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  3. Celofos 1000 Injection 1 ml

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Celofos 1000 Injection 1 ml, Pack of 1 Injection
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Celofos 1000 Injection 1 ml is used to treat blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer, and pancreatic cancer. It contains Ifosfamide which works by preventing the growth and multiplication of cancer cells. In some cases, this medicine may cause side effects such as nausea, vomiting, low number of red/white blood cells, hair loss, and infection. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

IFOSFAMIDE-1GM

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Celofos 1000 Injection 1 ml

Celofos 1000 Injection 1 ml belongs to a group of medications called ‘anti-neoplastic'. It is used in the treatment of blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer (a type of cancer that begins in the ovaries), testicular cancer (cancer occurs in the testicles (testes), (which are located inside the scrotum, a loose bag of skin underneath the penis), and pancreatic cancer (a type of cancer that begins in the pancreas). Blood cancer begins in blood-forming tissue, such as the bone marrow or the immune system's cells. Examples of blood cancer are leukemia ( a blood cancer caused by a rise in the number of white blood cells in your body), lymphoma (cancer that begins in infection-fighting cells of the immune system, called lymphocytes), and multiple myeloma (cancer that forms in a type of white blood cell called a plasma cell).

Celofos 1000 Injection 1 ml contains ‘ifosfamide’, which is an anti-cancer drug. Celofos 1000 Injection 1 ml works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication. 

Celofos 1000 Injection 1 ml will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side effects such as nausea, vomiting, anemia (low number of red blood cells), hair loss, decreased white blood cell count, infection, blood in urine, CNS toxicity. Most of these side effects of Celofos 1000 Injection 1 ml do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Do not take Celofos 1000 Injection 1 ml if you are allergic to any other ingredients present in it. Do not self-administer Celofos 1000 Injection 1 ml. Before taking Celofos 1000 Injection 1 ml, talk to your doctor if you have a history of kidney disease, heart diseases, liver diseases, bone marrow suppression, cystitis, CNS toxicity. Celofos 1000 Injection 1 ml is not recommended during pregnancy as it may affect the unborn baby. Tell your doctor if you are breastfeeding before taking Celofos 1000 Injection 1 ml. It is not recommended for use in children under 1 year of age. 

Uses of Celofos 1000 Injection 1 ml

Celofos 1000 Injection 1 ml is used in the treatment of cancer. The detailed uses of Celofos 1000 Injection 1 ml are as follows:

  • Blood cancer: Celofos 1000 Injection 1 ml is used to manage certain types of blood-related cancer.
  • Breast cancer: Celofos 1000 Injection 1 ml is used in the treatment of malignant tumors in the breast tissue.
  • Non-small cell lung cancer: Celofos 1000 Injection 1 ml is used to treat lung cancer that grows and spreads more slowly than small cell lung cancer.
  • Ovarian cancer: Celofos 1000 Injection 1 ml aids in the treatment of ovarian cancer.
  • Testicular cancer: Celofos 1000 Injection 1 ml is used to treat cancer affecting the testicles located in the scrotum.
  • Pancreatic cancer: Celofos 1000 Injection 1 ml helps in the treatment of tumors in the pancreas.

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Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication.
  • Celofos 1000 Injection 1 ml will be administered by a nurse or doctor.
  • Do not self-administer

Medicinal Benefits

Celofos 1000 Injection 1 ml contains ‘ifosfamide’, which is an anti-cancer drug. It is used to treat blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer, and pancreatic cancer. Celofos 1000 Injection 1 ml works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication. 

How Celofos 1000 Injection 1 ml Works

Celofos 1000 Injection 1 ml contains ‘ifosfamide’, which is an anti-cancer drug. Celofos 1000 Injection 1 ml works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.

