Celvestrant 250 mg PFS Injection 5 ml

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Celvestrant 250 mg PFS Injection 5 ml

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Celvestrant 250 mg PFS Injection 5 ml, Pack of 1

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Written By Veda Maddala , M Pharmacy

Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Celvestrant 250 mg PFS Injection 5 ml is used to treat breast cancer in postmenopausal women. It contains Fulvestrant, which works by inhibiting some of the actions of estrogen (female sex hormone which may help cancer cells grow in women with breast cancer) and reducing the amount that is in the body. Thus, it helps in reducing breast cancer tumour growth. In some cases, Celvestrant 250 mg PFS Injection 5 ml may cause certain common side effects such as injection site reactions like pain and/or inflammation, weakness, nausea, tiredness, headache or joint and musculoskeletal pain.

Composition :

FULVESTRANT-250MG

Manufacturer/Marketer :

Celon Laboratories Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Celvestrant 250 mg PFS Injection 5 ml

Celvestrant 250 mg PFS Injection 5 ml belongs to the class of estrogen blockers used to treat breast cancer in postmenopausal women. Breast cancer is a type of cancer that develops when the breast cells begin to grow abnormally.

Celvestrant 250 mg PFS Injection 5 ml contains Fulvestrant, which works by inhibiting some of the actions of estrogen (female sex hormone which may help cancer cells grow in women with breast cancer) and reducing the amount that is in the body. Thus, it helps in reducing breast cancer tumour growth.

Celvestrant 250 mg PFS Injection 5 ml will be administered by a healthcare professional; do not self-administer. In some cases, Celvestrant 250 mg PFS Injection 5 ml may cause certain common side effects such as injection site reactions like pain and/or inflammation, weakness, nausea, tiredness, headache or joint and musculoskeletal pain. Most of these side effects of Celvestrant 250 mg PFS Injection 5 ml do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor.

If you are allergic to Fulvestrant or any other medicines, please tell your doctor. Celvestrant 250 mg PFS Injection 5 ml is not recommended for pregnant women as it may harm an unborn baby. Celvestrant 250 mg PFS Injection 5 ml is contraindicated for use during lactation. Avoid alcohol consumption while receiving Celvestrant 250 mg PFS Injection 5 ml. Avoid driving or operating machinery if you feel tired or weak after receiving Celvestrant 250 mg PFS Injection 5 ml.

Uses of Celvestrant 250 mg PFS Injection 5 ml

Celvestrant 250 mg PFS Injection 5 ml is used in the treatment of Breast cancer in postmenopausal women. The detailed uses of Celvestrant 250 mg PFS Injection 5 ml are as follows:

Treatment of breast cancer: Celvestrant 250 mg PFS Injection 5 ml is used in the treatment of hormone receptor-positive (HR+), HER2-negative advanced or metastatic breast cancer in postmenopausal women.
Treatment of progressed cancer: Celvestrant 250 mg PFS Injection 5 ml is prescribed when the cancer has progressed following prior endocrine therapy.

Have a query?

Directions for Use

Your doctor will decide the dosage and timing of Celvestrant 250 mg PFS Injection 5 ml based on the stage of cancer and your body’s response to the treatment. Usually, it is given every two weeks for the first three doses, then once monthly.
Celvestrant 250 mg PFS Injection 5 ml will be administered by a doctor or nurse in a medical facility.
Do not self-administer.

Medicinal Benefits

Celvestrant 250 mg PFS Injection 5 ml contains Fulvestrant, used to treat breast cancer in postmenopausal women. Additionally, Celvestrant 250 mg PFS Injection 5 ml may be used in combination with palbociclib to treat women with a type of breast cancer called hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer that is locally advanced or has spread to other parts of the body (metastatic).

How Celvestrant 250 mg PFS Injection 5 ml Works

Storage

• Store in a cool and dry place away from sunlight.• Keep Celvestrant 250 mg PFS Injection 5 ml out of reach and sight of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC.

Side effects of Celvestrant 250 mg PFS Injection 5 ml

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Anemia

Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
Consume vitamin C-rich foods as they aid iron absorption.
Limit tea, cocoa, and coffee as these can slow iron absorption.
Exercise regularly; however, do not overdo it.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Loose And Watery Stools

Here are the precise steps to cope with diarrhoea caused by medication usage:

Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.

Low Platelet Count

Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
If you experience severe bleeding or bruising, seek emergency medical attention immediately.

Vomiting

To prevent, manage, and treat Constipation caused by medication usage, follow these steps:

Preventing Vomiting (Before it Happens)
Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
Having a small meal before taking your medication can help reduce nausea and vomiting.
Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
Managing Vomiting (If it Happens)
Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
What to Do if Vomiting Persists
Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

High Body Temperature

Here's a comprehensive approach to managing medication-triggered fever:

Inform your doctor immediately if you experience a fever after starting a new medication.
Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
Monitor your body temperature to monitor fever progression.
Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.

What if I have taken an overdose of Celvestrant 250 mg PFS Injection 5 ml

As Celvestrant 250 mg PFS Injection 5 ml is a parenteral formulation administered by experienced medical staff, the chance of overdose may be less. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly.

Drug Warnings

If you are allergic to Fulvestrant or any other medicines, please tell your doctor. Celvestrant 250 mg PFS Injection 5 ml is not recommended for pregnant women as it may harm an unborn baby. Using effective contraception while being treated with Celvestrant 250 mg PFS Injection 5 ml and for two years after the last dose is advised. Celvestrant 250 mg PFS Injection 5 ml is contraindicated for use during lactation. Avoid alcohol consumption while receiving Celvestrant 250 mg PFS Injection 5 ml. Avoid driving or operating machinery if you feel tired or weak after receiving Celvestrant 250 mg PFS Injection 5 ml.

