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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
CELGEM 1000MG INJECTION is an anti-cancer medicine used in the treatment of breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. This medicine works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include nausea, hair loss, skin rash, vomiting, and oedema.
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Whats That

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Composition :

GEMCITABINE-1000MG

Manufacturer/Marketer :

Hetero Drugs Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

NPPA :

Regulated

About CELGEM 1000MG INJECTION

CELGEM 1000MG INJECTION belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. Cancer is the uninhibited and uncontrolled growth of cells in the body.

CELGEM 1000MG INJECTION contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, CELGEM 1000MG INJECTION is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers. 

A healthcare professional will administer CELGEM 1000MG INJECTION. Do not self-administer. CELGEM 1000MG INJECTION may cause certain common side effects such as nausea, hair loss, skin rash, vomiting, and oedema. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if these side effects persist. 

It is advisable to inform the doctor if you are allergic to any of the components. Consult your doctor if you are pregnant, planning to get pregnant, or breastfeeding. Talk to your doctor if you are planning to father a child before taking CELGEM 1000MG INJECTION; your doctor may advise you regarding sperm storage. Avoid taking alcohol with CELGEM 1000MG INJECTION.

Uses of CELGEM 1000MG INJECTION

Treatment of Breast Cancer, Pancreatic Cancer, Non-small-cell Lung Cancer, Bladder Cancer, and Ovarian Cancer

Directions for Use

• Your doctor will decide the dosage and timing of CELGEM 1000MG INJECTION based on the type of cancer and your body's response to the treatment.• CELGEM 1000MG INJECTION is administered by the doctor or nurse in a medical setting.• Do not self-administer it.

Medicinal Benefits

CELGEM 1000MG INJECTION is an anti-cancer drug used in the treatment of various types of cancers. CELGEM 1000MG INJECTION is used either independently or in conjunction with other chemotherapy medications to treat breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer. CELGEM 1000MG INJECTION works by interfering with DNA synthesis. It blocks the production of new DNA, by locking itself into the DNA strands and inhibiting any further proliferation or growth of the cell. Hence, CELGEM 1000MG INJECTION has widespread application in the field of oncology (cancer-related medicine) and chemotherapy.

How CELGEM 1000MG INJECTION Works

CELGEM 1000MG INJECTION contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. Thus, CELGEM 1000MG INJECTION is very effective in controlling cancer cells from multiplying and is used in the treatment of various types of cancers.

Storage

Keep CELGEM 1000MG INJECTION out of reach and sight of children.
Side effects of Celgem 1000mg Injection
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Tell your doctor if you notice any unusual symptoms after taking the medication, such as flat purple, or red spots on your skin.
  • Your doctor may change your medication, lower the dose, or stop the treatment to help manage the symptoms.
  • Avoid heavy physical activity and get plenty of rest to prevent further worsening of the symptoms.
  • Apply cold packs to the affected areas for relief.
  • Drink plenty of fluids to stay hydrated, and eat fruits and vegetables or take supplements to get enough vitamins.
  • Over-the-counter pain relievers can help with discomfort.
  • Regularly wash your hands with alcohol-based sanitizer or soap and water.
  • Also, avoid sharing personal items like glasses or utensils with other individuals.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of CELGEM 1000MG INJECTION

Since CELGEM 1000MG INJECTION is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as severe rash, pain, burning, or tingling in the hands or feet, unusual bleeding or bruising, red/black/tarry stools, pink/red/dark brown urine, coughing up or vomiting blood or material that looks like coffee grounds, signs of infection (fever, sore throat, ongoing cough and congestion), and extreme tiredness.

Drug Warnings

CELGEM 1000MG INJECTION should not be used in case of any known allergy to any of the components. CELGEM 1000MG INJECTION should be used with caution in case of high risk or previous history of heart disease, vascular disease, liver problems, kidney disease or alcoholism. Keep your doctor informed if you suffer from any shortness of breath, kidney problems, hypertension diabetes or epilepsy. Avoid CELGEM 1000MG INJECTION during pregnancy and breastfeeding. Offer a detailed medical history, vaccination history, and inform the doctor especially if you are on any radiotherapy.

Drug-Drug Interactions

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GemcitabineCertolizumab
Severe

Drug-Drug Interactions

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How does the drug interact with Celgem 1000mg Injection:
Using Fingolimod together with Celgem 1000mg Injection may increase the risk or severity of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Celgem 1000mg Injection and Fingolimod, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you pee. Do not discontinue any medications without consulting a doctor.
GemcitabineCertolizumab
Severe
How does the drug interact with Celgem 1000mg Injection:
Combining Celgem 1000mg Injection with Certolizumab can increase the risk of infections.

How to manage the interaction:
Co-administration of Celgem 1000mg Injection with Certolizumab can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Celgem 1000mg Injection:
Combining Celgem 1000mg Injection with Natalizumab can increase the risk of side effects.

