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  3. CRIZALK 250MG CAPSULE

CRIZALK 250MG CAPSULE, Pack of 1 CAPSULE
CRIZALK 250MG CAPSULE, Pack of 1 CAPSULE
CRIZALK 250MG CAPSULE, Pack of 1 CAPSULE
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
CRIZALK 250MG CAPSULE is an anti-cancer medicine used in the treatment of Non-small cell lung cancer (NSCLC). This medicine contains crizotinib which works by stopping the tyrosine kinase enzyme and stops the cancerous cell growth. Common side effects include visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness.
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Composition :

CRIZOTINIB-250MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About CRIZALK 250MG CAPSULE

CRIZALK 250MG CAPSULE belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine exactly as your doctor has told you. You must keep to your doctor's instructions to get the maximum benefit. Sometimes, you may experience specific common side effects, such as visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Inform your healthcare professional if you are a pregnant or breastfeeding woman so that your doctor decides whether CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. While on CRIZALK 250MG CAPSULE treatment, you should avoid eating grapefruit or consuming grapefruit juice since they may alter the amount of CRIZALK 250MG CAPSULE in your body.

Uses of CRIZALK 250MG CAPSULE

Treatment of Non-small cell lung cancer (NSCLC)

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Directions for Use

• CRIZALK 250MG CAPSULE can be taken with or without food as advised by your doctor.• CRIZALK 250MG CAPSULE is usually taken twice a day, or as prescribed by your doctor.• Swallow CRIZALK 250MG CAPSULE as a whole with a glass of water.• Do not crush, chew, split or open it.

Medicinal Benefits

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with non-small cell lung cancer (NSCLC). CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth.

How CRIZALK 250MG CAPSULE Works

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Storage

• Store in a cool and dry place away from sunlight.
• Keep CRIZALK 250MG CAPSULE out of sight and reach of children.
• Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Crizalk 250mg Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of CRIZALK 250MG CAPSULE

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol along with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Consult your doctor if you are a pregnant or breastfeeding woman; your doctor will decide whether the CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. It is essential to take CRIZALK 250MG CAPSULE every day, as long as your doctor prescribes it. Contact your doctor immediately if you cannot take medicine as your doctor prescribed or feel you do not need it anymore. Do not stop taking this medicine on your own. People with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders should consult the doctor before taking the CRIZALK 250MG CAPSULE.

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
CrizotinibLenvatinib
Severe

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Crizalk 250mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizalk 250mg Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CrizotinibLenvatinib
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking lenvatinib and Crizalk 250mg Capsule together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Lenvatinib and Crizalk 250mg Capsule together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath, it's important to call your doctor immediately. Do not stop using any medications without first talking to your doctor.
CrizotinibGranisetron
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking granisetron with Crizalk 250mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Granisetron and Crizalk 250mg Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibIbrutinib
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Ibrutinib with Crizalk 250mg Capsule may increase the levels of Ibrutinib.

How to manage the interaction:
Although there is a possible interaction between Ibrutinib and Crizalk 250mg Capsule, you can take these medicines together if prescribed by a doctor. However, if you experience paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in coughing fluid, red or inflamed skin, body sores, pain or burning during urination, nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, irregular heart rhythm, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
CrizotinibVenlafaxine
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Venlafaxine with Crizalk 250mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Crizalk 250mg Capsule, you can take these medicines together if prescribed by a doctor. However, consult your doctor immediately if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CrizotinibMirtazapine
Severe
How does the drug interact with Crizalk 250mg Capsule:
Using Crizalk 250mg Capsule together with mirtazapine can increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
There may be a possibility of interaction between Mirtazapine and Crizalk 250mg Capsule, but it can be taken if prescribed by a doctor. If you have any of these symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibSotalol
Severe
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Crizalk 250mg Capsule with Sotalol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Crizalk 250mg Capsule, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
CrizotinibItraconazole
Severe
How does the drug interact with Crizalk 250mg Capsule:
Using Crizalk 250mg Capsule together with itraconazole may significantly increase the blood levels and effects of Crizalk 250mg Capsule.

