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About Derbaset 40 PFS Injection 0.4 ml
Derbaset 40 PFS Injection 0.4 ml belongs to the class of medication called 'blood-forming agent' primarily used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Derbaset 40 PFS Injection 0.4 ml helps to reverse anaemia and reduce the need for blood transfusion. Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.
Derbaset 40 PFS Injection 0.4 ml contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. Derbaset 40 PFS Injection 0.4 ml is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, Derbaset 40 PFS Injection 0.4 ml stimulates the production of this protein in the bone marrow.
Derbaset 40 PFS Injection 0.4 ml will be injected by the healthcare provider. Do not self-administer. The most common side effects of Derbaset 40 PFS Injection 0.4 ml are shortness of breath, cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these sides effects of Derbaset 40 PFS Injection 0.4 ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.
If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to darbepoetin alfa or epoetin alfa, please inform your doctor before taking Derbaset 40 PFS Injection 0.4 ml to avoid any complications. Also, mention all the other medications you are taking to affect the way Derbaset 40 PFS Injection 0.4 ml works. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be signs that the body has stopped responding to Derbaset 40 PFS Injection 0.4 ml.
Uses of Derbaset 40 PFS Injection 0.4 ml
Directions for Use
Medicinal Benefits
Derbaset 40 PFS Injection 0.4 ml is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn cause low red blood cells count causing anaemia. This medicine is primarily indicated for treating anaemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells' cancer. Derbaset 40 PFS Injection 0.4 ml contains a protein 'Darbepoetin alfa' which works by providing signals to the bone marrow to make more red blood cells.
How Derbaset 40 PFS Injection 0.4 ml Works
Storage
What if I have taken an overdose of Derbaset 40 PFS Injection 0.4 ml
Drug Warnings
Derbaset 40 PFS Injection 0.4 ml can enhance the risk of serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may also shorten survival time in some people with certain types of cancer. Inform your doctor before taking Derbaset 40 PFS Injection 0.4 ml if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take Derbaset 40 PFS Injection 0.4 ml if you are pregnant or breastfeeding unless prescribed by the doctor. Derbaset 40 PFS Injection 0.4 ml may affect a person's ability to drive as it may cause convulsion during initial days of treatment, so a person taking Derbaset 40 PFS Injection 0.4 ml should avoid driving or operating any machine. Derbaset 40 PFS Injection 0.4 ml should not be given to children below 12 years of age, as safety and effectiveness have not been established. Avoid consuming alcohol along with Derbaset 40 PFS Injection 0.4 ml as it could lead to increased dizziness and sleepiness.
Diet & Lifestyle Advise
Habit Forming
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Product Substitutes
Alcohol
Unsafe
Avoid consumption of alcohol while taking Derbaset 40 PFS Injection 0.4 ml as it may increase dizziness and sleepiness.
Pregnancy
Caution
Avoid taking Derbaset 40 PFS Injection 0.4 ml if you are pregnant unless prescribed by a doctor as Derbaset 40 PFS Injection 0.4 ml is a pregnancy category C drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks.
Breast Feeding
Caution
Consult your doctor before taking Derbaset 40 PFS Injection 0.4 ml; your doctor will decide whether Derbaset 40 PFS Injection 0.4 ml can be taken by breastfeeding mothers or not.
Driving
Unsafe
Derbaset 40 PFS Injection 0.4 ml causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.
Liver
Caution
Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.
Kidney
Caution
Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.
Children
Caution
Derbaset 40 PFS Injection 0.4 ml should not be given to children as the safety and efficacy have not been established.
Have a query?
Derbaset 40 PFS Injection 0.4 ml is used to treat anaemia (low red blood cell count) in person with long-term serious (chronic) kidney disease and persons receiving chemotherapy for some types of cancer (except for bone marrow or blood cells' cancer). Derbaset 40 PFS Injection 0.4 ml helps to reverse anaemia and reduce the need for blood transfusion.
It is suggested to store the Derbaset 40 PFS Injection 0.4 ml in the refrigerator and protect it from light. However, a person should not freeze it.
It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.
A person who is allergic to any chemical compound present in Derbaset 40 PFS Injection 0.4 ml or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.
Consult your doctor before taking Derbaset 40 PFS Injection 0.4 ml if you are pregnant or planning for pregnancy. Your doctor will prescribe Derbaset 40 PFS Injection 0.4 ml only if the benefits outweigh the risks.
Derbaset 40 PFS Injection 0.4 ml contains a protein "Darbepoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.
Derbaset 40 PFS Injection 0.4 ml may cause side effects such as injection site pain, cough, low blood pressure, headache, diarrhoea, body pains, shortness of breath or stomach pain. If these side effects persist or worsen, please consult your doctor.
After beginning treatment with Derbaset 40 PFS Injection 0.4 ml, it takes around 2 to 6 weeks for increase in haemoglobin level in blood.
Derbaset 40 PFS Injection 0.4 ml is used only if anaemia is due to chronic (long term) kidney disease and chemotherapy for some types of cancer (except for bone marrow and blood cells).
Derbaset 40 PFS Injection 0.4 ml may cause high blood pressure particularly in patients with long term kidney disease due to the rapid increase of red blood cells in the initial 3 months after starting Derbaset 40 PFS Injection 0.4 ml.
Derbaset 40 PFS Injection 0.4 ml is not used in the treatment of cancer. It is used in treatment of anemia (low levels of healthy red blood cells) in patients receiving chemotherapy for some types of cancer (except for bone marrow or blood cells cancer).
Derbaset 40 PFS Injection 0.4 ml should be used with extreme caution as it can cause serious side effects and can even be life-threatening. The patient should follow doctor’s recommendations strictly.
If you have deficiencies of folic acid, vitamin B12 or iron, you may not respond to Derbaset 40 PFS Injection 0.4 ml. It is important that you take measures to correct these deficiencies. Other reasons may be infections, bleeding, inflammation and bone marrow fibrosis. If you have any concerns, consult your doctor.
Derbaset 40 PFS Injection 0.4 ml is usually not recommended for children as the safety and effectiveness were not established. However, if you have any concerns regarding the use of Derbaset 40 PFS Injection 0.4 ml for children, please consult your doctor.
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