Bestofen 400 mg/325 mg Tablet
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Composition :
IBUPROFEN-400MG + PARACETAMOL-325MG
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
About Bestofen 400 mg/325 mg Tablet
Bestofen 400 mg/325 mg Tablet is used to relieve symptoms of muscle pain, arthritis pain, dysmenorrhea (painful periods or menstrual cramps), and dental pain and reduces fever. Pain can be temporary (acute) or long-lasting (chronic).
Bestofen 400 mg/325 mg Tablet contains Ibuprofen and Paracetamol. This medicine works by blocking the effect of prostaglandin, which is responsible for inducing pain and inflammation in the body.
Like all medicines, Bestofen 400 mg/325 mg Tablet may cause side effects, although not everybody gets them. Stop taking this medicine if you experience symptoms like tightness of the chest, breathing difficulties, fever, skin rashes, increased heart rate, or any signs of hypersensitivity.
Inform your doctor if you are allergic to any of the components present in it. It is not recommended for use in children, people with liver disease, heart disease or gastric ulcers/bleeding problems. Avoid consumption of alcohol as it may damage your liver and cause increased side effects on taking this drug.
Uses of Bestofen 400 mg/325 mg Tablet
Bestofen 400 mg/325 mg Tablet is used for the treatment of Pain and Fever. The detailed uses of Bestofen 400 mg/325 mg Tablet are as follows:
- Pain Relief: Bestofen 400 mg/325 mg Tablet is widely used to alleviate mild to moderate pain, such as headaches, toothaches, menstrual cramps, and muscle aches.
- Fever Reduction: Combining Ibuprofen and Paracetamol, Bestofen 400 mg/325 mg Tablet effectively reduces fever caused by infections or other health conditions.
- Anti-inflammatory Benefits: Its anti-inflammatory properties make Bestofen 400 mg/325 mg Tablet valuable for managing inflammation and swelling in conditions like arthritis and other inflammatory diseases.
- Post-Surgical Pain Management: Bestofen 400 mg/325 mg Tablet is often prescribed to manage pain and discomfort following surgical procedures, aiding recovery.
- Managing Chronic Pain: Bestofen 400 mg/325 mg Tablet is sometimes included in chronic pain management plans, particularly for conditions like osteoarthritis or persistent back pain, under a healthcare professional's supervision.
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Directions for Use
- Bestofen 400 mg/325 mg Tablet should be taken with food.
- Follow your doctor's instructions on the dosage and timing of this medication.
- Swallow Bestofen 400 mg/325 mg Tablet as a whole with a glass of water.
- Do not crush, break, or chew it.
Medicinal Benefits
- Bestofen 400 mg/325 mg Tablet is prescribed mainly to treat pain and relieve discomfort caused by conditions like tooth pain, arthritis, period pain and other types of short-term pains.
- Bestofen 400 mg/325 mg Tablet comprises Ibuprofen and Paracetamol, primarily used to treat mild to moderate pain.
- Ibuprofen works by blocking the effect of a chemical known as prostaglandin, which is responsible for inducing pain and inflammation in the body.
- Paracetamol lowers the elevated body temperature and mild pain by inhibiting the synthesis of prostaglandin by promoting heat loss (through sweating) that helps reset the hypothalamic thermostat.
- Paracetamol has the advantage of producing less gastric irritation than other painkillers like aspirin.
How Bestofen 400 mg/325 mg Tablet Works
Bestofen 400 mg/325 mg Tablet is composed of two medicines, namely Ibuprofen and Paracetamol. Ibuprofen is known to have an analgesic and anti-inflammatory effect for reducing mild to moderate pain. It works by blocking the effect of a chemical known as prostaglandin, responsible for inducing pain and inflammation in our body. Paracetamol acts as a mild analgesic and antipyretic (fever reducer). It lowers the elevated body temperature and mild pain by inhibiting the synthesis of a chemical messenger (prostaglandin) and promoting heat loss (through sweating) that helps reset the hypothalamic thermostat. Together, these two medicines help reduce mild to moderate pain in a shorter duration.
Storage
• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Bestofen 400 mg/325 mg Tablet
- Drink water or other clear fluids.
- To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
- Include bland foods like rice, toast, crackers, and rice in your diet.
- Avoid lying down immediately after eating as it may cause indigestion or heartburn.
- Avoid acidic and spicy food as it may cause indigestion.
- Drink fluids: Water, clear broth, or electrolyte-rich beverages.
- Follow a balanced diet, which would be rich in fruits, vegetables, whole grains, lean proteins, and healthy fats.
- Mindfulness: Manage stress with meditation, deep breathing or yoga.
- Stay away from smoke, dust and other irritants.
- Get adequate rest to facilitate recovery.
- Wash hands and avoid close contact, do not share personal items.
