apollo
0

Welcome User

Login/Sign Up

Home
Buy Medicines
Lab Tests
Doctor Consult
Circle Membership
insurance
Blogs
Contact Us
Privacy Policy
Return & Refunds
Need Help
Terms and Conditions
  1. Home
  2. Medicine

  3. BU-Stim 60 mg Injection 10 ml

BU-Stim 60 mg Injection 10 ml, Pack of 1 Injection
Offers on medicine orders
All offers
axis icici
Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

BU-Stim 60 mg Injection 10 ml is used to treat certain cancers. It contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

Read more

Composition :

BUSULFAN-6MG/ML

Manufacturer/Marketer :

Zydus Healthcare Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About BU-Stim 60 mg Injection 10 ml

BU-Stim 60 mg Injection 10 ml belongs to a group of medicines called cytotoxics (also called chemotherapy). Busulfan is used for certain blood problems and cancers of the blood such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis. On the other side, it can be used in bone marrow or stem cell transplant therapy. Blood cancers are cancers that develop in the blood. This can affect the production of blood cells and also how they work.

BU-Stim 60 mg Injection 10 ml contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

BU-Stim 60 mg Injection 10 ml should be administered to patients only in a hospital setting under the supervision of a physician qualified by training and experience to administer cancer chemotherapeutic agents. The most common adverse reactions that occur while on therapy are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection, Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. Most of these side effects of BU-Stim 60 mg Injection 10 ml do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

To treat your condition effectually, continue taking BU-Stim 60 mg Injection 10 ml for as long as your doctor has prescribed. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this BU-Stim 60 mg Injection 10 ml should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using BU-Stim 60 mg Injection 10 ml in patients with infections, hepatic, renal, heart dysfunction and or Lower-than-normal levels of blood count, so inform your doctor about all your medical conditions and medications you are currently taking.

Uses of BU-Stim 60 mg Injection 10 ml

BU-Stim 60 mg Injection 10 ml is used in the treatment of Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis. The detailed uses of BU-Stim 60 mg Injection 10 ml are as follows:

  • Chronic myelogenous leukemia (CML): BU-Stim 60 mg Injection 10 ml is used in combination with other medications to treat CML by destroying cancerous white blood cells and preparing the body for a bone marrow or stem cell transplant.
  • Conditioning regimen before transplantation: BU-Stim 60 mg Injection 10 ml is used as part of a conditioning regimen prior to allogeneic hematopoietic progenitor cell transplantation (HPCT), helping to suppress the immune system and clear existing bone marrow cells to allow successful engraftment of donor cells.
  • Alkylating agent in cancer therapy: BU-Stim 60 mg Injection 10 ml is used as an alkylating agent that interferes with the DNA of cancer cells, preventing them from dividing and leading to cell death. This makes it effective in treating certain blood cancers and in preparing patients for transplant procedures.

Have a query?

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure effective use.
  • The healthcare provider or nurse will administer BU-Stim 60 mg Injection 10 ml.
  • Do not self-administer.

Medicinal Benefits

BU-Stim 60 mg Injection 10 ml contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

How BU-Stim 60 mg Injection 10 ml Works

BU-Stim 60 mg Injection 10 ml contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Storage

• Store in a cool and dry place away from sunlight.• Keep BU-Stim 60 mg Injection 10 ml out of reach and sight of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of BU-Stim 60 mg Injection 10 ml
  • Eat well-cooked food to minimize infection risk.
  • Practice good hand hygiene to prevent infections.
  • Avoid crowds and people with illnesses to reduce exposure.
  • Wear a mask when necessary to lower infection risk.
  • Rest adequately to support your body's healing process.
  • Stay hydrated by drinking plenty of water.
  • Regularly monitor blood cell counts for changes.
  • Seek immediate medical help if symptoms like fever, chills, or fatigue occur.
  • Consult your doctor right away if concerning symptoms arise.
  • Follow your doctor's guidance on managing myelosuppression and infection prevention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Maintaining adequate hydration will help you control your magnesium levels and improve your general health.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.

What if I have taken an overdose of BU-Stim 60 mg Injection 10 ml

As BU-Stim 60 mg Injection 10 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. However, if you think there has been an overdose or experiencing any adverse events, get medical care right away. Overdose of BU-Stim 60 mg Injection 10 ml may cause black, tarry stools, red urine, unusual bruising or bleeding, and unusual tiredness or weakness.

Drug Warnings

Before taking the BU-Stim 60 mg Injection 10 ml, let your doctor know about all your allergic or hypersensitivity reactions to medicines or food. Before taking BU-Stim 60 mg Injection 10 ml, inform your doctor about your medical history and other medications you are currently taking in order to rule out any potential negative effects. BU-Stim 60 mg Injection 10 ml may cause fertility problems in women if they take it. Please discuss this with their doctor before starting treatment. Women of childbearing age should use effective contraception during and up to 3 months after treatment with BU-Stim 60 mg Injection 10 ml. Avoid the consumption of alcoholic beverages. Busulfan may raise your chances of developing other types of cancer. Discuss the risks of receiving busulfan with your doctor. It is recommended not to take you. You have taken Busulfan before, and it did not work.

Drug-Drug Interactions

verifiedApollotooltip
BusulfanThiotepa
Severe
BusulfanDeferiprone
Severe

Drug-Drug Interactions

Login/Sign Up

BusulfanThiotepa
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Combining BU-Stim 60 mg Injection 10 ml with Thiotepa can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Thiotepa and BU-Stim 60 mg Injection 10 ml, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
BusulfanDeferiprone
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Deferiprone with BU-Stim 60 mg Injection 10 ml can increase the risk of developing infections.

