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  3. Bicnu 100 mg Injection 1's

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Bicnu 100 mg Injection 1's, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Bicnu 100 mg Injection is used in the treatment of brain tumors. Bicnu 100 mg Injection is also used in the treatment of multiple myeloma in combination with prednisone, Hodgkin’s Disease, and non-Hodgkin’s Disease in combination with other approved drugs. It contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

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Composition :

CARMUSTINE-100MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Bicnu 100 mg Injection

Bicnu 100 mg Injection is a chemotherapeutic medicine used in the treatment of brain tumors. A tumor is defined as the formation of solid mass tissue due to the abnormal growth of cells. A brain tumor is a serious condition where the cells (cancerous or non-cancerous) grow abnormally in the brain. Bicnu 100 mg Injection is also used in the treatment of multiple myeloma in combination with prednisone, Hodgkin’s Disease, and non-Hodgkin’s Disease in combination with other approved drugs.

Bicnu 100 mg Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Bicnu 100 mg Injection may cause certain side effects, such as nausea, vomiting, headache, pale skin, dizziness, stomach upset, tiredness, loss of balance, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor. Bicnu 100 mg Injection is a parenteral preparation. A trained healthcare professional will administer it. Hence, do not self-administer.

Bicnu 100 mg Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, or respiratory conditions. Bicnu 100 mg Injection may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence, careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment.

Uses of Bicnu 100 mg Injection

Bicnu 100 mg Injection is used in the treatment of certain types of cancer. The detailed uses of Bicnu 100 mg Injection are as follows:<br/>• Palliative treatment of brain tumors: Bicnu 100 mg Injection is used alone or with other drugs for glioblastoma, brainstem glioma, medulloblastoma, astrocytoma, ependymoma, and metastatic brain tumors.<br/>• Management of multiple myeloma: Bicnu 100 mg Injection is used in combination with prednisone to help control disease progression.<br/>• Secondary therapy for Hodgkin’s disease: Bicnu 100 mg Injection is used with other approved drugs in patients who relapse or fail to respond to primary treatment.<br/>• Secondary therapy for non-Hodgkin’s lymphomas: Bicnu 100 mg Injection is combined with other approved drugs in patients with disease recurrence or resistance to initial therapy.<br/>

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Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Bicnu 100 mg Injection will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Bicnu 100 mg Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

How Bicnu 100 mg Injection Works

Bicnu 100 mg Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis. This causes shrinkage of tumor cells and thereby prevents the growth and further spread of cancerous or non-cancerous cells.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Bicnu 100 mg Injection out of the sight and reach of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Bicnu 100 mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
  • Drink adequate water to stay hydrated and support kidney function.
  • Limit sodium intake and avoid processed foods to reduce blood pressure.
  • Consume moderate amounts of high-quality protein from sources like lean meats, fish, and plant-based options.
  • Restrict potassium-rich foods and control phosphorus intake to minimize kidney strain.
  • Include antioxidant-rich foods like fruits, vegetables, and omega-3 fatty acids in your diet.
  • Avoid consuming processed and high-sugar foods that can worsen kidney damage.
  • Limit alcohol consumption and caffeine intake to reduce kidney stress.
  • Quit smoking to significantly lower the risk of kidney damage.
  • Engage in regular exercise to control weight, improve circulation, and lower blood pressure.
  • Consider taking nutritional supplements like omega-3 fatty acids, vitamin D, and antioxidants under medical guidance.
  • Regularly schedule medical checkups to monitor kidney function and adjust your plan as needed.
  • Collaborate with a healthcare provider to develop a personalized diet and lifestyle plan tailored to your needs.

What if I have taken an overdose of Bicnu 100 mg Injection

As Bicnu 100 mg Injection is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

Bicnu 100 mg Injection should be avoided if you are allergic to it or any other components present in it. Let your doctor know about your complete medical history, including current medication, to rule out any side effects/interactions. Before administration, inform your doctor if you have liver/kidney disease, cardiac disorders, or respiratory conditions. Bicnu 100 mg Injection may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence careful monitoring should be done during the entire treatment. This medicine is known to cause fetal harm in pregnant women. Hence, inform your doctor if you are pregnant or are planning to become pregnant. Breastfeeding should be discontinued in nursing mothers during the treatment. It is unknown whether Bicnu 100 mg Injection can be administered in children or not. If administered, close monitoring of the child is needed. Avoid alcohol consumption and smoking as it can lead to serious adverse effects.

