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  3. Combither Tablet 8's

Combither Tablet 8's, Pack of 8
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Written By Veda Maddala , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Combither Tablet 8's is used to treat and prevent malaria. It contains Artemether and Lumefantrine, which interfere with the Plasmodium parasite's growth in the red blood cells of the human body. It is a combination medicine used to treat non-severe malaria caused by a parasite called Plasmodium falciparum. It may cause common side effects, such as headache, dizziness, loss of appetite, weakness, fever, chills, tiredness, muscle or joint pain, nausea, vomiting, abdominal pain, cough, and trouble sleeping. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

ARTEMETHER-20MG + LUMEFANTRINE-120MG

Manufacturer/Marketer :

Aristo Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Combither Tablet 8's

Combither Tablet 8's belongs to the class of 'anti-malarial drugs', primarily used to treat and prevent malaria. Malaria is a disease caused by a plasmodium parasite, transmitted by the bite of infected Anopheles mosquitoes. When an infected mosquito bites a healthy person, it sends the 'Plasmodium parasite' into the bloodstream, which affects the red blood cells and liver cells. Malaria symptoms typically begin 10 days to 4 weeks after infection. They include chills, high fever, profuse sweating, headache, nausea, vomiting, abdominal pain, diarrhoea, anaemia, muscle pain, convulsions, coma and bloody stools.

Combither Tablet 8's contains two medicines, namely: Artemether and Lumefantrine. These are anti-malarial drugs that interfere with the Plasmodium parasite's growth in the red blood cells of the human body. Combither Tablet 8's is a combination that is used to treat non-severe malaria caused by a parasite called 'Plasmodium falciparum,' and other Plasmodium species. It works by inhibiting nucleic acid and protein synthesis in Plasmodium falciparum. Artemether is known to reduce parasite biomass, and Lumefantrine eliminates residual parasites.

Your doctor will decide the dose and duration based on your medical condition. Common side effects of Combither Tablet 8's include headache, dizziness, loss of appetite, weakness, fever, chills, tiredness, muscle/joint pain, nausea, vomiting, abdominal pain, cough and trouble sleeping. These side effects are not familiar to everyone and vary from person to person. If you notice any side effects that are not manageable, please consult your doctor.

Before using Combither Tablet 8's, inform your doctor if you have recently used any prescription and non-prescription medications, including other anti-malarial or antibiotic drugs. Let your doctor know if you are allergic to Combither Tablet 8's or its components. Inform your doctor if you have any liver or kidney problems, severe heart diseases or electrolyte imbalance. It is essential to let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother. Avoiding alcohol is recommended to rule out any possibility of side effects.

Uses of Combither Tablet 8's

Combither Tablet 8's is used in the treatment of malaria. The detailed uses of Combither Tablet 8's are as follows: <br/>• Malaria Treatment: Combither Tablet 8's is frequently used to treat and prevent malaria, especially in regions where the parasite that causes the disease is resistant to other drugs. <br/>• Prevention of Some Autoimmune illnesses: It can be used to avoid flare-ups in people with autoimmune diseases, which helps them manage their conditions over the long term. <br/>

Directions for Use

  • Combither Tablet 8's can be taken with food to help reduce the risk of stomach upset.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Combither Tablet 8's as a whole with a glass of water. For patients such as infants and children who cannot swallow tablets, crush the tablet and mix it with 1 to 2 teaspoons of water in a clean container, then administer it.
  • Rinse the container with more water and swallow the contents. You can also give the crushed tablet preparation with food or drink, such as milk, formula, pudding, broth, and porridge.
  • Do not crush, break, or chew it.

Medicinal Benefits

Combither Tablet 8's contains two anti-malarial drugs, namely: Artemether and Lumefantrine. It is a combination that treats non-severe malaria caused by a parasite called 'Plasmodium falciparum', and other Plasmodium species. It interferes with the growth of Plasmodium parasites in the red blood cells of the human body. Combither Tablet 8's works by inhibiting nucleic acid and protein synthesis in Plasmodium falciparum. Artemether reduces parasite biomass, and Lumefantrine eliminates residual parasites.

