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  3. Divalsha 500mg Tablet

Divalsha 500mg Tablet, Pack of 1 Tablet
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

Divalsha 500mg Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines. It contains Divalproex, which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. It helps block nerve transmission across the brain and provides a calming effect. In some cases, it may cause side effects such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

DIVALPROEX-500MG

Manufacturer/Marketer :

Suraksha Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Divalsha 500mg Tablet

Divalsha 500mg Tablet is used to treat epilepsy/seizures/fits. Additionally, Divalsha 500mg Tablet is also used to treat manic episodes associated with bipolar disorder and prevent migraines. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Divalsha 500mg Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Divalsha 500mg Tablet increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder. 

Take Divalsha 500mg Tablet with or without food. Depending on your medical condition, you are advised to take Divalsha 500mg Tablet for as long as your doctor has prescribed it for you. In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Please do not stop taking Divalsha 500mg Tablet without consulting your doctor to avoid worsening seizures. Do not take Divalsha 500mg Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Divalsha 500mg Tablet. Consult your doctor before taking Divalsha 500mg Tablet if you are breastfeeding. Avoid driving or operating machinery as Divalsha 500mg Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Divalsha 500mg Tablet as it could lead to increased dizziness. Keep your doctor informed about your health condition and medicines to rule out any side effects.

Uses of Divalsha 500mg Tablet

Divalsha 500mg Tablet is used in the treatment of epilepsy, bipolar disorder, migraine. The detailed uses of Divalsha 500mg Tablet are as follows:<br/> • Seizure Management: Divalsha 500mg Tablet is primarily used to manage various types of seizures in individuals with epilepsy, helping to stabilise electrical activity in the brain.<br/> • Bipolar Disorder Treatment: Divalsha 500mg Tablet can be utilized in the treatment of bipolar disorder, aiding in mood stabilization and reducing the frequency of mood swings.<br/> • Migraine Prevention: Divalsha 500mg Tablet may also be prescribed to prevent migraines, providing relief from recurrent headaches.<br/> • Insomnia Treatment: Divalsha 500mg Tablet can improve sleep quality by inducing sedation, offering relief for those suffering from insomnia or other sleep disturbances.<br/>

Directions for Use

  • Divalsha 500mg Tablet can be taken with or without food.
  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Swallow Divalsha 500mg Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

Divalsha 500mg Tablet belongs to a group of medicines called anticonvulsants or anti-epileptics. Divalsha 500mg Tablet is used to treat epilepsy/seizures/fits. Also, Divalsha 500mg Tablet is used to treat mood disorders and prevent migraine headaches. Divalsha 500mg Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures. Divalsha 500mg Tablet treats mood disorders by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Divalsha 500mg Tablet prevents migraine headaches by limiting the transmission of nerve pain. Divalsha 500mg Tablet is used alone or in combination to treat simple, complex partial, and complex absence seizures. Divalsha 500mg Tablet is used in combination to treat multiple seizures, such as absence seizures.

How Divalsha 500mg Tablet Works

Divalsha 500mg Tablet contains 'Divalproex', which decreases the brain's excessive and abnormal nerve activity. Thereby helping in controlling seizures. Divalsha 500mg Tablet increases the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect. Thereby helping treat bipolar disorder.

Storage

Store in a cool and dry place away from sunlight
Side effects of Divalsha 500mg Tablet
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Eat eggs for zinc and other nutrients that support healthy vision.
  • Consume blueberries as antioxidants to combat eye strain.
  • Include broccoli in your diet for diverse eye-boosting nutrients.
  • Eat sweet potatoes as a natural source of vitamin A.
  • Snack on almonds for vitamin E and eye protection.
  • Add tomatoes to your diet for lycopene and vision protection.
  • Perform exercises that improve binocular vision, such as dot-to-dot cards, coloring within lines, and Brock string tests.
  • Wear an eye patch and perform tasks like playing games and solving puzzles.
  • Patching and eye exercises can improve symptoms.
  • Get plenty of rest and sleep.
  • Keep your body warm.
  • Drink plenty of fluids to stay hydrated.
  • Avoid strenuous activities.
  • Maintain good hygiene to prevent flu from spreading.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

