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  3. Bleomycin Injection

Bleomycin Injection, Pack of 1 INJECTION
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Bleomycin Injection is used to treat cancers in the head and neck, cervix and external genitalia, lymph node cancer, testicular cancer, and fluid accumulation in the lungs (as a result of cancer). It contains Bleomycin which works by preventing the cancer cells from multiplying and eventually kills them. In some cases, this medicine may cause side effects such as nausea, vomiting, weight loss, loss of appetite, nausea, vomiting, and hair loss. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

BLEOMYCIN-15IU

Manufacturer/Marketer :

Dabur India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Bleomycin Injection

Bleomycin Injection belongs to a group of anti-cancer medicines used to treat certain types of cancer (squamous cell carcinomas) in the head and neck, cervix and external genitalia, lymph node cancer, testicular cancer, and fluid accumulation in the lungs (as a result of cancer). Cancer is a disease in which abnormal cells divide uncontrollably and destroy body tissue. Some of the body's cells begin to divide into all cancer types without stopping and spread into surrounding tissues. Cancer can be localized (benign) or spread to the whole body (metastasized).

Bleomycin Injection contains 'Bleomycin' that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them. Bleomycin Injection is used as chemotherapy for various cancers.

Bleomycin Injection will be administered by a qualified healthcare professional. Kindly do not self-administer. You may experience nausea, vomiting, weight loss, loss of appetite, nausea, vomiting, itching, tenderness, hair loss, and swelling of the fingertips. Most of these side effects of Bleomycin Injection do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

To treat your condition effectually, continue taking Bleomycin Injection for as long as your doctor has prescribed. Do not stop the Bleomycin Injection midway. Talk to your doctor before taking Bleomycin Injection; if you have allergies, heart problems, one marrow depression, kidney disease, liver disease, chickenpox, lung disease, and treatment with chemotherapy or radiation, inform your doctor. Avoid taking Bleomycin Injection if you are pregnant or breastfeeding because this Bleomycin Injection can cause harmful effects on the unborn baby. Both women and men using this Bleomycin Injection should use birth control to avoid pregnancy. Possible side effects of chemotherapy with Bleomycin Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

Uses of Bleomycin Injection

Treatment of Certain types of cancers in the head and neck, cervix and external genitalia, lymph node cancer, testicular cancer, and fluid accumulation in the lungs (as a result of cancer).

Directions for Use

Bleomycin Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Bleomycin Injection belongs to the group of anti-cancer medicines called antimetabolite. It treats certain types of cancer in the head and neck, cervix and external genitalia, lymph node cancer, testicular cancer, and fluid accumulation in the lungs (resulting from cancer). Bleomycin Injection contains bleomycin that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them.

How Bleomycin Injection Works

Bleomycin Injection contains 'Bleomycin' that works by interfering with the growth of genetic material (DNA and RNA) of the cancer cells. This prevents the cancer cells from multiplying and growing and eventually kills them.

Storage

Store in a cool and dry place away from sunlight
Side effects of Bleomycin Injection
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.
  • Inflammation in the lungs needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Intake of cod liver oil can smoothen the functioning of the body process.
  • Rest and refrain from physical activity, and restart after a few days.
  • Avoid smoking as it can worsen the swelling.
  • Practice meditation and yoga to enhance lung efficiency gradually after consulting with your doctor.
  • Weight loss without physical activity needs immediate medical attention.
  • Get a physical examination and blood tests done to identify factors causing weight loss that could be related to metabolism and thyroid function.
  • Avoid smoking and alcohol intake as it can alter your liver condition and increase your weight loss.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of weight loss.
  • Talk to your dietician and consume food which can maintain ideal weight.
  • If you experience abnormal breath sounds as a side effect of a medicine, consult your doctor.
  • Use a humidifier to add moisture in the air and relieve cough.
  • Drink hot tea with lemon, honey and a dash of cinnamon to help relieve cough and fight infection.
  • Take steam to help loosen phlegm.
  • Eat a healthy diet to boost immune system.
  • If you work in a toxic environment, cover your nose and mouth with a mask.
  • If you are breathing rapidly for a while, try to calm your mind and body.
  • For a while, try to breathe through your nose and breathe out through your mouth to control rapid breathing.
  • Take deep breaths and let them flow deep down; don't force yourself; let it out gently by counting from 1-5.
  • Sit in a place that is well-ventilated and has fresh air.
  • Take enough rest and stay pleasant to control rapid breathing.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.

What if I have taken an overdose of Bleomycin Injection

Since Bleomycin Injection is given by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

To treat your condition effectually, continue taking Bleomycin Injection for as long as your doctor has prescribed. Do not stop the Bleomycin Injection midway. Before taking Bleomycin Injection, inform your doctor if you have any infection because Bleomycin Injection may worsen the conditions. Talk to your doctor. If you have any allergy symptoms, metabolic disorders, heart problems, bone marrow depression, kidney disease, liver disease, and treatment with chemotherapy or radiation, inform your doctor. Some patients may experience a sensitivity to light while taking Bleomycin Injection and avoiding prolonged exposure to sunlight is recommended. Consult your doctor if you are pregnant because this Bleomycin Injection can cause harmful effects on the unborn baby. Both women and men using this Bleomycin Injection should use birth control to avoid pregnancy. Using this Bleomycin Injection by either parent may result in birth defects. You should not take this Bleomycin Injection during breastfeeding; inform your doctor if you take Bleomycin Injection. Use the Bleomycin Injection with caution in elderly patients (aged more than 60 years). Inform your doctor if you are being administered oxygen. And also, do not take live vaccines three months after your last chemotherapy.

