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compositionComposition:BUSULFAN-2MG
prescription
Prescription Medicine
info
Bucelon 2 Tablet 25's

Bucelon 2 Tablet is used to treat certain cancers. It contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

BUSULFAN-2MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Bucelon 2 Tablet

Bucelon 2 Tablet belongs to a group of medicines called cytotoxics (also called chemotherapy). Busulfan is used for certain blood problems and cancers of the blood such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis. On the other side, it can be used in bone marrow or stem cell transplant therapy. Blood cancers are cancers that develop in the blood. This can affect the production of blood cells and also how they work.

Bucelon 2 Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.

Bucelon 2 Tablet is a prescription-only medicine. Take Bucelon 2 Tablet as prescribed. The most common adverse reactions that occur while on therapy are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection, Symptoms include a change in temperature, aching muscles, headaches, feeling cold and shivery and generally unwell. Most of these side effects of Bucelon 2 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

To treat your condition effectually, continue taking Bucelon 2 Tablet for as long as your doctor has prescribed. It is expected to cause fetal harm when administered to a pregnant woman, so it should not be used in pregnant women. Both women and men using this Bucelon 2 Tablet should use birth control to avoid pregnancy. Discontinue nursing while on therapy, considering the importance of the drug to the mother. Caution should be exercised while using Bucelon 2 Tablet in patients with infections, hepatic, renal, heart dysfunction and or Lower-than-normal levels of blood count, so inform your doctor about all your medical conditions and medications you are currently taking.

Uses of Bucelon 2 Tablet

Bucelon 2 Tablet is used in the treatment of Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis. The detailed uses of Bucelon 2 Tablet are as follows:

  • Chronic myeloid leukemia (CML): Bucelon 2 Tablet is used to treat CML, a type of blood cancer that affects white blood cells. It works by interfering with the DNA of cancer cells, preventing them from multiplying and eventually causing them to die.
  • Bone marrow transplantation preparation: Bucelon 2 Tablet is used as part of a conditioning regimen before hematopoietic progenitor cell transplantation (HPCT). It helps suppress the immune system and clear out existing bone marrow cells to make space for new, healthy stem cells.
  • Polycythemia vera and essential thrombocythemia: Bucelon 2 Tablet is used in some cases to manage these rare blood disorders by reducing the number of blood cells produced in the bone marrow.

Key Benefits

Bucelon 2 Tablet contains Busulfan, which belongs to a group of medicines called cytotoxics (also called chemotherapy). It works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells. Thereby, it treats certain blood problems and cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.

Side effects of Bucelon 2 Tablet
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • High levels of bilirubin in blood leads to yellow discolouration of skin and eyes which is a significant liver issue that needs immediate medical attention.
  • Eating a balanced diet can help manage such side effects and must be taken as a dietician suggests.
  • Exercise regularly to maintain a good metabolism in your body.
  • Avoid alcohol consumption as it can affect liver functioning and worsen if there is a yellow discolouration of the skin and eyes.
  • Prevent toxins from chemicals that can be touched and inhaled. Ensure to manage your medications carefully.
  • Maintain a healthy diet with fruits, whole grains, and vegetables.
  • Include easy-to-digest and antioxidant-rich food in your diet.
  • Drink plenty of water and unsweetened liquids.
  • Limit sugary foods, alcohol, refined carbs and fried foods.

Directions for Use

  • Bucelon 2 Tablet can be taken with or without food.
  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Swallow the tablet as a whole with a glass of water.
  • Do not crush, chew or break it.

How Bucelon 2 Tablet Works

Bucelon 2 Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Bucelon 2 Tablet .

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Pregnancy

Unsafe

Bucelon 2 Tablet should not be used during pregnancy because it can harm your fetus (newborn baby).

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Breast Feeding

Caution

Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for a certain period after taking the final medication.

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Driving

Caution

Bucelon 2 Tablet may make you feel dizzy or tired. Do not drive or use machines if you feel tired or dizzy.

