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Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cabotib 40 mg Tablet is used to treat renal cell carcinoma. It contains Cabozantinib as an active ingredient, which works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding. Cabotib 40 mg Tablet may cause side effects such as diarrhoea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, reduced weight, dizziness, and constipation.

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Whats That

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Composition :

CABOZANTINIB-40MG

Manufacturer/Marketer :

Glenmark Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Cabotib 40 mg Tablet

Cabotib 40 mg Tablet is an anti-cancer medicine used in the treatment of renal cell carcinoma. It is a disease in which cancer cells grow uncontrollably in the kidney and form a tumor. Cabotib 40 mg Tablet is used in treating advanced renal cell carcinoma as first-line therapy for advanced renal cell carcinoma in combination with nivolumab and hepatocellular carcinoma in patients who have previously been treated with sorafenib.

Cabotib 40 mg Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Cabotib 40 mg Tablet may cause certain side effects such as diarrhea, decreased appetite, nausea, vomiting, increased blood pressure, muscle cramps, decreased weight, dizziness, and constipation. Inform your doctor if any of these side effects bother you. Cabotib 40 mg Tablet should be taken as advised by your doctor.

Avoid taking Cabotib 40 mg Tablet if you are allergic to it or any other components of it. Before taking Cabotib 40 mg Tablet , inform your doctor if you have/had liver or kidney disease, gastrointestinal disorders, heart problems, blood or bleeding disorders, open or healing wounds, and a history of recent surgery. This medicine is known to cause embryo-fetal toxicity. Hence, it is not recommended for use in pregnancy and breastfeeding.

Uses of Cabotib 40 mg Tablet

Treatment of Renal Cell Carcinoma and Hepatocellular carcinoma

Directions for Use

Take Cabotib 40 mg Tablet as prescribed by the doctor. It should be taken at least one hour before food or 2 hours after food. Swallow it as a whole with a glass of water. Do not crush, break, or chew the medicine. Avoid taking more than the prescribed dose of medicine.

Medicinal Benefits

Cabotib 40 mg Tablet contains Cabozantinib, which is used in treating advanced renal cell carcinoma and liver cancer. It works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells. This helps stop the abnormal growth of cancer cells and thus reduce the further spread to other parts of the body. It also decreases the blood supply to cancer tumors to slow down the growth of the tumor.  In this way, Cabotib 40 mg Tablet stops the body's production, spread and growth of cancerous cells.

How Cabotib 40 mg Tablet Works

Cabotib 40 mg Tablet contains Cabozantinib as an active ingredient, which belongs to the class of medicines known as kinase inhibitors. It works by inhibiting the action of an enzyme (tyrosine kinase) and thus stops the abnormal growth of cancer cells.

Storage

Store in a cool and dry place away from sunlight
Side effects of Cabotib 40 mg Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Maintain your magnesium levels and general health by drinking lots of water.
  • Maintain a diet high in magnesium-rich foods such as spinach, almonds, chickpeas and brown rice.
  • Limit your alcohol intake because too much of it lowers your magnesium levels.
  • Plan blood testing on a regular basis to monitor magnesium levels.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
  • To improve liver health and aid in the removal of toxins, drink lots of water.
  • Alcohol consumption should be reduced or stopped because it can raise ALT levels and impair liver function.
  • Consume a well-rounded diet full of whole grains, fruits, and vegetables. Limit items that strain the liver, such as processed, fatty, or fried foods.
  • You can monitor your ALT levels and make treatment modifications with the support of routine blood tests.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Cabotib 40 mg Tablet

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of Cabotib 40 mg Tablet may include memory loss, confusion, and weight loss. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort.

Drug Warnings

To treat your condition effectually, continue taking Cabotib 40 mg Tablet for the period that your doctor has prescribed. Caution should be exercised if you have/had liver or kidney disease, any planned surgery, heart disease, blood or bleeding disorders, open/healing of wound, or gastrointestinal disorders. Inform your doctor if you are pregnant or are planning to become pregnant before starting the treatment, as this medicine is known to cause embryo-fetal toxicity. Cabotib 40 mg Tablet may cause hypertension, thrombotic events, hemorrhagic events, gastrointestinal perforation and fistula, Reversible Posterior Leukoencephalopathy Syndrome (RPLS), hepatotoxicity, severe diarrhoea, Osteonecrosis of the jaw (ONJ), Palmar-Plantar Erythrodysesthesia (PPE), adrenal insufficiency, impaired wound healing, and proteinuria in some patients. Hence, inform your doctor about your complete medication and medical history before taking Cabotib 40 mg Tablet . Breastfeeding should be discontinued in nursing mothers during the treatment as it passes into breast milk and may cause a possible risk to the infant. Avoid driving and operating machines, as this medicine may cause dizziness. This medicine is not recommended for use in children below 18 years of age as the safety and efficacy are not established.

