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Benzz Injection 1's

Benzz Injection 1's

Prescription drug
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Synonym

BENDAMUSTINE HYDROCHLORIDE

Manufacturer/Marketer

Intas Pharmaceuticals Ltd

Consume Type

PARENTERAL

Return Policy

Not Returnable

Expires on or after

Jan-25

About Benzz Injection 1's

Benzz Injection 1's belongs to a class of anti-cancer medicines used in the treatment of Leukemia. Leukemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. This medicine is used in the treatment of Chronic lymphocytic leukemia (CLL) and indolent B-cell non-Hodgkin’s leukemia (NHL) that has progressed during six months of treatment with rituximab or rituximab-containing treatment.

Benzz Injection 1's contains Bendamustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Benzz Injection 1's may cause certain side effects, such as nausea, vomiting, diarrhea, stomach pain, anorexia, decreased weight, constipation, fever, decreased platelet count, fatigue, cough, headache, rash, injection site reactions and pain at the site of injection. If the side effects bother you, inform your doctor. A trained healthcare professional will administer Benzz Injection 1's. Hence, do not self-administer.

Benzz Injection 1's should be avoided if you are allergic to it or any other components present in it. Before receiving this injection, inform your doctor if you have any pre-existing or a history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Benzz Injection 1's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Benzz Injection 1's

Treatment of Non-Hodgkin's disease and Chronic Lymphocytic Leukaemia

Medicinal Benefits

Benzz Injection 1's contains Bendamustine, which belongs to the class of alkylating agents. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells. This medicine is used in the treatment of chronic lymphocytic leukemia and non-Hodgkin’s leukemia.

Directions for Use

A trained healthcare professional will administer Benzz Injection 1's. Hence, do not self-administer. 

Storage

Store in a cool and dry place away from sunlight

Side Effects of Benzz Injection 1's

  • Diarrhoea
  • Back pain
  • Vomiting
  • Stomach pain
  • Cough
  • Bruising or bleeding gums
  • Pain at the site of injection
  • Fever
  • Anorexia
  • Constipation
  • Decreased platelet count
  • Rashes
  • Decreased weight
  • Injection site reactions

Drug Warnings

Benzz Injection 1's should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before receiving this injection, inform your doctor if you have any history of liver/kidney disease, cardiac disorders, cancer, active infections, skin problems, or any allergic conditions. Benzz Injection 1's may cause myelosuppression, active infections, severe skin reactions, tumor lysis syndrome (tumor cells release their contents into the bloodstream), other malignancies, and hypersensitivity reactions in some patients. Hence, careful monitoring should be done during the entire treatment. Benzz Injection 1's may cause embryo-fetal toxicity. Hence, if you are pregnant or planning to become pregnant, inform your doctor beforehand. Before nursing, a breastfeeding mother should ask her oncologist whether this medicine is safe for use or not. Benzz Injection 1's is not recommended for use in children as the safety and efficacy are not established.

Drug Interactions

Drug-Drug Interactions: Benzz Injection 1's may interact with vaccines, CYP1A2 inhibitors (ketoconazole, clopidogrel, ritonavir, imipramine, clozapine), CYP1A2 inducers (Cimetidine, rifampicin, verapamil, phenytoin), monoclonal antibodies ((etanercept, baricitinib, certolizumab, golimumab, infliximab), vaccines and other medicines.

Drug-Food Interactions: Avoid alcohol consumption and smoking.

Drug-Disease Interactions: Inform your doctor if you have kidney or liver disease, skin diseases, and infections before receiving Benzz Injection 1's.

Drug-Drug Interactions Checker List

  • KETOCONAZOLE
  • CLOPIDOGREL
  • RITONAVIR
  • CLOZAPINE
  • CIMETIDINE
  • RIFAMPICIN
  • PHENYTOIN
  • ETANERCEPT
  • GOLIMUMAB
  • INFLIXIMAB
  • BARICITINIB

Habit Forming

No

Diet & Lifestyle Advise

  • After your treatment begins, dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Special Advise

  • A blood test should be performed, such as a liver function test, or renal function test, to check for liver/kidney function.
  • Weekly blood tests should be done during the treatment to check for CBC (Complete blood count).

Disease/Condition Glossary

Indolent B-cell Non-Hodgkin’s Leukemia: Non-Hodgkin’s disease or Non-Hodgkin’s lymphoma is a blood cancer that affects your lymph system. It causes the uncontrollable growth of cancer cells in the lymph nodes. The lymph system is a part of the immune system which protects your body from disease and infections. In indolent B cell Non-Hodgkin’s lymphoma, the cancer cells grow slowly in the B lymphocytes. Symptoms include lymph node swelling, abdominal pain, chest pain, cough, fever, and night sweats.

Chronic Lymphocytic Leukaemia: It is a type of cancer that occurs in the bone marrow and blood. It increases the number of lymphocytes (a type of white blood cell). The symptoms include fever, enlarged liver, bone or joint pain, shortness of breath, weakness, and bleeding from gums or bruises.

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Alcohol

Caution

Limit or avoid consumption of alcohol as it may worsen your condition.

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Pregnancy

Unsafe

Benzz Injection 1's is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Benzz Injection 1's. Use reliable methods of birth control while on treatment with Benzz Injection 1's.

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Breast Feeding

Caution

If you are a nursing mother, inform your doctor before receiving Benzz Injection 1's. You should not breastfeed while on treatment with Benzz Injection 1's.

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Driving

Not applicable

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Benzz Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. Benzz Injection 1's is not recommended for use in patients with severe liver disease.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Benzz Injection 1's. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition. This medicine should be avoided for patients with CrCl <40 ml/min.

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Children

Unsafe

Benzz Injection 1's is not recommended for use in children as the safety and efficacy is not established.

Country of origin

INDIA

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info -

FAQs

Benzz Injection 1's contains Bendamustine, which inhibits the DNA and RNA transcription essential for cancer cell growth.
Benzz Injection 1's may cause reactivation of serious infections, myelosuppression, tumour lysis syndrome, and anaphylactic reactions in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.
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Keep Refrigerated. Do not freeze.

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