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  3. Clozapil 50 Tablet 10's

Clozapil 50 Tablet 10's, Pack of 10 TabletS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
Clozapil 50 Tablet is used to treat schizophrenia. Additionally, it is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. It contains Clozapine, which helps in improving mood, behaviour and thoughts. It may cause side effects such as tachycardia (fast heartbeat), dizziness, headache, tremor, sweating, dry mouth, nausea, constipation and visual disturbances. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

CLOZAPINE-50MG

Manufacturer/Marketer :

Arbour Biotec Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Clozapil 50 Tablet

Clozapil 50 Tablet is used to treat schizophrenia. Additionally, Clozapil 50 Tablet is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Schizophrenia is a medical condition in which the person may feel, hear or see things that are not there, believe things that are not true, or feel unusually suspicious or confused.

Clozapil 50 Tablet contains ‘Clozapine’, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps in improving mood, behaviour and thoughts.

You are advised to take Clozapil 50 Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, Clozapil 50 Tablet may cause side effects such as tachycardia (fast heartbeat), dizziness, headache, tremor, sweating, dry mouth, nausea, constipation and visual disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Clozapil 50 Tablet suddenly, as it might cause withdrawal symptoms. Consult your doctor if you are pregnant. Do not take Clozapil 50 Tablet if you are breastfeeding, as it may pass into breastmilk. Avoid driving as Clozapil 50 Tablet may cause drowsiness and dizziness. Clozapil 50 Tablet should not be given to children as safety and effectiveness have not been established. Avoid consuming alcohol with Clozapil 50 Tablet as it could lead to increased drowsiness and dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Clozapil 50 Tablet

Treatment of Schizophrenia

Directions for Use

Tablet/Capsule: Swallow it as a whole with a glass of water; do not chew or crush it.Orodispersible/Mouth dissolving tablet: Check the label for directions before use. Place the tablet in the mouth and allow it to dissolve.

Medicinal Benefits

Clozapil 50 Tablet belongs to a group of medicines called antipsychotics. Clozapil 50 Tablet is used to treat schizophrenia and to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders. Clozapil 50 Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby helping in improving mood, behaviour and thoughts. Clozapil 50 Tablet is used to treat schizophrenia when other antipsychotic drugs are ineffective or have caused severe adverse effects. Clozapil 50 Tablet is also used to treat psychotic disorders in patients with Parkinson’s disease when standard treatments have failed.

How Clozapil 50 Tablet Works

Clozapil 50 Tablet contains ‘Clozapine’, which works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin. Thus, it helps in improving mood, behaviour and thoughts.

Storage

Store in a cool and dry place away from sunlight
Side effects of Clozapil 50 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Regularly brush your tongue and teeth to prevent Excessive Saliva Production.
  • Avoid eating foods high in sugar or acid since these foods might increase saliva production, which increases the Excessive Saliva Production.
  • Keep your head up straight and maintain proper posture to prevent saliva from collecting in your mouth.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.

What if I have taken an overdose of Clozapil 50 Tablet

Do not take more than the prescribed dose of Clozapil 50 Tablet as it may cause overdose. The symptoms of overdose include sedation, fast heart rate, high blood pressure, respiratory depression or failure, delirium (serious changes in mental abilities), coma or excess saliva production. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Clozapil 50 Tablet if you are allergic to any of its contents if you have galactose intolerance, total lactase deficiency, glucose-galactose malabsorption, low number of white blood cells or if you are taking medicines that can cause low levels of white blood cells, bone marrow disorder, epilepsy, circulatory collapse (pronounced fall in blood pressure that can lead to unconsciousness), brain disorders, severe kidney disease, heart disease, liver disease with jaundice, liver failure or paralytic ileus (small intestine disorder). Inform your doctor if you have a low number of white blood cells or platelet count, orthostatic hypotension, epilepsy, enlarged prostate or difficulty urinating, glaucoma, severe constipation, diabetes, heart, liver or kidney problems. Consult your doctor if you are pregnant. Do not take Clozapil 50 Tablet if you are breastfeeding, as it may pass into breastmilk.

Drug-Drug Interactions

verifiedApollotooltip
ClozapineMetoclopramide
Critical
ClozapineRopinirole
Critical

Drug-Drug Interactions

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ClozapineMetoclopramide
Critical
How does the drug interact with Clozapil 50 Tablet:
Co-administration of Metoclopramide with Clozapil 50 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Metoclopramide with Clozapil 50 Tablet is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
ClozapineRopinirole
Critical
How does the drug interact with Clozapil 50 Tablet:
When Ropinirole is taken with Clozapil 50 Tablet, it may not work as well.

How to manage the interaction:
Taking Ropinirole with Clozapil 50 Tablet is not recommended as it can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as drowsiness, low blood pressure, dizziness, and lightheadedness. Do not stop using any medications without consulting doctor.
ClozapineCisapride
Critical
How does the drug interact with Clozapil 50 Tablet:
When Clozapil 50 Tablet is taken with Cisapride, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Clozapil 50 Tablet with Cisapride there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapineFlibanserin
Critical
How does the drug interact with Clozapil 50 Tablet:
When Flibanserin and Clozapil 50 Tablet are taken together, may increase side effects.