How to manage the interaction:
Taking BU-Stim 60 mg Injection 10 ml with Deferiprone together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're having any of these symptoms, like fever, chills, sore throat, or muscle aches, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
BusulfanNatalizumab
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Taking these two medications may raise the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between BU-Stim 60 mg Injection 10 ml and Natalizumab, you can take these medicines together if prescribed by your doctor. It is important to be aware of any symptoms such as infections, neurological problems, fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, weakness on one side of the body, clumsiness, vision problems, or confusion. If you experience any of these symptoms, contact your doctor right away. Do not stop using any medications without talking to your doctor.
BusulfanAdalimumab
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Adalimumab with BU-Stim 60 mg Injection 10 ml may increase the risk of developing infections.

How to manage the interaction:
Although taking BU-Stim 60 mg Injection 10 ml and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, diarrhea, sore throat, muscle aches, or pain while urinating, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
BusulfanGolimumab
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Golimumab with BU-Stim 60 mg Injection 10 ml may increase the risk of developing infections.

How to manage the interaction:
Taking BU-Stim 60 mg Injection 10 ml with Golimumab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, diarrhea, sore throat, muscle aches, difficulty breathing, or burning when you pee, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.
BusulfanMetronidazole
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of BU-Stim 60 mg Injection 10 ml and Metronidazole may increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole and BU-Stim 60 mg Injection 10 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bruising or bleeding, fever, diarrhea, sore throat, muscle aches, shortness of breath, or burning during urination, contact a doctor immediately. Do not discontinue the medication without a doctor's advice.
BusulfanCladribine
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Combining Cladribine with BU-Stim 60 mg Injection 10 ml can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladribine and BU-Stim 60 mg Injection 10 ml, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, and pain or burning urination. Do not stop using any medications without talking to your doctor.
BusulfanLeflunomide
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of leflunomide with BU-Stim 60 mg Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Although there is a possible interaction between BU-Stim 60 mg Injection 10 ml and Leflunomide, you can take these medicines together if prescribed by your doctor. However, if you experience fever, diarrhea, sore throat, muscle aches, body sores, or burning during urination, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
BusulfanClozapine
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of BU-Stim 60 mg Injection 10 ml with Clozapine can increase the risk of developing infection.

How to manage the interaction:
Although there is an interaction between BU-Stim 60 mg Injection 10 ml and Clozapine, it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle pain, or pain while urinating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
BusulfanFilgrastim
Severe
How does the drug interact with BU-Stim 60 mg Injection 10 ml:
Coadministration of Filgrastim with BU-Stim 60 mg Injection 10 ml can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is a possible interaction between Filgrastim and BU-Stim 60 mg Injection 10 ml, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Login/Sign Up

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
bannner image

Alcohol

Caution

Avoid alcohol consumption while on treatment with BU-Stim 60 mg Injection 10 ml.

bannner image

Pregnancy

Unsafe

BU-Stim 60 mg Injection 10 ml should not be used during pregnancy because it can harm your fetus (newborn baby).

bannner image

Breast Feeding

Caution

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period of time after the final medication is taken.

bannner image

Driving

Caution

BU-Stim 60 mg Injection 10 ml may make you feel dizzy or tired. Do not drive or use machines if you feel tired or dizzy.

bannner image

Liver

Caution

This treatment may affect how your liver works. Please inform your doctor before prescribing BU-Stim 60 mg Injection 10 ml if you have liver impairment. Your doctor will weigh the benefits and potential risks before prescribing BU-Stim 60 mg Injection 10 ml.

bannner image

Kidney

Caution

This treatment may affect how your kidneys work. Please inform your doctor before prescribing BU-Stim 60 mg Injection 10 ml if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing BU-Stim 60 mg Injection 10 ml.

bannner image

Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

bannner image

Heart

Exercise caution before using BU-Stim 60 mg Injection 10 ml in case of heart problems. Please consult your doctor if you have any concerns.

bannner image

Geriatrics

Caution

BU-Stim 60 mg Injection 10 ml should be used with caution in elderly patients. Please consult your doctor before use.

FAQs

BU-Stim 60 mg Injection 10 ml is used to treat Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

BU-Stim 60 mg Injection 10 ml contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Suppose you have polycythaemia vera (PV). Busulfan can control your blood count, which helps to reduce the risk of both blood clots and bleeding.

If you have essential thrombocythemia (ET), using busulfan to reduce and control platelet counts minimises the risk of blood clotting, bleeding and developing MF.

It is recommended not to be used in the population who are allergic to Busulfan or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.

Yes, BU-Stim 60 mg Injection 10 ml can cause a severe decrease in the number of blood cells in your bone marrow. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.

With a high dose of Busulfan, women's periods may stop, fertility may be compromised, and menopause may begin early. Please seek medical advice from your doctor if you have any concerns regarding this.

Country of origin

India

Manufacturer/Marketer address

Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481
Other Info - BUS0057

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.mpnvoice.org.uk/wp-content/uploads/2021/03/Drug_Bulsulfan_Sep2020_A5web.pdf
  2. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/busulfan
  3. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/busulfan
  4. https://medlineplus.gov/druginfo/meds/a611033.html
  5. https://www.cancer.org/cancer/types/chronic-myeloid-leukemia/about/what-is-cml.html
  6. https://www.lls.org/myeloproliferative-neoplasms/myelofibrosis

Buy best Neoplastic Disorders products by

whatsapp Floating Button