Drug-Drug Interactions

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BleomycinBaricitinib
Severe
BleomycinFilgrastim
Severe

Drug-Drug Interactions

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BleomycinBaricitinib
Severe
How does the drug interact with Bleomycin Injection Injection:
Combining Bleomycin Injection with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
Although taking Baricitinib and Bleomycin Injection together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
BleomycinFilgrastim
Severe
How does the drug interact with Bleomycin Injection Injection:
Combining Filgrastim with Bleomycin Injection can increase the risk of developing lung disorders.

How to manage the interaction:
There may be a possibility of interaction between Filgrastim and Bleomycin Injection, it can be taken if prescribed by a doctor. Do not stop using any medications without a doctor's advice.
BleomycinCladribine
Severe
How does the drug interact with Bleomycin Injection Injection:
The combined use of Bleomycin Injection and cladribine can increase the risk of infections.

How to manage the interaction:
Although there is a possible interaction between Bleomycin Injection and Cladribine, you can take these medicines together if prescribed by your doctor. If you have any of these symptoms - fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - make sure to contact your doctor right away. Do not stop using any medications without talking to your doctor.
BleomycinLeflunomide
Severe
How does the drug interact with Bleomycin Injection Injection:
The use of leflunomide together with Bleomycin Injection may raise the risk of severe infections.

How to manage the interaction:
Although there is a possible interaction between Bleomycin Injection and Leflunomide, you can take these medicines together if prescribed by your doctor. If you notice any signs of infection like fever, chills, or a sore throat, or if you experience symptoms like diarrhea, muscle aches, or difficulty breathing, contact your doctor immediately. Additionally, if you notice any weight loss or pain or burning while urinating, let your doctor know." Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs in your diet.
  • Get optimal sleep; rest well.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Bleomycin Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

You are recommended to avoid alcohol consumption while taking Bleomycin Injection. It could lead to avoiding unpleasant side-effects.

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Pregnancy

Unsafe

Bleomycin Injection should not be used during pregnancy because it causes harm to the fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Bleomycin Injection and at least six months afterwards. Please discuss with your doctor any concerns regarding this.

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Breast Feeding

Unsafe

Bleomycin Injection should not be taken during breastfeeding as it passes into the breastmilk and may harm the nursing baby. It is contraindicated in breastfeeding mothers.

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Driving

Caution

Bleomycin Injection may affect your reactions and your ability to drive. Possible side effects of chemotherapy with Bleomycin Injection may occur, such as nausea and vomiting. If you are affected by these side effects, you should not drive and/or operate machines that require you to be alert.

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Liver

Caution

If you have had a history or evidence of any liver-related diseases, please consult the doctor before taking Bleomycin Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Kidney

Caution

If you have had a history or evidence of any kidney-related diseases, please consult the doctor before taking Bleomycin Injection. Your doctor will weigh the benefits and potential risks before prescribing them.

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Children

Unsafe

Bleomycin Injection should not be used by children, as the efficacy and safety have not been established.

Have a query?

FAQs

Bleomycin Injection is used to treat cancer of the head and neck, cervix and external genitalia, lymph node cancer, testicular cancer, and fluid accumulation in the lungs (as a result of cancer).

Bleomycin Injection contains 'Bleomycin' is an anti-cancer medication that interferes with the growth of genetic material (DNA and RNA) of the cancer cells. This slows the growth of cancer cells and eventually kills them.

Yes, the Bleomycin Injection commonly affects the hair by making it thin, which further causes hair loss. However, it is not very common. Hair reduction possibly happens due to the estrogen-lowering effect of Bleomycin Injection. These effects are not long-lasting and may return after some time. If it matters to you, then inform your doctor for further advice.

Your doctor will decide the number of treatment cycles and the frequency of Bleomycin Injection to be taken, depending on the type and stage of cancer treated.

Bleomycin Injection should not be taken during pregnancy or if you are trying to become pregnant as Bleomycin Injection can cause birth defects, miscarriages, or harm unborn babies. Avoid becoming pregnant for at least six months after stopping the treatment with Bleomycin Injection.

Bleomycin Injection should be used with caution if you have a medical history of liver or kidney diseases, lung diseases (pulmonary fibrosis), alcohol use, suppressed immune system, blood cell/bone marrow disorders, gastrointestinal diseases (peptic ulcer, ulcerative colitis), and active infections (including chickenpox).

Yes, Bleomycin Injection may cause pulmonary fibrosis, nausea or hair loss as side effects. However, consult your doctor if you notice these side effects.

Bleomycin Injection can cause pulmonary fibrosis due to its effect on lung tissue. The exact mechanism involves the lack of an enzyme in the lungs that metabolizes bleomycin, leading to the accumulation of the drug in lung tissue. This accumulation can cause oxidative damage and inflammation, resulting in scarring (fibrosis) of the lung tissue.

The common side effects of Bleomycin Injection are nausea, vomiting, weight loss, loss of appetite, nausea, vomiting, itching, tenderness, hair loss, and swelling of the fingertips. If any of these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

8/3, Asaf Ali Road, New Delhi-110002
Other Info - BLE0007

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:47 PM IST

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Reference

  1. https://www.southtees.nhs.uk/services/plastic-surgery/vascular-birthmark-clinic/intralesional-bleomycin-injection-treatment/http://mri.cts-mrp.eu/download/NL_H_1792_001_FinalSPC_2of2.pdf
  2. https://www.medicines.org.uk/emc/files/pil.9333.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/50443slr035_blenoxane_lbl.pdf
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