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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Buloc 0.25 Injection is used to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures. It contains Bupivacaine, which works by blocking the transmission of pain signals and numbing the area. In some cases, this medicine may cause side effects such as weakness, numbness or tingling, restlessness, drowsiness, headache, nausea and vomiting. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Whats That

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Synonym :

BUPIVACAINE HYDROCHLORIDE

Composition :

BUPIVACAINE-50MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Buloc 0.25 Injection

Buloc 0.25 Injection belongs to the class of 'local anaesthetics', primarily used to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures. It produces local numbness and relieves pain. Buloc 0.25 Injection is given in the form of an epidural injection at the spinal cord to prevent pain during labour and Caesarean section. Pain is a symptom triggered by the nervous system, which causes uncomfortable sensations in the body. Pain may be dull or sharp, and it might be constant or intermittent. The tolerance level of pain might vary from person to person.

Buloc 0.25 Injection contains 'Bupivacaine' that belongs to the group of medicines called 'amide-type anaesthetics'. Bupivacaine is a numbing medication that blocks the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus, Buloc 0.25 Injection helps in numbing the area and provides relief from pain.

Your doctor will decide the dose and duration based on the severity of your pain and response to treatment. Common side effects of Buloc 0.25 Injection include weakness, numbness or tingling, restlessness, drowsiness, tremors or shakiness, headache, blurred vision, irregular heartbeat, chills or shivering, back pain, nausea and vomiting. These side effects are not familiar to everyone and vary individually. If you notice any side effects that are not manageable, please consult your doctor.

Inform your doctor if you have liver, kidney or heart diseases, high or low blood pressure, excess fat in the body and breathing problems before starting Buloc 0.25 Injection. It is essential to let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother before using Buloc 0.25 Injection. Buloc 0.25 Injection causes drowsiness, so do not drive until you are mentally alert. Avoid alcohol to further prevent the worsening of side effects like drowsiness. Buloc 0.25 Injection is not recommended for children less than one year of age.

Uses of Buloc 0.25 Injection

Buloc 0.25 Injection is used to relieve pain. The detailed uses of Buloc 0.25 Injection are as follows:<br/> • Surgical anaesthesia: Effectively numbs the surgical area, helping prevent pain during major or minor operations.<br/> • Labour pain relief: Administered as an epidural injection to ease pain during childbirth without affecting consciousness.<br/> • Dental procedures: Used to numb the mouth, gums, or jaw to ensure a pain-free dental treatment.<br/> • Minor surgeries: Provides localised numbness aiding minor surgeries.<br/>

Directions for Use

  • Buloc 0.25 Injection will be administered by the doctor or nurse in a healthcare setting.
  • Do not self-administer it.

Medicinal Benefits

Buloc 0.25 Injection contains 'Bupivacaine,' a local anaesthetic used to relieve pain and discomfort during labour, surgery, dental treatment and other medical procedures. It works by blocking the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus, Buloc 0.25 Injection helps in numbing the localised area and provides relief from pain. Buloc 0.25 Injection, when injected as an epidural injection at the spinal cord, it prevents pain during labour and Caesarean section.

How Buloc 0.25 Injection Works

Buloc 0.25 Injection contains 'Bupivacaine' that belongs to the group of medicines called 'amide-type anaesthetics'. Bupivacaine is a numbing medication that blocks the transmission of pain signals in the pain area by acting on the nervous system and nerves. This blockage causes the loss of pain sensation and promotes temperature, touch, deep pressure and muscle control. Thus, Buloc 0.25 Injection helps in numbing the area and provides relief from pain.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Buloc 0.25 Injection

Since Buloc 0.25 Injection is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Brief your medical history to the doctor if you have any liver, kidney or heart diseases, high or low blood pressure, excess fat in the body, breathing problems, excess fluid in womb during pregnancy (a condition called hydramnios), a tumour of the ovary, blood poisoning (septicaemia) and fluid around lungs before starting Buloc 0.25 Injection. Let your doctor know if you use any prescription and non-prescription medications, including vitamins and herbal supplements, before starting Buloc 0.25 Injection. Buloc 0.25 Injection may affect the foetus when used by a pregnant mother. It is also released into breast milk during breastfeeding. Please consult your doctor if you are pregnant, planning to conceive or a breastfeeding mother. Buloc 0.25 Injection causes dizziness and drowsiness, so do not drive until you are mentally alert. Avoid alcohol to prevent the worsening of side effects further. Buloc 0.25 Injection is not recommended in children younger than one year of age.

