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  3. Domsafe 5mg/5ml/500mg/5ml Suspension

Domsafe 5mg/5ml/500mg/5ml Suspension, Pack of 1 Suspension
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Domsafe 5mg/5ml/500mg/5ml Suspension is used to treat duodenal ulcers, nausea, and vomiting. It contains Sucralfate and Domperidone which protect the ulcers from acid and facilitate their healing. Besides this, it blocks dopamine receptors that stimulate the vomiting centre. This medicine may sometimes cause side effects such as dry mouth, diarrhoea, constipation, drowsiness, dizziness, or headache. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

DOMPERIDONE-5MG/5ML + SUCRALFATE-500MG/5ML

Manufacturer/Marketer :

Eskag Pharma Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

About Domsafe 5mg/5ml/500mg/5ml Suspension

Domsafe 5mg/5ml/500mg/5ml Suspension belongs to a class of medication called gastrointestinal agents used to treat duodenal ulcers, nausea, and vomiting. Duodenal ulcer is a peptic ulcer that develops in the duodenum (first part of the small intestine) due to erosion of the stomach's protective lining. Nausea is a feeling of uneasiness in the stomach that often comes before vomiting. On the other hand, vomiting is the forcible voluntary or involuntary emptying of stomach contents through the mouth.

Domsafe 5mg/5ml/500mg/5ml Suspension is a combination of two drugs: Sucralfate (gastrointestinal protectant) and Domperidone (antinausea agent). Sucralfate belongs to the protectants class which forms a protective layer over the ulcer and protects the stomach from an ulcer due to excess stomach acid, thereby healing it. Domperidone belongs to the dopamine antagonist class that works by blocking dopamine receptors that stimulate the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. Together they prevent ulcers, nausea, and vomiting.

Take Domsafe 5mg/5ml/500mg/5ml Suspension as prescribed by your doctor. You are advised to take Domsafe 5mg/5ml/500mg/5ml Suspension for as long as your doctor has prescribed it for you based on your medical condition. You may experience dry mouth, diarrhea, constipation, drowsiness, dizziness, or headache in some cases. Most of these side effects of Domsafe 5mg/5ml/500mg/5ml Suspension do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Domsafe 5mg/5ml/500mg/5ml Suspension or any other medicines, please tell your doctor. Domsafe 5mg/5ml/500mg/5ml Suspension is not recommended for children below 18 years and those weighing less than 35 kg as the safety and effectiveness were not established. If you are pregnant or breastfeeding, please inform your doctor before taking $your name. Drive only if you are alert as Domsafe 5mg/5ml/500mg/5ml Suspension may cause drowsiness or dizziness. Avoid alcohol consumption as it may increase adverse effects or irritate the stomach lining. Avoid taking Domsafe 5mg/5ml/500mg/5ml Suspension if you have black, tarry stools or notice blood in stools as these might be signs of bleeding in the stomach or intestines.

Uses of Domsafe 5mg/5ml/500mg/5ml Suspension

Treatment of Duodenal ulcer, Nausea, Vomiting.

Directions for Use

• Domsafe 5mg/5ml/500mg/5ml Suspension should be taken on an empty stomach, 1 hour before a meal, or as advised by your doctor.• Follow your doctor's instructions on the dosage and timing of this medication.• Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper provided by the pack.• Avoid using regular household spoons, as they may not measure the dose correctly. Shake well before use.

Medicinal Benefits

Domsafe 5mg/5ml/500mg/5ml Suspension is a combination of two drugs: Sucralfate and Domperidone used to treat duodenal ulcers, nausea, and vomiting. Sucralfate is a protectant that forms a protective layer over the ulcer and protects the ulcer from stomach acid. Thereby, it allows healing. Domperidone is a dopamine antagonist that works by blocking dopamine receptors that stimulate the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting. Also, domperidone acts as a prokinetic agent that increases muscle movements and contractions in the stomach. Thereby prevents vomiting and reduces bloating, nausea and fullness. 

How Domsafe 5mg/5ml/500mg/5ml Suspension Works

Domsafe 5mg/5ml/500mg/5ml Suspension is a combination of two drugs: Sucralfate (gastrointestinal protectant) and Domperidone (antinausea agent). Sucralfate belongs to the protectants class which forms a protective layer over the ulcer and protects the stomach from an ulcer due to excess stomach acid, thereby healing it. Domperidone belongs to the dopamine antagonist class that works by blocking dopamine receptors that stimulate the vomiting center (chemoreceptor trigger zone – CTZ) located in the brain. Together they  prevent ulcers, nausea, and vomiting.

Storage

• Store in a cool and dry place away from sunlight.• Keep Domsafe 5mg/5ml/500mg/5ml Suspension out of reach and sight of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Domsafe 5mg/5ml/500mg/5ml Suspension

Avoid exceeding the recommended dose as it might cause an overdose. Seek immediate medical attention if you experience any unusual symptoms.

