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  3. Cancrinase 3750 IU Injection 1's

Cancrinase 3750 IU Injection 1's, Pack of 1 Injection
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Cancrinase 3750 IU Injection is used to treat acute lymphoblastic leukaemia (ALL). It is also used with other chemotherapy drugs to treat a specific type of ALL in people who have had allergic reactions to medications similar to Pegaspargase, such as asparaginase. It contains Pegaspargase, an enzyme that breaks down asparagine, an essential building block of proteins without which cells cannot survive. It lowers the asparagine levels in blood cancer cells and stops them from growing.

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Synonym :

PEG L ASPARAGINASE

Composition :

PEGASPARGASE-3750IU

Manufacturer/Marketer :

Mankind Pharma Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Cancrinase 3750 IU Injection

Cancrinase 3750 IU Injection is used in the treatment of acute lymphoblastic leukaemia (ALL). It is also used with other chemotherapy drugs to treat a certain type of ALL in people who have had allergic reactions to medications similar to pegaspargase, such as asparaginase.

Cancrinase 3750 IU Injection contains Pegaspargase, an enzyme that breaks down asparagine, an important building block of proteins without which cells cannot survive. Cancrinase 3750 IU Injection lowers the asparagine levels in blood cancer cells and stops the cancer cells from growing.

In some cases, Cancrinase 3750 IU Injection may cause side effects such as tiredness, dizziness, fever, nausea, vomiting, and diarrhoea. Most of these side effects may not require medical attention and resolve gradually over time. Do not be reluctant to talk with the doctor if any of the side effects persist or worsen.

Do not receive Cancrinase 3750 IU Injection if you are pregnant or breastfeeding. Avoid driving or using machines as Cancrinase 3750 IU Injection may cause drowsiness, tiredness, and confusion. Keep the doctor informed about your health condition and medications to rule out any side effects/interactions.

Uses of Cancrinase 3750 IU Injection

Cancrinase 3750 IU Injection is used in the treatment of Acute Lymphoblastic Leukaemia (ALL). The detailed use of Cancrinase 3750 IU Injection is as follows:<br/>• Treatment of Acute Lymphoblastic Leukaemia (ALL): Cancrinase 3750 IU Injection is used to treat acute lymphoblastic leukemia (ALL) by depleting asparagine, a crucial amino acid for cancer cell growth, ultimately killing or stopping the growth of these cells.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication.• Cancrinase 3750 IU Injection will be administered by a healthcare professional.• Do not self-administer it.

Medicinal Benefits

Cancrinase 3750 IU Injection is used to treat acute lymphoblastic leukaemia (ALL). It is also used with other chemotherapy drugs to treat a certain type of ALL in people who have had allergic reactions to medications similar to pegaspargase, such as asparaginase. Cancrinase 3750 IU Injection contains Pegaspargase, an enzyme that breaks down asparagine, an important building block of proteins without which cells cannot survive. Normal cells can make asparagine for themselves, while some cancer cells cannot. Cancrinase 3750 IU Injection lowers asparagine levels in blood cancer cells and stops the cancer cells from growing.

How Cancrinase 3750 IU Injection Works

Cancrinase 3750 IU Injection contains Pegaspargase, an enzyme that breaks down asparagine, an important building block of proteins without which cells cannot survive. Cancrinase 3750 IU Injection lowers the asparagine levels in blood cancer cells and stops the cancer cells from growing.

Storage

• Store in a cool and dry place away from sunlight.
• Keep Cancrinase 3750 IU Injection out of reach and sight of children.
• Cold chain - To be stored in cold places at 2ºC to 8ºC.

What if I have taken an overdose of Cancrinase 3750 IU Injection

As Cancrinase 3750 IU Injection is a parenteral formulation, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away.

Drug Warnings

Do not use Cancrinase 3750 IU Injection if you are allergic to any of its components if you have severe liver disease, pancreatitis (inflammation of the pancreas) or if you have ever had severe bleeding or blood clots following asparaginase therapy. Inform the doctor if you have had serious allergic reactions to other forms of asparaginase, if you suffer from a bleeding disorder or have had serious blood clots, if you get a fever if you have poor liver function, diabetes, stroke or abdominal pain. Seek medical attention if you experience symptoms of osteonecrosis (pain in the knee, back or hip), liver or pancreas problems (loss of appetite, upper stomach pain, nausea or vomiting, fast heart rate, dark urine, or yellowing of the skin or eyes), low blood cell count (fever, mouth sores, skin sores, sore throat, cough, trouble breathing), blood clot (sudden numbness or weakness, problems with vision or speech, swelling or redness in an arm or leg), high blood sugar (increased thirst, increased urination, dry mouth, fruity breath odour) or if you notice unusual bleeding, easy bruising, or purple/red spot under the skin.

