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compositionComposition:DISULFIRAM-500MG
prescription
Prescription Medicine
info
Disfit 500 Tablet

Disfit 500 Tablet is used to treat alcohol dependence or chronic alcoholism. It contains Disulfiram, which works by blocking an enzyme that breaks down alcohol in our body. This results in a higher level of acetaldehyde in the blood, causing discomfort and physical reactions. It can help alcohol-addicted people who have decided to quit alcohol drinking by deterring them from drinking again. So, it acts as a supportive agent in the treatment of alcoholism. It may cause common side effects such as drowsiness, tiredness, headache, acne, flushing (warmth, redness, or tingly feeling), sweating, increased thirst, swelling, rapid weight gain, nausea, severe vomiting, neck pain, throbbing headache, blurred vision, fast or pounding heartbeats or fluttering in your chest, confusion, weakness, spinning sensation, feeling unsteady, or and metallic/garlic-like taste in the mouth may occur as your body gets used to the medication. Do not take this medicine if you have consumed alcohol within the past 12 hours.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

DISULFIRAM-500MG

Manufacturer/Marketer :

Austro Labs Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Disfit 500 Tablet

Disfit 500 Tablet is an oral prescription medication used to help treat chronic alcohol dependence. It acts as a physical deterrent by causing highly unpleasant reactions if even small amounts of alcohol are consumed. This medication is designed to support individuals who are fully committed to maintaining sobriety as part of a structured recovery plan.

For the best results, you must take Disfit 500 Tablet consistently every single day exactly as your doctor directs. You can take this medication with or without food, though taking it with food or at bedtime may help if you experience mild stomach upset or drowsiness. Alongside taking this medicine, participating in behavioural counselling, attending support groups, and making strict lifestyle changes to avoid all sources of alcohol are essential for your long-term success.

While using Disfit 500 Tablet, some people may experience mild side effects, such as a metallic taste in the mouth, mild headaches, or drowsiness. However, you must contact your doctor immediately if you experience any serious side effects, particularly signs of liver damage, such as dark urine, severe stomach pain, or yellowing of your skin or eyes.

Do not take this if you have consumed alcohol in the past 12 hours, have severe heart disease, or have had a severe allergic reaction to this medication in the past. It is also important to talk to your doctor before starting this medicine if you have a history of liver disease, kidney problems, diabetes, an underactive thyroid, or mental health conditions like depression.

This medication can interact with other substances, such as blood thinners, certain seizure medications, and some antibiotics, potentially increasing the risk of side effects. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, talk to your doctor or pharmacist to discuss if this treatment is appropriate for you.

Uses of Disfit 500 Tablet

Disfit 500 Tablet is used as part of a comprehensive treatment programme for alcohol dependence, helping individuals maintain abstinence and support long-term recovery goals.

  • Alcohol dependence: Disfit 500 Tablet helps support long-term sobriety by causing a highly uncomfortable physical reaction if you consume alcohol, reinforcing your behavioural therapy goals.
     

Key Benefits

By creating a strong deterrent to alcohol consumption and supporting ongoing recovery efforts, Disfit 500 Tablet offers several important benefits, including:

  • Supports Long-Term Sobriety: Helps reduce the likelihood of drinking by causing an unpleasant reaction when alcohol is consumed.
  • Encourages Accountability: Acts as a physical reminder of recovery goals, helping resist impulsive or unplanned alcohol use.
  • Strengthens Behavioural Therapy Efforts: Complements counselling, support groups, and other recovery strategies by reinforcing abstinence.
  • Provides Psychological Reassurance: Offers added confidence to both patients and their support network by creating a clear barrier against alcohol consumption.
  • Promotes Focus on Recovery: Helps individuals concentrate on lifestyle changes, emotional well-being, and long-term behavioural improvements without the temptation of casual drinking.
     

Directions for Use

  • Disfit 500 Tablet can be taken with or without food as advised by your doctor.
  • It should be taken once a day or as directed by the doctor.
  • Swallow Disfit 500 Tablet as a whole with a glass of water.
  • If you have difficulty swallowing, crush them and mix with a liquid like water, milk, or juice.

How Disfit 500 Tablet Works

Disfit 500 Tablet works by altering how your body processes alcohol. Normally, your liver breaks down alcohol into a toxic chemical called acetaldehyde, which is then quickly broken down by an enzyme into a harmless substance. This medicine blocks that specific enzyme from doing its job. Because the enzyme is blocked, if you drink alcohol, acetaldehyde rapidly builds up in your bloodstream. This sudden buildup triggers what is known as a Disfit 500 Tablet reaction, causing highly unpleasant symptoms like sweating, flushing, a pounding headache, nausea, and a rapid heart rate. This physical reaction serves as a strong deterrent to help you avoid alcohol entirely.
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Alcohol

Unsafe

Not recommended for alcoholism as Disfit 500 Tablet and alcohol causes severe 'aldehyde reaction' causing life-threatening conditions.