What if I have taken an overdose of Divalsha 500mg Tablet

Do not take more than the prescribed dose of Divalsha 500mg Tablet as it may cause overdose resulting in heart block, excess sleepiness and deep coma. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Divalsha 500mg Tablet if you are allergic to any of its contents, have/ had liver problems or urea cycle disorders. Inform your doctor before taking Divalsha 500mg Tablet if you have pancreatitis, blood problems or multi-organ hypersensitivity. Consult your doctor immediately if you experience suicidal tendencies while taking Divalsha 500mg Tablet. Divalsha 500mg Tablet may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature) and liver problems. Please do not stop taking Divalsha 500mg Tablet without consulting your doctor to avoid worsening of seizures. Do not take Divalsha 500mg Tablet if you are pregnant, as it could cause serious birth defects. If you are of childbearing age, use effective contraception while taking Divalsha 500mg Tablet. Consult your doctor before taking Divalsha 500mg Tablet if you are breastfeeding. Avoid driving or operating machinery as Divalsha 500mg Tablet causes dizziness and may affect thinking and motor skills. Avoid consuming alcohol along with Divalsha 500mg Tablet as it could lead to increased dizziness. Care should be taken while giving Divalsha 500mg Tablet to children below 2 years as there is a higher risk of liver intoxication during the first six months of treatment.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexMeropenem
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Divalsha 500mg Tablet:
Coadministration of Glycerol phenylbutyrate and Divalsha 500mg Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Divalsha 500mg Tablet together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexMeropenem
Severe
How does the drug interact with Divalsha 500mg Tablet:
Co-administration of Divalsha 500mg Tablet and Meropenem can reduce the blood levels of Divalsha 500mg Tablet sodium.

How to manage the interaction:
Co-administration of Divalsha 500mg Tablet with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
DivalproexBuprenorphine
Severe
How does the drug interact with Divalsha 500mg Tablet:
Co-administration of buprenorphine with Divalsha 500mg Tablet may increase the risk of developing side effects.

How to manage the interaction:
Co-administration of Buprenorphine with Divalsha 500mg Tablet can result in an interaction, it can be taken when a doctor has advised it. However, if you experience shortness of breath, irregular heart rhythms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexSodium phenylbutyrate
Severe
How does the drug interact with Divalsha 500mg Tablet:
Co-administration of Sodium phenylbutyrate and Divalsha 500mg Tablet can increase ammonia levels in the blood and is generally not recommended for patients with urea cycle disorders.

How to manage the interaction:
Co-administration of Divalsha 500mg Tablet with Sodium phenylbutyrate can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without first consulting your doctor.
DivalproexLamotrigine
Severe
How does the drug interact with Divalsha 500mg Tablet:
Coadministration of Divalsha 500mg Tablet and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Divalsha 500mg Tablet and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.
DivalproexVorinostat
Severe
How does the drug interact with Divalsha 500mg Tablet:
Coadministration of Divalsha 500mg Tablet and Vorinostat can increase the risk of bleeding.

How to manage the interaction:
Although there is a possible interaction between Divalsha 500mg Tablet and Vorinostat, you can take these medicines together if prescribed by your doctor. If you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor immediately. Do not discontinue any medications without consulting your doctor.
DivalproexTeriflunomide
Severe
How does the drug interact with Divalsha 500mg Tablet:
Co-administration of Divalsha 500mg Tablet and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divalsha 500mg Tablet and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DivalproexDoripenem
Severe
How does the drug interact with Divalsha 500mg Tablet:
Co-administration of Divalsha 500mg Tablet and Doripenem can reduce the blood levels of Divalsha 500mg Tablet sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Divalsha 500mg Tablet with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
DivalproexMipomersen
Severe
How does the drug interact with Divalsha 500mg Tablet:
Co-administration of Divalsha 500mg Tablet and mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divalsha 500mg Tablet and mipomersen can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol consumption, and Do not stop using any medications without a doctor's advice.
DivalproexBexarotene
Severe
How does the drug interact with Divalsha 500mg Tablet:
Co-administration of Divalsha 500mg Tablet and Bexarotene can increase the risk of pancreatitis (inflammation of the pancreas).

How to manage the interaction:
Co-administration of Divalsha 500mg Tablet and Bexarotene can lead to an interaction, but it can be taken when advised by your doctor. However, if you experience any symptoms like nausea, vomiting, or stomach cramps, consult a doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilising fat instead of glucose for the generation of energy.

  • Atkins diet (high fay and controlled carbohydrates) is recommended for adolescents and adults.

  • Exercising regularly helps in maintaining weight and improving overall health. 

  • Rest well, get plenty of sleep.

  • Avoid smoking and alcohol consumption.

