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  3. CO-Trimoxazole DS 400mg/80mg Tablet

CO-Trimoxazole DS 400mg/80mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

CO-Trimoxazole DS 400mg/80mg Tablet is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). It contains Trimethoprim and Sulfamethoxazole, which stop the growth of bacteria and kill them. Therefore, it helps treat bacterial infections. In some cases, you may experience specific common side effects, such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

SULFAMETHOXAZOLE-400MG + TRIMETHOPRIM-80MG

Manufacturer/Marketer :

Cadila Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About CO-Trimoxazole DS 400mg/80mg Tablet

CO-Trimoxazole DS 400mg/80mg Tablet is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused by the multiplication of harmful bacteria inside or on the body. CO-Trimoxazole DS 400mg/80mg Tablet does not work against infections caused by the virus, including cold and flu. 

CO-Trimoxazole DS 400mg/80mg Tablet combines two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for forming proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, CO-Trimoxazole DS 400mg/80mg Tablet stops the growth of bacteria and kills them. Therefore, it helps treat bacterial infections.

Your doctor will decide the dose and duration of CO-Trimoxazole DS 400mg/80mg Tablet based on your condition and the severity of the infection. In some cases, you may experience specific common side effects, such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting CO-Trimoxazole DS 400mg/80mg Tablet, please inform your doctor if you have any allergy (against any antibiotic), kidney or liver problems. Do not take CO-Trimoxazole DS 400mg/80mg Tablet on your own as self-medication may lead to antibiotic resistance in which antibiotics fail to act against specific bacterial infections. Consult your doctor before taking CO-Trimoxazole DS 400mg/80mg Tablet if you are pregnant or breastfeeding. Avoid alcohol consumption to prevent unpleasant side effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting. CO-Trimoxazole DS 400mg/80mg Tablet is not recommended for children below 12 years.

Uses of CO-Trimoxazole DS 400mg/80mg Tablet

CO-Trimoxazole DS 400mg/80mg Tablet is used to treat bacterial infections. The detailed uses of CO-Trimoxazole DS 400mg/80mg Tablet are as follows:
•Urinary Tract Infections (UTIs): CO-Trimoxazole DS 400mg/80mg Tablet is often utilized to treat urinary tract infections caused by susceptible bacteria. It prevents bacterial growth and allows the immune system to eliminate the disease.
•Respiratory Tract Infection: CO-Trimoxazole DS 400mg/80mg Tablet can be used to treat specific respiratory infections, including bronchitis and pneumonia, and prevent breathing difficulties caused by bacterial infection.
•Gastrointestinal infections: CO-Trimoxazole DS 400mg/80mg Tablet is often helpful against gastrointestinal infections, especially those caused by Shigella or Salmonella strains. It reduces symptoms like diarrhea and abdominal pain.
•Skin and Soft Tissue Infections: CO-Trimoxazole DS 400mg/80mg Tablet effectively treats bacterial skin infections such as infected cuts, burns, or surgical wounds.
•Pneumocystis Pneumonia (PCP): CO-Trimoxazole DS 400mg/80mg Tablet prevents a potentially life-threatening condition in those with weakened immune systems.

Directions for Use

Swallow CO-Trimoxazole DS 400mg/80mg Tablet as a whole with water; do not crush or chew it.

Medicinal Benefits

CO-Trimoxazole DS 400mg/80mg Tablet belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). CO-Trimoxazole DS 400mg/80mg Tablet is a combination of two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, CO-Trimoxazole DS 400mg/80mg Tablet kills the bacteria and stops their growth. Therefore, it helps treat bacterial infections. CO-Trimoxazole DS 400mg/80mg Tablet is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria such as Streptococcus pneumonia, Escherichia coli, Klebsiella species, Enterobacter species, Haemophilus influenzae, etc.

