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  3. CLOKERAN 5MG TABLET 30'S

CLOKERAN 5MG TABLET 30'S, Pack of 1 TABLET
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

CLOKERAN 5MG TABLET is used to treat various cancer conditions such as Hodgkin's disease, certain forms of non-Hodgkin's lymphoma, Chronic lymphocytic leukaemia, Waldenstrom's macroglobulinaemia, Advanced ovarian adenocarcinoma and breast cancer. CLOKERAN 5MG TABLET contains Chlorambucil, works by slowing or stopping the growth of cancer cells in your body. Thus, it treats cancer efficiently.

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Composition :

CHLORAMBUCIL-5MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About CLOKERAN 5MG TABLET

CLOKERAN 5MG TABLET belongs to a class of cytotoxic drugs, also known as chemotherapeutic agents, primarily used to treat various cancer conditions such as Hodgkin's disease, certain forms of non-Hodgkin's lymphoma, Chronic lymphocytic leukaemia, Waldenstrom's macroglobulinaemia, advanced Ovarian adenocarcinoma and Breast cancer. Cancer is a genetic change in which the body's cells divide uncontrollably and spread into surrounding tissues.

CLOKERAN 5MG TABLET contains Chlorambucil, which works by slowing or stopping the growth of cancer cells in the body. Thus, it treats cancer efficiently.

Use CLOKERAN 5MG TABLET as directed by your doctor. It may cause side effects, such as a drop in the number of blood cells and platelets, feeling sick (nausea), being sick (vomiting), sores in the mouth and throat, tiredness and missed menstrual periods (in girls and women). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Tell your doctor before prescribing CLOKERAN 5MG TABLET if you have a history of bleeding disorders, heart or liver problems, radiation treatment, or any infection. Many other medications can interact with or be impacted by CLOKERAN 5MG TABLET , so let your doctor know all your medications. This medicine has been shown to reduce the number of blood cells, making you more susceptible to infections. During treatment with this medication, you will need to have regular blood tests to assess your blood cells, as well as your kidney, liver, and heart function.

Do not take CLOKERAN 5MG TABLET if you are allergic (hypersensitive) to Chlorambucil or any of the other ingredients of this medicine. Chlorambucil may increase the risk of developing other cancers. CLOKERAN 5MG TABLET can disrupt a woman's natural menstrual cycle (period) and stop sperm production in men. It may induce permanent infertility (difficulty becoming pregnant); If you are pregnant, inform your doctor before starting this medication. It is not recommended for use in the first trimester of pregnancy. Effective birth control measures are advised for men and women while on treatment with this medicine. Call your doctor right away if you become pregnant while taking Chlorambucil. 

Uses of CLOKERAN 5MG TABLET

CLOKERAN 5MG TABLET is used to treat certain types of blood cancers. The detailed uses of CLOKERAN 5MG TABLET are as follows:<br/>• Treats chronic lymphocytic leukemia (CLL): CLOKERAN 5MG TABLET is used to manage chronic lymphocytic leukemia (CLL), a cancer of the white blood cells.<br/>• Used to treat non-Hodgkin’s lymphoma (NHL): CLOKERAN 5MG TABLET helps treat non-Hodgkin’s lymphoma (NHL), a cancer that starts in immune system cells.<br/>• Manages Hodgkin’s disease: CLOKERAN 5MG TABLET is also used to treat Hodgkin’s lymphoma, another type of cancer affecting white blood cells.<br/>

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Directions for Use

• Take CLOKERAN 5MG TABLET on an empty stomach, as co-administration with food can reduce its bioavailability. It can be taken 1 hour before a meal or 2 hours after a meal.• Follow the prescribed dosage and timing to ensure the medication works effectively.• Swallow the whole tablet with a glass of water.• Do not crush, chew or break it.

Medicinal Benefits

CLOKERAN 5MG TABLET is a cytotoxic medicine, also known as a chemotherapeutic agent, primarily used to treat various cancer conditions such as Hodgkin's disease, certain forms of non-Hodgkin's lymphoma, Chronic lymphocytic leukaemia, Waldenstrom's macroglobulinaemia, Advanced ovarian adenocarcinoma and breast cancer. Chlorambucil, present in CLOKERAN 5MG TABLET , works by slowing or stopping the growth of cancer cells in your body. Thus, it treats cancer efficiently.

How CLOKERAN 5MG TABLET Works

CLOKERAN 5MG TABLET contains Chlorambucil, which works by slowing or stopping the growth of cancer cells in the body. Thus, it treats cancer efficiently.

