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  3. Capbrusam 100 mg Capsule 60's

Capbrusam 100 mg Capsule 60's, Pack of 1 Capsule
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Capbrusam 100 mg Capsule 60's is used to treat Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL). It contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

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Composition :

ACALABRUTINIB-100MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Capbrusam 100 mg Capsule 60's

Capbrusam 100 mg Capsule 60's is a tyrosine kinase inhibitor or cancer growth inhibitor that is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy (cancer), as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Cancer is caused by a genetic mutation that causes our cells to divide uncontrollably and spread into neighbouring tissues.

Capbrusam 100 mg Capsule 60's contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

To treat your condition effectually, continue using Capbrusam 100 mg Capsule 60's for as long as your doctor has prescribed it. The most common adverse reactions are anaemia (lack of blood), neutropenia (low count of neutrophils), upper respiratory tract infection, thrombocytopenia (Low platelet level), headache, diarrhoea, and musculoskeletal pain. You should talk to your doctor if you persistently experience these side effects.

It is recommended not to use if you are hypersensitive to any component present in Capbrusam 100 mg Capsule 60's and suffer from Severe Hepatic Impairment. Capbrusam 100 mg Capsule 60's can cause fetal harm when administered to a pregnant woman. It is critical not to become pregnant or get pregnant while undergoing therapy and for several months after the treatment. Using effective contraceptive methods is recommended while on therapy with Capbrusam 100 mg Capsule 60's. Contact your doctor immediately if you or your partner becomes pregnant while undergoing therapy. Breastfeeding is usually not advised during this treatment. Alcohol should be avoided during treatment with this medicine. Safety and effectiveness in children have not been established.

Uses of Capbrusam 100 mg Capsule 60's

Capbrusam 100 mg Capsule 60's is used in the treatment of Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL). The detailed uses of Capbrusam 100 mg Capsule 60's are as follows:<br/>• Chronic Lymphocytic Leukemia (CLL): Capbrusam 100 mg Capsule 60's is used in the treatment of chronic lymphocytic leukemia.<br/>• Small Lymphocytic Lymphoma (SLL): Capbrusam 100 mg Capsule 60's is used to treat small lymphocytic lymphoma.<br/>• Mantle Cell Lymphoma (MCL): Capbrusam 100 mg Capsule 60's is used to treat mantle cell lymphoma, especially in patients who have received at least one prior therapy.<br/>

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Directions for Use

• Capbrusam 100 mg Capsule 60's can be taken with or without food as advised by your doctor.• It is advised to take Capbrusam 100 mg Capsule 60's twice a day; however, follow your doctor's advice regarding the dosage and duration.• Swallow the medicine as a whole with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

Capbrusam 100 mg Capsule 60's is primarily used to treat people with mantle cell lymphoma (MCL) who have had at least one prior treatment for their malignancy, as well as adults with chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma (SLL). Capbrusam 100 mg Capsule 60's contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

How Capbrusam 100 mg Capsule 60's Works

Capbrusam 100 mg Capsule 60's contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that transmit signals to cells, telling them to grow and divide. Acalabrutinib inhibits these signals to cancer cells. Cells die when their signals are disrupted. This could help to slow the progression of the cancer.

Storage

• Store in a cool and dry place away from sunlight.
• Keep out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Capbrusam 100 mg Capsule
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Avoid taking raw fruits, nuts and vegetables.
  • Do not share your personal things with others like toothbrushes.
  • Clean the wounds and cuts using soap and water.
  • Wash your hands thoroughly and frequently and maintain hygiene.
  • Get a good quality of sleep.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

What if I have taken an overdose of Capbrusam 100 mg Capsule 60's

Do not take more than the prescribed dose. Using more medication will not improve your symptoms; instead, they may cause serious side effects or poisoning. If you suspect that you may have overdosed of Capbrusam 100 mg Capsule 60's or observe any side effects, please go to the emergency department of the closest hospital or nursing home. No specific side effects have been reported under these circumstances.

Drug Warnings

Before taking the Capbrusam 100 mg Capsule 60's, inform your doctor about all your medical conditions, sensitivities, and medications you are using. If you are a woman capable of having children, you should use an effective method of contraception during Acalabrutinib treatment and for at least one week after the last dose. If you are a man, you should use a barrier method of contraception to prevent your partner from becoming pregnant while taking Acalabrutinib and for at least one week after the last dose. Unless the doctor suggests, do not use any other medicine, including herbal or vitamin supplements.

Drug-Drug Interactions

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AcalabrutinibEtanercept
Severe
AcalabrutinibRabeprazole
Severe

Drug-Drug Interactions

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AcalabrutinibEtanercept
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
When Etanercept is used with Capbrusam 100 mg Capsule, the likelihood or severity of infection may increase.