How to manage the interaction:
Co-administration of Celgem 1000mg Injection with Natalizumab can result in an interaction, but it can be taken if your doctor has advised it. If you experience any symptoms such as fever, diarrhea, sore throat, muscle aches, or vision changes, contact a doctor right away. Do not discontinue any medications without consulting a doctor.
GemcitabineVoclosporin
Severe
How does the drug interact with Celgem 1000mg Injection:
When Celgem 1000mg Injection is taken with Voclosporin, the amount of Celgem 1000mg Injection in the blood can go up. This can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Celgem 1000mg Injection and Voclosporin, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination contact a doctor right away. Do not stop using any medications without talking to a doctor.
GemcitabineMipomersen
Severe
How does the drug interact with Celgem 1000mg Injection:
Coadministration of Celgem 1000mg Injection with Mipomersen can lead to or increase the risk of liver injury.

How to manage the interaction:
Taking Celgem 1000mg Injection with Mipomersen together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, or bleeding contact a doctor immediately. Do not stop using any medications without talking to a doctor.
GemcitabineLomitapide
Severe
How does the drug interact with Celgem 1000mg Injection:
When Celgem 1000mg Injection is taken with Lomitapide, the amount of Celgem 1000mg Injection in the blood can go up. This can increase the risk or severity of liver injury.

How to manage the interaction:
Co-administration of Celgem 1000mg Injection with Lomitapide can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms - liver problems, fever, joint pain, swelling, rash, itching, loss of appetite, tiredness, nausea, vomiting, stomach pain, dark urine, or bleeding please call a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Celgem 1000mg Injection:
Combining Celgem 1000mg Injection with Teriflunomide can increase the risk or severity of side effects.

How to manage the interaction:
There may be a possibility of interaction between Celgem 1000mg Injection and Teriflunomide, but it can be taken if prescribed by a doctor. If you notice any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain or burning when urinating, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Celgem 1000mg Injection:
Combining Adalimumab with Celgem 1000mg Injection can increase the risk of side effects like developing serious infections.

How to manage the interaction:
Although taking Celgem 1000mg Injection and Adalimumab together can cause an interaction, it can be taken if your doctor has suggested it. If you have any of these symptoms like feeling sick, having a fever, diarrhea, a sore throat, muscle aches, weight loss, pain when you pee, or having trouble breathing it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
How does the drug interact with Celgem 1000mg Injection:
Coadministration of Tofacitinib and Celgem 1000mg Injection can lead to or increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Celgem 1000mg Injection, but it can be taken if advised by a doctor. Contact your doctor immediately if you develop symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Celgem 1000mg Injection:
Combining Infliximab with Celgem 1000mg Injection can increase the risk of infection.

How to manage the interaction:
There may be a possibility of interaction between Celgem 1000mg Injection and Infliximab, but it can be taken if prescribed by a doctor. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, pain, or burning during urination. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Cancer can take a toll on anyone. Make sure you regularly see a therapist and take care of your mental health.
  • Meditation and yoga have also proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables and whole-grain foods to give you more energy. 
  • Avoid taking CELGEM 1000MG INJECTION with alcohol as there may be an interaction.
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid tobacco use.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY
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Alcohol

Unsafe

It is not recommended to use alcohol with CELGEM 1000MG INJECTION as it might lead to increased drowsiness.

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Pregnancy

Unsafe

CELGEM 1000MG INJECTION should be avoided during pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

CELGEM 1000MG INJECTION is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

CELGEM 1000MG INJECTION may cause drowsiness and sleepiness, which may affect your ability to drive. Do not drive if you experience any side effects after using CELGEM 1000MG INJECTION.

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Liver

Caution

Exercise caution before using CELGEM 1000MG INJECTION in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using CELGEM 1000MG INJECTION in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

CELGEM 1000MG INJECTION is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

Have a query?

FAQs

CELGEM 1000MG INJECTION belongs to the group of anti-cancer drugs called cytotoxics used alone or in combination with other anti-cancer drugs to treat various types of cancers like breast cancer, pancreatic cancer, non-small cell lung cancer, bladder cancer, and ovarian cancer.

CELGEM 1000MG INJECTION works blocking DNA synthesis and causing cell death, thereby preventing the cells from proliferating beyond normal.

Men taking CELGEM 1000MG INJECTION are advised not to father a child during the treatment with CELGEM 1000MG INJECTION and for 6months after the treatment. Consult your doctor before starting CELGEM 1000MG INJECTION if you are planning to father a child. Your doctor may advise you regarding sperm storage.

If you suffer from CKD, please consult with your doctor before using CELGEM 1000MG INJECTION and discuss any concerns with them. CELGEM 1000MG INJECTION is to be used with caution in those suffering from kidney and liver problems.

CELGEM 1000MG INJECTION might cause low white blood cell count leading to increased risk of infections. Consult your doctor if you have a fever, sweating, and any signs of infections.

CELGEM 1000MG INJECTION may cause bleeding and bruising due to less platelet count. Consult a doctor if you notice unexpected bruising, pinkish or reddish urine, bleeding from gums, mouth, or nose.

CELGEM 1000MG INJECTION contains Gemcitabine which works by interfering with the synthesis of DNA, thereby causing cell death and arresting the uncontrolled production of new cells. It is very effective in controlling cancer cells from multiplying and is used for the treatment of various types of cancers.

The side effects of CELGEM 1000MG INJECTION include hair loss, vomiting, nausea, skin rash and oedema. Consult the doctor if any of these symptoms persist or worsen.

Country of origin

India

Manufacturer/Marketer address

7-2-A2, Hetero Corporate, Industrial Estates, Sanath Nagar, Hyderabad – 500 018. Telangana, INDIA
Other Info - CEL0019

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