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compositionComposition:ADAPALENE-0.1%W/W
prescription
Prescription Medicine
info
Derpalin 0.1% Gel

Derpalin 0.1% Gel is used to treat acne (pimples) in patients aged 12 years and older. It helps reduce pimples, blackheads, and whiteheads. Regular use helps maintain clear skin and prevents new breakouts. It also improves skin texture and appearance over time.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ADAPALENE-0.1%W/W

Manufacturer/Marketer :

Leeford Healthcare Ltd

Consume Type :

Topical

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Derpalin 0.1% Gel

Derpalin 0.1% Gel is a topical skin treatment used to clear up acne breakouts, blackheads, and whiteheads. It helps reduce the number and severity of pimples while promoting quicker healing of the skin. This medicine is designed for individuals dealing with mild to moderate acne lesions.

For the best results, you should apply Derpalin 0.1% Gel consistently once a day, preferably at bedtime. It works best when applied to clean, dry skin on a regular daily schedule. Alongside using this medicine, adopting a gentle skincare routine, staying hydrated, and avoiding picking at your acne can greatly improve your treatment results.

While using this medicine, you may experience some mild skin dryness, redness, or peeling, especially during the first few weeks. These effects are usually normal as your skin adjusts, but you should contact your doctor if you experience severe burning, swelling, or signs of an allergic reaction.

Do not use this if you have extremely sensitive skin, severe eczema, or a bad sunburn on the areas you need to treat. You should also speak with your healthcare provider before starting this treatment if you have any other chronic skin conditions.

Avoid using other harsh skin products like abrasive soaps, strong chemical peelers, or drying cosmetics while using Derpalin 0.1% Gel, as they can cause severe skin irritation. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor or pharmacist before using this medicine.

Uses of Derpalin 0.1% Gel

Derpalin 0.1% Gel is used to to clear up acne breakouts, blackheads, and whiteheads. The detailed uses of Derpalin 0.1% Gel are as follows:

  • Acne Vulgaris: Derpalin 0.1% Gel helps clear active acne pimples and prevents new breakouts from forming by keeping skin pores clear.
  • Blackheads and Whiteheads: It targets and dissolves the plugs of oil and dead skin cells that form stubborn blackheads and whiteheads.
     

Key Benefits

Derpalin 0.1% Gel helps treat acne by targeting the underlying causes of breakouts and promoting healthier skin. By keeping pores clear and reducing inflammation, it helps improve skin appearance and supports long-term acne management.

  • Helps Clear Acne and Prevent New Breakouts: By preventing blocked pores and reducing the formation of acne lesions, Derpalin 0.1% Gel helps treat existing pimples while lowering the risk of future breakouts.
  • Reduces Skin Inflammation: Derpalin 0.1% Gel helps minimise redness, swelling, and irritation associated with acne, promoting clearer and healthier-looking skin.
  • Supports Long-Term Skin Health: With regular use, Derpalin 0.1% Gel helps improve skin texture, reduce the likelihood of acne scarring, and maintain clearer skin by preventing the recurrence of acne lesions.
     

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Wash the affected area with water and dry it thoroughly. Apply a thin layer of Derpalin 0.1% Gel to clean, dry skin at night, or as directed by your physician.
  • Derpalin 0.1% Gel is for external use only.
  • Wash your hands before and after applying Derpalin 0.1% Gel.

How Derpalin 0.1% Gel Works

The active ingredient in Derpalin 0.1% Gel is a topical retinoid called adapalene, which is a class of medications related to vitamin A. It works by regulating the growth of skin cells and preventing them from sticking together. When skin cells shed normally, they do not clog your pores, which prevents pimples from forming in the first place. Additionally, this medicine has natural anti-inflammatory properties. This helps reduce the swelling, redness, and soreness associated with active acne breakouts, allowing your skin to heal more quickly and evenly.
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Alcohol

Caution

The interaction of Derpalin 0.1% Gel with alcohol is unknown. Please consult a doctor before consuming alcohol while using Derpalin 0.1% Gel.

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Pregnancy

Caution

Derpalin 0.1% Gel is a category C pregnancy drug and is usually not recommended for pregnant women. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

It is unknown whether Derpalin 0.1% Gel is excreted in human milk. Therefore, Derpalin 0.1% Gel is recommended for breastfeeding mothers only if the physician determines that the benefits outweigh the risks. However, do not apply Derpalin 0.1% Gel on the chest area to avoid contact with the baby.