How to manage the interaction:
Taking Etanercept with Capbrusam 100 mg Capsule together can result in an interaction, but it can be taken if a doctor has advised it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
AcalabrutinibRabeprazole
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
Taking Rabeprazole together with Capbrusam 100 mg Capsule results in a decreased effectiveness of Capbrusam 100 mg Capsule.

How to manage the interaction:
Although taking Rabeprazole and Capbrusam 100 mg Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. Do not discontinue any medications without a doctor's advice.
AcalabrutinibDiclofenac Diethylamine
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
The combined use of Capbrusam 100 mg Capsule and Diclofenac Diethylamine can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Capbrusam 100 mg Capsule and Diclofenac Diethylamine can lead to an interaction, but it can be taken if a doctor advises. However, if you experience any symptoms like unusual bleeding or bruising, dizziness, tarry stools, coughing up or vomiting blood, severe headache, or weakness, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
AcalabrutinibDexlansoprazole
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
Co-administration of Dexlansoprazole may interfere with the absorption of Capbrusam 100 mg Capsule capsules and reduce its effectiveness.

How to manage the interaction:
Consult your doctor if you are taking dexlansoprazole and Capbrusam 100 mg Capsule. The doctor may prescribe alternatives that do not interact with Capbrusam 100 mg Capsule or interact to a lesser extent.
AcalabrutinibDiltiazem
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
Co-administration of Capbrusam 100 mg Capsule and Diltiazem can significantly increase the blood levels of Capbrusam 100 mg Capsule.

How to manage the interaction:
Although taking Diltiazem and Capbrusam 100 mg Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like feeling sick, stomach pain, or unusual bleeding, make sure to call your doctor right away. Do not stop using any medications without first talking to your doctor.
AcalabrutinibAprepitant
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
Coadministration of Aprepitant can significantly increase the blood levels of Capbrusam 100 mg Capsule.

How to manage the interaction:
Although there is an interaction between Aprepitant and Capbrusam 100 mg Capsule, it can be taken if prescribed by a doctor. A doctor should be consulted if you experience any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in the phlegm, red or irritated skin, body sores, and discomfort when urinating. Without consulting a doctor, never stop taking medicines.
AcalabrutinibFluconazole
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
When Capbrusam 100 mg Capsule is taken with Fluconazole, can significantly increase the blood levels of Capbrusam 100 mg Capsule.

How to manage the interaction:
Co-administration of Fluconazole with Capbrusam 100 mg Capsule can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms - feeling sick, throwing up, having diarrhea, stomach pain, bleeding, heart problems, feeling weak, dizzy, or tired, having a fever, sore throat, muscle pain, trouble breathing, losing weight, or experiencing pain, bleeding, or bruising, make sure to call a doctor right away. Do not discontinue any medications without consulting a doctor.
AcalabrutinibEsomeprazole
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
Esomeprazole may interfere with the absorption of Capbrusam 100 mg Capsule and reduce their efficacy.

How to manage the interaction:
Taking Esomeprazole with Capbrusam 100 mg Capsule together can result in an interaction, but it can be taken if your doctor has advised it. Do not stop using any medications without talking to your doctor.
AcalabrutinibOmeprazole
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
Omeprazole, through decreasing stomach acidity, may interfere with the absorption of Capbrusam 100 mg Capsule capsules and reduce their effectiveness.

How to manage the interaction:
Although taking omeprazole with Capbrusam 100 mg Capsule can lead to interaction, they can be taken if recommended by a doctor. Do not stop using any medications without talking to a doctor.
AcalabrutinibItraconazole
Severe
How does the drug interact with Capbrusam 100 mg Capsule:
Capbrusam 100 mg Capsule blood levels may be significantly raised by combining itraconazole and Capbrusam 100 mg Capsule.

How to manage the interaction:
Although there is a possible interaction between Capbrusam 100 mg Capsule and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast, fried, processed meats, refined carbs, and added sugars.

Habit Forming

No

Therapeutic Class

KINASE INHIBITORS

Capbrusam 100 mg Capsule 60's Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid alcohol consumption while on treatment with Capbrusam 100 mg Capsule 60's.

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Pregnancy

Unsafe

Capbrusam 100 mg Capsule 60's should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Capbrusam 100 mg Capsule 60's should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Capbrusam 100 mg Capsule 60's does not influence the ability to drive or use machines. However, go only if you are alert, as the Capbrusam 100 mg Capsule 60's may cause tiredness in some people.

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Liver

Caution

Avoid using Capbrusam 100 mg Capsule 60's in patients with severe hepatic impairment. The safety of Capbrusam 100 mg Capsule 60's has not been evaluated in patients with moderate or severe hepatic impairment. So, caution should be exercised while using Capbrusam 100 mg Capsule 60's in patients with liver impairment. If you have a pre-existing or a history of liver disease, inform your doctor before taking the Capbrusam 100 mg Capsule 60's. Your doctor will weigh the benefits and potential risks before prescribing Capbrusam 100 mg Capsule 60's.

