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About Combigan Ophthalmic Solution 5 ml
Combigan Ophthalmic Solution 5 ml is used to lower elevated intraocular pressure in patients with glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye due to poor drainage of aqueous humour (fluid in the eye that maintains normal pressure by its continuous flow).
Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate (alpha-2 adrenergic receptor agonists), Timolol (beta-blocker), and Benzalkonium chloride (preservative). Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.
You are advised to use Combigan Ophthalmic Solution 5 ml for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience common side effects such as a burning sensation, eye redness, itching, irritation, and vision disturbances. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
Consult a doctor if you are pregnant or breastfeeding. Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years as safety and effectiveness have not been established. Combigan Ophthalmic Solution 5 ml might cause drowsiness, so drive only if you are alert. Avoid touching the tip of the dropper as it may contaminate the contents. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.
Directions for Use
Medicinal Benefits
Combigan Ophthalmic Solution 5 ml is a combination of three drugs: Brimonidine tartrate, Timolol, and Benzalkonium chloride. Combigan Ophthalmic Solution 5 ml is indicated for lowering intraocular pressure in patients with glaucoma or ocular hypertension. Brimonidine tartrate belongs to a group of medicines called alpha-2 adrenergic receptor agonists, and Timolol belongs to a group of medicines called beta-blockers. They work by decreasing the production of aqueous humour and increasing the amount of liquid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.
How Combigan Ophthalmic Solution 5 ml Works
Storage
What if I have taken an overdose of Combigan Ophthalmic Solution 5 ml
Drug Warnings
Do not use Combigan Ophthalmic Solution 5 ml if you are allergic to any of its contents, if you have/had bronchial asthma, severe chronic obstructive bronchitis, low heart rate, heartbeat disorder, heart failure, if you are taking anti-depressants or monoamine oxidase inhibitors. Inform your doctor if you have/had coronary heart disease, slow heartbeat, breathing problems, chronic obstructive pulmonary disease, poor blood circulation disease, diabetes, overactive thyroid, tumour of the adrenal gland, corneal disease, excess acidity in the blood, kidney or liver problems. If you are due to have any surgery or eye surgery, inform the doctor/surgeon that you are taking Combigan Ophthalmic Solution 5 ml. Consult a doctor if you are pregnant or breastfeeding. Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years. Combigan Ophthalmic Solution 5 ml might cause drowsiness, blurred vision; so, drive only if you are alert.
Drug-Drug Interactions
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Diet & Lifestyle Advise
Include fresh fruits and vegetables in your diet.
Avoid smoking and alcohol consumption.
Avoid intake of baked foods such as cakes, cookies, doughnuts or fried items such as french fries and stick margarine as these foods may worsen glaucoma and damage the optic nerve.
Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.
Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.
Habit Forming
Therapeutic Class
Alcohol
Caution
It is not known if alcohol interacts with Combigan Ophthalmic Solution 5 ml. Please consult your doctor if you have any concerns.
Pregnancy
Caution
Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
Caution
Consult your doctor if you are breastfeeding. Your doctor will decide if Combigan Ophthalmic Solution 5 ml can be used by breastfeeding mothers or not.
Driving
Caution
Combigan Ophthalmic Solution 5 ml might cause tiredness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.
Liver
Caution
Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with liver impairment.
Kidney
Caution
Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with kidney impairment.
Children
Unsafe
Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years as safety and effectiveness have not been established.
Have a query?
Combigan Ophthalmic Solution 5 ml is indicated for lowering elevated intraocular pressure in patients with glaucoma or ocular hypertension.
Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.
Do not stop using Combigan Ophthalmic Solution 5 ml without consulting your doctor. Continue using Combigan Ophthalmic Solution 5 ml for as long as your doctor has prescribed it to you to treat your condition effectually. Consult the doctor if you experience any difficulty while using Combigan Ophthalmic Solution 5 ml.
Combigan Ophthalmic Solution 5 ml might cause blurred vision and vision disturbances. So, avoid driving or operating machinery until your vision is clear to prevent any mishappening.
Combigan Ophthalmic Solution 5 ml contains benzalkonium chloride; it might discolour soft contact lenses. Therefore, do not wear contact lens while using Combigan Ophthalmic Solution 5 ml. Remove contact lenses before using Combigan Ophthalmic Solution 5 ml and put them back 15 minutes after using Combigan Ophthalmic Solution 5 ml.
Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you have hypertension. Regularly monitor blood pressure levels while taking Combigan Ophthalmic Solution 5 ml to prevent unpleasant events.
Dry mouth could be a side-effect of Combigan Ophthalmic Solution 5 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Combigan Ophthalmic Solution 5 ml can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Combigan Ophthalmic Solution 5 ml and other eye medications.
Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you are diabetic as Combigan Ophthalmic Solution 5 ml contains timolol; it might lower the blood glucose levels and may mask the symptoms of low blood sugar levels. Regular monitoring of blood glucose levels whilst taking Combigan Ophthalmic Solution 5 ml is advised.
Combigan Ophthalmic Solution 5 ml is a highly effective eye drop combination for reducing intraocular pressure (IOP) in glaucoma or ocular hypertension patients. Clinical studies have demonstrated that this combination reduces IOP by 25-30% or more, and its efficacy is superior to either brimonidine or timolol alone. Additionally, Combigan Ophthalmic Solution 5 ml has a rapid onset of action, with significant IOP reduction observed within 1-2 hours, and its effectiveness is maintained over time with long-term use.
Combigan Ophthalmic Solution 5 ml should be stored in a cool, dry place at a temperature between 15°C to 30°C (59°F to 86°F). Do not refrigerate or freeze.
Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes. If any liquid spills out of your eye, gently blot it away with a clean tissue.
Combigan Ophthalmic Solution 5 ml should not be stopped when symptoms are relieved, as glaucoma is a chronic condition that requires ongoing management. When Combigan Ophthalmic Solution 5 ml is stopped, intraocular pressure (IOP) can rise again, potentially leading to vision loss. Therefore, it's essential to continue using Combigan Ophthalmic Solution 5 ml as directed by your doctor, even if symptoms improve, to maintain control over IOP and prevent long-term damage. However, if your condition is well-controlled and your doctor determines it's safe to do so, they may adjust or discontinue Combigan Ophthalmic Solution 5 ml to minimize potential side effects and ensure the best possible outcome for your eye health.
Storage: Store Combigan Ophthalmic Solution 5 ml at room temperature between 15°C and 30°C (59°F and 86°F). Keep the bottle away from direct light and excessive heat. Always replace the cap tightly after use to prevent contamination.Disposal: Do not dispose of unused or expired medication in household trash or wastewater. Follow local regulations for proper medication disposal. Dispose of empty bottles according to local guidelines for medical waste.
Combigan Ophthalmic Solution 5 ml has several contraindications, including hypersensitivity to its components, reactive airway disease, severe cardiovascular disease, and certain heart conditions. It is also not recommended for neonates, infants, pregnant, or breastfeeding women, unless the benefits outweigh the risks. However, this list is not exhaustive, and it's crucial to consult with your doctor before using this medication. They will evaluate your individual situation and provide personalized guidance on safe use.
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