Drug-Drug Interactions

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PegaspargaseClozapine
Severe
PegaspargaseInfliximab
Severe

Drug-Drug Interactions

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PegaspargaseClozapine
Severe
How does the drug interact with Cancrinase 3750 IU Injection:
Co-administration of clozapine with Cancrinase 3750 IU Injection may increase the risk and/or severity of infection.

How to manage the interaction:
Although there is a possible interaction between Cancrinase 3750 IU Injection and Clozapine, you can take these medicines together if prescribed by your doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without first consulting your doctor.
PegaspargaseInfliximab
Severe
How does the drug interact with Cancrinase 3750 IU Injection:
Combining Cancrinase 3750 IU Injection with Infliximab can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Cancrinase 3750 IU Injection with Infliximab can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Avoid smoking and alcohol consumption.
  • Include vegetables and fruits in your diet.
  • Avoid fast food, fried food, processed meats, refined carbs and added sugar.
  • Get optimal sleep; rest well.
  • Drink enough water and eat fibre-rich foods, vegetables and fruits.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

Cancrinase 3750 IU Injection Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Caution

Please consult your doctor before consuming alcohol while on treatment with Cancrinase 3750 IU Injection as it may increase the risk of side effects such as liver damage.

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Pregnancy

Caution

Pegaspargase belongs to pregnancy category C. The effects of Cancrinase 3750 IU Injection during pregnancy have not been studied. If you are pregnant, planning for pregnancy or think you may be pregnant, talk to the doctor for advice.

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Breast Feeding

Unsafe

It is not known if Pegaspargase passes into breast milk. As a precautionary measure, breastfeeding should be discontinued during treatment and should not be re-started until after treatment with Cancrinase 3750 IU Injection has been discontinued.

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Driving

Caution

Do not drive or operate machinery as Cancrinase 3750 IU Injection may cause tiredness, confusion, and drowsiness.

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Liver

Caution

Cancrinase 3750 IU Injection is not recommended if you have severe liver disease. If you have a history of liver disease, inform your doctor before receiving Cancrinase 3750 IU Injection.

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Kidney

Consult your doctor

If you have a history of kidney disease, inform your doctor before receiving Cancrinase 3750 IU Injection.

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Children

Safe if prescribed

Cancrinase 3750 IU Injection is safe for use in children if prescribed by the doctor.

Have a query?

FAQs

Cancrinase 3750 IU Injection is used to treat Acute lymphoblastic leukaemia (ALL).

Cancrinase 3750 IU Injection works by killing or stopping the growth of cancer cells.

If anticoagulants are used at the same time as Cancrinase 3750 IU Injection, there may be a higher risk of bleeding disorders. Therefore, consult the doctor if you are taking anticoagulant/blood thinner medicines.

Oral contraceptive is not an effective method of contraception whilst on treatment with Cancrinase 3750 IU Injection. Ask your doctor about the best contraceptive to use.

Cancrinase 3750 IU Injection may cause osteonecrosis (bone damage), especially when taken concomitantly with glucocorticoids. If you experience any new bone pain, like pain in the hip, back or knee, inform the doctor as soon as possible.

Consult the doctor if you are undergoing immunisation with live vaccines within 3 months of completing the treatment, as it may increase the risk of severe infections.

Cancrinase 3750 IU Injection can lead to fluctuations in clotting factors and may increase the risk of bleeding and/or clotting. If you notice unusual bleeding or bruising, consult the doctor.

Country of origin

India

Manufacturer/Marketer address

208, Okhla Industrial Estate, Phase Iii, New Delhi -.
Other Info - CAN0741

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10824.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/103411s5126lbl.pdf
  3. https://medlineplus.gov/druginfo/meds/a695031.html
  4. https://www.drugs.com/mtm/pegaspargase.html

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