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  3. Clexane 40 mg Injection 0.4 ml

Clexane 40 mg Injection 0.4 ml, Pack of 1 INJECTION
Clexane 40 mg Injection 0.4 ml, Pack of 1 INJECTION
Clexane 40 mg Injection 0.4 ml, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Clexane 40mg Injection is used to prevent or treat blood clots caused by medical conditions, such as unstable angina, after an operation or long periods of bed rest due to illness, after a heart attack, and the formation of blood clots in the dialysis machine tubes. It contains Enoxaparin, which prevents existing blood clots from growing larger, allowing your body to break them down and prevent them from harming you. Also, it inhibits the formation of new blood clots in your blood. It may cause side effects such as increased liver enzymes, skin rash (hives,urticaria), itchy red skin, bruising or pain at the injection site, and headache. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

ENOXAPARIN-40MG

Manufacturer/Marketer :

Sanofi India Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Clexane 40mg Injection

Clexane 40mg Injection is used to prevent or treat blood clots caused by medical conditions, such as unstable angina, after an operation or long periods of bed rest due to illness, after a heart attack, and the formation of blood clots in the dialysis machine tubes. A blood clot is a mass of blood that forms when platelets, proteins, and cells in the blood stick together. A blood clot can occur in any body part, leading to a heart attack, stroke, and organ damage (even coma or death).

Clexane 40mg Injection contains Enoxaparin, which is a low molecular weight heparin that works by preventing existing blood clots from growing larger, allowing your body to break them down and prevent them from harming you. On the other hand, it inhibits the formation of new blood clots in your blood.

Clexane 40mg Injection will be administered by a healthcare professional; do not self-administer. Side effects of Clexane 40mg Injection include increased liver enzymes, skin rash (hives, urticaria), itchy red skin, bruising or pain at the injection site, and headache. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects are persistent, report to your doctor immediately. 

If you are known to be allergic to Clexane 40mg Injection or any other medicines, inform your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before receiving the Clexane 40mg Injection . Also, disclose to your doctor if you have any pre-existing medical conditions like a stomach ulcer, recent surgery of the brain or eyes or spine, recent bleeding stroke, diabetes, high blood pressure, or recent onset of stroke or kidney or liver disorders. Also, let your doctor know if you are underweight or overweight or if you have high levels of potassium in your blood.

Uses of Clexane 40mg Injection

Treatment and prevention of blood clots

Directions for Use

Clexane 40mg Injection will be administered by a qualified healthcare professional. Kindly do not self-administer.

Medicinal Benefits

Clexane 40mg Injection contains Enoxaparin, which is a low molecular weight heparin (LMWH) that helps to treat harmful blood clots due to medical conditions, including unstable angina, after an operation or long periods of bed rest due to illness, after a heart attack, and blood clots forming in the tubes of your dialysis machine. Clexane 40mg Injection works by stopping existing blood clots from getting any bigger; this helps your body break them down and prevents them from causing you harm. On the other hand, it stops new blood clots from forming in your blood.

How Clexane 40mg Injection Works

Clexane 40mg Injection contains Enoxaparin, which is a low molecular weight heparin that works by preventing existing blood clots from growing larger, allowing your body to break them down and prevent them from harming you. On the other hand, it inhibits the formation of new blood clots in your blood.

Storage

Store in a cool and dry place away from sunlight
Side effects of Clexane 40mg Injection 0.4 ml
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.
  • Follow a balanced diet by including fruits, vegetables, and whole grains.
  • Increase fibre intake as it aids toxin removal.
  • Avoid processed foods and sugary drinks.
  • Aim for moderate-intensity exercise for most days of the week.
  • Quit smoking, as it can worsen liver health.
  • Manage stress with meditation or yoga.
  • Monitor liver function through regular blood tests.
  • Consume more fruits, vegetables, and cruciferous foods like cabbage, kale, and broccoli.
  • Reduced alcohol intake can enhance liver enzyme function.
  • Oxidative stress can be managed by eating foods rich in antioxidants, such as vitamins C and E.
  • Liver function tests regularly can help manage increased levels of AST.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Apply pressure for 5-10 minutes to reduce bleeding.
  • Apply cold compresses or ice packs for 15-20 minutes, repeat every few hours.
  • Consult the doctor and use antihistamines if advised to minimise injection site reaction.
  • Use pain relief medication, like acetaminophen if recommended by the doctor, but avoid NSAIDs if bleeding is a concern.
  • Rotate injection sites and use proper needle size and technique if you are self-administering the medication.
  • Monitor signs such as increased pain, redness, warmth, or pus, and seek medical attention if symptoms worsen.
  • Injection site reaction can include numbness or redness.
  • Get a physical examination, follow your doctor's instructions, if it worsens or gets swollen.
  • Apply cold compress for pain relief.
  • Practice good hygiene and keep the injection site away from heat and pressure.

