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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
Cotrim 5Ml Inj is a combination medicine used in the treatment of bacterial infections of the urinary tract, respiratory tract, ear, lungs, skin, brain and toxoplasmosis. It contains trimethoprim and sulfamethoxazole which stops the production of tetrahydrofolic acid and dihydrofolic acid and thereby stops the growth of the infection-causing bacteria. Sometimes, your may experience common side effects like headache, nausea, diarrhoea, and skin rashes.
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Manufacturer/Marketer :

Zyphar's Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Cotrim 5Ml Inj

Cotrim 5Ml Inj belongs to the group of medicines called ‘antibiotics’ used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Bacterial infections are caused due to the multiplication of harmful bacteria inside or on the body. Cotrim 5Ml Inj does not work against infections caused by the virus, including cold and flu. 

Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim and Sulfamethoxazole. Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Cotrim 5Ml Inj stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Cotrim 5Ml Inj will be administered by a healthcare professional; do not self-administer. In some cases, you may experience certain common side effects such as high levels of potassium in the blood, palpitations (abnormal heartbeats), thrush or candidiasis (fungal infection), headache, nausea, diarrhoea, and skin rashes. Most of these side effects do not require medical attention and resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Before starting Cotrim 5Ml Inj, please inform your doctor if you have any allergy (against any antibiotic), severe kidney or liver problems, porphyria (blood disorder), or blood problems which may cause bleeding or bruising. Inform your doctor if you are pregnant or breastfeeding before receiving this injection. Cotrim 5Ml Inj is not recommended for infants below 6 weeks. Keep your doctor informed about your medical history and your ongoing medications to rule out any side effects/interactions.

Uses of Cotrim 5Ml Inj

Treatment of Bacterial infections

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Cotrim 5Ml Inj will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Cotrim 5Ml Inj belongs to the group of medicines called ‘antibiotics’ used to treat various bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma). Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Cotrim 5Ml Inj kills the bacteria and stops their growth. Thereby, it helps to treat bacterial infections. Cotrim 5Ml Inj is a broad-spectrum antibiotic which is active against a wide range of gram-positive and gram-negative bacteria.

How Cotrim 5Ml Inj Works

Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim and Sulfamethoxazole. Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. Tetrahydrofolic acid and dihydrofolic acid are essential for the formation of proteins and nucleic acids in the bacterial cell, which is necessary for the survival of the bacteria. By inhibiting these, Cotrim 5Ml Inj stops the growth of bacteria and kills them. Thereby, it helps to treat bacterial infections.

Storage

• Store in a cool and dry place away from sunlight.• Keep Cotrim 5Ml Inj out of reach and sight of children.• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Cotrim 5Ml Inj

Cotrim 5Ml Inj is administered by a health care professional in a hospital setting. Hence, the chances of overdose are less. Overdose of Cotrim 5Ml Inj may cause nausea/vomiting, headache, mental depression, confusion, thrombocytopenia, uremia, and loss of appetite. Your doctor will initiate necessary measures when an overdose is suspected.

Drug Warnings

Do not take Cotrim 5Ml Inj if you are allergic to any of its contents; if you have severe liver or kidney problems, thrombocytopenia (low levels of platelets in the blood), or porphyria (a rare blood problem). Consult your doctor immediately if you experience skin rash or prolonged, significant diarrhoea with abdominal pain. Talk to your doctor before taking Cotrim 5Ml Inj if you have severe allergies, asthma, ulcers, blood disorders, thyroid dysfunction, diabetes, are elderly, underweight or malnourished; if you have a folic acid deficiency, glucose-6-phosphate dehydrogenase deficiency, or high levels of potassium in the blood. Consult your doctor if you are pregnant or breastfeeding. 

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
TrimethoprimCaptopril
Severe

Drug-Drug Interactions

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TrimethoprimBCG vaccine
Critical
How does the drug interact with Cotrim 5Ml Inj:
Taking Cotrim 5Ml Inj with BCG vaccine can reduce the effectiveness of the BCG vaccine

How to manage the interaction:
Although there is an interaction between Cotrim 5Ml Inj and BCG vaccine is not recommended, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimCaptopril
Severe
How does the drug interact with Cotrim 5Ml Inj:
Taking captopril with Cotrim 5Ml Inj may increase the risk of hyperkalemia (high level of potassium in the blood) and kidney problems.

How to manage the interaction:
Although there is a interaction between Cotrim 5Ml Inj and captopril, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
TrimethoprimPotassium citrate
Severe
How does the drug interact with Cotrim 5Ml Inj:
Taking Potassium citrate with Cotrim 5Ml Inj may increase potassium levels in the blood, which can lead to kidney failure, muscular paralysis, and abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Cotrim 5Ml Inj and Potassium citrate, you can take these medicines together if prescribed by your doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Cotrim 5Ml Inj:
Taking Cotrim 5Ml Inj with telmisartan may increase potassium levels in the blood.

How to manage the interaction:
Although there is an interaction between telmisartan and Cotrim 5Ml Inj, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, and a weak pulse. Do not discontinue the medications without consulting a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Potassium chloride with Cotrim 5Ml Inj may increase potassium levels in the blood. High potassium levels can cause hyperkalemia (a high level of the electrolyte potassium in the blood.).