Drug-Drug Interactions

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CarmustineLeflunomide
Severe
CarmustineInfliximab
Severe

Drug-Drug Interactions

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CarmustineLeflunomide
Severe
How does the drug interact with Bicnu 100 mg Injection:
Combining Bicnu 100 mg Injection with Leflunomide can increase the risk of negative side effects.

How to manage the interaction:
Co-administration of Bicnu 100 mg Injection with Leflunomide can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - liver problems, complications, infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding - contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
CarmustineInfliximab
Severe
How does the drug interact with Bicnu 100 mg Injection:
When Bicnu 100 mg Injection is taken with Infliximab it can increase the risk or severity of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Infliximab and Bicnu 100 mg Injection, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, losing weight, or experiencing pain or burning while urinating, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
CarmustineClozapine
Severe
How does the drug interact with Bicnu 100 mg Injection:
Combining Bicnu 100 mg Injection with Clozapine can increase the risk of neutropenia.

How to manage the interaction:
Taking Clozapine with Bicnu 100 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience any of these symptoms - severe infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, or pain during urination, contact your doctor immediately. Do not stop using any medications without talking to a doctor.
CarmustineBaricitinib
Severe
How does the drug interact with Bicnu 100 mg Injection:
Coadministration of baricitinib and Bicnu 100 mg Injection can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Bicnu 100 mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
CarmustineCladribine
Severe
How does the drug interact with Bicnu 100 mg Injection:
Taking Cladribine with Bicnu 100 mg Injection can increase the risk of developing serious infections.

How to manage the interaction:
Although there is a possible interaction between Cladribine and Bicnu 100 mg Injection, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CarmustineEtanercept
Severe
How does the drug interact with Bicnu 100 mg Injection:
When Etanercept is used with Bicnu 100 mg Injection, the severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Bicnu 100 mg Injection can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans, and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Bicnu 100 mg Injection Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Bicnu 100 mg Injection to prevent serious adverse effects.

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Pregnancy

Unsafe

Bicnu 100 mg Injection is not recommended for use in pregnancy as it may harm your fetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Bicnu 100 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Caution

Limited data is available on the effect of Bicnu 100 mg Injection on breastfeeding. Hence, if you are a nursing mother, inform your doctor before receiving Bicnu 100 mg Injection. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Unsafe

Bicnu 100 mg Injection will be administered in the hospital setting. Hence, avoid driving.

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Liver

Caution

If you have a pre-existing or a history of liver disease, inform your doctor before receiving Bicnu 100 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before receiving Bicnu 100 mg Injection. A dose adjustment of this medicine or a suitable alternative may be advised based on your condition.

bannner image

Children

Consult your doctor

Limited information is available for the use of Bicnu 100 mg Injection in children. Hence, it will be given to the children only if needed. If administered, careful monitoring of the child is needed.

FAQs

Bicnu 100 mg Injection is used to treat Brain Tumors, Multiple Myeloma, Hodgkin’s Disease and Non-Hodgkin’s Disease.

Bicnu 100 mg Injection contains Carmustine, which belongs to the alkylating agents class. It works by inhibiting the DNA and RNA transcription that is essential for protein synthesis.

Bicnu 100 mg Injection may cause pulmonary toxicity, bone marrow suppression, gastrointestinal toxicity, nephrotoxicity and hepatotoxicity in some patients. Hence, inform your oncologist about your complete medical history, including current medication, to rule out any side effects/interactions.

Bicnu 100 mg Injection is safe if taken at the prescribed dose and duration as advised by your doctor. It is effectively used in the treatment of brain tumours, multiple myeloma, Hodgkin's disease, and non-Hodgkin's disease. However, it may cause some side effects like nausea, vomiting, headache, pale skin, dizziness, stomach upset, tiredness, loss of balance, and pain at the site of injection while taking it.

Bicnu 100 mg Injection is typically classified as an irritant among chemotherapy drugs. However, when given in high doses, it can have stronger effects and be considered a vesicant.

Yes, Bicnu 100 mg Injection works by preventing DNA and RNA transcription which is essential for protein synthesis.

The common side effects of Bicnu 100 mg Injection may include nausea, vomiting, headache, pale skin, dizziness, stomach upset, tiredness, loss of balance, and pain at the site of injection. These side effects do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

A €“ 504, Shapath-4, B/S Hotel Crowne Plaza, Opp. Karnavati Club, S. G. Highway ,Ahmedabad 380 051 Gujarat
Other Info - BIC0045

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://medlineplus.gov/druginfo/meds/a682060.html
  2. https://pubchem.ncbi.nlm.nih.gov/compound/Carmustine
  3. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/carmustine
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/017422s038lbl.pdf

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