time for the next dose, do not take a double dose to make up for a missed one.

Diarrhoea might be a side effect of ATZ 50 Tablet . Drink lots of fluids and eat food rich in fibre if you experience diarrhoea. If you find blood in your stools (tarry stools) or experience excess diarrhoea, consult your doctor. Do not take anti-diarrheal medicine on your own.

ATZ 50 Tablet is a Category D pregnancy drug that is not recommended for pregnant women or given only under the strict guidance of the doctor, as there is no clinical data available on use in pregnant women.

ATZ 50 Tablet starts to work gradually. It can take up to 12 weeks of taking the right adjusted dose before you notice any benefits.

If you miss a prescription dose, take it as soon as you recall and resume your regular routine. If you are near the next dose, skip the missing dose and resume your regular schedule. Do not take a double dose to make up for a forgotten dose.

It depends on your individual medical condition and response to the medication. Your doctor will determine the appropriate duration of treatment based on your specific needs.

Taking ATZ 50 Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. As a result, avoid direct sunlight, apply sunscreen (SPF 30 or higher), and wear clothes that shield your arms and legs.

You'll have regular blood tests while taking azathioprine. These tests will ensure that any concerns or problems are found quickly.

ATZ 50 Tablet may have an effect on your liver, kidneys, or bone marrow. Before you begin taking this medication, you will undergo blood tests to assess your liver function, renal function, and blood count. From week one to week eight of your treatment, you will undergo at least one blood test every week.

Yes, taking ATZ 50 Tablet for a long time can increase your risk of developing some types of cancer, including skin cancer. Seek medical attention if you experience any changes in your body.

Using Cyclosporine together with ATZ 50 Tablet may decrease the effects of cyclosporine. Caution is advised if Cyclosporine must be taken with ATZ 50 Tablet . You may need a dose adjustment or a special test if you use both medications.

Alcohol does not affect the way azathioprine works. However, both azathioprine and alcohol can affect your liver. For this reason, limiting or avoiding the consumption of alcohol is recommended.

Common side effects of ATZ 50 Tablet may include nausea, headache, vomiting, diarrhoea, unusual fatigue, dizziness, loss of appetite, increased liver enzymes, lowered resistance to infections, tingling sensation, stomach pain, leukopenia (decreased number of white blood cells), and sore throat. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ATZ0009

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