Here are the precise steps to cope with diarrhoea caused by medication usage:
- Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
- Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
- Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
- Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
- Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
- Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
- Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
- High levels of liver enzymes need immediate medical attention.
- Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
- Regularly do strengthening exercises to control your cholesterol levels.
- Avoid drinking alcohol as it can affect your liver.
- Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
- Practice yoga and meditation to improve liver functioning and overall health.
What if I have taken an overdose of Bestofen 400 mg/325 mg Tablet
Do not take more than the prescribed dose of Bestofen 400 mg/325 mg Tablet as it may cause severe side effects. If you suspect you have taken overdose, please consult a doctor immediately.
Drug Warnings
- Caution is advised in people with underlying sensitivity to aspirin and other painkillers.
- Bestofen 400 mg/325 mg Tablet is contraindicated in children below 12 years of age, weighing under 40 kg.
- If treatment is required for more than three days, consult your doctor.
- Bestofen 400 mg/325 mg Tablet should be taken with caution if you have an allergy to paracetamol, ibuprofen, aspirin, or other pain killers, highly sensitive reactions (asthma, lip/face/throat swelling), existing stomach ulcer or bleeding associated pain killers, blood clotting disorder, heart diseases (like congestive heart failure), kidney disease, peptic ulcer, another active bleeding (like brain stroke bleeding), and severe dehydration (due to vomiting, diarrhea).
- Liver damage might occur if taken for a longer duration, as it contains paracetamol.
- The skin should be closely monitored as skin allergic reactions like Stevens-Johnson syndrome (SJS), and toxic epidermal necrolysis (TEN) have been reported with Bestofen 400 mg/325 mg Tablet.
- Blood pressure and cardiovascular (heart) status should be monitored closely during the treatment with Bestofen 400 mg/325 mg Tablet, especially in people affected with high blood pressure and who have a history of heart failure.
- Consult your doctor if your pain, inflammation, and fever symptoms do not disappear even after ten days.
Drug-Drug Interactions
Drug-Drug Interactions
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How does the drug interact with Bestofen 400 mg/325 mg Tablet:
Combining Meloxicam and Bestofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.
How to manage the interaction:
Taking Meloxicam and Bestofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Combining Meloxicam and Bestofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.
How to manage the interaction:
Taking Meloxicam and Bestofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
Taking Ketorolac and Bestofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.
How to manage the interaction:
Taking Ketorolac and Bestofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Taking Ketorolac and Bestofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding and ulceration.
How to manage the interaction:
Taking Ketorolac and Bestofen 400 mg/325 mg Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, red or black, dark stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
The combined use of Cabozantinib and Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding.
How to manage the interaction:
using Cabozantinib and Bestofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
The combined use of Cabozantinib and Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding.
How to manage the interaction:
using Cabozantinib and Bestofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, lightheadedness, red or black tarry stools, coughing or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
The combined use of Leflunomide and Bestofen 400 mg/325 mg Tablet can increase the risk of liver damage.
How to manage the interaction:
Co-administration of Leflunomide and Bestofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
The combined use of Leflunomide and Bestofen 400 mg/325 mg Tablet can increase the risk of liver damage.
How to manage the interaction:
Co-administration of Leflunomide and Bestofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark-colored urine, light-colored stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
Coadministration of methotrexate with Bestofen 400 mg/325 mg Tablet can increase the effect and side effects of methotrexate.
How to manage the interaction:
Although there is a possible interaction between methotrexate and Bestofen 400 mg/325 mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
Coadministration of methotrexate with Bestofen 400 mg/325 mg Tablet can increase the effect and side effects of methotrexate.
How to manage the interaction:
Although there is a possible interaction between methotrexate and Bestofen 400 mg/325 mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as mouth sores or ulcers, nausea, vomiting, diarrhea, rash, appetite loss, joint pain or swelling, yellowing of the skin or eyes, dark urine, shortness of breath, a dry cough, pallor, dizziness or fainting, unusual bruising or bleeding, seizures, infection; as well as flu-like signs (fever, chills, body pains, sore throat, and weakening of the muscles), consult a doctor immediately. Do not stop using medications without a doctor's advice.
IbuprofenFenoprofen
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
The combined use of Fenoprofen and Bestofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.
How to manage the interaction:
Taking Fenoprofen and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising,dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
The combined use of Fenoprofen and Bestofen 400 mg/325 mg Tablet can increase the risk of side effects in the gastrointestinal tract such as inflammation, bleeding, ulceration, and rarely, perforation.
How to manage the interaction:
Taking Fenoprofen and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising,dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
The combined use of Enoxaparin and Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding problems.
How to manage the interaction:
Co-administration of Enoxaparin and Bestofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
The combined use of Enoxaparin and Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding problems.
How to manage the interaction:
Co-administration of Enoxaparin and Bestofen 400 mg/325 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenDanaparoid
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
The combined use of Danaparoid and Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding complications.