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Kidney

Caution

Caution should be exercised while using Capbrusam 100 mg Capsule 60's in patients with kidney impairment. If you have a pre-existing or a history of kidney disease, inform your doctor before taking the Capbrusam 100 mg Capsule 60's. Your doctor will weigh the benefits and potential risks before prescribing Capbrusam 100 mg Capsule 60's.

bannner image

Children

Caution

Safety and effectiveness in patients below the age of 18 years have not been established. Hence, use is not recommended.

FAQs

Capbrusam 100 mg Capsule 60's is used to treat Mantle cell lymphoma (MCL), chronic lymphocytic leukaemia (CLL) and small lymphocytic lymphoma (SLL).

Capbrusam 100 mg Capsule 60's contains Acalabrutinib, a tyrosine kinase inhibitor. Tyrosine kinases are enzymes in the body that send signals to cells, directing them to grow and divide. Acalabrutinib blocks these signals to cancer cells. Cancer cells die when their signals are interrupted. This could help to delay the progression of the cancer.

While taking Capbrusam 100 mg Capsule 60's, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Capbrusam 100 mg Capsule 60's.

Mantle cell lymphoma (MCL) is diagnosed by taking a biopsy of tumour tissue and examining the cells under a microscope.

You can take the missed dose if you forget to take your acalabrutinib, which is less than 3 hours after your usual time. Then, take the next dose at the regular time. Do not take your missed dose if more than 3 hours have passed. Wait and take the next dose at the regular time. Do not take a double dose to make up for a missing one.

Capbrusam 100 mg Capsule 60's may cause nausea as a side effect. If you experience nausea, you can manage it by drinking plenty of clear liquids like water, fruit juices, or flat soda to prevent dehydration. Eat smaller, more frequent meals of bland foods that are easy to digest, like crackers, toast, or bananas. Avoid greasy, fried, sweet, or spicy foods. However, consult your doctor if nausea persists or worsens.

To relieve diarrhoea caused by Capbrusam 100 mg Capsule 60's, stay hydrated by drinking plenty of water and clear fluids. Follow a bland diet of bananas, rice, applesauce, and toast. Avoid spicy, fatty, or high-fiber foods that can make diarrhoea worse. Talk to the doctor if you experience severe diarrhoea.

Avoid eating grapefruit and drinking grapefruit juice while taking Capbrusam 100 mg Capsule 60's, as it may interact with the medication. Limit intake of alcohol as it may increase the risk of bleeding.

Consult the doctor if you notice changes in your skin like rash, light bruising, and small red or purple spots on your skin after taking Capbrusam 100 mg Capsule 60's.

Capbrusam 100 mg Capsule 60's may cause bleeding gums due to reduced platelets. Try gentle brushing with a soft-bristled toothbrush. If the issue persists, consult your doctor for appropriate treatment.

After starting treatment with Capbrusam 100 mg Capsule 60's, you may feel tired or weak. To cope with this, prioritize rest and pace yourself. Take breaks, nap if needed, and engage in gentle exercises like yoga or short walks. Stay hydrated, eat small, frequent meals, and avoid heavy lifting or strenuous activities.

The doctor may advise regular blood tests before and during the treatment with Capbrusam 100 mg Capsule 60's to check blood count. Additionally, liver and kidney function tests may also be recommended by the doctor.

The common side effects of Capbrusam 100 mg Capsule 60's include anaemia (lack of blood), neutropenia (low count of neutrophils), upper respiratory tract infection, thrombocytopenia (Low platelet level), headache, diarrhoea, and musculoskeletal pain. You should talk to your doctor if you persistently experience these side effects.

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - CAP0300

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/216387Orig2s000Correctedlbl.pdf
  2. https://lymphoma.org/wp-content/uploads/2023/04/LRF_Mantle_Cell_Lymphoma_Factsheet.pdf
  3. https://lymphoma.org/understanding-lymphoma/aboutlymphoma/nhl/mantle-cell-lymphoma/
  4. https://www.macmillan.org.uk/cancer-information-and-support/treatments-and-drugs/acalabrutinib
  5. https://den8dhaj6zs0e.cloudfront.net/50fd68b9-106b-4550-b5d0-12b045f8b184/e2a005a7-65a0-4388-a671-dc887815a938/e2a005a7-65a0-4388-a671-dc887815a938_pi_med_guide_rendition__c.pdf
  6. https://www.calquence.com/
  7. https://medlineplus.gov/druginfo/meds/a618004.html
  8. https://www.drugs.com/drug-interactions/acalabrutinib.html

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