CLADRIM 10MG INJECTION
MRP ₹12362
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About CLADRIM 10MG INJECTION
CLADRIM 10MG INJECTION belongs to a group of anticancer medicines called purine analogue used in the treatment of hairy cell leukaemia. Leukaemia, also known as blood cancer, is a cancer of blood cells or blood-forming tissues. It causes excessive production of immature white blood cells by the bone marrow and reduces the body’s ability to fight infections.
CLADRIM 10MG INJECTION contains Cladribine, which belongs to the class of purine antimetabolites. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.
CLADRIM 10MG INJECTION may cause certain side effects such as insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. A trained healthcare professional will administer CLADRIM 10MG INJECTION. Hence, do not self-administer.
If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, hemolytic anaemia, or severe bone marrow suppression before starting the treatment, as it may worsen your condition. Inform your doctor if you have received any vaccination before starting the treatment.
Uses of CLADRIM 10MG INJECTION
CLADRIM 10MG INJECTION is used in the treatment of Hairy cell Leukemia. The detailed use of CLADRIM 10MG INJECTION is as follows:
- Hairy Cell Leukemia: CLADRIM 10MG INJECTION is used to reduce abnormal white blood cells and restore normal bone marrow function.
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Directions for Use
- Follow your doctor's instructions on the dosage and timing of this medication.
- CLADRIM 10MG INJECTION is administered by the doctor or nurse in a clinical setting.
- Do not self-administer.
Key Benefits
CLADRIM 10MG INJECTION contains Cladribine, which is used in the treatment of multiple sclerosis. It works by inhibiting DNA synthesis (responsible for DNA elongation, synthesis, and repair) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes. Thus, CLADRIM 10MG INJECTION stops the multiplication of abnormal cells and causes the death of cancer cells.
How CLADRIM 10MG INJECTION Works
Storage
- Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
- Avoid contact with people who are sick.
- Wash your hands regularly with soap and water.
- Avoid unpasteurized dairy products.
- Inform your doctor immediately if you experience a fever after starting a new medication.
- Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
- Monitor your body temperature to monitor fever progression.
- Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
- Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
- Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
- If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
- Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
- Consume vitamin C-rich foods as they aid iron absorption.
- Limit tea, cocoa, and coffee as these can slow iron absorption.
- Exercise regularly; however, do not overdo it.
- Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
- Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
- Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
- Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
- If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
- In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
- Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
- If you experience severe bleeding or bruising, seek emergency medical attention immediately.
- Receive vaccinations to guard against bacterial infections.
- Maintain good hygiene by washing hands often and covering your mouth/nose when coughing or sneezing.
- Make sure to store, cook, and handle food properly, to prevent food-borne infections.
- Regularly clean surfaces that are touched often with disinfectants.
- Protect yourself from insect bites by using repellents and wearing appropriate clothing, especially in high-risk areas.
- Use latex or polyurethane condoms during sex to minimize the risk of infections.
- Hydrate your body: Drink enough water to prevent dehydration and headaches.
- Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
- Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
- Take rest: lie down in a quiet, dark environment.
- Cold or warm compresses can help reduce tension.
- Stay Upright: Maintain good posture to keep symptoms from getting worse.
- To treat headaches naturally, try acupuncture or massage therapy.
- Over-the-counter pain relievers include acetaminophen and ibuprofen.
- Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
- Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
- Frequent Headaches: If you get reoccurring headaches, consult your doctor.
- Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
- Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
- Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
- Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
- If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
What if I have taken an overdose of CLADRIM 10MG INJECTION
Drug Warnings
If you are allergic to CLADRIM 10MG INJECTION, inform your doctor and avoid receiving it. Inform your doctor about your complete medical and medication history before starting treatment with CLADRIM 10MG INJECTION. CLADRIM 10MG INJECTION is contraindicated for pregnant women and breastfeeding women due to serious embryo-fetal toxicity. Hence, consult your doctor if you are pregnant, planning to become pregnant or breastfeeding. Let the doctor know if you have/had kidney or liver disease, haemolytic anaemia, severe bone marrow suppression, thrombocytopenia (low number of platelets), or neutropenia (low white blood cells) before starting the treatment, as it may worsen your condition. If you are about to receive any vaccinations, inform your doctor beforehand, as it may cause infection.
Drug-Drug Interactions
Drug-Drug Interactions
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The combined Cladrim 10mg Injection with Certolizumab can increase the risk of developing serious infections.
How to manage the interaction:
There may be a possibility of interaction between Cladrim 10mg Injection and Certolizumab, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Using Cladrim 10mg Injection and carboplatin together can increase the risk of serious infections.
How to manage the interaction:
Co-administration of carboplatin and Cladrim 10mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, red or inflamed skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Taking Cladrim 10mg Injection with Pemetrexed can increase the risk of developing serious infections.
How to manage the interaction:
Although taking Cladrim 10mg Injection and Pemetrexed together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Combining Cladrim 10mg Injection with Temsirolimus can increase the risk of developing serious infections.
How to manage the interaction:
Although taking Cladrim 10mg Injection and Temsirolimus together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Coadministration of Cladrim 10mg Injection and bortezomib may increase the risk of infections.
How to manage the interaction:
Although using Bortezomib and Cladrim 10mg Injection together can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscle pains, red or irritated skin, body sores, and a burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Taking Cladrim 10mg Injection together with roflumilast may increase the risk of infections.