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Pregnancy

Caution

Not enough data available but Disfit 500 Tablet is not given in pregnant females unless recommended in a doctor.

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Breast Feeding

Unsafe

Not recommended as such, as not enough data is available. Breastfeeding mothers should consult a doctor before taking the Disfit 500 Tablet.

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Driving

Caution

Not recommended before driving. Disfit 500 Tablet has been found to cause drowsiness in the patient. Hence, taking Disfit 500 Tablet before driving or performing hazardous tasks is not recommended.

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Liver

Caution

Not recommended in liver patients. Disfit 500 Tablet has been found to cause liver damage in patients & hence not recommended to be taken without doctors consultation.

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Kidney

Caution

Not recommended in kidney patients. Disfit 500 Tablet should be taken by kidney patients only on doctors consultation.

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Children

Unsafe

Strictly not recommended in children. it may result in neurological interactions resulting in harmful symptoms.

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Heart

Caution

Disfit 500 Tablet can generally be used with caution in patients with heart problems, but only under close medical supervision.

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Geriatrics

Unsafe

Disfit 500 Tablet is generally not recommended for use in elderly patients.

What if I have taken an overdose of Disfit 500 Tablet

If you suspect an accidental overdose, seek emergency medical attention or contact a poison control centre immediately. Symptoms of an overdose may include severe nausea, vomiting, dizziness, extreme coordination loss, or unusual drowsiness.

Diet & Lifestyle Advise

  • Avoid all forms of alcohol: You must completely avoid beer, wine, spirits, and non-alcoholic or low-alcohol beers, as even trace amounts of alcohol can trigger a severe reaction.
  • Check food labels: Read ingredient lists carefully to ensure your food does not contain alcohol, wine vinegars, cooking wines, or spirits (often found in sauces, soups, and desserts).
  • Screen personal care products: Many everyday items like mouthwashes, aftershaves, perfumes, colognes, and hand sanitizers contain alcohol that can be absorbed through the skin or inhaled. Opt for alcohol-free alternatives.
  • Be cautious with over-the-counter medicines: Many liquid cough syrups, cold remedies, and tonics contain alcohol. Always read the labels or ask your pharmacist for alcohol-free choices.
     

Have a query?

How Soon It Starts Working

The time required for Disfit 500 Tablet to start to work: The time required for Disfit 500 Tablet to start to work is 30 to 60 minutes after administration. The time for which the effects of Disfit 500 Tablet last: The effect of Disfit 500 Tablet lasts for 2 weeks.

What if you forget to take Disfit 500 Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Disfit 500 Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F). •Keep the tablets in their original container to protect them from moisture and direct sunlight.

Drug Warnings

  • The 12-hour rule: Never take your first dose of Disfit 500 Tablet unless you are 100% sure you have not consumed any alcohol for at least 12 hours.
  • Carry medical identification: Always carry an emergency medical card or wear a medical alert bracelet stating that you are taking this medicine, as this is crucial information for emergency medical staff.
  • Understand the lingering effect: Be aware that your body will remain highly sensitive to alcohol for up to 14 days after you stop taking Disfit 500 Tablet. Do not drink alcohol during this two-week window.
  • Keep up with blood tests: Attend all scheduled medical appointments. Your doctor will need to perform routine blood tests to monitor your liver function while you are on this medicine.
  • Report nerve changes: Inform your doctor immediately if you notice any numbness, tingling, or 'pins and needles' sensations in your fingers or toes.
     

Drug-Drug Interactions

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Drug-Drug Interactions

Disfit 500 Tablet can interact with medicines that affect blood clotting, seizure control, or brain function, including:

  • Blood thinners (like warfarin): Disfit 500 Tablet can increase the effects of blood thinners, which may raise your risk of bleeding. Your doctor may need to adjust your blood thinner dose.
  • Certain seizure medications (like phenytoin): This medication can slow down how your body clears seizure drugs, leading to toxic levels in your system.
  • Certain antibiotics (like metronidazole): Taking these medications together can cause severe confusion, mental changes, or hallucinations.

