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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Combigan Ophthalmic Solution 5 ml is used to lower intraocular pressure in conditions like glaucoma and ocular hypertension. It works by decreasing the production of aqueous humour and increasing the amount of liquid that is drained. In some cases, this medicine may cause side effects such as a burning sensation, eye redness, itching, irritation, and vision disturbances. Avoid touching the container's tip to the eye, eyelids, or surrounding areas, as it may contaminate the product.

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Manufacturer/Marketer :

Allergan Healthcare India Pvt Ltd

Consume Type :

OPHTHALMIC

Return Policy :

Not Returnable

Expires on or after :

About Combigan Ophthalmic Solution 5 ml

Combigan Ophthalmic Solution 5 ml is used to lower elevated intraocular pressure in patients with glaucoma or ocular hypertension. Glaucoma is an eye disease that causes damage to the optic nerve and results in reduced vision. Ocular hypertension is increased pressure in the eye.

Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative.

In some cases, Combigan Ophthalmic Solution 5 ml may cause side effects such as a burning sensation, redness, itching, irritation, and vision disturbances. Most of these side effects do not require medical attention and resolve over time. However, talk to your doctor if the side effects persist or worsen.

Consult a doctor if you are pregnant or breastfeeding. Avoid touching the tip of the dropper as it may contaminate the contents. Keep your doctor informed about your health condition and the medicines you are taking to prevent any side effects/interactions.

Uses of Combigan Ophthalmic Solution 5 ml

Combigan Ophthalmic Solution 5 ml used in the treatment of Glaucoma and Ocular Hypertension. The detailed uses of Combigan Ophthalmic Solution 5 ml are as follows:

  • Treatment of Glaucoma: Combigan Ophthalmic Solution 5 ml reduces intraocular pressure (IOP) in patients with glaucoma by decreasing aqueous humour production and increasing outflow, helping prevent progressive vision loss.
  • Ocular Hypertension: Combigan Ophthalmic Solution 5 ml lowers high pressure in the eye, reducing the risk of optic nerve damage and vision loss.

Directions for Use

  • It is recommended to use Combigan Ophthalmic Solution 5 ml twice daily, approximately 12 hours apart, or as advised by your doctor.
  • Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the prescribed number of drops into the pocket. Close your eyes for 1-2 minutes.
  • Avoid touching the container tip to the eye or eyelids to prevent contamination.

Medicinal Benefits

  • Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride, used to lower elevated intraocular pressure in patients with glaucoma or ocular hypertension.
  • Brimonidine tartrate is an alpha-2 adrenergic receptor agonist that decreases aqueous humour production and increases its drainage.
  • Timolol is a beta-blocker that primarily reduces aqueous humour production in the ciliary body.
  • Benzalkonium chloride acts as a preservative to maintain the sterility of the solution, ensuring safe and prolonged use.
  • Using a fixed-dose combination like Combigan Ophthalmic Solution 5 ml reduces the number of eye drops needed, improving patient compliance and simplifying treatment regimens.
  • By effectively lowering intraocular pressure, Combigan Ophthalmic Solution 5 ml helps prevent optic nerve damage and supports the long-term preservation of vision in patients at risk of glaucomatous damage.

How Combigan Ophthalmic Solution 5 ml Works

Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate (alpha-2 adrenergic receptor agonists), Timolol (beta-blocker), and Benzalkonium chloride (preservative). Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.

Storage

• Store in a cool and dry place away from sunlight.• Keep Combigan Ophthalmic Solution 5 ml out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Combigan Ophthalmic Solution 5 ml

Do not exceed the recommended dose, as it might cause an overdose. Signs and symptoms of an overdose in babies and children may include floppiness, sleepiness, low body temperature, paleness and breathing difficulties. Seek immediate medical attention if you experience these symptoms.

Drug Warnings

  • Do not use Combigan Ophthalmic Solution 5 ml if you are allergic to any of its contents, if you have/had bronchial asthma, severe chronic obstructive bronchitis, low heart rate, heartbeat disorder, heart failure, or if you are taking anti-depressants or monoamine oxidase inhibitors.
  • Inform your doctor if you have/had coronary heart disease, slow heartbeat, breathing problems, chronic obstructive pulmonary disease, poor blood circulation disease, diabetes, overactive thyroid, tumour of the adrenal gland, corneal disease, excess acidity in the blood, or kidney or liver problems.
  • If you are due to have any surgery or eye surgery, inform the doctor/surgeon that you are using Combigan Ophthalmic Solution 5 ml.
  • Consult your doctor if you are pregnant or breastfeeding.
  • Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years.
  • Combigan Ophthalmic Solution 5 ml might cause drowsiness, blurred vision; so, drive only if you are alert.
  • Let your doctor know if you are taking any other medicines, including herbal products.

Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of aminophylline with Combigan Ophthalmic Solution 5 ml can make Combigan Ophthalmic Solution 5 ml less effective and increase the effects of aminophylline.

How to manage the interaction:
Taking Aminophylline with Combigan Ophthalmic Solution 5 ml can lead to an interaction, however, it can be taken only if a doctor has advised it. If you experience symptoms such as nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Taking Combigan Ophthalmic Solution 5 ml with theophylline, could make Combigan Ophthalmic Solution 5 ml less effective and enhance the effects of theophylline.

How to manage the interaction:
Although taking Combigan Ophthalmic Solution 5 ml and theophylline together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, or difficulty breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
TimololPirbuterol
Severe
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Pirbuterol with Combigan Ophthalmic Solution 5 ml can decrease the action of both the medications, can increase the risk or severity of side effects including increased risk of asthma, breathing problems.

How to manage the interaction:
Although taking pirbuterol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of salbutamol with Combigan Ophthalmic Solution 5 ml can increase the risk of narrowing of the airways.

How to manage the interaction:
Although taking salbutamol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience Coughing, wheezing, shortness of breath, and high-pitched breathing, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Combigan Ophthalmic Solution 5 ml together with disopyramide can increase the effects of disopyramide.

How to manage the interaction:
Although taking disopyramide and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as dizziness, fainting, palpitations, slow or fast pulse, or irregular heartbeats, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
TimololOlodaterol
Severe
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of Olodaterol with Combigan Ophthalmic Solution 5 ml can decrease the action of both the medications, can increase the risk or severity of side effects including increased risk of asthma, breathing problems.

How to manage the interaction:
Although taking olodaterol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Taking Combigan Ophthalmic Solution 5 ml with formoterol could reduce the benefits of both medications because they have opposite effects on the body.

How to manage the interaction:
Although taking formoterol and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms, contact your doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of atazanavir with Combigan Ophthalmic Solution 5 ml can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking atazanavir and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as sudden dizziness, lightheadedness, fainting, or irregular heartbeat consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of verapamil with Combigan Ophthalmic Solution 5 ml can increase the risk or severity of side effects.

How to manage the interaction:
Although taking verapamil and Combigan Ophthalmic Solution 5 ml together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience symptoms such as fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Combigan Ophthalmic Solution 5 ml:
Co-administration of ceritinib with Combigan Ophthalmic Solution 5 ml can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking certinib and Combigan Ophthalmic Solution 5 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as dizziness, lightheadedness, fainting, or irregular heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include fresh fruits and vegetables in your diet.
  • Avoid smoking and alcohol consumption.
  • Avoid intake of baked foods or fried items.
  • Cut down your coffee intake as it may increase pressure in the eye. Replace coffee with green tea.
  • Avoid exercises such as any position where the head is lower than the body, like an inverted yoga pose, as it may increase pressure in the eye. Doing selective exercises is advised for glaucoma patients.

Habit Forming

No

Therapeutic Class

OPHTHALMOLOGIC AGENTS
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Alcohol

Caution

It is not known if alcohol interacts with Combigan Ophthalmic Solution 5 ml. Please consult your doctor if you have any concerns.

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Pregnancy

Caution

Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor if you are breastfeeding. Your doctor will decide if Combigan Ophthalmic Solution 5 ml can be used by breastfeeding mothers or not.

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Driving

Caution

Combigan Ophthalmic Solution 5 ml might cause tiredness, drowsiness, and blurred/abnormal vision. So, avoid driving or operating machinery until your vision is clear.

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Liver

Caution

Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with liver impairment.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding the usage of Combigan Ophthalmic Solution 5 ml in patients with kidney impairment.

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Children

Unsafe

Combigan Ophthalmic Solution 5 ml is not recommended for children below 17 years, as safety and effectiveness have not been established.

Have a query?

FAQs

Combigan Ophthalmic Solution 5 ml is indicated for lowering elevated intraocular pressure in patients with glaucoma or ocular hypertension.