Storage

• Store in a cool and dry place away from sunlight.
• Keep CLOKERAN 5MG TABLET out of reach and sight of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Clokeran 5mg Tablet
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • Include iron-rich foods like dark leafy vegetables, lean red meat, legumes and fish in your diet.
  • Consume vitamin C-rich foods as they aid iron absorption.
  • Limit tea, cocoa, and coffee as these can slow iron absorption.
  • Exercise regularly; however, do not overdo it.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
  • Talk to your doctor about medicines to manage neutropenia based on the underlying cause.
  • Avoid contact with people who are sick.
  • Wash your hands regularly with soap and water.
  • Avoid unpasteurized dairy products.
  • Managing a low platelet count (thrombocytopenia) caused by medication usage requires a multi-step approach. Here are some steps to help manage the condition:
  • Inform your doctor about your low platelet count and medication usage. They will assess the situation and guide the best course of action.
  • Your doctor may recommend adjusting or stopping the medication that is causing a low platelet count. This could involve switching to alternative medication or reducing the dosage.
  • Monitor your platelet count regularly through blood tests to track any changes. This will help the doctor determine the effectiveness of the treatment plan.
  • If an underlying condition, such as infection or inflammation, contributes to the low platelet count, your doctor will treat it.
  • In some cases, alternative treatments like platelet transfusions or medications that stimulate platelet production may be necessary.
  • Avoid risky activities and certain medications; eat a balanced diet with plenty of water to reduce bleeding risk and boost overall health.
  • If you experience severe bleeding or bruising, seek emergency medical attention immediately.

What if I have taken an overdose of CLOKERAN 5MG TABLET

Please do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose of CLOKERAN 5MG TABLET may include agitation, bruising, bleeding gums, fast heartbeats, nosebleeds, skin rash, signs of infection (fever, chills, weakness), and trouble breathing. Seek immediate medical attention if you observe any symptoms or think you have taken too much. Do this even if there are no signs of discomfort or poisoning.

Drug Warnings

Before taking CLOKERAN 5MG TABLET , inform your doctor about your medical history and ongoing therapies to rule out potential adverse effects or interactions. Always take CLOKERAN 5MG TABLET as prescribed by your doctor. It's crucial to take your medication as directed. The dosage of this medicine is based on your condition. Your doctor may adjust your dose during therapy based on the treatment results. The drug chlorambucil can reduce the number of blood cells in your bone marrow. Your doctor will request laboratory testing before, during, and after therapy to determine whether this drug affects your blood cells. Keep all lab appointments. Before taking CLOKERAN 5MG TABLET , inform your doctor if you are pregnant or breastfeeding. If you become pregnant while on treatment with Chlorambucil, tell your doctor.

Drug-Drug Interactions

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ChlorambucilEtanercept
Severe
ChlorambucilCladribine
Severe

Drug-Drug Interactions

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ChlorambucilEtanercept
Severe
How does the drug interact with Clokeran 5mg Tablet:
When Etanercept is used with Clokeran 5mg Tablet, the likelihood or severity of infection may increase.

How to manage the interaction:
Although taking Etanercept and Clokeran 5mg Tablet together can cause an interaction, it can be taken if a doctor has suggested it. However, if you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
ChlorambucilCladribine
Severe
How does the drug interact with Clokeran 5mg Tablet:
The combined Cladribine with Clokeran 5mg Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Clokeran 5mg Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
ChlorambucilThalidomide
Severe
How does the drug interact with Clokeran 5mg Tablet:
Taking thalidomide together with Clokeran 5mg Tablet may increase the risk of blood clots.

How to manage the interaction:
Although taking thalidomide and Clokeran 5mg Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ChlorambucilBaricitinib
Severe
How does the drug interact with Clokeran 5mg Tablet:
Coadministration of baricitinib and Clokeran 5mg Tablet can raise the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Clokeran 5mg Tablet if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular aches, shortness of breath, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
ChlorambucilTofacitinib
Severe
How does the drug interact with Clokeran 5mg Tablet:
Taking Tofacitinib with Clokeran 5mg Tablet may increase the risk of serious infection.