How Combither Tablet 8's Works

Combither Tablet 8's contains two medicines, namely: Artemether and Lumefantrine. These are anti-malarial drugs that interfere with the Plasmodium parasite's growth in the red blood cells of the human body. Combither Tablet 8's is a combination that is used to treat non-severe malaria caused by a parasite called 'Plasmodium falciparum,' and other Plasmodium species. It works by inhibiting nucleic acid and protein synthesis in Plasmodium falciparum. Artemether is known to reduce parasite biomass, and Lumefantrine eliminates residual parasites.

Storage

Keep Combither Tablet 8's out of sight and reach of children.

What if I have taken an overdose of Combither Tablet 8's

Do not take more than the prescribed dose of Combither Tablet 8's as it may cause an overdose. The symptoms of overdose include fainting, severe dizziness and irregular or slow heartbeat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Let your doctor know if you use any antibiotic drugs or have recently undergone treatment with other anti-malarial drugs. Brief your medical history to the doctor if you have any liver or kidney problems, malarial infection of the brain, lungs or kidneys, severe heart diseases and electrolyte imbalance. It is essential to inform your doctor if you have hypokalemia (low potassium levels) or hypomagnesemia (low magnesium levels) before starting Combither Tablet 8's. Combither Tablet 8's may affect QT prolongation, which can cause a severe, fast/irregular heartbeat. Hence, it is advised to inform your doctor if you have any heart-related problems like heart failure, slow heartbeat, QT prolongation in EKG or ECG (electrocardiogram), and a family history of heart diseases. It is essential to let your doctor know if you are pregnant, planning to conceive or a breastfeeding mother before starting Combither Tablet 8's. Avoiding alcohol is recommended to rule out any possibility of side effects like dizziness or drowsiness.

Drug-Drug Interactions

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ArtemetherCarbamazepine
Critical
ArtemetherMetoprolol
Severe

Drug-Drug Interactions

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ArtemetherCarbamazepine
Critical
How does the drug interact with Combither Tablet:
Using Carbamazepine with Combither Tablet may decrease the blood levels of Combither Tablet, which may make Combither Tablet less effective in treating your malaria.

How to manage the interaction:
Taking Carbamazepine with Combither Tablet is not recommended, but can be taken if prescribed by the doctor. However, if you experience any unusual symptoms, consult the doctor. Do not discontinue any medications without consulting a doctor.
ArtemetherMetoprolol
Severe
How does the drug interact with Combither Tablet:
Both Metoprolol and Combither Tablet may increase the blood levels and effects of metoprolol activity.

How to manage the interaction:
Taking Metoprolol and Combither Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience blurry vision, confusion, dizziness, fainting, lightheadedness, nausea or vomiting, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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ARTEMETHER-20MG+LUMEFANTRINE-120MGGrapefruit and Grapefruit Juice
Moderate

Drug-Food Interactions

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ARTEMETHER-20MG+LUMEFANTRINE-120MGGrapefruit and Grapefruit Juice
Moderate
Common Foods to Avoid:
Grapefruit, Grapefruit Juice

How to manage the interaction:
Coadministration with grapefruit juice may increase the plasma concentrations of artemether and lumefantrine. Avoid consumption of grapefruit juice and grape fruit.

Diet & Lifestyle Advise

  • Take nutritious food, including fresh fruits and vegetables, which helps in recovering from malaria fever.
  • During malarial fever, the patient may experience a loss of appetite. In such cases, drink glucose water, fresh fruit juices and coconut water.
  • Include high-fibre foods like green, leafy vegetables and fruits to aid digestion.
  • Take proper rest to help your body relax and recover more quickly.
  • Avoid or limit the intake of alcohol and caffeine.