How to manage the interaction:
There may be a possibility of interaction between Clozapil 50 Tablet and Flibanserin, but it can be taken if prescribed by a doctor. If you notice any of these signs - like dizziness, drowsiness, fatigue, and difficulty concentrating, call a doctor right away. Do not stop using any medications without a doctor's advice.
ClozapinePimozide
Critical
How does the drug interact with Clozapil 50 Tablet:
When Clozapil 50 Tablet is taken with Pimozide, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Clozapil 50 Tablet with Pimozide there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapineSparfloxacin
Critical
How does the drug interact with Clozapil 50 Tablet:
When Clozapil 50 Tablet is taken with Sparfloxacin, can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Clozapil 50 Tablet with Sparfloxacin there may be a possibility of interaction, but it can be taken if prescribed by a doctor. Call a doctor immediately if you notice any of these signs - like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without a doctor's advice.
ClozapinePotassium citrate
Critical
How does the drug interact with Clozapil 50 Tablet:
Taking Clozapil 50 Tablet and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and other gastrointestinal injury.

How to manage the interaction:
Co-administration of Potassium citrate with Clozapil 50 Tablet is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ClozapineDactinomycin
Severe
How does the drug interact with Clozapil 50 Tablet:
Combining Dactinomycin with Clozapil 50 Tablet can increase the risk of risk.

How to manage the interaction:
Although taking Dactinomycin and Clozapil 50 Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you experience symptoms such as infection, fever, sore throat, muscle aches, or weight loss, it is important to contact your doctor right away. Do not stop using any medications without first talking to your doctor.
ClozapineDisopyramide
Severe
How does the drug interact with Clozapil 50 Tablet:
Combining Disopyramide with Clozapil 50 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Co-administration of Clozapil 50 Tablet with Disopyramide can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include an irregular heartbeat, severe or long-lasting diarrhoea, vomiting, complications, dizziness or lightheadedness, fainting, having trouble breathing or experiencing heart palpitations. Contact your doctor if you experience any of these symptoms. Do not discontinue any medications without consulting your doctor.
ClozapineFluorouracil
Severe
How does the drug interact with Clozapil 50 Tablet:
Co-administration of Fluorouracil with Clozapil 50 Tablet can increase the risk of neutropenia (low levels of neutrophils in blood).

How to manage the interaction:
There may be a possibility of interaction between Fluorouracil and Clozapil 50 Tablet, but it can be taken if prescribed by a doctor. If you experience any symptoms such as infection, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, weight loss, or pain or burning during urination, it is important to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly.
  • Include fruits, vegetables, and fibre-rich food in your diet.
  • Cut down on sugars, salts and saturated fats.
  • Drink enough fluids to stay hydrated.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga.
  • Follow a regular sleep pattern.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

Clozapil 50 Tablet Substitute

Substitutes safety advice

  • Sizopin 50 Tablet 10's

    by Others

    ₹5.22per tablet

  • SKIZORIL 50MG TABLET

    by Others

    ₹5.22per tablet

  • Alkepin ODT 50 Tablet 10's

    by AYUR

    ₹5.22per tablet

  • Cipin 50 mg Tablet 10's

    by Others

    ₹5.22per tablet

  • Closin-50 mg Tablet 10's

    by Others

    ₹5.22per tablet

Product Substitutes

bannner image

Alcohol

Unsafe

Avoid consumption of alcohol while taking Clozapil 50 Tablet as it may cause increased drowsiness.

bannner image

Pregnancy

Caution

Clozapil 50 Tablet belongs to pregnancy category B. Please consult your doctor if you are pregnant before taking this medicine; your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Breast Feeding

Unsafe

Clozapil 50 Tablet is not recommended for use during breastfeeding.

bannner image

Driving

Unsafe

Clozapil 50 Tablet causes tiredness, dizziness and vision problems. Do not drive or operate machinery if you experience these symptoms.

bannner image

Liver

Consult your doctor

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have liver problems or any concerns regarding this.

bannner image

Kidney

Consult your doctor

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney problems or any concerns regarding this.

bannner image

Children

Unsafe

Clozapil 50 Tablet should not be given to children as safety and effectiveness have not been established.

FAQs

Clozapil 50 Tablet is used to treat schizophrenia. Additionally, it is also used to reduce the risk of suicidal behaviour in patients with schizophrenia or other similar disorders.

Clozapil 50 Tablet works by blocking the effects of chemical receptors in the brain, such as dopamine and serotonin, thereby improving mood, behaviour and thoughts.

Do not discontinue Clozapil 50 Tablet without consulting your doctor, as it could cause withdrawal symptoms. To treat your condition effectually, continue taking Clozapil 50 Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Clozapil 50 Tablet .

Clozapil 50 Tablet may cause agranulocytosis (low levels of white blood cells), making you more prone to infections. Consult your doctor immediately if you experience flu-like symptoms, sore throat or fever.

Dry mouth could be a side-effect of Clozapil 50 Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Orthostatic hypotension could be a side-effect of Clozapil 50 Tablet . Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking; instead, lie down and get up slowly only when you feel better.

Clozapil 50 Tablet may cause tachycardia (fast heartbeat). Talk to your doctor if you experience irregular or fast heartbeat even at rest, chest pain, unexplained tiredness or breathing problems.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take your regular dose. Please don't take a double dose to make up for a missed one.

Country of origin

India

Manufacturer/Marketer address

B-213, Someshwar Complex-1, Popular Plaza,Satellite,Ahmedabad-380015
Other Info - CLO1574

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Author Details

Doctor imageDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jan 1, 2025 | 2:48 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.6078.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019758s073lbl.pdf
  3. https://www.medsafe.govt.nz/Consumers/cmi/c/Clozaril.pdf
  4. https://www.drugs.com/clozapine.html
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