How CO-Trimoxazole DS 400mg/80mg Tablet Works

CO-Trimoxazole DS 400mg/80mg Tablet is a combination of two antibiotics: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids, which are necessary for the survival of the bacteria. By inhibiting these, CO-Trimoxazole DS 400mg/80mg Tablet stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of CO-Trimoxazole DS 400mg/80mg Tablet

Do not take more than the prescribed dose of CO-Trimoxazole DS 400mg/80mg Tablet as it may cause overdose. The symptoms of overdose include headache, dizziness, nausea, vomiting, confusion, loss of appetite, drowsiness, or mental depression. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take CO-Trimoxazole DS 400mg/80mg Tablet if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking CO-Trimoxazole DS 400mg/80mg Tablet if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. Avoid alcohol consumption while taking CO-Trimoxazole DS 400mg/80mg Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

Drug-Drug Interactions

verifiedApollotooltip
TrimethoprimBCG vaccine
Critical
sulfamethoxazoleClozapine
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
Taking CO-Trimoxazole DS 400mg/80mg Tablet with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between CO-Trimoxazole DS 400mg/80mg Tablet and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
sulfamethoxazoleClozapine
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
The combined use of CO-Trimoxazole DS 400mg/80mg Tablet and clozapine may increase the risk or severity of toxicity.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and CO-Trimoxazole DS 400mg/80mg Tablet, but it can be taken if prescribed by a doctor. If you're having any of these symptoms like fever, chills, sore throat, or muscle aches, it's important to contact your doctor right away. They may be able to recommend other options for you that won't cause any problems. Don't worry, there are solutions available to help you feel better. Do not discontinue any medications without first consulting your doctor.
TrimethoprimRopivacaine
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
Using ropivacaine with CO-Trimoxazole DS 400mg/80mg Tablet can cause higher levels of CO-Trimoxazole DS 400mg/80mg Tablet in the blood.

How to manage the interaction:
Although taking Ropivacaine and CO-Trimoxazole DS 400mg/80mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience gray discoloration of the skin, abnormal blood coloration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion contact your doctor immediately. Do not stop using any medications without a doctor's advice.
TrimethoprimPerindopril
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
Taking perindopril with CO-Trimoxazole DS 400mg/80mg Tablet can cause hyperkalemia(high levels of potassium in blood) which can increase the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Co-administration of Perindopril with CO-Trimoxazole DS 400mg/80mg Tablet can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not stop using any medications without a doctor's advice. Do not discontinue any medications without consulting your doctor.
TrimethoprimAmiloride
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
When amiloride is taken with CO-Trimoxazole DS 400mg/80mg Tablet it may raise potassium levels in the blood. (High potassium levels can cause hyperkalemia, which can lead to kidney failure, muscular paralysis, abnormal heart rhythm).

How to manage the interaction:
Although there is an interaction between amiloride and CO-Trimoxazole DS 400mg/80mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse. Do not discontinue any medications without consulting a doctor.
TrimethoprimIvacaftor
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
When CO-Trimoxazole DS 400mg/80mg Tablet is taken with Ivacaftor, the amount of CO-Trimoxazole DS 400mg/80mg Tablet in the blood increases.

How to manage the interaction:
Taking CO-Trimoxazole DS 400mg/80mg Tablet with Ivacaftor together can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting your doctor.
TrimethoprimTetracaine
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
Co-administration of CO-Trimoxazole DS 400mg/80mg Tablet with tetracaine can result in blood disorders.

How to manage the interaction:
Although there is an interaction between CO-Trimoxazole DS 400mg/80mg Tablet and tetracaine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, headache, dizziness, lightheadedness, fatigue, or shortness of breath. Do not discontinue any medications without consulting a doctor.
TrimethoprimProcaine
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
Co-administration of CO-Trimoxazole DS 400mg/80mg Tablet with procaine may increase the risk of blood disorders.

How to manage the interaction:
Taking CO-Trimoxazole DS 400mg/80mg Tablet with Procaine together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms like gray skin, feeling sick, headache, dizziness, tiredness, trouble breathing, fast heartbeat, or feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrimethoprimPotassium iodide
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
Taking Potassium Iodide with CO-Trimoxazole DS 400mg/80mg Tablet can make high levels of potassium in the blood which can increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and CO-Trimoxazole DS 400mg/80mg Tablet, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
TrimethoprimCalcium folinate
Severe
How does the drug interact with CO-Trimoxazole DS 400mg/80mg Tablet:
Co-administration of Calcium folinate with CO-Trimoxazole DS 400mg/80mg Tablet may increase rates of treatment failure.