How to manage the interaction:
Crisotinib and itraconazole may interact, however they can still be taken if a doctor prescribes them to. Consult a physician if you feel dizziness, lightheadedness, fainting, or rapid heartbeats. Never stop taking any medications without talking to a doctor.
CrizotinibClofazimine
Severe
How does the drug interact with Crizalk 250mg Capsule:
Co-administration of Crizalk 250mg Capsule with clofazimine can increase the risk of irregular heart rhythm. If you suffer from any cardiac conditions, or electrolyte disturbances (such as magnesium or potassium deficiency brought on by severe or prolonged diarrhea or vomiting), you may be at higher risk.

How to manage the interaction:
Taking Crizalk 250mg Capsule with clofazimine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat. Do not discontinue any medications without consulting a doctor.
CrizotinibCeritinib
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Crizalk 250mg Capsule with Ceritinib may significantly increase the blood levels and effects of Crizalk 250mg Capsule.

How to manage the interaction:
Co-administration of Ceritinib with Crizalk 250mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms like an irregular heart rhythm, dizziness, fainting, or a fast or pounding heartbeat, it is important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
  • Exercise moderately. Eat healthily.
  • Follow a pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
  • Quit smoking and alcohol.
  • Get ample rest.
  • Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
  • Lean proteins such as fish, meat, and poultry are the best.
  • Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
  • Avoid processed and refined foods.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC
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Alcohol

Caution

Consuming alcohol while using CRIZALK 250MG CAPSULE is not recommended since it may produce side effects or make you more sensitive to the effects of alcohol.

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Pregnancy

Caution

CRIZALK 250MG CAPSULE is not typically recommended during the pregnancy. Please consult the healthcare professional if you have any concerns regarding this.

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Breast Feeding

Caution

CRIZALK 250MG CAPSULE is not typically recommended if you are a nursing woman. Please consult the healthcare professional if you have any concerns regarding this.

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Driving

Caution

Do not drive, or you should take special care when driving and using machines as patients taking CRIZALK 250MG CAPSULE may experience visual disturbances, dizziness, and tiredness.

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Liver

Caution

Caution should be taken while using CRIZALK 250MG CAPSULE in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Caution should be taken while using CRIZALK 250MG CAPSULE in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for children as the safety and efficacy have not been established.

FAQs

CRIZALK 250MG CAPSULE belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults.

Crizotinib is the active ingredient in CRIZALK 250MG CAPSULE. It works by inhibiting an enzyme called tyrosine kinase and causing cancer cells to die. CRIZALK 250MG CAPSULE is only provided to individuals whose condition is caused by an ALK tyrosine kinase gene mutation.

In elderly patients, the risk of side effects is more if you take the CRIZALK 250MG CAPSULE. For the elderly, it might require dose adjustment, or your doctor might prescribe any other medication safe for the elderly.

No, avoid smoking before starting the treatment and while taking CRIZALK 250MG CAPSULE as smoking might alter the effectiveness of CRIZALK 250MG CAPSULE.

Take the missed dose as soon as you remember. Skip the missing dose and return to your regular dosing plan if it is time for the next dose. Do not take a double dose to make up for a missing dose.

CRIZALK 250MG CAPSULE may cause visual disturbances such as flashes of light, blurred vision, or double vision as a temporary side effect. If it continues or worsens your condition, seek medical advice immediately.

CRIZALK 250MG CAPSULE should be taken orally. Swallow it as a whole with a glass of water. Do not chew, crush or break it.

The side effects of CRIZALK 250MG CAPSULE include dizziness, diarrhoea, visual disturbances or stomach upset, including vomiting, nausea, and tiredness. Consult the doctor if any of these side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Other Info - CRI0067

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Veda MaddalaDoctor badge

Reviewed By

Veda Maddala

M Pharmacy

Last Updated

Jul 18, 2025 | 9:24 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.2857.pdf
  2. https://www.medicines.org.uk/emc/product/2857/smpc#gref
  3. https://www.nhs.uk/conditions/lung-cancer/
  4. https://pubmed.ncbi.nlm.nih.gov/24756793/

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