Drug-Drug Interactions

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BupivacaineEtidocaine
Severe
BupivacaineNitric oxide
Severe

Drug-Drug Interactions

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BupivacaineEtidocaine
Severe
How does the drug interact with Buloc 0.25 Injection 20 ml:
Combining Buloc 0.25 Injection 20 ml with etidocaine can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
Although there is a possible interaction between Etidocaine and Buloc 0.25 Injection 20 ml, you can take these medicines together if prescribed by your doctor. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without consulting a doctor.
BupivacaineNitric oxide
Severe
How does the drug interact with Buloc 0.25 Injection 20 ml:
Taking Buloc 0.25 Injection 20 ml and Nitric oxide may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Buloc 0.25 Injection 20 ml and nitric oxide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buloc 0.25 Injection 20 ml:
Taking phenazopyridine with Buloc 0.25 Injection 20 ml can increase the risk of methemoglobinemia,(a blood disorder that affects how red blood cells deliver oxygen throughout your body).

How to manage the interaction:
Although taking Buloc 0.25 Injection 20 ml and phenazopyridine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buloc 0.25 Injection 20 ml:
Taking Buloc 0.25 Injection 20 ml with chloroquine may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Although taking Buloc 0.25 Injection 20 ml and chloroquine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buloc 0.25 Injection 20 ml:
Coadministration of Buloc 0.25 Injection 20 ml and Metoclopramide can increase the risk of methemoglobinemia (a condition in which the iron in the hemoglobin molecule (the red blood pigment) is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although there is a possible interaction between metoclopramide and Buloc 0.25 Injection 20 ml, you can take these medicines together if prescribed by a doctor. However, if you experience symptoms such as grey discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineRopivacaine
Severe
How does the drug interact with Buloc 0.25 Injection 20 ml:
Combining Ropivacaine with Buloc 0.25 Injection 20 ml can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
Although there is a possible interaction between Ropivacaine and Buloc 0.25 Injection 20 ml, you can take these medicines together if prescribed by a doctor. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Buloc 0.25 Injection 20 ml:
Taking Buloc 0.25 Injection 20 ml and Quinine may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking Buloc 0.25 Injection 20 ml and quinine together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
BupivacaineProcaine
Severe
How does the drug interact with Buloc 0.25 Injection 20 ml:
C0-administration of Buloc 0.25 Injection 20 ml with procaine can have additive toxic effects, so using them together increases the risk of serious side effects like methemoglobinemia (a condition that can deprive tissues and organs of oxygen), reactions in the central nervous system (e.g-convulsions, unconsciousness, coma, respiratory arrest), and cardiovascular disorders (e.g- low blood pressure, heart block, irregular heart rhythm).

How to manage the interaction:
Co-administration of Buloc 0.25 Injection 20 ml with Procaine can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience pale, grey, or blue-coloured skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without consulting a doctor.
How does the drug interact with Buloc 0.25 Injection 20 ml:
Taking Buloc 0.25 Injection 20 ml and Trimethoprim may cause methemoglobinemia, (blood disorder that affects how red blood cells deliver oxygen throughout the body).

How to manage the interaction:
Although there is an interaction between Buloc 0.25 Injection 20 ml and trimethoprim, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, headache, dizziness, lightheadedness, fatigue, or shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Buloc 0.25 Injection 20 ml:
Combining Buloc 0.25 Injection 20 ml with Chloroprocaine can increase the risk and severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Chloroprocaine and Buloc 0.25 Injection 20 ml, but it can be taken if prescribed by a doctor.However, if you experience pale, gray, or blue colored skin, headache, rapid heart rate, shortness of breath, lightheadedness, or fatigue, consult a doctor. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
  • Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

LOCAL ANESTHETICS

Buloc 0.25 Injection Substitute

Substitutes safety advice
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Alcohol

Caution

You are recommended to limit or avoid alcohol consumption while taking Buloc 0.25 Injection. Alcohol intake, along with Buloc 0.25 Injection, may cause increased drowsiness.