How to manage the interaction:
Although there is a possible interaction between Cotrim 5Ml Inj and Potassium chloride, you can take these medicines together if prescribed by a doctor. However, consult the doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Cotrim 5Ml Inj:
Coadministration of Cotrim 5Ml Inj with methotrexate can increase the risk or severity of blood disorders.

How to manage the interaction:
Although there is a possible interaction between Cotrim 5Ml Inj and methotrexate, you can take these medicines together if prescribed by your doctor. However, if you experience any symptoms such as pale skin, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact a doctor immediately. Do not stop using any medications without consulting to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Co-administration of Cotrim 5Ml Inj with phenytoin may increase the blood levels and effects of phenytoin.

How to manage the interaction:
Although there is an interaction between Cotrim 5Ml Inj and phenytoin but can be taken together if prescribed by doctor. However, if you experience nausea, vomiting, twitching eye movements, blurred vision, difficult to speak, loss of balance or coordination, tremors (shaking of hands legs), and confusion contact a doctor immediately. Do not discontinue any medications without consulting to a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking Lidocaine with Cotrim 5Ml Inj may cause methemoglobinemia (blood disorder in which too little oxygen is delivered to your cells).

How to manage the interaction:
Co-administration of Cotrim 5Ml Inj with Lidocaine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience, gray skin color, feeling sick, having a headache, feeling dizzy or lightheaded, feeling tired, having trouble breathing, a fast or irregular heartbeat, feeling anxious or confused, contact your doctor right away. Do not stop using any medications without talking to your doctor.
TrimethoprimFosphenytoin
Severe
How does the drug interact with Cotrim 5Ml Inj:
Taking fosphenytoin with Cotrim 5Ml Inj may increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between fosphenytoin and Cotrim 5Ml Inj, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience, weakness, vomiting, blurry vision, or trouble speaking. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Cotrim 5Ml Inj:
Taking perindopril with Cotrim 5Ml Inj can cause hyperkalemia(high levels of potassium in blood) which can increase the risk of kidney problems and abnormal heart rhythm.

How to manage the interaction:
Co-administration of Perindopril with Cotrim 5Ml Inj can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not stop using any medications without a doctor's advice. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.
  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.
  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.
  • Avoid consumption of alcohol and usage of tobacco.

 

Habit Forming

No

Therapeutic Class

ANTIBIOTIC COMBINATION
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Alcohol

Caution

Avoid alcohol consumption while taking Cotrim 5Ml Inj to prevent unpleasant side effects.

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Pregnancy

Caution

Please inform your doctor before taking Cotrim 5Ml Inj if you are pregnant. Cotrim 5Ml Inj may cause fetal harm. Your doctor will prescribe Cotrim 5Ml Inj only if the benefits outweigh the risks.

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Breast Feeding

Unsafe

Avoid breastfeeding whilst on treatment with Cotrim 5Ml Inj as it may cause bilirubin displacement and kernicterus (brain damage resulting from high levels of bilirubin in the blood). Please consult your doctor if you have any concerns.

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Driving

Caution

It is unknown whether Cotrim 5Ml Inj affects your ability to drive and operate machinery. Drive only if you are physically stable and mentally focused.

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Liver

Caution

Please inform your doctor before taking Cotrim 5Ml Inj if you have liver impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative if necessary based on your condition.

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Kidney

Caution

Please inform your doctor before taking Cotrim 5Ml Inj if you have kidney impairment. Your doctor may adjust the dose of this medicine or prescribe a suitable alternative if necessary based on your condition.

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Children

Caution

Cotrim 5Ml Inj is not recommended for infants below 6 weeks.

Have a query?

FAQs

Cotrim 5Ml Inj belongs to the group of medicines called antibiotics used to treat bacterial infections of the urinary tract, respiratory tract (bronchitis), ear (otitis media), lungs (pneumonia), skin, brain and toxoplasmosis (infection caused by a bacteria called toxoplasma).

Cotrim 5Ml Inj is a combination of two antibiotics, namely: Trimethoprim (folic acid inhibitors) and Sulfamethoxazole (sulfonamides). Trimethoprim prevents the formation of tetrahydrofolic acid, and sulfamethoxazole stops the bacteria from making dihydrofolic acid. By inhibiting these, Cotrim 5Ml Inj kills the bacteria and stops their growth. Thus, it helps to treat bacterial infections.

Cotrim 5Ml Inj causes thrush or candidiasis, which is a fungal infection occurring due to the overgrowth of yeast-like fungus in the mouth or throat. Regularly rinse your mouth with water to prevent the growth of fungus.

Diarrhoea might be a side-effect of Cotrim 5Ml Inj. Drink lots of fluids and eat non-spicy food if you experience diarrhoea. If you find blood in stools (tarry stools) or if you experience prolonged diarrhoea with abdominal pain, inform your doctor. Do not take anti-diarrheal medicine on your own.

Cotrim 5Ml Inj may affect certain laboratory test results. Inform the lab technician that you are taking Cotrim 5Ml Inj.

Cotrim 5Ml Inj may cause high levels of potassium in the blood, which could lead to abnormal heartbeats (palpitations). Regular monitoring of potassium levels and heart rate is advised while taking Cotrim 5Ml Inj.

Country of origin

India

Manufacturer/Marketer address

102/103, Park Plaza, Opp. Kamla Nehru Park, Off. Bhandarkar Road, Pune - 411004, Maharashtra (India)
Other Info - COT0162

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