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Liver

Caution

This treatment may affect how your liver works. Please inform your doctor before prescribing Bucelon 2 Tablet if you have liver impairment. Your doctor will weigh the benefits and potential risks before prescribing Bucelon 2 Tablet .

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Kidney

Caution

This treatment may affect how your kidneys work. Please inform your doctor before prescribing Bucelon 2 Tablet if you have kidney impairment. Your doctor will weigh the benefits and potential risks before prescribing Bucelon 2 Tablet .

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Children

Caution

Talk to your care team about the use of this medication in children. Special care may be needed.

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Heart

Caution

If you have a history of heart disease, please inform the doctor before receiving Bucelon 2 Tablet .

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Geriatrics

Caution

Bucelon 2 Tablet should be used with caution in elderly patients, as it may increase the risk of side effects.

What if I have taken an overdose of Bucelon 2 Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Bucelon 2 Tablet may include black, tarry stools, red urine, unusual bruising or bleeding, unusual tiredness or weakness, sore throat, cough, fever, or other signs of infection, nausea, vomiting, diarrhea, sores in the mouth and throat. Seek immediate medical attention if you observe these symptoms or think you might have taken too much. Do this even if there are no signs of discomfort or poisoning.

Diet & Lifestyle Advise

  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Have a query?

How Soon It Starts Working

The time required for Bucelon 2 Tablet to start to work: The time required for Bucelon 2 Tablet to show its action is unknown. The time for which the effects of Bucelon 2 Tablet last: The duration of action for Bucelon 2 Tablet is unknown.

What if you forget to take Bucelon 2 Tablet

If you miss a dose, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep Bucelon 2 Tablet out of reach and sight of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.

Drug Warnings

Before taking the Bucelon 2 Tablet , inform your doctor about all your allergic or hypersensitivity reactions to medicines or food. Before taking Bucelon 2 Tablet , tell your doctor about your medical history and other medications you are currently taking to rule out any potential negative effects. Bucelon 2 Tablet may cause fertility problems in women if they take it. Please discuss this with their doctor before starting treatment. Women of childbearing age should use effective contraception during and up to 3 months after treatment with Bucelon 2 Tablet . Avoid the consumption of alcoholic beverages. Busulfan may raise your chances of developing other types of cancer. Discuss the risks of receiving Busulfan with your doctor. It is recommended not to take you. You have taken Busulfan before, and it did not work.

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions: Bucelon 2 Tablet interacts with immunomodulatory medication (e..g adalimumab, ozanimod), vaccinations (e.g. BCG Vaccine, dengue vaccine, influenza virus vaccine, live), antipsychotic medications (e.g. Clozapine), medication used for the treatment of moderate-to-severe plaque psoriasis (e.g. deucravacitinib) and antirheumatic drug (e.g. leflunomide).

Drug-Food Interactions: Do not drink grapefruit juice or alcoholic beverages while you are being treated with Bucelon 2 Tablet . It can affect the way the medicine works.

Drug-Disease Interactions: Bucelon 2 Tablet may potentially interact with various disease conditions, including infections (bacterial/fungal/protozoal/viral), myelosuppression (Bone Marrow Depression/Low Blood Counts, Fever, Bleeding), severe hepatic and renal impairment.

BusulfanClozapine
Severe
BusulfanCyclophosphamide
Severe

Drug-Drug Interactions

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BusulfanClozapine
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Bucelon 2 Tablet with Clozapine can increase the risk of developing infection.

How to manage the interaction:
Although there is an interaction between Bucelon 2 Tablet and Clozapine, it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle pain, or pain while urinating, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
BusulfanCyclophosphamide
Severe
How does the drug interact with Bucelon 2 Tablet:
Co-administration of Cyclophosphamide with Bucelon 2 Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Bucelon 2 Tablet and Cyclophosphamide, they can be taken together if prescribed by a doctor. However, if you experience any vomiting, diarrhea, mouth sores, or stomach pain, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
BusulfanTioguanine
Severe
How does the drug interact with Bucelon 2 Tablet:
Combining Tioguanine with Bucelon 2 Tablet can increase the likelihood and seriousness of side effects.