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Driving

Safe if prescribed

Derpalin 0.1% Gel usually does not affect your ability to drive or operate machinery.

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Liver

Safe if prescribed

If you have any concerns regarding the use of Derpalin 0.1% Gel in patients with liver problems, please consult a doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of Derpalin 0.1% Gel in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Derpalin 0.1% Gel is not recommended for children under 12 years of age, as its safety and efficacy have not been established.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems.

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Geriatrics

Consult your doctor

Limited information available for use of Derpalin 0.1% Gel in elderly patients. Please consult your doctor.

What if I have taken an overdose of Derpalin 0.1% Gel

Using too much of this medicine will not make your acne clear up faster and may cause severe skin peeling and redness. If you apply too much, wash it off with cool water. If someone accidentally swallows the medicine, seek immediate medical attention.

Diet & Lifestyle Advise

  • Protect your skin from the sun: This medicine makes your skin highly sensitive to sunlight. Wear a broad-spectrum sunscreen with SPF 30 or higher daily, and wear protective clothing when outdoors.
  • Use a gentle moisturiser: To combat dryness and peeling, apply a gentle, oil-free (non-comedogenic) moisturiser regularly.
  • Avoid harsh skin products: Stay away from exfoliating scrubs, astringents, alcohol-based toners, and products containing alpha-hydroxy acids or salicylic acid unless advised by your doctor.
  • Do not pick or squeeze pimples: Squeezing or popping acne can worsen inflammation, delay healing, and increase the risk of permanent scarring.

 

Have a query?

How Soon It Starts Working

  • The time required for Derpalin 0.1% Gel to start to work: The time required for Derpalin 0.1% Gel to show its action is not clinically established.
  • The time for which the effects of Derpalin 0.1% Gel last: The duration of action for Derpalin 0.1% Gel is not clinically established.

What if you forget to take Derpalin 0.1% Gel

If you miss an application, apply it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed application and continue with your regular schedule. Do not apply extra medicine to make up for a missed dose.

Storage

•Store Derpalin 0.1% Gel at room temperature, ideally between 20°C to 25°C. •Keep the tube tightly closed when not in use to protect the medicine from moisture and air.

Drug Warnings

  • Check the packaging before use to ensure the safety seal is intact and the gel or cream appears uniform.
  • Expect a temporary increase in acne breakouts (known as skin purging) during the first few weeks of treatment; this is a sign that the medicine is working to clear deep blockages.
  • Do not apply this medicine to broken, cut, scraped, or sunburnt skin.
  • Avoid wax depilation (waxing) on any areas of the skin where you are applying this medicine, as it can cause skin tearing.
  • Be careful not to let the medicine build up in the creases of your nose or mouth, where irritation is more likely to occur.
     

verifiedApollotooltip
  • Peeling or abrasive agents: Combining Derpalin 0.1% Gel with products containing sulphur, resorcinol, or salicylic acid can cause severe skin irritation.
  • Drying cosmetics or soaps: Using medicated soaps, astringents, or alcohol-rich cosmetics alongside this medicine can severely dry and irritate your skin.
     

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verifiedApollotooltip

No clinically significant food interactions are known with Derpalin 0.1% Gel when used as directed.

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[RETINOIDS]