What if I have taken an overdose of Clexane 40mg Injection

The overdose of Clexane 40mg Injection is unlikely as it is administered by a doctor. However, if you suspect any adverse reactions or unusual symptoms while on treatment with Clexane 40mg Injection , please inform your doctor immediately.

Drug Warnings

Patients should inform the doctor if they are on active treatment with this Clexane 40mg Injection before any surgery is scheduled. If you are known to be allergic to Clexane 40mg Injection or any other medicines, inform your doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using the Clexane 40mg Injection . Before using this Clexane 40mg Injection , disclose to your doctor if you have any pre-existing medical conditions like stomach ulcer, recent surgery of the brain or eyes or spine, recent bleeding stroke, diabetes, high blood pressure, or recent onset of stroke or kidney or liver disorders, And also let your doctor know if you are underweight or overweight or if you have high levels of potassium in your blood.

Drug-Drug Interactions

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EnoxaparinDefibrotide
Critical
EnoxaparinMifepristone
Critical

Drug-Drug Interactions

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EnoxaparinDefibrotide
Critical
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Combining Defibrotide with Clexane 40mg Injection 0.4 ml can increase the risk of bleeding.

How to manage the interaction:
Taking Clexane 40mg Injection 0.4 ml with Defibrotide is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EnoxaparinMifepristone
Critical
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Combining Mifepristone with Clexane 40mg Injection 0.4 ml can increase the risk or severity of side effects of vaginal bleeding.

How to manage the interaction:
Taking Clexane 40mg Injection 0.4 ml with Mifepristone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience prolonged, excessive bleeding, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EnoxaparinDextran
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Combining Clexane 40mg Injection 0.4 ml with Dextran can increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Dextran and Clexane 40mg Injection 0.4 ml, but it can be taken if prescribed by a doctor. If you notice any symptoms like bleeding, bruising, dizziness, black or tarry stools, severe headache, weakness, or vomiting contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EnoxaparinKetorolac
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Taking Clexane 40mg Injection 0.4 ml and ketorolac together can increase the risk or severity of bleeding problems.

How to manage the interaction:
Although taking Ketorolac and Clexane 40mg Injection 0.4 ml together can result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
EnoxaparinOmacetaxine mepesuccinate
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Combining Clexane 40mg Injection 0.4 ml with Omacetaxine mepesuccinate can increase the risk or severity of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Clexane 40mg Injection 0.4 ml and Omacetaxine mepesuccinate, but it can be taken if prescribed by a doctor. If you notice any symptoms like bleeding, bruising, dizziness, or severe headache, it's crucial to contact a doctor right away. They can help you address these concerns and prevent any serious complications. Do not stop using any medications without talking to a doctor.
EnoxaparinAspirin
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Using Clexane 40mg Injection 0.4 ml along with aspirin, may enhance the risk of bleeding problems.

How to manage the interaction:
Although there is a possible interaction between aspirin and Clexane 40mg Injection 0.4 ml, you can take these medicines together if prescribed by a doctor. However, if you notice unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness while taking these drugs, inform a doctor immediately. Do not stop using any medications without consulting a doctor.
EnoxaparinEtodolac
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Taking Etodolac with Clexane 40mg Injection 0.4 ml can increase the risk of bleeding and hemorrhage.