Drug-Food Interactions

Alcohol can trigger a severe reaction while taking Disfit 500 Tablet, including alcohol that may be hidden in foods, beverages, or other products:

  • Alcohol-containing foods and beverages: Consuming even trace amounts of alcohol will trigger a highly dangerous physical reaction, including severe headache, rapid breathing, vomiting, chest pain, and a dangerous drop in blood pressure.

Drug-Disease Interactions

Disfit 500 Tablet may require special caution in people with conditions affecting the liver, heart, or mental health, including:

  • Liver disease: Because this medicine is processed by the liver and carries a risk of liver damage, it must be used with extreme caution if you have pre-existing liver problems.
  • Heart disease: The physical strain of an accidental alcohol reaction can be dangerous to your cardiovascular system, making this medication risky for those with severe heart conditions.
  • Mental health disorders: This medication can affect brain chemicals and may worsen symptoms of depression, psychoses, or other psychiatric conditions.
     
DisulfiramBenznidazole
Critical
DisulfiramParaldehyde
Critical

Drug-Drug Interactions

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DisulfiramBenznidazole
Critical
How does the drug interact with Disfit 500 Tablet:
Coadministration of Disfit 500 Tablet with Benznidazole can increase the risk of side effects.

How to manage the interaction:
Taking benznidazole and Disfit 500 Tablet together is advised as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, weakness, shortness of breath, or palpitations, contact your doctor immediately.
DisulfiramParaldehyde
Critical
How does the drug interact with Disfit 500 Tablet:
Coadministration of Paraldehyde and Disfit 500 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Paraldehyde and Disfit 500 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience palpitations, difficulty breathing, vomiting, sweating, chest pain, dizziness, or blurred vision contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DisulfiramMetronidazole
Critical
How does the drug interact with Disfit 500 Tablet:
Coadministration of Disfit 500 Tablet with Metronidazole can increase the risk of side effects.

How to manage the interaction:
Taking Metronidazole and Disfit 500 Tablet together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, confusion, weakness, shortness of breath, or palpitations, contact your doctor. Do not discontinue any medications without consulting a doctor.
DisulfiramAmprenavir
Critical
How does the drug interact with Disfit 500 Tablet:
Coadministration of Amprenavir and Disfit 500 Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Amprenavir and Disfit 500 Tablet together is generally avoided as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like difficulty breathing, vomiting, sweating, palpitation, or dizziness, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DisulfiramEthanol
Severe
How does the drug interact with Disfit 500 Tablet:
Co-administration of Ethanol with Disfit 500 Tablet can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Ethanol with Disfit 500 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any vomiting, blurred vision, shortness of breath, or palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DisulfiramLomitapide
Severe
How does the drug interact with Disfit 500 Tablet:
Coadministration of Disfit 500 Tablet and Lomitapide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Disfit 500 Tablet and Lomitapide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DisulfiramRitonavir
Severe
How does the drug interact with Disfit 500 Tablet:
Co-administration of Ritonavir with Disfit 500 Tablet can increase the risk or severity of side effects.

How to manage the interaction:
Co-administration of Disfit 500 Tablet with ritonavir can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor if you experience headaches, difficulty breathing, vomiting, excessive sweating, chest pain, palpitations, dizziness, or blurred vision. Do not stop using any medications without a doctor's advice.
DisulfiramSertraline
Severe
How does the drug interact with Disfit 500 Tablet:
Co-administration of Disfit 500 Tablet and Sertraline can increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Disfit 500 Tablet with Sertraline can lead to an interaction, it can be taken if advised by your doctor. However, consult the doctor immediately if you experience headache, vomiting, excessive sweating, or thirst. Do not stop using any medications without a doctor's advice.
DisulfiramLeflunomide
Severe
How does the drug interact with Disfit 500 Tablet:
Coadministration of Disfit 500 Tablet and Leflunomide can increase the risk of liver problems.

How to manage the interaction:
There may be a possibility of interaction between Disfit 500 Tablet and Leflunomide, but it can be taken if prescribed by a doctor. If you have any of these symptoms fever, vomiting, stomach pain, dark urine, or yellowing of skin and eyes, contact your doctor right away. Do not discontinue any medications without consulting your doctor.
DisulfiramTipranavir
Severe
How does the drug interact with Disfit 500 Tablet:
Co-administration of Tipranavir with Disfit 500 Tablet can increase the risk of side effects.