Storage

• Store in a cool and dry place away from sunlight.• Keep Celofos 1000 Injection 1 ml out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Celofos 1000 Injection 1 ml
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Staying hydrated helps prevent hematuria by increasing urine production. You should drink about eight glasses of fluid per day, and more in hot weather.
  • Avoiding smoking as it is linked to urinary tract cancers.
  • Eat berries like Cranberries, blueberries, and raspberries can help promote urinary tract health and protect against infection.
  • Taking Vitamin C can help treat urinary tract infections.
  • Avoid irritants that can contribute to hematuria.
  • Empty the bladder regularly, as it can helps in preventing hematuria.
  • Wash your hands regularly with soap and water or use a hand sanitizer to prevent the spread of infections.
  • Wear masks, gloves and other protective clothing.
  • Cover sneezes and coughs with a medical mask or tissue or your elbow.
  • Take vaccinations to enhance your immunity to specific diseases.
  • Clean your utensils, linen and surfaces regularly.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Celofos 1000 Injection 1 ml

Since Celofos 1000 Injection 1 ml is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take Celofos 1000 Injection 1 ml if you are allergic to any other ingredients present in it. Do not self-administer Celofos 1000 Injection 1 ml. Before taking Celofos 1000 Injection 1 ml, talk to your doctor if you have a history of kidney disease, heart diseases, liver diseases,  cystitis, CNS toxicity. Celofos 1000 Injection 1 ml is not recommended during pregnancy as it may affect the unborn baby. Tell your doctor if you are breastfeeding before taking Celofos 1000 Injection 1 ml. It is not recommended for use in children under 1 year of age. Celofos 1000 Injection 1 ml should be used with caution in infections. Because the chances of infections are more in patients receiving this medicine. Hold the chemotherapy and start with broad-spectrum antibiotics if there are any signs and symptoms of fever. Close monitoring of the body temperature and the blood cell count is necessary. Consumption of alcohol is not recommended while receiving this Celofos 1000 Injection 1 ml as it may increase the risk of adverse effects such as dizziness, drowsiness, abnormal muscle movements, seizures. Celofos 1000 Injection 1 ml may cause bone marrow suppression, which lowers the white blood cell count (neutrophils) and platelets. Close monitoring of blood cell count is necessary.

Drug-Drug Interactions

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IfosfamideCidofovir
Critical
IfosfamideEtanercept
Severe

Drug-Drug Interactions

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IfosfamideCidofovir
Critical
How does the drug interact with Celofos 1000 Injection 1 ml:
Taking cidofovir with Celofos 1000 Injection 1 ml can increase the risk of kidney problems.

How to manage the interaction:
Taking Celofos 1000 Injection 1 ml with Cidofovir together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
IfosfamideEtanercept
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
When Etanercept is used with Celofos 1000 Injection 1 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Celofos 1000 Injection 1 ml together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
IfosfamideTenofovir alafenamide
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
The combined use of Celofos 1000 Injection 1 ml and Tenofovir alafenamide can increase the risk of kidney problems.

How to manage the interaction:
Taking Celofos 1000 Injection 1 ml and Tenofovir alafenamide together can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
IfosfamideTofacitinib
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
Taking Celofos 1000 Injection 1 ml with Tofacitinib may increase the risk of serious infection.

How to manage the interaction:
Taking Tofacitinib with Celofos 1000 Injection 1 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. It is important to keep a close eye on your condition. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
IfosfamideBupivacaine
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
Taking Bupivacaine and Celofos 1000 Injection 1 ml may cause methemoglobinemia, (a condition in which the iron in the hemoglobin molecule -the red blood pigment is defective, making it unable to carry oxygen effectively to the tissues).

How to manage the interaction:
Although taking bupivacaine and Celofos 1000 Injection 1 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
IfosfamideThalidomide
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
Taking thalidomide together with Celofos 1000 Injection 1 ml may increase the risk of blood clots and other complications.