How to manage the interaction:
Co-administration of Etodolac with Clexane 40mg Injection 0.4 ml can result in an interaction, but it can be taken if a doctor has advised it. If you notice any of these signs like difficulty with bleeding, bleeding, bruising, swelling, throwing up, headache, feeling lightheaded, weakness, or seeing blood in your urine or stools it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
EnoxaparinPanobinostat
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Coadministration of Clexane 40mg Injection 0.4 ml and Panobinostat can increase the risk or severity of bleeding complications.

How to manage the interaction:
Although taking Clexane 40mg Injection 0.4 ml and Panobinostat together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any symptoms like bleeding, bruising, dizziness, severe headache red or black stools, vomiting, or weakness it's important to contact a doctor right away. Do not stop using any medications without talking to a doctor.
EnoxaparinTinzaparin
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Combining Clexane 40mg Injection 0.4 ml with Tinzaparin can increase the risk of bleeding.

How to manage the interaction:
Although taking Clexane 40mg Injection 0.4 ml and Tinzaparin together can cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms like back pain, bleeding, bruises, dizziness, lightheaded, dark or black stools, a severe headache, weakness, or vomiting it's important to call a doctor right away. Do not stop using any medications without talking to a doctor.
EnoxaparinHeparin
Severe
How does the drug interact with Clexane 40mg Injection 0.4 ml:
Taking Heparin with Clexane 40mg Injection 0.4 ml may increase the risk of bleeding.

How to manage the interaction:
There may be a possibility of interaction between Heparin and Clexane 40mg Injection 0.4 ml, but it can be taken if prescribed by a doctor. However, consult a doctor, if you experience any unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A low cholesterol diet and a regular exercise regime complement treatment with Clexane 40mg Injection effectively.
  • As a precautionary measure, you are recommended not to consume alcohol, or junk food items from outside, stick to a freshly prepared home-cooked meal and rest properly for a speedy recovery.
  • And also, trying to replace most of your saturated fats with unsaturated fats can reduce total cholesterol and LDL in a short time.
  • Foods like avocados, olive oil, fatty fish, and nuts contain many heart-healthy unsaturated fats, so eating them regularly is beneficial.
  • Option for foods high in vitamin K (liver, leafy green vegetables, or vegetable oils) as Clexane 40mg Injection may lower Vitamin K in your body.
  • Avoid drinking alcohol as it increases the risk of gastrointestinal ulcer/bleeding.
  • Cranberry juice, grapefruit juice, noni juice, and pomegranate juice may interact with Clexane 40mg Injection and lead to unwanted side effects. Hence try to avoid these juices while taking Clexane 40mg Injection .

Habit Forming

No

Therapeutic Class

ANTICOAGULANT/ANTITHROMBOTIC

Clexane 40mg Injection Substitute

Substitutes safety advice

  • Corparin 40 Injection 1's

    by AYUR

    ₹423.00per tablet

  • Lmwx 40 Injection 0.4 ml

    by Others

    ₹413.60per tablet

  • Enoxarin-40 Injection 0.4 ml

    by AYUR

    ₹423.00per tablet

  • Loparin 40 mg Injection 0.4 ml

    by Others

    ₹358.70per tablet

  • Parihep 40 mg Injection 0.4 ml

    by Others

    ₹423.00per tablet

Product Substitutes

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Alcohol

Caution

Limit intake of alcohol as it may increase the risk of bleeding.

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Pregnancy

Caution

Clexane 40mg Injection is not recommended for use in pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Clexane 40mg Injection .

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Breast Feeding

Caution

Clexane 40mg Injection is not recommended for use in breastfeeding unless clearly necessary. So, inform your doctor if you are a nursing mother. Your doctor will weigh the benefits and potential risks before prescribing Clexane 40mg Injection .

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Driving

Safe if prescribed

It does not affect your ability to drive.

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Liver

Caution

If you have a history of liver diseases or pre-existing liver conditions, please inform your doctor before taking this Clexane 40mg Injection . Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

If you have a history of kidney diseases or pre-existing kidney conditions, please inform your doctor before taking this Clexane 40mg Injection . Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for treatment in children under 18 years of age as safety and efficacy have not been established.