How to manage the interaction:
Although there is an interaction between calcium folinate and CO-Trimoxazole DS 400mg/80mg Tablet, but it can be taken together if prescribed by the doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION

CO-Trimoxazole DS 400mg/80mg Tablet Substitute

Substitutes safety advice

  • Cotrimoxazole 400 mg Tablet 10's

    by Others

    ₹1.62per tablet

  • Danatrim 400mg/80mg Tablet

    by Others

    ₹0.78per tablet

  • Cop-Trizole Injection 5 ml

    by Others

    ₹249.00per tablet

  • Cotrimoxazole SS Tablet 10's

    by Others

    ₹1.08per tablet

  • Cotrim 5Ml Inj

    by AYUR

    ₹10.62per tablet

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol consumption while taking CO-Trimoxazole DS 400mg/80mg Tablet to prevent unpleasant side-effects such as fast heartbeats, warmth or redness under your skin, tingly feeling, nausea, and vomiting.

bannner image

Pregnancy

Caution

Please consult your doctor before taking CO-Trimoxazole DS 400mg/80mg Tablet if you are pregnant. Your doctor will prescribe CO-Trimoxazole DS 400mg/80mg Tablet only if the benefits outweigh the risks.

bannner image

Breast Feeding

Caution

Please consult your doctor if you are breastfeeding, your doctor will prescribe CO-Trimoxazole DS 400mg/80mg Tablet only if the benefits outweigh the risks.

bannner image

Driving

Caution

It is unknown whether CO-Trimoxazole DS 400mg/80mg Tablet affects your ability to drive and operating machinery. Drive only if you are physically stable and mentally focussed.

bannner image

Liver

Caution

Please consult your doctor before taking CO-Trimoxazole DS 400mg/80mg Tablet if you have liver impairment/liver disease. Your doctor will weigh the benefits and any potential risks before prescribing it to you.

bannner image

Kidney

Caution

CO-Trimoxazole DS 400mg/80mg Tablet to be taken with caution, especially if you have a history of kidney impairment/kidney disease. The dose may have to be adjusted by your doctor.

bannner image

Children

Unsafe

CO-Trimoxazole DS 400mg/80mg Tablet is not recommended for children below 12 years.

FAQs

CO-Trimoxazole DS 400mg/80mg Tablet is used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma).

CO-Trimoxazole DS 400mg/80mg Tablet is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, CO-Trimoxazole DS 400mg/80mg Tablet kills the bacteria and stops their growth. Thereby, helps to treat bacterial infections.

CO-Trimoxazole DS 400mg/80mg Tablet causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of CO-Trimoxazole DS 400mg/80mg Tablet. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, stop taking CO-Trimoxazole DS 400mg/80mg Tablet and consult your doctor. Do not take anti-diarrheal medicine on your own.

It is recommended to complete the course of CO-Trimoxazole DS 400mg/80mg Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to recurring infections. Continue taking CO-Trimoxazole DS 400mg/80mg Tablet for as long as your doctor has prescribed to treat your condition effectually.

Do not take CO-Trimoxazole DS 400mg/80mg Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.

CO-Trimoxazole DS 400mg/80mg Tablet may affect certain laboratory test results. Inform the person doing the tests that you are taking CO-Trimoxazole DS 400mg/80mg Tablet.

CO-Trimoxazole DS 400mg/80mg Tablet may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking CO-Trimoxazole DS 400mg/80mg Tablet.

You can take CO-Trimoxazole DS 400mg/80mg Tablet with or without as advised by your doctor. Take CO-Trimoxazole DS 400mg/80mg Tablet preferably with food to avoid nausea or diarrhoea.

No, CO-Trimoxazole DS 400mg/80mg Tablet is not an addiction causing medicine. But the dose and duration should be followed as prescribed by your doctor.

Yes, CO-Trimoxazole DS 400mg/80mg Tablet can be used for urinary tract infection as CO-Trimoxazole DS 400mg/80mg Tablet is used to prevent infections caused by bacteria.

