Canrib 150 mg Tablet 60's
MRP ₹12938
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About Canrib 150 mg Tablet 60's
Canrib 150 mg Tablet 60's is an 'anti-cancer' drug used to treat various cancers, including ovarian, breast, pancreatic, and prostate. Cancer is a condition where cells in a specific body part grow and reproduce uncontrollably. The cancerous cells can attack and destroy surrounding healthy tissue, including organs.
Canrib 150 mg Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.
Use this medicine as directed by your doctor. You may sometimes experience shortness of breath (dyspnoea), feeling very tired, pale skin or fast heartbeat, anaemia, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Most of these side effects may gradually resolve over time. However, if the side effects persist or worsen, consult your doctor.
To treat your condition effectually, continue taking Canrib 150 mg Tablet 60's for as long as your doctor has prescribed. Do not stop using the Canrib 150 mg Tablet 60's midway. Talk to your doctor before taking Canrib 150 mg Tablet 60's if you have severe allergic reactions to Canrib 150 mg Tablet 60's or other medicines or suffer from severe infections, renal dysfunction, hepatic disorders and blood cell counts are too low. Avoid taking Canrib 150 mg Tablet 60's if you are pregnant or breastfeeding because this Canrib 150 mg Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Canrib 150 mg Tablet 60's should use birth control to avoid pregnancy. While on Canrib 150 mg Tablet 60's treatment, you should avoid eating grapefruit, Seville oranges or consuming grapefruit juice since it can affect how the medicine works.
Uses of Canrib 150 mg Tablet 60's
Canrib 150 mg Tablet 60's is used in the treatment of Ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. The detailed uses of Canrib 150 mg Tablet 60's are as follows:
- Ovarian Cancer: Canrib 150 mg Tablet 60's helps in maintenance treatment for advanced epithelial ovarian, fallopian tube, or primary peritoneal cancer after response to platinum-based chemotherapy and especially effective in patients with BRCA mutations or homologous recombination deficiency (HRD).
- Breast Cancer: Canrib 150 mg Tablet 60's is used for HER2-negative, BRCA-mutated metastatic or high-risk early breast cancer and used after chemotherapy and sometimes endocrine therapy.
- Pancreatic Cancer: Canrib 150 mg Tablet 60's helps in maintenance treatment for germline BRCA-mutated metastatic pancreatic cancer that hasn’t progressed after platinum-based chemotherapy.
- Prostate Cancer: Canrib 150 mg Tablet 60's is for BRCA-mutated metastatic castration-resistant prostate cancer, often after prior hormonal therapy.
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Directions for Use
- Canrib 150 mg Tablet 60's can be taken with or without food as prescribed by your doctor.
- It is usually taken twice a day in the morning and evening, or as prescribed by your doctor.
- Swallow the medicine as a whole with a glass of water.
- Do not break, crush or chew Canrib 150 mg Tablet 60's.
Medicinal Benefits
Canrib 150 mg Tablet 60's belongs to a group of medicines known as 'anti-cancer' drugs used to treat various cancers, including Ovarian, breast, pancreatic, and prostate. Canrib 150 mg Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP (polyadenosine 5’-diphosphoribose polymerase) is a protein that helps damaged cells repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.
How Canrib 150 mg Tablet 60's Works
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- Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
- Divide your daily food intake into smaller, more frequent meals to reduce nausea.
- Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
- Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
- Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
- Use ginger (tea, ale, or candies) to help relieve nausea.
- Get adequate rest and also avoid strenuous activities that can worsen nausea.
- Talk to your doctor about taking anti-nausea medication if your nausea is severe.
- Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
- Rest well; get enough sleep.
- Eat a balanced diet and drink enough water.
- Manage stress with yoga and meditation.
- Limit alcohol and caffeine.
- Physical activities like walking or jogging might help boost energy and make you feel less tired.
- Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
- Consume vitamin C-rich foods as they aid iron absorption.
- Limit tea, cocoa, and coffee as these can slow iron absorption.
- Exercise regularly; however, do not overdo it.
- Preventing Vomiting (Before it Happens)
- Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
- Having a small meal before taking your medication can help reduce nausea and vomiting.
- Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
- Managing Vomiting (If it Happens)
- Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
- What to Do if Vomiting Persists
- Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
- Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
- Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
- Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
- Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
- Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
- Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
- Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
- Hydrate your body: Drink enough water to prevent dehydration and headaches.
- Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
- Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
- Take rest: lie down in a quiet, dark environment.
- Cold or warm compresses can help reduce tension.
- Stay Upright: Maintain good posture to keep symptoms from getting worse.
- To treat headaches naturally, try acupuncture or massage therapy.
- Over-the-counter pain relievers include acetaminophen and ibuprofen.
- Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
- Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
- Frequent Headaches: If you get reoccurring headaches, consult your doctor.
- Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
- Regularly brush and floss your teeth.