How to manage the interaction:
Although there is a interaction between Cladrim 10mg Injection and Roflumilast, but it can be taken together if prescribed by your doctor. However. if you experience fever, chills, loose stools, sore throat, muscle aches, difficulty breathing, and pain or burning while passing urine, contact a doctor immediately. Do not stop using any medications without a doctor's advice.
Combining Cladrim 10mg Injection with Procarbazine can increase the risk and severity of serious infections.
How to manage the interaction:
Although there is a possible interaction between Cladrim 10mg Injection and Procarbazine, you can take these medicines together if prescribed by your doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Combining Cladrim 10mg Injection with Bendamustine can increase the risk of developing serious infections.
How to manage the interaction:
There may be a possibility of interaction between Bendamustine and Cladrim 10mg Injection, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
Using Cladrim 10mg Injection together with tacrolimus may increase the risk of serious infections
How to manage the interaction:
Although taking tacrolimus and clozapine together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting doctor.
Co-administration of Cladrim 10mg Injection with Mercaptopurine together can increase the risk of infection.
How to manage the interaction:
There may be a possibility of interaction between Cladrim 10mg Injection and Mercaptopurine, but it can be taken if prescribed by a doctor. If you have any of these symptoms, contact your doctor right away. These symptoms include fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, and pain or burning when you urinate. Do not stop using any medications without a doctor's advice.
Drug-Food Interactions
Drug-Food Interactions
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Diet & Lifestyle Advise
- Maintain a balanced diet including fruits and vegetables rich in nutrients and low-fat proteins like lean meats, fish and poultry.
- Drink plenty of water daily while receiving the medication, as some cancer therapies may cause dehydration.
- Exercise regularly and maintain a healthy body weight.
- Regularly wash your hands and avoid contact with people having infections.
- Quit smoking.
Habit Forming
Therapeutic Class
Alcohol
Safe if prescribed
It is not known if alcohol interacts with CLADRIM 10MG INJECTION. Please consult the doctor.
Pregnancy
Consult your doctor
CLADRIM 10MG INJECTION is not recommended for use in pregnancy as it may harm the foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving CLADRIM 10MG INJECTION. You should not become pregnant while on treatment with CLADRIM 10MG INJECTION.
Breast Feeding
Consult your doctor
CLADRIM 10MG INJECTION is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. If you are breastfeeding, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may suggest you stop feeding while on treatment with this medicine.
Driving
Safe if prescribed
CLADRIM 10MG INJECTION will be administered to hospitalized patients. Hence, avoid driving.
Liver
Consult your doctor
If you have a pre-existing or a history of liver disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Kidney
Consult your doctor
If you have a pre-existing or a history of kidney disease, inform your doctor before receiving CLADRIM 10MG INJECTION. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative based on your condition.
Children
Safe if prescribed
CLADRIM 10MG INJECTION is not recommended for use in children as safety and effectiveness have not been established.
Heart
Please consult your doctor before receiving CLADRIM 10MG INJECTION if you have pre-existing heart problems. Your doctor will prescribe CLADRIM 10MG INJECTION if the benefits outweigh the risks.
Geriatrics
Consult your doctor
Please consult a doctor before administering CLADRIM 10MG INJECTION to geriatric patients. Your doctor will prescribe CLADRIM 10MG INJECTION if the benefits outweigh the risks.
FAQs
CLADRIM 10MG INJECTION is used to treat Hairy cell Leukemia.
CLADRIM 10MG INJECTION contains Cladribine, which works by inhibiting the production of genetic material (DNA) in cancer cells by interfering with the ribonucleotide reductase and DNA polymerase enzymes.
It is said that concomitant use of CLADRIM 10MG INJECTION along with live vaccines may cause serious adverse effects. Hence, inform your doctor if you have taken any vaccines recently before receiving CLADRIM 10MG INJECTION.
No, CLADRIM 10MG INJECTION is not a vesicant. CLADRIM 10MG INJECTION belongs to a group of anticancer medications called purine analogues used in the treatment of hairy cell leukaemia (a rare type of blood and bone marrow cancer).
CLADRIM 10MG INJECTION may cause hair loss in some cases. However, it is an uncommon side effect of CLADRIM 10MG INJECTION. Consult the doctor if you notice hair loss during treatment with CLADRIM 10MG INJECTION.
The common side effects of CLADRIM 10MG INJECTION may include insomnia, dizziness, cough, abdominal pain, rash, constipation, fatigue, vomiting, nausea, headache, cough, constipation, weakness, and pain at the site of injection. Most of these side effects of CLADRIM 10MG INJECTION do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, consult the doctor.
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Disclaimer
Keep Refrigerated. Do not freeze.Prepaid payment required.
Author Details
Reference
- https://www.mayoclinic.org/drugs-supplements/cladribine-intravenous-route/description/drg-20062966
- https://reference.medscape.com/drug/mavenclad-cladribine-342213
- https://medlineplus.gov/druginfo/meds/a693015.html
- https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a2592a9b-bca6-4a5a-89c2-855a0634d5fe&type=display
- https://www.drugs.com/mtm/cladribine-injection.html
- https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/020229s034lbl.pdf