How to manage the interaction:
There may be a possibility of interaction between Tofacitinib and Clokeran 5mg Tablet, but it can be taken if prescribed by a doctor. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blo, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • After your treatment begins, several dietary adjustments can help you control side effects.
  • Anyone suffering from a chronic illness, including cancer, should consume foods high in protein, healthy fats, whole grains, and vitamins and minerals.
  • Plant-based proteins are among the greatest meals to take during chemotherapy or other cancer treatments. They have the highest concentrations of vitamins and minerals, such as nuts, seeds, beans and legumes.
  • Eat a healthy diet and exercise regularly to maintain proper weight.
  • Include leafy vegetables, citrus fruits, fatty fish, berries, yoghurt, apples, peaches, cauliflower, cabbage, broccoli, beans, and herbs.
  • De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
  • Performing yoga may also help in improving both physical and mental health.
  • Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
  • Get optimal sleep; rest well.
  • Avoid smoking and alcohol consumption.
  • Avoid fast and fried food, processed meats, refined carbs and added sugars.

Habit Forming

No

Therapeutic Class

CHEMOTHERAPY

CLOKERAN 5MG TABLET Substitute

Substitutes safety advice
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Alcohol

Caution

Avoid alcohol consumption while on treatment with CLOKERAN 5MG TABLET .

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Pregnancy

Unsafe

CLOKERAN 5MG TABLET is not recommended for use during pregnancy, especially in the first trimester. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

CLOKERAN 5MG TABLET should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

It is unknown whether CLOKERAN 5MG TABLET alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Caution

Patients with liver impairment should be closely monitored for signs and symptoms of toxicity. If you have a pre-existing or a history of liver disease, inform your doctor before taking CLOKERAN 5MG TABLET . Your doctor will weigh the benefits and potential risks before prescribing CLOKERAN 5MG TABLET .

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor before taking CLOKERAN 5MG TABLET . Your doctor may titrate the dose if required based on your condition.

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Children

Consult your doctor

CLOKERAN 5MG TABLET can be used to treat Hodgkin's disease and non-Hodgkin's lymphomas in children. Please consult your doctor for more information.

FAQs

CLOKERAN 5MG TABLET is used to treat Cancer.

CLOKERAN 5MG TABLET contains Chlorambucil, which works by slowing or stopping the growth of cancer cells in your body. Thus, it treats cancer efficiently.

Attend all your doctor&amp;#039;s appointments while taking CLOKERAN 5MG TABLET to ensure the therapy is effective. Regular blood tests and weight checks must be performed. While taking the CLOKERAN 5MG TABLET , both men and women should use an effective means of contraception. Do not use any other medications unless prescribed by the doctor.

Do not stop taking CLOKERAN 5MG TABLET on your own. Take CLOKERAN 5MG TABLET for as long as your doctor prescribes it, depending on your medical condition. Do not hesitate to speak with your doctor if you experience difficulty taking CLOKERAN 5MG TABLET .

Chlorambucil can cause a significant decrease in the number of blood cells and platelets. Your doctor may suggest laboratory tests before and during the treatment.

Chlorambucil may increase the risk that you will develop other cancers. Talk to your doctor about this risk.

Some dietary changes can help you manage side effects; for example, in case of diarrhoea-Choose foods or drinks with sodium (sports drinks or broth) and potassium (bananas and all-natural fruit juices).

CLOKERAN 5MG TABLET should be taken orally. Swallow CLOKERAN 5MG TABLET as a whole with a glass of water. Do not break, crush or chew it.

CLOKERAN 5MG TABLET doesn’t have the potential to cause hair loss or constipation. However, if you experience hair loss or constipation, consult your doctor immediately.

CLOKERAN 5MG TABLET is metabolised in the liver and excreted in the urine.

Yes, CLOKERAN 5MG TABLET should be stored at 2-8°C (36-46°F). Keep it out of sight and reach of children.

The common side effects of CLOKERAN 5MG TABLET may include feeling sick (nausea), being sick (vomiting), sores in the mouth and throat, and tiredness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - CLO0030

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 9:22 AM IST

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Reference

  1. https://www.medsafe.govt.nz/profs/datasheet/l/Leukerantab.pdf
  2. https://issuu.com/tajpharmaceutical/docs/chlorambusil_tablets_2mg_taj_pharma-smpc
  3. https://www.drugs.com/chlorambucil.html
  4. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/chlorambucil
  5. https://reference.medscape.com/drug/leukeran-chlorambucil-342112
  6. https://go.drugbank.com/drugs/DB00291
  7. https://medlineplus.gov/druginfo/meds/a682899.html#:~:text=Expand%20Section,cells%20that%20normally%20fight%20infection).
  8. https://www.cancer.org/cancer/types/chronic-lymphocytic-leukemia/about/what-is-cll.html
  9. https://www.hopkinsmedicine.org/health/conditions-and-diseases/cancer/cancer-diet-foods-to-add-and-avoid-during-cancer-treatment

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