FAQs

Clexane 40mg Injection is used to prevent or treat blood clots caused by medical conditions, such as unstable angina, after an operation or long periods of bed rest due to illness, after a heart attack, and the formation of blood clots in the dialysis machine tubes.

Clexane 40mg Injection contains Enoxaparin, which is low molecular weight heparin or LMWH. Clexane 40mg Injection works by stopping existing blood clots from getting any bigger. This helps your body to break them down and prevents them from causing you harm. On the other hand, it stops new blood clots from forming in your blood.

Yes, this Clexane 40mg Injection is given based on your age and body weight. If you have low body weight, the chances of increased risk of bleeding are high, so mostly low doses are prescribed by your doctor. You may be monitored closely for signs of clot formation.

No, do not take this Clexane 40mg Injection if you have a stomach ulcer. Please inform your doctor about this condition before receiving it.

Yes, Clexane 40mg Injection may cause bleeding. If you notice purple spots on the skin or unusual bruising, blood in urine, black tarry stools, or unusual bleeding from the gums or nose, please inform your doctor immediately as these are signs of bleeding more easily.

Increases in liver enzymes are the most common side effect with Clexane 40mg Injection . Regular lipid profile tests are recommended to avoid any additional complications.

Clexane 40mg Injection typically starts showing its effect within 1 to 2 hours and it remains in the body for about 12 hours.

No, Clexane 40mg Injection dosage should be given exactly as prescribed by the doctor.

Clexane 40mg Injection contains Enoxaparin as it active ingredient.

Clexane 40mg Injection is mostly prescribed for angina (chest pain), deep vein thrombosis (blood clot in veins) and as a post-surgery precautionary step.

Yes, there are many substitutes available in the market. However, please note that all these substitutes have the same composition and thus should be administered with the same set of precautions.

Clexane 40mg Injection will be administered by a doctor or nurse in the hospital or clinic. Do not self-administer.

Bleeding is one of the side effects of Clexane 40mg Injection in some individuals. If you experience any kind of unusual symptoms such as black tarry stool, unusual bleeding, etc., inform the doctor immediately.

The side effects of Clexane 40mg Injection include bleeding, increases in liver enzymes, bruise more easily than usual, pink patches on your skin, skin rash (hives, urticaria), itchy red skin, pain or bruising at the injection site and headache. If these side effects persist or worsen, please inform your doctor.

The dose and duration of Clexane 40mg Injection is prescribed by a doctor based on the underlying condition and the patient’s response to the treatment.

Clexane 40mg Injection is injected beneath the skin. Fix the medicine dose and make a fold by pinching the skin of your stomach between your finger and thumb. After cleansing the area, hold the syringe like a pencil and insert the full length of the needle into the skin fold. Inject Clexane 40mg Injection and discard the syringe as instructed by your doctor. Follow the instructions given by the doctor strictly. In case of any doubt or any reactions associated with the medicine, contact your doctor.

Tell your doctor if you have a heart valve fitted or have high blood pressure, gastric ulcer, kidney problems or diabetes. Also, let your doctor know if you ever had a reaction to heparin or had a recent stroke, spinal or brain surgery. The chances of complications and side effects increase in these conditions.

Store Clexane 40mg Injection below 25°C. Do not freeze. Keep it out of reach and sight of children.

Yes, Clexane 40mg Injection is used in the treatment of heart attack and chest pain once the patient has received the standard treatment. It is administered along with another blood thinner like aspirin. As it is a blood thinner, it prevents the blood from clotting and prevents any further episodes and complications.

Yes, you can push the air bubbles into the injection site. Removing the air bubbles causes loss of the medicine thereby changing the prescribed dose.

Country of origin

France

Manufacturer/Marketer address

CT Survey No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072.
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Author Details

Doctor imageDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:49 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.hpra.ie/img/uploaded/swedocuments/bacb76b5-7e4a-4f47-b8f0-4e18706c5070.pdf
  2. https://www.healthline.com/health/enoxaparin-injectable-solution#other-warnings
  3. https://www.webmd.com/drugs/2/drug-3475/enoxaparin-subcutaneous/details
  4. https://www.drugs.com/mtm/enoxaparin.html
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