How to manage the interaction:
Although taking thalidomide and Celofos 1000 Injection 1 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
IfosfamideCladribine
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
Combining Cladribine with Celofos 1000 Injection 1 ml can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Celofos 1000 Injection 1 ml and Cladribine, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
IfosfamideInfliximab
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
Combining Infliximab with Celofos 1000 Injection 1 ml can speed up the breakdown of Celofos 1000 Injection 1 ml in the body. This can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Celofos 1000 Injection 1 ml with Infliximab can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate, contact a doctor right away. Don't hesitate to reach out to your doctor if you experience any of these. Do not stop using any medications without a doctor's advice.
IfosfamideLidocaine
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
Coadministration of Celofos 1000 Injection 1 ml with Lidocaine can increase the risk of methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
There may be a possibility of interaction between Celofos 1000 Injection 1 ml and Lidocaine, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you develop gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion. Do not stop using any medications without consulting doctor.
IfosfamideClozapine
Severe
How does the drug interact with Celofos 1000 Injection 1 ml:
Co-administration of Celofos 1000 Injection 1 ml with Clozapine can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
Taking Celofos 1000 Injection 1 ml with Clozapine together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice any signs of infection like fever, chills, or a sore throat, or experience discomfort while urinating, it's best to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat a variety of protein-rich foods that are low in fat. Include seafood, lean meat and poultry, greek yoghurts, eggs, beans, soy products, and unsalted nuts and seeds.
  • Take vitamin A foods, found in green- or orange-coloured fruits and vegetables, such as sweet potatoes, carrots, kale, spinach, and apricots.
  • Stay away from strong-smelling foods to avoid aggravating any disorders of taste.
  • Avoid fatty fried, spicy, and overly sweet foods, as they may induce nausea.
  • Avoid refined sugars (including raw, brown, and palm sugar) and refined carbohydrates, as most tumours prefer glucose as an energy source.
  • Avoid drinking alcohol.
  • Quit smoking.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

All Substitutes & Brand Comparisons

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Alcohol

Caution

Consumption of alcohol is not recommended while receiving this Celofos 1000 Injection 1 ml as it may increase the risk of adverse effects such as dizziness, drowsiness, abnormal muscle movements, seizures.

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Pregnancy

Unsafe

Celofos 1000 Injection 1 ml is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this Celofos 1000 Injection 1 ml.

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Breast Feeding

Caution

Celofos 1000 Injection 1 ml is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before receiving this medicine. Your doctor may advise you to discontinue breastfeeding for a specific period of time or prescribe an alternative medicine based on your clinical condition.

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Driving

Caution

Use of this Celofos 1000 Injection 1 ml may cause blurred vision or dizziness in some patients. It is advised that you do not perform any activities such as driving a vehicle or operating machinery if you experience any of these symptoms during treatment with this Celofos 1000 Injection 1 ml.

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Liver

Caution

Celofos 1000 Injection 1 ml should be used with caution in patients with liver disease. A dose adjustment of Celofos 1000 Injection 1 ml may be needed. Please consult your doctor.

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Kidney

Caution

Celofos 1000 Injection 1 ml should be used with caution in patients with kidney disease. A dose adjustment of Celofos 1000 Injection 1 ml may be needed. Please consult your doctor.

bannner image

Children

Caution

Celofos 1000 Injection 1 ml is not recommended for use in patients below 18 years of age unless prescribed by your physician. Your doctor may prescribe this medicine if the benefits significantly outweigh the risks. In such a case, the patient should be monitored closely for any adverse effects.

FAQs

Celofos 1000 Injection 1 ml is used to treat blood cancer, breast cancer, non-small cell lung cancer, ovarian cancer, testicular cancer and pancreatic cancer.

Celofos 1000 Injection 1 ml contains ‘ifosfamide’, which is an anti-cancer drug. Celofos 1000 Injection 1 ml works by damaging the genetic material (DNA and RNA) of the cancer cells. This stops their growth and multiplication.Â

Celofos 1000 Injection 1 ml causes common side effects like nausea, vomiting, anemia (low number of red blood cells), hair loss, decreased white blood cell count, infection, blood in urine, CNS toxicity. Most of these side effects of Celofos 1000 Injection 1 ml do not require medical attention and gradually resolve over time. However, if these side effects persist longer, please consult your doctor.

Celofos 1000 Injection 1 ml is available in the form of injection. Celofos 1000 Injection 1 ml should be taken as advised by your doctor. Kindly do not self-administer. Your doctor or nurse will give you this medicine.

Yes, Celofos 1000 Injection 1 ml used in combination with other chemotherapy medicines, radiotherapy, and surgery to treat cancer of blood, breast, lung, ovaries, pancreas, testes, and lymph nodes.

Celofos 1000 Injection 1 ml may increase the risk of toxic effects on the heart and could lead to congestive heart failure. So Celofos 1000 Injection 1 ml should be taken as advised by your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081
Other Info - CEL0221

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 10, 2025 | 3:14 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019763s017lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a695023.html#precautions
  3. https://www.rxlist.com/ifex-drug.htm
  4. https://www.medicines.org.uk/emc/product/1834/smpc#CLINICAL_PRECAUTIONS
  5. https://www.drugs.com/mtm/ifosfamide.html

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