Combigan Ophthalmic Solution 5 ml contains Brimonidine tartrate, Timolol, and Benzalkonium chloride. Brimonidine tartrate and timolol decrease the production of aqueous humour and increase the amount of fluid that is drained. Benzalkonium chloride acts as a preservative. Together, Combigan Ophthalmic Solution 5 ml helps lower the increased pressure in the eye.

Do not stop using Combigan Ophthalmic Solution 5 ml without consulting your doctor. Continue using Combigan Ophthalmic Solution 5 ml for as long as your doctor has prescribed it to you to treat your condition effectually. Consult the doctor if you experience any difficulty while using Combigan Ophthalmic Solution 5 ml.

Combigan Ophthalmic Solution 5 ml might cause blurred vision and vision disturbances. So, avoid driving or operating machinery until your vision is clear to prevent any mishappening.

Combigan Ophthalmic Solution 5 ml contains benzalkonium chloride; it might discolour soft contact lenses. Therefore, do not wear contact lens while using Combigan Ophthalmic Solution 5 ml. Remove contact lenses before using Combigan Ophthalmic Solution 5 ml and put them back 15 minutes after using Combigan Ophthalmic Solution 5 ml.

Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you have hypertension. Regularly monitor blood pressure levels while taking Combigan Ophthalmic Solution 5 ml to prevent unpleasant events.

Dry mouth could be a side-effect of Combigan Ophthalmic Solution 5 ml. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Combigan Ophthalmic Solution 5 ml can be used with other eye medications if prescribed by the doctor. However, maintain a gap of 5-10minutes between Combigan Ophthalmic Solution 5 ml and other eye medications.

Consult your doctor before using Combigan Ophthalmic Solution 5 ml if you are diabetic as Combigan Ophthalmic Solution 5 ml contains timolol; it might lower the blood glucose levels and may mask the symptoms of low blood sugar levels. Regular monitoring of blood glucose levels whilst taking Combigan Ophthalmic Solution 5 ml is advised.

Combigan Ophthalmic Solution 5 ml is a highly effective eye drop combination for reducing intraocular pressure (IOP) in glaucoma or ocular hypertension patients. Clinical studies have demonstrated that this combination reduces IOP by 25-30% or more, and its efficacy is superior to either brimonidine or timolol alone. Additionally, Combigan Ophthalmic Solution 5 ml has a rapid onset of action, with significant IOP reduction observed within 1-2 hours, and its effectiveness is maintained over time with long-term use.

Combigan Ophthalmic Solution 5 ml should be stored in a cool, dry place at a temperature between 15°C to 30°C (59°F to 86°F). Do not refrigerate or freeze.

Lie down and tilt your head backwards. Gently pull your lower eyelid with your index finger to form a pocket. Instil the number of drops advised by the doctor into the pocket of the lower eyelid. Close your eyes for 1-2 minutes. If any liquid spills out of your eye, gently blot it away with a clean tissue.

Combigan Ophthalmic Solution 5 ml should not be stopped when symptoms are relieved, as glaucoma is a chronic condition that requires ongoing management. When Combigan Ophthalmic Solution 5 ml is stopped, intraocular pressure (IOP) can rise again, potentially leading to vision loss. Therefore, it's essential to continue using Combigan Ophthalmic Solution 5 ml as directed by your doctor, even if symptoms improve, to maintain control over IOP and prevent long-term damage. However, if your condition is well-controlled and your doctor determines it's safe to do so, they may adjust or discontinue Combigan Ophthalmic Solution 5 ml to minimize potential side effects and ensure the best possible outcome for your eye health.

Storage: Store Combigan Ophthalmic Solution 5 ml at room temperature between 15°C and 30°C (59°F and 86°F). Keep the bottle away from direct light and excessive heat. Always replace the cap tightly after use to prevent contamination.Disposal: Do not dispose of unused or expired medication in household trash or wastewater. Follow local regulations for proper medication disposal. Dispose of empty bottles according to local guidelines for medical waste.

Combigan Ophthalmic Solution 5 ml has several contraindications, including hypersensitivity to its components, reactive airway disease, severe cardiovascular disease, and certain heart conditions. It is also not recommended for neonates, infants, pregnant, or breastfeeding women, unless the benefits outweigh the risks. However, this list is not exhaustive, and it's crucial to consult with your doctor before using this medication. They will evaluate your individual situation and provide personalized guidance on safe use.

Country of origin

INDIA

Manufacturer/Marketer address

No.3, Kasturba Road, Level 2, Prestige Obelisk, Bangalore – 560 001., KARNATAKA, INDIA
Other Info - COM0005

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