How to manage the interaction:
Taking Danaparoid and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness during treatment with these medications, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
The combined use of Danaparoid and Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding complications.
How to manage the interaction:
Taking Danaparoid and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness during treatment with these medications, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
IbuprofenAminolevulinic acid
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
The combined use of Aminolevulinic acid and Bestofen 400 mg/325 mg Tablet can increase the risk of severe sunburn.
How to manage the interaction:
Using Aminolevulinic acid and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, they can be taken together if advised by your doctor. After treatment, avoid exposing your eyes and skin to sunlight or bright interior lights for 48 hours. Do not stop using any medications without a doctor's advice.
The combined use of Aminolevulinic acid and Bestofen 400 mg/325 mg Tablet can increase the risk of severe sunburn.
How to manage the interaction:
Using Aminolevulinic acid and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, they can be taken together if advised by your doctor. After treatment, avoid exposing your eyes and skin to sunlight or bright interior lights for 48 hours. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Bestofen 400 mg/325 mg Tablet:
Coadministration of fondaparinux with Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding.
How to manage the interaction:
Taking Fondaparinux and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Coadministration of fondaparinux with Bestofen 400 mg/325 mg Tablet can increase the risk of bleeding.
How to manage the interaction:
Taking Fondaparinux and Bestofen 400 mg/325 mg Tablet together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience bleeding, severe back pain, dizziness, black or red stools, severe headache, weakness, and vomiting contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Diet & Lifestyle Advise
- Include more glucosamine, chondroitin sulphate, vitamin D, and calcium-enriched supplements. Besides this, turmeric and fish oils can help reduce inflammation in the tissue.
- Please do not go for heavy exercise as it may increase your joint pain in arthritis. Instead, you can do low-impact aerobic exercises like walking on the treadmill, bike riding and swimming. You can also strengthen your muscles by lifting light weights.
- In the chronic condition of arthritis or joint pain, try to include fish like salmon, trout, tuna, and sardines. These fishes are enriched with omega-3 fatty acids that minimum level of chemical called cytokines, which ramp up inflammation.
- Your sitting posture is important, especially when you have pain and inflammation. Try to sit as little as possible and only for a short time. Long-term immobility is harmful in conditions like arthritis. Use back support like a rolled-up towel to minimise pain at the back of your spine curve. Keep your knees and hips at a right angle. Besides this, you can also use a footrest if required.
Habit Forming
No
Therapeutic Class
ANALGESIC AND ANTIPYRETIC AGENT
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Alcohol
Unsafe
Taking Bestofen 400 mg/325 mg Tablet with alcohol may cause dizziness or drowsiness. Besides this, it can also damage your liver if taken for a longer duration. So, avoid or limit intake of alcoholic beverages with Bestofen 400 mg/325 mg Tablet.
Pregnancy
Unsafe
Use of Bestofen 400 mg/325 mg Tablet during pregnancy is not recommended as taking this medicine during the last 3 months of pregnancy may harm the unborn baby.
Breast Feeding
Consult your doctor
Take Bestofen 400 mg/325 mg Tablet only if prescribed by your doctor.
Driving
Unsafe
After taking Bestofen 400 mg/325 mg Tablet you may notice dizziness, sleepiness, drowsiness or fatigue.
Liver
Caution
Bestofen 400 mg/325 mg Tablet to be taken with caution, especially if you have a history of liver disease. Dose may have to be adjusted by your doctor.
Kidney
Caution
Bestofen 400 mg/325 mg Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Dose may have to be adjusted by your doctor.
Children
Caution
Bestofen 400 mg/325 mg Tablet is contraindicated in children below 20 kg body weight or younger than 6 years of age. It may cause kidney problems in children and adolescents who are dehydrated.
Heart
Bestofen 400 mg/325 mg Tablet should be avoided in cardiac patients as it can lead to serious cardiavascular risks
Geriatrics
Caution
Bestofen 400 mg/325 mg Tablet should be used under caution in geriatric patients as it can lead to serious side effects.
FAQs
Country of origin
India
Other Info - BE77662
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Reference
- https://www.medicines.org.uk/emc/files/pil.7020.pdf
- https://www.medicines.org.uk/emc/files/pil.1958.pdf
- https://www.ciplamed.com/content/ibugesic-plus-oral-suspension
- https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=&cad=rja&uact=8&ved=2ahUKEwjdjZ6y3fXsAhVD6XMBHfAoDaYQFjAAegQIAxAC&url=https%3A%2F%2Fwww.sanofi.in%2F-%2Fmedia%2FProject%2FOne-Sanofi-Web%2FWebsites%2FAsia-Pacific%2FSanofi-IN%2FHome%2Fscience-and-innovation%2Ffor-healthcare-professionals%2Fproduct-information%2FCombiflam-tablets-PI_08072019.pdf&usg=AOvVaw0eY32ELNXM94knsmS25x-D