Habit Forming

No

Therapeutic Class

ANTI- MALARIALS

Combither Tablet 8's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid alcohol while using Combither Tablet 8's since it can worsen your side effects.

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Pregnancy

Unsafe

Combither Tablet 8's is not recommended during the first three months of pregnancy. Your doctor may recommend other alternative medications. Please seek medical advice if you are pregnant or planning to conceive.

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Breast Feeding

Unsafe

Combither Tablet 8's is not recommended during breastfeeding. Once you have completed the course, you should wait at least one week before starting to breastfeed again. Please consult your doctor before taking Combither Tablet 8's.

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Driving

Unsafe

Combither Tablet 8's may cause you to feel sleepy, dizzy, or generally weak. In such cases, do not drive or operate machinery.

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Liver

Caution

Close monitoring of patients with liver disease while they are treated with Combither Tablet 8's is required. Let your doctor know if you have any history of liver disease before using Combither Tablet 8's.

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Kidney

Caution

Therapy with Combither Tablet 8's is to be cautiously administered in patients with renal impairment. Let your doctor know if you have any history of kidney disease before using Combither Tablet 8's.

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Children

Caution

Your doctor will decide the dose based on your child's age and body weight.

Have a query?

FAQs

Combither Tablet 8's belongs to the class of anti-malarial drugs, used to treat and prevent malaria.

Combither Tablet 8's contains a combination of anti-malarial drugs, Artemether and Lumefantrine. It treats malaria by interfering with Plasmodium parasite's growth in the red blood cells of the human body.

Combither Tablet 8's may affect the heart rhythm and cause QT prolongation (heart muscle takes longer than usual to recharge between beats). This QT prolongation can cause serious fast/irregular heartbeat. Hence it is advised to inform your doctor if you have any heart-related problems like heart failure, slow heartbeat, QT prolongation in EKG or ECG (electrocardiogram) and a family history of heart diseases.

Combither Tablet 8's is not recommended in cases of any liver or kidney problems, malarial infection of the brain, lungs or kidneys, severe heart diseases and electrolyte imbalance. Also, let your doctor know if you have recently undergone treatment with other anti-malarial drugs.

Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.

Combither Tablet 8's should be swallowed as a whole with water; do not crush or chew it.

Combither Tablet 8's is not recommended during the first three months of pregnancy. Your doctor may recommend other alternative medications. Please seek medical advice if you are pregnant or planning to conceive.

Combither Tablet 8's is contraindicated if you are allergic to any of its components.

Store Combither Tablet 8's at room temperature, in a dry place. Keep it out of sight and reach of children.

Combither Tablet 8's should be taken with food as it aids in better absorption of the medicine.

Take another dose of Combither Tablet 8's if you have vomited within 1-2 hours of taking the medicine.

Combither Tablet 8's may cause side effects such as headache, dizziness, loss of appetite, weakness, fever, chills, tiredness, muscle or joint pain, nausea, vomiting, abdominal pain, cough, and trouble sleeping. These side effects are not familiar to everyone and vary from person to person. If you notice any side effects that are not manageable, please consult your doctor.

Do not discontinue Combither Tablet 8's without consulting your doctor. To treat your condition effectively, keep taking Combither Tablet 8's for the prescribed duration.

Country of origin

India

Manufacturer/Marketer address

Mercantile Chamber, 3Rd Floor, 12, J.N. Heredia Marg, Ballard Estate, Mumbai - 400 001, India.
Other Info - COM0830

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 18, 2025 | 6:45 AM IST

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Reference

  1. https://www.webmd.com/drugs/2/drug-152191/artemether-lumefantrine-oral/details
  2. https://www.drugs.com/mtm/artemether-and-lumefantrine.html
  3. https://www.medicines.org.uk/emc/files/pil.1628.pdf
  4. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/022268lbl.pdf

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