How to manage the interaction:
There may be a possibility of interaction between Tioguanine and Bucelon 2 Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
BusulfanThalidomide
Severe
How does the drug interact with Bucelon 2 Tablet:
Taking thalidomide together with Bucelon 2 Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Bucelon 2 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
BusulfanFilgrastim
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Filgrastim with Bucelon 2 Tablet can reduce the effects of Filgrastim.

How to manage the interaction:
Although there is a possible interaction between Filgrastim and Bucelon 2 Tablet, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without talking to your doctor.
BusulfanNatalizumab
Severe
How does the drug interact with Bucelon 2 Tablet:
Taking these two medications may raise the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Bucelon 2 Tablet and Natalizumab, you can take these medicines together if prescribed by your doctor. It is important to be aware of any symptoms such as infections, neurological problems, fever, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, weakness on one side of the body, clumsiness, vision problems, or confusion. If you experience any of these symptoms, contact your doctor right away. Do not stop using any medications without talking to your doctor.
BusulfanNalidixic acid
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Bucelon 2 Tablet with Nalidixic acid can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Bucelon 2 Tablet and Nalidixic acid, you can take these medicines if prescribed by your doctor. Contact your doctor immediately if you notice unusual bruising, stomach discomfort, fever, or weakness. Do not stop using any medications without contacting your doctor.
BusulfanCladribine
Severe
How does the drug interact with Bucelon 2 Tablet:
Combining Cladribine with Bucelon 2 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Cladribine and Bucelon 2 Tablet, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, diarrhea, sore throat, muscle aches, and pain or burning urination. Do not stop using any medications without talking to your doctor.
BusulfanThiotepa
Severe
How does the drug interact with Bucelon 2 Tablet:
Combining Bucelon 2 Tablet with Thiotepa can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Thiotepa and Bucelon 2 Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to your doctor.
BusulfanGolimumab
Severe
How does the drug interact with Bucelon 2 Tablet:
Coadministration of Golimumab with Bucelon 2 Tablet may increase the risk of developing infections.

How to manage the interaction:
Taking Bucelon 2 Tablet with Golimumab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, diarrhea, sore throat, muscle aches, difficulty breathing, or burning when you pee, consult a doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Bucelon 2 Tablet is used to treat Cancers of the blood, such as Chronic myeloid leukaemia, Polycythaemia vera, Thrombocythemia, and Myelofibrosis.
Bucelon 2 Tablet contains Busulfan, which works by interfering with the production of blood cell DNA. Thus, it prevents the cells from growing and maturing, which ultimately leads to the death of these cells.
Suppose you have polycythaemia vera (PV). Busulfan can control your blood count, which helps to reduce the risk of both blood clots and bleeding.
If you have essential thrombocythemia (ET), using busulfan to reduce and control platelet counts minimises the risk of blood clotting, bleeding and developing MF.
It is recommended not to be used in the population who are allergic to Busulfan or any other ingredients in this medication, is a pregnant woman, has too low blood cell counts, or suffers from severe liver or hepatic impairment.
Yes, Bucelon 2 Tablet can cause a severe decrease in the number of blood cells in your bone marrow. Your doctor will monitor peripheral blood cell counts and adjust the dose as appropriate.
With a high dose of Busulfan, women's periods may stop, fertility may be compromised, and menopause may begin early. Please seek medical advice from your doctor if you have any concerns regarding this.
Yes, Bucelon 2 Tablet can cause hair loss as a side effect. Some chemotherapy medications, including Bucelon 2 Tablet can causes this side effect. If you experience excessive hair loss, it's important to discuss this with your doctor.
Yes, Bucelon 2 Tablet is a vesicant (irritant).
The common side effects of Bucelon 2 Tablet are feeling or being sick, anaemia, bruising, bleeding gums or nosebleeds, headaches, tummy pain, constipation, diarrhoea, loss of appetite, liver changes, and increased risk of getting an infection. If any of these side effects persist or worsen, please consult your doctor.

Disclaimer

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Country of origin

INDIA

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - BUC0004

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