Drug-Drug Interactions

FulvestrantFluoroestradiol (18f)

Severe

Drug-Drug Interactions

FulvestrantFluoroestradiol (18f)

Severe

How does the drug interact with Celvestrant 250 mg PFS Injection 5 ml:
Coadministration of Celvestrant 250 mg PFS Injection 5 ml with Fluoroestradiol (18f) can reduce the action of Fluoroestradiol (18f) in detecting cancer.

How to manage the interaction:
Taking Celvestrant 250 mg PFS Injection 5 ml with Fluoroestradiol (18f) together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

Diet & Lifestyle Advise

Avoid fried and processed foods.
Include fibre-rich foods such as whole grains, fruits, and vegetables in your diet.
Avoid refined carbohydrates that are high in sugars.
Replace animal proteins (like eggs, fish, and meat) with vegetable protein sources (nuts, seeds, and beans).
Avoid drinking excess alcohol or caffeinated drinks, as they can worsen the symptoms.
Maintain a healthy weight and do moderate exercise regularly.
Avoid smoking and alcohol intake.

Habit Forming

Therapeutic Class

ANTINEOPLASTIC

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Alcohol

Caution

Avoid alcohol consumption while receiving this medicine. If you have any concerns, please discuss them with your doctor.

Pregnancy

Unsafe

Celvestrant 250 mg PFS Injection 5 ml is not recommended for use during pregnancy as it may harm the unborn baby. You are advised to use effective contraception while being treated with Celvestrant 250 mg PFS Injection 5 ml and for two years after your last dose.

Breast Feeding

Unsafe

Celvestrant 250 mg PFS Injection 5 ml is contraindicated for use during lactation, or you are recommended to avoid breastfeeding while on treatment with Celvestrant 250 mg PFS Injection 5 ml.

Driving

Safe if prescribed

Celvestrant 250 mg PFS Injection 5 ml usually does not affect your ability to drive or operate machinery. However, avoid driving or operating machinery if you feel tired or weak after receiving Celvestrant 250 mg PFS Injection 5 ml.

Liver

Caution

Celvestrant 250 mg PFS Injection 5 ml is not recommended for patients with severe liver problems. Therefore, if you have liver problems, inform your doctor before receiving Celvestrant 250 mg PFS Injection 5 ml.

Kidney

Caution

If you have kidney problems, inform your doctor before receiving Celvestrant 250 mg PFS Injection 5 ml.

Children

Unsafe

Celvestrant 250 mg PFS Injection 5 ml is not recommended for children and adolescents below 18 years of age.

Heart

Please inform your doctor if you have any pre-existing heart problems before using Celvestrant 250 mg PFS Injection 5 ml. Your doctor will prescribe Celvestrant 250 mg PFS Injection 5 ml if the benefits outweigh the risk.

Geriatrics

Safe if prescribed

Celvestrant 250 mg PFS Injection 5 ml is generally considered safe when used under medical supervision in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

FAQs

What is the use of Celvestrant 250 mg PFS Injection 5 ml?

Celvestrant 250 mg PFS Injection 5 ml is used to treat Breast cancer in postmenopausal women.

How does Celvestrant 250 mg PFS Injection 5 ml work?

Celvestrant 250 mg PFS Injection 5 ml contains Fulvestrant which works by inhibiting some of the actions of estrogen (female sex hormone) and reducing the amount that is in the body. Thus, it helps in reducing breast cancer tumour growth.

Is Celvestrant 250 mg PFS Injection 5 ml safe for patients with liver problems?

Celvestrant 250 mg PFS Injection 5 ml is not recommended for patients with severe liver problems. Therefore, if you have any liver problems, inform your doctor before receiving Celvestrant 250 mg PFS Injection 5 ml.

Does Celvestrant 250 mg PFS Injection 5 ml cause weakness?

Celvestrant 250 mg PFS Injection 5 ml may cause weakness or tiredness as a common side effect. However, if weakness persists or worsens, please consult your doctor.

What is Celvestrant 250 mg PFS Injection 5 ml?

Celvestrant 250 mg PFS Injection 5 ml contains Fulvestrant, which belongs to a class of medications called estrogen receptor antagonists. It helps to slow or stop the growth of specific breast tumours that depend on estrogen (a female sex hormone) to grow.

How and in what dose should I use Celvestrant 250 mg PFS Injection 5 ml?

Celvestrant 250 mg PFS Injection 5 ml is administered as a liquid injection into a muscle in the buttocks by a doctor in a medical setting. It is typically injected slowly over 1 to 2 minutes. For the first three doses, you will receive an injection every two weeks (on days 1, 15, and 29). After that, it is usually given once a month. Your doctor will determine the exact schedule based on your condition and how you respond to the medication. The injection will be given as two separate shots (one in each buttock). Please do not self-administer it.

What are the common side effects of using Celvestrant 250 mg PFS Injection 5 ml?

Celvestrant 250 mg PFS Injection 5 ml may cause common side effects, such as injection site reactions like pain and inflammation, weakness, nausea, tiredness, headache, or joint and musculoskeletal pain in some individuals. Most of these side effects of Celvestrant 250 mg PFS Injection 5 ml do not require medical attention and gradually resolve over time. However, if these side effects persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Plot No 264, Patrika Nagar Madhapur, Hitech City Hyderabad, Telangana India - 500081

Other Info - CEL0409

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Author Details

Written By

Veda Maddala

M Pharmacy

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 18, 2025 | 11:51 AM IST

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