How to manage the interaction:
Co-administration of Tipranavir with Disfit 500 Tablet can lead to an interaction, it can be taken if your doctor advises. However, consult the doctor immediately if you experience any symptoms like palpitations, excessive sweating, chest pain, or ringing of the ears. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI-ALCOHOLIC AGENT]

FAQs

Disfit 500 Tablet is used to treat alcohol dependence or chronic alcoholism.
Disfit 500 Tablet contains 'Disulfiram', which belongs to 'Antabuse' used to treat alcohol dependence. It works by blocking an enzyme (acetaldehyde) that helps break alcohol in the body. Disfit 500 Tablet helps alcohol-dependent people who have decided to quit alcohol drinking by deterring them from drinking again.
An asthmatic patient, if already on cough-suppressing medications like diphenhydramine, is not recommended to take Disfit 500 Tablet. Disfit 500 Tablet and diphenhydramine are contraindicated and may result in harmful implications.
Not recommended in patients taking blood thinners like warfarin to prevent blood clot formation inside heart/brain vessels. Warfarin (blood thinner) and Disfit 500 Tablet are contraindicated and should not be taken together.
Yes, Disfit 500 Tablet has been implicated in altering the results of tests done for adrenal tumours & hence not recommended to be taken before any diagnostic test is done.
The common side effects of Disfit 500 Tablet are usually temporary, including headaches, nausea, a metallic taste in the mouth and feeling tired.
Take the missed dose as soon as you remember. Take the rest of the day's doses at evenly spaced intervals unless otherwise directed by your doctor.
Disfit 500 Tablet is safe if taken in the dose and duration prescribed by the doctor.
Disfit 500 Tablet is not an over-the-counter medicine. It can be taken only when prescribed by the doctor.
Disfit 500 Tablet is not addictive. It does not have habit-forming tendencies.
Disfit 500 Tablet will not work for everyone. It is used to help people with an alcohol addiction who have already stopped drinking and are maintaining their ability to no longer drink alcohol. Disfit 500 Tablet is not recommended for people with heart failure or coronary artery disease.
Disfit 500 Tablet takes 1-2 hours to start working. For the full benefits, keep taking Disfit 500 Tablet for the prescribed duration.
No, you should avoid non-alcoholic or "alcohol-free" beers and wines. Many of these products still contain trace amounts of alcohol, which can be enough to trigger a highly unpleasant physical reaction. Talk to your doctor or pharmacist if you have questions about specific beverages.
You must wait at least 14 days after your last dose of Disfit 500 Tablet before consuming any alcohol. The medication remains active in your body for up to two weeks, and drinking during this time can still trigger a severe reaction.
If you experience a reaction, even a mild one, monitor your symptoms closely. If you experience severe symptoms like chest pain, severe shortness of breath, rapid heart rate, or extreme dizziness, seek emergency medical care immediately.
Some people can experience a mild skin reaction or headache from absorbing alcohol through the skin or inhaling strong vapours from aftershaves, perfumes, or hand sanitisers. It is safest to use alcohol-free personal care products while on this medication.
Disfit 500 Tablet does not directly reduce or stop physical cravings for alcohol. Instead, it acts as a behavioural deterrent by making the physical consequences of drinking highly unpleasant. It is most effective when combined with counselling and support groups.
Disfit 500 Tablet is generally not recommended during pregnancy unless your doctor decides the benefits heavily outweigh the risks. If you are pregnant or planning to become pregnant, talk to your doctor to discuss safer treatment alternatives for alcohol dependence.
Yes, experiencing a metallic or garlic-like taste in your mouth is a very common and usually harmless side effect of Disfit 500 Tablet. This symptom typically fades as your body adjusts to the medication.
Yes, your doctor will likely order routine blood tests to check your liver function before you start taking this medicine and at regular intervals during your treatment. This helps ensure the medication is not causing any strain on your liver.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.11168 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026] Check here
  2. MIMS Drug Reference Compendium. Disulfiram Monograph. Singapore: MIMS; 2025. [Accessed on 02 Jun. 2026] Check here
  3. Drugs.com Clinical Review Team. Disulfiram Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  4. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026] Check here
  5. ANTABUSE (Disulfiram Tablets USP) IN ALCOHOLISM [Internet]. Dailymed.nlm.nih.gov. 2022 [Accessed on 7 March 2022] Check here
  6. Disulfiram 200 mg tablets - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2022 [Accessed on 7 March 2022] Check here
  7. Maranda Stokes; Sara Abdijadid. Disulfiram. StatPearls [Internet]. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. [Revised in November 2021]. [Accessed on 2nd December 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Hall No.4 And 5 Plot No.508 Block C, Phase 1 Sector- 38, Rai Industrial Estate, Sonepat, Haryana-131029
Other Info - DISF843
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