- Rinse your mouth with water and baking soda a solution to neutralize acid in the mouth. This makes your food taste as it should.
- Drink plenty of water or non-caffeinated drinks to prevent dry mouth which may lead to altered taste.
- Try ginger, peppermint, fruit or green teas, lemonade, ginger ale or fruit juice to help mask unpleasant tastes.
- Try sucking on sugar-free ice pops or ice cubes to prevent dry mouth.
What if I have taken an overdose of Canrib 150 mg Tablet 60's
Drug Warnings
Always take this medicine exactly as your doctor or healthcare professional has told you. To treat your condition effectually, continue taking Canrib 150 mg Tablet 60's for as long as your doctor has prescribed. Do not stop Canrib 150 mg Tablet 60's midway. Talk to your doctor before taking Canrib 150 mg Tablet 60's if you have severe allergic reactions to Canrib 150 mg Tablet 60's or other medicines or suffer from any medical illness. Avoid taking Canrib 150 mg Tablet 60's if you are pregnant or breastfeeding because this Canrib 150 mg Tablet 60's can cause harmful effects on the unborn baby. Both women and men using this Canrib 150 mg Tablet 60's should use birth control to avoid pregnancy. Do not start Canrib 150 mg Tablet 60's unless patients have recovered from haematological damage induced by previous chemotherapy (Grade 1). Check full blood count for cytopenia at baseline and monthly afterwards for clinically significant changes during treatment. For persistent haematological toxicity, discontinue Canrib 150 mg Tablet 60's and monitor blood count weekly until recovery. Do not receive any immunization or vaccination without your doctor's approval while taking the Canrib 150 mg Tablet 60's.
Drug-Drug Interactions
Drug-Drug Interactions
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Combining Cladribine with Canrib 150 mg Tablet can increase the risk of developing serious infections.
How to manage the interaction:
Co-administration of Canrib 150 mg Tablet with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Taking Clarithromycin and Canrib 150 mg Tablet can increase the blood levels of Canrib 150 mg Tablet. This can increase the risk and/or severity of side effects.
How to manage the interaction:
Combining Clarithromycin and Canrib 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
Using Dronedarone and Canrib 150 mg Tablet can increase the blood levels of Canrib 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.
How to manage the interaction:
Combining Dronedarone and Canrib 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
Co-administration of Dexamethasone together with Canrib 150 mg Tablet can reduce the blood levels of Canrib 150 mg Tablet.
How to manage the interaction:
Although taking Canrib 150 mg Tablet and Dexamethasone together can evidently cause an interaction, it can be taken if a doctor has suggested it. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without talking to a doctor.
Using Conivaptan and Canrib 150 mg Tablet can increase the blood levels of Canrib 150 mg Tablet.This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.
How to manage the interaction:
Combining Conivaptan and Canrib 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
Fluconazole may increase the blood levels of Canrib 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low blood cell count.
How to manage the interaction:
Although there is a possible interaction, fluconazole can be taken with Canrib 150 mg Tablet if prescribed by the doctor. Consult the doctor if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination.
Using Certolizumab together with Canrib 150 mg Tablet may increase the risk of infections.
How to manage the interaction:
Combining Certolizumab and Canrib 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
Using Darunavir and Canrib 150 mg Tablet can increase the blood levels of Canrib 150 mg Tablet. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.
How to manage the interaction:
Combining Darunavir and Canrib 150 mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
When Canrib 150 mg Tablet is taken with Fosaprepitant, can increase the levels of Canrib 150 mg Tablet in the body. This can increase the risk or severity of side effects.
How to manage the interaction:
Taking Canrib 150 mg Tablet with Fosaprepitant together can result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, it's a good idea to call a doctor right away. Do not discontinue any medications without consulting a doctor.
When Canrib 150 mg Tablet and Clozapine are taken together, can increase the risk of neutropenia (low white blood count).
How to manage the interaction:
Taking Canrib 150 mg Tablet with Clozapine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you're having any of these symptoms - like infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain or burning during urination - it's important to contact a doctor right away. Do not discontinue any medications without consulting a doctor.
Drug-Food Interactions
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Diet & Lifestyle Advise
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Performing yoga may also help in improving both physical and mental health.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Eat a healthy diet and exercise regularly to maintain proper weight.
- Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
- Get optimal sleep; rest well.
- Avoid smoking and alcohol consumption.
- Avoid fast, fried, processed meats, refined carbs and added sugars.
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Alcohol
Caution
Avoid alcohol consumption while on treatment with Canrib 150 mg Tablet 60's.
Pregnancy
Unsafe
Canrib 150 mg Tablet 60's should not be used during pregnancy because it can harm your fetus (newborn baby). Both women of childbearing potential and men must use an effective contraception method while taking Canrib 150 mg Tablet 60's and at least for six months later treatment. Your doctor will weigh the benefits and risks before prescribing this medicine.