FAQs

Derpalin 0.1% Gel is used to treat acne, a common skin condition that occurs when hair follicles are blocked with dead skin cells and oil.
Derpalin 0.1% Gel works by loosening cells on the skin's surface and unblocking pores by reducing the production of sebum. Thereby, decreases pimples, spots, whiteheads and blackheads. Also, adapalene increases the production of new skin cells and supports natural exfoliation (removal of dead skin cells) in the outer layers of the skin.
Derpalin 0.1% Gel may cause photosensitivity (increased skin sensitivity to sunlight) in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen (SPF 30 or more) and wear protective clothing while going out to prevent sunburn.
No, Derpalin 0.1% Gel is not recommended for patients with eczema (itchy, cracked, swollen, or rough skin) because it may cause severe irritation. Therefore, if you have eczema, inform your physician before using Derpalin 0.1% Gel.
Yes, Derpalin 0.1% Gel may cause skin irritation as a side effect. However, if the irritation persists or worsens, discontinue use of Derpalin 0.1% Gel and consult a physician.
You are advised not to use other acne products containing erythromycin, benzoyl peroxide or clindamycin with Derpalin 0.1% Gel at the same time, as it may cause excessive irritation or dry skin. Therefore, it is recommended to use Derpalin 0.1% Gel at night and other products in the morning. However, please consult a doctor before using any other medicines or products with Derpalin 0.1% Gel.
Yes, Derpalin 0.1% Gel may cause skin dryness. You can use a moisturiser while using Derpalin 0.1% Gel to prevent dry skin. However, do not apply Derpalin 0.1% Gel and the moisturiser simultaneously, as this may reduce the effectiveness of Derpalin 0.1% Gel. Please consult a doctor before using other products with Derpalin 0.1% Gel.
Derpalin 0.1% Gel may cause side effects such as skin irritation, skin redness, a burning sensation, sunburn, peeling, or dry skin. If these side effects persist or worsen, please consult your doctor.
Yes, Derpalin 0.1% Gel helps reduce scars after acne.
Blackheads are a type of acne. Thus, Derpalin 0.1% Gel can be used to manage and treat acne. However, it is advisable to use Derpalin 0.1% Gel only after a doctor's advice. The doctor will prescribe the same after a proper skin diagnosis. Do not self-medicate.
Derpalin 0.1% Gel is usually not recommended for pregnant women. Please consult a doctor if you are pregnant.
It is advisable to avoid cosmetic procedures while using Derpalin 0.1% Gel. Cosmetic products with abrasive, peeling, or drying actions may increase irritant effects. Please consult your doctor if you have any concerns regarding this.
Yes, Derpalin 0.1% Gel may cause a burning sensation as a common side effect. Additionally, during the first 4 weeks of treatment, you may experience dryness, redness, and scaling, which usually improve as you continue to use Derpalin 0.1% Gel. If the side effects persist or worsen, inform your doctor.
If necessary, moisturisers may be used; however, products containing glycolic or alpha hydroxy acids should be avoided.
Derpalin 0.1% Gel should be applied at night before bedtime or should be used as advised by your doctor. Clean the affected area with water and ensure it is dry before applying Derpalin 0.1% Gel. Apply it as a thin layer over the entire face and any other affected areas by taking a small amount onto your fingertips. It is important to clean your hands after applying Derpalin 0.1% Gel.
You are advised to limit your time outdoors in the sun, as Derpalin 0.1% Gel can make your skin sensitive. If you must be in direct sunlight, wear sunscreen, a hat, and clothing that covers the treated areas. You should avoid exposure to extreme weather, such as cold and wind, as this may irritate your skin. Avoid using certain skin products, such as astringents, harsh soaps, and cosmetics with strong skin-drying effects. In addition, products with high alcohol levels should be avoided, as they may further irritate or dry your skin.
Mild peeling is a common reaction when starting this medicine. You can manage this by applying a gentle, oil-free moisturiser or talking to your doctor about gradually increasing how often you apply it to give your skin time to adapt.
Yes, you can wear makeup, but it is best to apply Derpalin 0.1% Gel at night on clean skin. If you wear makeup during the day, choose non-comedogenic (pore-clearing) products so they do not block the medicine's effects. Talk to your doctor or pharmacist for product recommendations.
Skin purging is a temporary phase where your acne may seem to get worse before it gets better, as deep-seated clogs are pushed to the surface. This is normal and usually subsides within a few weeks. Talk to your doctor if the breakout remains severe or painful.
No, you should never apply this medicine to broken, cut, or scraped skin, as it can cause intense burning and irritation. Wait until your skin has fully healed before applying. Talk to your doctor if you have concerns about skin healing.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.920 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Adapalene Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. Adapalene [EMC SmPC. 2022. [Accessed on 16 Jan. 2026] Check here
  4. Adapalene [Prescribing Information]. 2012. [Accessed on 20 Feb. 2024] Check here
  5. Piskin S, Uzunali E. A review of the use of adapalene for the treatment of acne vulgaris. NIH National Library of Medicine, National Center for Biotechnology Information. PubMed Central. 2007. [Accessed on 7th May 2026] Check here
  6. Galderma (U.K.) Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022]. [Accessed on 7th May 2026] Check here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 03 Apr. 2019]Check here

Manufacturer/Marketer address

Leeford Healthcare Limited , Leo House, Shaheed Bhagat Singh Nagar, Dugri-Dhandra Road, Near Joseph School , Ludhiana-141116.
Other Info - DERP566
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