Drug-Drug Interactions

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CabozantinibAmitriptyline
Severe
CabozantinibNortriptyline
Severe

Drug-Drug Interactions

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CabozantinibAmitriptyline
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Coadministration of Amitriptyline and Cabotib 40 mg Tablet may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Cabotib 40 mg Tablet may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
CabozantinibNortriptyline
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Coadministration of Nortriptyline with Cabotib 40 mg Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Nortriptyline with Cabotib 40 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CabozantinibVoriconazole
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Taking Cabotib 40 mg Tablet with Voriconazole may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Cabotib 40 mg Tablet and Voriconazole together can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience dizziness, shortness of breath, heart palpitations (irregular heartbeat), fever, and pain or burning during urination, consult a doctor. Do not stop using any medications without consulting a doctor.
CabozantinibImipramine
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Taking Imipramine and Cabotib 40 mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Imipramine and Cabotib 40 mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CabozantinibApixaban
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Coadministration of Cabotib 40 mg Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Cabotib 40 mg Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
CabozantinibLevofloxacin
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Taking levofloxacin with Cabotib 40 mg Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Concomitant administration of levofloxacin with Cabotib 40 mg Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
CabozantinibPrimaquine
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Taking primaquine and Cabotib 40 mg Tablet together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Primaquine and Cabotib 40 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult a doctor immediately. Do not stop using any medications without talking to a doctor.
CabozantinibBicalutamide
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Co-administration of Bicalutamide and Cabotib 40 mg Tablet together can increase the chance of a serious abnormal heart rhythm.

How to manage the interaction:
Taking Bicalutamide and Cabotib 40 mg Tablet together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CabozantinibPiroxicam
Severe
How does the drug interact with Cabotib 40 mg Tablet:
Using Cabotib 40 mg Tablet together with piroxicam may increase the risk of bleeding.

How to manage the interaction:
Taking Piroxicam with Cabotib 40 mg Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not stop using any medications without talking to a doctor.
CabozantinibCiprofloxacin
Severe
How does the drug interact with Cabotib 40 mg Tablet:
When Cabotib 40 mg Tablet is taken with Ciprofloxacin, it can increase the chance of a serious abnormal heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Although there is a possible interaction between Ciprofloxacin and Cabotib 40 mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, or rapid heartbeat, consult the doctor immediately. Do not stop any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Physical activity helps strengthen muscles, reduces fatigue, helps in weight loss, and gives strength. Gentle activities like 20-30 minutes of walking or swimming would be helpful.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Getting adequate sleep as resting helps improve your health and mental ability and improves attention.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath, or listening to soothing music.
  • Eat food rich in antioxidants such as berries, spinach, etc.
  • Foods containing fibre help in better digestion. These include beans, peas, lentils, whole grains, nuts, and seeds.
  • Avoid smoking and alcohol consumption.
  • Maintain a healthy weight.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Cabotib 40 mg Tablet Substitute

Substitutes safety advice
  • Cabolong 40 Tablet 30's

    by Others

    256.39per tablet
  • Cazanat 40Mg Tab 30'S

    by Others

    235.07per tablet
  • Cabotres 40 Tablet 30's

    by Others

    451.73per tablet
  • Cabzored 40 mg Tablet 30's

    by Others

    255.00per tablet
  • Cabotriq 40 mg Tablet 30's

    by Others

    300.00per tablet
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Alcohol

Caution

Avoid consumption of alcohol while on treatment with Cabotib 40 mg Tablet as it may cause serious side effects.

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Pregnancy

Unsafe

Cabotib 40 mg Tablet is not recommended for use in pregnancy as it may cause embryo-fetal toxicity and harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before taking Cabotib 40 mg Tablet . You should not become pregnant while you are taking Cabotib 40 mg Tablet for at least four months from the last dose of Cabotib 40 mg Tablet . Using effective birth control methods while on treatment is suggested.

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Breast Feeding

Unsafe

Cabotib 40 mg Tablet should not be taken if you are breastfeeding as it passes into breast milk and may harm your infant. Avoid nursing your child while on treatment with this medicine and for at least four months from the last dose of medicine.

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Driving

Unsafe

In some cases, Cabotib 40 mg Tablet may cause dizziness and visual problems. As a result, do not drive, operate machinery, or engage in any activity that requires clear vision until you are satisfied you can drive while on Cabotib 40 mg Tablet therapy.

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Liver

Caution

If you have a pre-existing or a history of liver problems, tell your doctor before taking this medicine. Cabotib 40 mg Tablet is known to cause hepatotoxicity when taken in combination with nivolumab. Hence, this medicine should be taken cautiously in patients with moderate liver impairment. Your doctor may suggest tests to monitor your liver function while on treatment with this medicine.

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Kidney

Caution

If you have a pre-existing or a history of kidney diseases, inform your doctor before taking Cabotib 40 mg Tablet . Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.

bannner image

Children

Unsafe

Cabotib 40 mg Tablet is not recommended for use in children as the safety and efficacy are not established.

FAQs

Cabotib 40 mg Tablet is used to treat Renal Cell Carcinoma and Hepatocellular carcinoma.

Cabotib 40 mg Tablet contains Cabozantinib, which works by stopping the action of a tyrosine kinase enzyme that causes the multiplication of cancerous cells.

Cabotib 40 mg Tablet may cause thyroid dysfunction, leading to decreased thyroid hormone levels. This effect causes hypothyroidism. So, notify your doctor if you feel extremely tired, colder than others, sudden weight gain/ weight loss, hair loss, or change in voice while using this medicine.

Country of origin

India

Manufacturer/Marketer address

Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai €“ 400 026.
Other Info - CAB0086

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