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Pregnancy

Caution

Buloc 0.25 Injection is a pregnancy category C drug. Please consult your doctor before taking Buloc 0.25 Injection if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Buloc 0.25 Injection is excreted into the breast milk. Please consult your doctor before taking Buloc 0.25 Injection if you are a nursing mother.

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Driving

Unsafe

Buloc 0.25 Injection may make you feel dizzy and drowsy that can affect your ability to drive. Do not drive or operate machinery if you experience these side effects.

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Liver

Caution

Please consult your doctor since Buloc 0.25 Injection should be used with caution in patients with liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor since Buloc 0.25 Injection should be used with caution in patients with kidney impairment/kidney disease.

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Children

Caution

Buloc 0.25 Injection is not recommended in children, unless prescribed by a doctor.

Have a query?

FAQs

Buloc 0.25 Injection is used to induce anaesthesia to reduce pain and discomfort during labour, surgery, dental treatment and other medical procedures.

Buloc 0.25 Injection temporarily blocks the pain signals from the nerves of the painful area to the brain, thereby causing numbness at the affected site and providing relief from pain.

Buloc 0.25 Injection may affect your blood pressure. It is advised to inform your doctor before using Buloc 0.25 Injection if you have high blood pressure during pregnancy or low blood pressure.

You are recommended to consult your doctor to know the after-effects of Buloc 0.25 Injection if you are using an epidural injection of Buloc 0.25 Injection. Some epidural numbing medications may have long-lasting or permanent effects on body functions like bowel movement or bladder control, sexual function and movement in your legs. Please discuss the risks and benefits thoroughly with your doctor.

After using Buloc 0.25 Injection, you may not be able to move your body or the localised part for a certain time. You may feel numbness in the injected area. When you are injected with an epidural, you may not be able to move the lower part of your body for a certain period. It is advised to stay careful during such times to avoid any injuries. After a dental procedure with the usage of Buloc 0.25 Injection, please don't eat, chew gum or drink hot beverages until your mouth is completely free of numbness.

Buloc 0.25 Injection should be used with caution and only under doctor's supervision if you have any liver, kidney or heart diseases, high or low blood pressure, excess fat in the body, breathing problems, excess fluid in womb during pregnancy (a condition called hydramnios), a tumour of the ovary, blood poisoning (septicaemia) and fluid around lungs. Please let your doctor know if you suffer from any medical issues before using Buloc 0.25 Injection.

The common side effects of the Buloc 0.25 Injection may include weakness, numbness or tingling, restlessness, drowsiness, tremors or shakiness, headache, blurred vision, chills or shivering, back pain, nausea, and vomiting. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

Buloc 0.25 Injection contains Bupivacaine, which belongs to the group of medicines called amide-type anesthetics.

Pregnancy Category C means that animal studies have shown potential risks, but there are no good studies in pregnant women. As a result, the medication should only be used during pregnancy if the potential benefits justify the possible risks. Always consult your healthcare provider for personalized guidance.

Buloc 0.25 Injection is not an opioid or narcotic. It belongs to the class of local anesthetics. It primarily reduces pain and discomfort during surgery, dental treatments, and other medical procedures.

Buloc 0.25 Injection is a local anesthetic for numbing a specific area during surgeries or medical procedures. Depending on your condition, pain extent, and overall health, your doctor may combine it with other medications for optimal pain relief. Following your doctor's advice is best to avoid any potential interactions.

Both Ropivacaine and Buloc 0.25 Injection are safe and effective local anesthetics. Your doctor will prescribe the one most suitable for you based on your health status and the severity of your condition.

Early signs of local anesthesia toxicity can include symptoms like perioral numbness (numbness around the mouth), tinnitus (ringing in the ears), agitation, difficulty speaking (dysarthria), and confusion. These may be followed by more severe central nervous system (CNS) derangements such as seizures and coma.

Country of origin

INDIA

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - BUL0022

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