Breast Feeding
Unsafe
Do not breastfeed during this treatment because the medicine may pass into your milk. Doctors normally advise against breastfeeding throughout this treatment and for one month after the final medication is taken.
Driving
Caution
Canrib 150 mg Tablet 60's may affect your reactions and your ability to drive. Do not drive and/or operate machines that require your alertness.
Liver
Caution
In patients with mild or moderate liver impairment, there is no need to alter the initial dose. There is no information available on patients with severe liver impairment.
Kidney
Caution
In patients with mild or moderate kidney impairment, there is no need to alter the initial dose. There is no information available on patients with severe kidney impairment.
Children
Caution
The safety and effectiveness of Canrib 150 mg Tablet 60's in pediatric patients have not been established.
Heart
Please consult your doctor before receiving Canrib 150 mg Tablet 60's if you have pre-existing heart problems. Your doctor will prescribe Canrib 150 mg Tablet 60's if the benefits outweigh the risks.
Geriatrics
Consult your doctor
Please consult a doctor before administering Canrib 150 mg Tablet 60's to geriatric patients. Your doctor will prescribe Canrib 150 mg Tablet 60's if the benefits outweigh the risks.
FAQs
Canrib 150 mg Tablet 60's is used to treat ovarian, breast, pancreatic, and prostate cancers.
Canrib 150 mg Tablet 60's contains Olaparib, a targeted drug called a PARP inhibitor. PARP is a protein that helps damaged cells to repair themselves. Olaparib stops PARP working. Some cancer cells rely on PARP to keep their DNA healthy. So, the cancer cells die when Olaparib stops PARP from repairing DNA damage.
If you are allergic to Olaparib or any other ingredients in this medication, are breastfeeding, or have too low blood cell counts, you should not use Canrib 150 mg Tablet 60's.
Yes, Canrib 150 mg Tablet 60's can cause low neutrophils levels, a type of white blood cells that help fight infections. If your white blood cells become low, you can be at higher risk for infections. Tell your doctor if you develop a fever or have an infection.
Do not have immunizations/vaccinations without talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Canrib 150 mg Tablet 60's is not a traditional chemotherapy pill. It's a targeted therapy, also known as a PARP inhibitor, which works differently from chemotherapy.
When taking Canrib 150 mg Tablet 60's, avoid or limit foods high in grapefruit or grapefruit juice, as these can interact with the medication. Additionally, consult your doctor or pharmacist for personalized dietary advice.
The duration of Canrib 150 mg Tablet 60's treatment can vary depending on the type of cancer being treated and the patient's response to the medication. Generally, Canrib 150 mg Tablet 60's is taken until disease progression, unacceptable toxicity, or completion of a specified treatment period. Therefore, follow your doctor's instructions carefully.
Before taking Canrib 150 mg Tablet 60's, inform your doctor about all your medical conditions, sensitivities, and medications. Also, mention if you're pregnant, planning to become pregnant, or breastfeeding. This will ensure safe use and help avoid any potential interactions.
Canrib 150 mg Tablet 60's can interact with other medications, so do not use any other medications unless your doctor advises. Your doctor will check for potential interactions and advise you on how to take them safely with Canrib 150 mg Tablet 60's.
No, Canrib 150 mg Tablet 60's is not recommended for use during pregnancy and breastfeeding, and it causes unwanted side effects. However, please consult your doctor if you have any concerns.
The common side effects of Canrib 150 mg Tablet 60's are feeling very tired, pale skin, feeling sick (nausea), being sick (vomiting), indigestion or heartburn (dyspepsia), loss of appetite, headache, changes in taste of foods (dysgeusia), feeling dizzy, cough and diarrhoea. Please consult your doctor if any of these side effects persist or worsen.
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Reference
- https://www.myeloma.org.uk/wp-content/uploads/2023/04/Myeloma-UK-Panobinostat-Treatment-Guide.pdf
- https://www.lynparza.com/
- https://medlineplus.gov/druginfo/meds/a614060.html#:~:text=Olaparib%20is%20used%20alone%20or,tissue%20that%20lines%20the%20abdomen)
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208558s001lbl.pdf
- https://www.medicines.org.uk/emc/product/9204/pil#gref
- https://reference.medscape.com/drug/lynparza-olaparib-999934
- https://www.medicines.org.uk/emc/files/pil.9204.pdf
- https://www.lynparzahcp.com/
- https://www.cancerresearchuk.org/about-cancer/treatment/drugs/olaparib-lynparza#:~:text=Olaparib%20stops%20PARP%20working.&text=healthy.,damage%2C%20the%20cancer%20cells%20die.
- https://www.lynparza.com/what-is-lynparza.html
- https://www.drugs.com/drug-interactions/olaparib-index.html?filter=3