Pimples are caused due to various reasons. Therefore, please consult your doctor before taking CO-Trimoxazole DS 400mg/80mg Tablet. If you have any concerns regarding acne, discuss with your doctor.

Yes, CO-Trimoxazole DS 400mg/80mg Tablet is a stronger antibiotic. It contains two antibiotics namely, Sulfamethoxazole and Trimethoprim.

CO-Trimoxazole DS 400mg/80mg Tablet can cause side effects such as high levels of potassium in your blood, which can cause abnormal heart beats. Also, it may cause fungal infections like thrush or candidiasis which can affect mouth or vagina and other common side effects like headache, nausea, diarrhoea and skin rashes. If these effects worsen or persist, consult your doctor.

Yes, CO-Trimoxazole DS 400mg/80mg Tablet is safe to use in most patients. However consult your doctor if you experience any side effects like nausea, vomiting, skin rash, allergic reaction.

Yes, CO-Trimoxazole DS 400mg/80mg Tablet can cause nausea and vomiting. If these persist or worsen, consult your doctor.

CO-Trimoxazole DS 400mg/80mg Tablet is contraindicated in patients who have a history of drug-induced immune thrombocytopenia from using trimethoprim and/or sulfonamides, who have a known hypersensitivity to these medications, or who have megaloblastic anemia from a folate deficiencies and in patients with severe renal insufficiency or obvious liver impairment.

Avoid spicy, acidic, and greasy foods while taking CO-Trimoxazole DS 400mg/80mg Tablet as they may increase your risk of side effects such upset stomach and diarrhoea. Also, CO-Trimoxazole DS 400mg/80mg Tablet can interact with alcohol. It's best to avoid drinking alcohol while taking CO-Trimoxazole DS 400mg/80mg Tablet.

Yes, CO-Trimoxazole DS 400mg/80mg Tablet expires. The expiry date can be found on the packaging.

No, do not stop taking CO-Trimoxazole DS 400mg/80mg Tablet without first consulting your doctor. Complete the full course of treatment even if you feel better as you may notice an improvement in your symptoms before the infection is cured completely.

If you miss a dose of CO-Trimoxazole DS 400mg/80mg Tablet, do not worry. Take it as soon as you remember. But, if it is time for your next dose, skip the missed dose and take your regular dose. Do not take a double dose to make up for the missed dose.

If you don't feel better after completing the full course of treatment with CO-Trimoxazole DS 400mg/80mg Tablet, inform your doctor. Also, let your doctor know if your symptoms are worsening while taking CO-Trimoxazole DS 400mg/80mg Tablet.

CO-Trimoxazole DS 400mg/80mg Tablet should be used in children above 12 years of age if advised by a doctor.

Avoid taking CO-Trimoxazole DS 400mg/80mg Tablet if you are allergic to Sulfamethoxazole, Trimethoprim or any other ingredients of CO-Trimoxazole DS 400mg/80mg Tablet. If you have severe liver or kidney problems, or have ever had thrombocytopenia (blood problem causing bleeding or bruises) or have porphyria (a rare blood problem), inform your doctor before taking CO-Trimoxazole DS 400mg/80mg Tablet.

Take CO-Trimoxazole DS 400mg/80mg Tablet as advised by your doctor. It should be taken with food and it must be taken at a fixed time to ensure better efficacy. Do not consume more than the recommended dose. Swallow it as whole with a glass of water. Do not crush or chew it.

Store the CO-Trimoxazole DS 400mg/80mg Tablet in the original package at room temperature. Keep it out of the reach and sight of children.

Country of origin

India
Other Info - CO36479

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Author Details

Doctor imageDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Doctor imageDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Apr 7, 2025 | 9:09 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.medicines.org.uk/emc/files/pil.6997.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/018374s025lbl.pdf
  3. https://www.drugs.com/mtm/sulfamethoxazole-and-trimethoprim.html
  4. https://medlineplus.gov/druginfo/meds/a684026.html#:~:text=Co%2Dtrimoxazole%20is%20a%20combination,flu%2C%20or%20other%20viral%20infections
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