  • Meditation and yoga can help lower the stress, decrease pain sensitivity and improves coping skills.

  • Have a seizure response plan, help those around you know what to do.

  • Prepare your living area, small changes may reduce the risk of physical injury during a seizure.

  • Understand what triggers seizures and try reducing or avoiding them.

  • Please pay attention to overall health as it can help in reducing seizure activity.

  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

ANTICONVULSANT

Divalsha 500mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Divalsha 500mg Tablet as it may cause increased dizziness.

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Pregnancy

Unsafe

Divalsha 500mg Tablet belongs to pregnancy category D. Avoid taking Divalsha 500mg Tablet if you are pregnant as it could lead to serious birth defects. Consult your doctor for further advice.

bannner image

Breast Feeding

Caution

Divalsha 500mg Tablet may pass into breastmilk. Consult your doctor before taking Divalsha 500mg Tablet if you are breastfeeding.

bannner image

Driving

Unsafe

Divalsha 500mg Tablet causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery.

bannner image

Liver

Caution

Divalsha 500mg Tablet should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

Divalsha 500mg Tablet can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below two years as they are at a higher risk of liver toxicity.

Have a query?

FAQs

Divalsha 500mg Tablet is used to treat epilepsy/seizures/fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and prevent migraines.

Divalsha 500mg Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.

Divalsha 500mg Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, this helps in blocking the nerve transmission across the brain and provides a calming effect.

Divalsha 500mg Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition which is characterized by intense headaches.

Divalsha 500mg Tablet may interact with aspirin and cause abnormal side-effects. So, it is recommended to take any medication along with Divalsha 500mg Tablet only after consulting a doctor.

Divalsha 500mg Tablet may improve the symptoms of depression. However, do not use it without consulting a doctor as it may also cause mood disturbances and suicidal thoughts in some patients.

Do not discontinue Divalsha 500mg Tablet without consulting your doctor. To treat your condition effectually, continue taking Divalsha 500mg Tablet for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Divalsha 500mg Tablet; your doctor will gradually reduce the dose to avoid worsening seizures.

Before taking Divalsha 500mg Tablet, certain laboratory tests are recommended. These include a Complete Blood Count (CBC), liver function tests (LFTs), kidney function tests, blood urea nitrogen (BUN) and creatinine levels, and a pregnancy test for women of childbearing age. Additionally, blood glucose levels should be checked for patients with diabetes or at risk of developing diabetes. Platelet count and coagulation tests (PT/INR/APTT) are also recommended. Please note that this list may not be exhaustive, and additional tests or monitoring may be necessary based on individual circumstances.

Divalsha 500mg Tablet may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Divalsha 500mg Tablet.

Topiramate (anticonvulsant) should not be taken along with Divalsha 500mg Tablet as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

It's crucial to consult with your doctor before discontinuing Divalsha 500mg Tablet. Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.

Divalsha 500mg Tablet is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

Divalsha 500mg Tablet can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, you must talk to your doctor.

Yes, Divalsha 500mg Tablet can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Divalsha 500mg Tablet, it's essential to consult with your doctor.

Yes, Divalsha 500mg Tablet can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Divalsha 500mg Tablet, seeking medical attention is crucial.

Avoid consumption of alcohol while taking Divalsha 500mg Tablet as it may cause increased dizziness.

If you experience abdominal pain, nausea, and anorexia while taking Divalsha 500mg Tablet, it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

Overdose of Divalsha 500mg Tablet can be a severe medical emergency. If you or someone you know has taken an overdose of Divalsha 500mg Tablet, it's crucial to seek immediate medical attention.

Divalsha 500mg Tablet can be taken with or without food. However, it is recommended to take it with food to reduce stomach upset and improve absorption. Food can help buffer any potential stomach irritation and enhance the body's absorption of the medication.

Take the missed dose as soon as you remember, unless it's almost time for your next dose. In this case, skip the missed dose and take your next dose at the regular time. Never take a double dose to make up for a missed one.

Manufacturer/Marketer address

Hindnagar Colony, Transport Nagar, Lucknow, Uttar Pradesh 226012
Other Info - DI31741

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Jul 22, 2025 | 11:25 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/018723s037lbl.pdf
  2. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e26005ef-77f0-4393-a2dc-b5fe460cead8&amp;type=display
  3. https://www.drugs.com/mtm/divalproex-sodium.html
  4. https://www.depakote.com/depakote-formulations
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