Drug Warnings

If you are allergic to Domsafe 5mg/5ml/500mg/5ml Suspension or any other medicines, please tell your doctor. Domsafe 5mg/5ml/500mg/5ml Suspension is not recommended for children below 18 years and those weighing less than 35 kg as the safety and effectiveness were not established. If you are pregnant or breastfeeding, please inform your doctor before taking Domsafe 5mg/5ml/500mg/5ml Suspension. If you have a prolactinoma (tumor of the pituitary gland), kidney, liver, or heart problems, diabetes, high potassium levels in the blood, or black tarry stools, inform your doctor before taking Domsafe 5mg/5ml/500mg/5ml Suspension. Drive only if you are alert as Domsafe 5mg/5ml/500mg/5ml Suspension may cause drowsiness or dizziness. Avoid alcohol consumption as it may increase adverse effects or irritate the stomach lining. If you experience heart rhythm disorders like difficulty in breathing, loss of consciousness, or palpitations (strong or irregular heartbeat) while taking Domsafe 5mg/5ml/500mg/5ml Suspension, contact your doctor immediately. You are not recommended to take antacids such as cimetidine and sodium bicarbonate with Domsafe 5mg/5ml/500mg/5ml Suspension simultaneously as it may affect the absorption of Domsafe 5mg/5ml/500mg/5ml Suspension. Avoid taking Domsafe 5mg/5ml/500mg/5ml Suspension if you have black, tarry stools or notice blood in stools as these might be signs of bleeding in the stomach or intestines.

Diet & Lifestyle Advise

  • Eat a healthy diet and a low-fat diet, especially in small portions, as it will be easy for digestion. Avoid eating over over-sweet and include more salty food, especially if you have been vomiting.
  • If you like to vomit at a specific time, avoid eating your favorite food at that particular time as your taste for that food may get turned off.
  • Include more cool beverages in your food like flavored gelatin, and carbonated beverages. And also, when you drink with a stray, sip slowly to avoid swallowing air that may lead to gas or acidity.
  • Drink any other liquid at least 30 minutes after eating food.
  • If the smell of food makes you feel sick (vomit), do not cook food, which may worsen your condition. Let someone else do the cooking or use prepared food from the freezer.
  • Avoid sitting continuously as it may trigger acidity. Take 5 minutes for every hour by doing brisk walking or stretching.
  • Avoid consumption of alcohol as it may increase adverse effects.

Habit Forming

No

Therapeutic Class

GASTROINTESTINAL AGENTS
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Alcohol

Unsafe

Avoid alcohol consumption as it may increase adverse effects such as irregular heartbeat, drowsiness or may irritate the stomach lining.

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Pregnancy

Caution

Domsafe 5mg/5ml/500mg/5ml Suspension is given to pregnant women only if the doctor thinks benefits outweigh risks. Please consult a doctor if you are pregnant.

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Breast Feeding

Caution

Domsafe 5mg/5ml/500mg/5ml Suspension may be excreted in human milk in small amounts and cause adverse effects in the baby. Therefore, Domsafe 5mg/5ml/500mg/5ml Suspension is given to breastfeeding women only if the doctor thinks benefits are greater than risks. Please consult a doctor before taking Domsafe 5mg/5ml/500mg/5ml Suspension if you are breastfeeding.

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Driving

Caution

Domsafe 5mg/5ml/500mg/5ml Suspension may cause drowsiness or dizziness in some people. Therefore, avoid driving or operating heavy machinery if you feel drowsy or dizzy after taking Domsafe 5mg/5ml/500mg/5ml Suspension.

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Liver

Caution

Take Domsafe 5mg/5ml/500mg/5ml Suspension with caution, especially if you have a history of Liver diseases/conditions. The dose may be adjusted by your doctor as required. Domsafe 5mg/5ml/500mg/5ml Suspension is not recommended for patients with moderate or severe liver disease.

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Kidney

Caution

Take Domsafe 5mg/5ml/500mg/5ml Suspension with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required.

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Children

Unsafe

Domsafe 5mg/5ml/500mg/5ml Suspension is not recommended for children below 18 years and those weighing less than 35 kg as the safety and effectiveness were not established.

Have a query?

FAQs

Domsafe 5mg/5ml/500mg/5ml Suspension is used to treat duodenal ulcers, nausea, and vomiting.

Domsafe 5mg/5ml/500mg/5ml Suspension contains Sucralfate and Domperidone. Sucralfate is a protectant that works by forming a protective layer over the ulcer and protects the stomach from getting ulcer due to excess of the stomach acid. Thereby, it allows healing. Domperidone belongs to the class of dopamine antagonist that works by blocking dopamine receptors that stimulate the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.

You are not recommended to take antacids with Domsafe 5mg/5ml/500mg/5ml Suspension such as sodium bicarbonate or cimetidine at the same time as it may affect the absorption of Domsafe 5mg/5ml/500mg/5ml Suspension and reduce its effectiveness. However, if you are supposed to take these medicines together, you are recommended to maintain a time gap of 30 minutes between taking antacids and Domsafe 5mg/5ml/500mg/5ml Suspension. Please consult your doctor before taking other medicines with Domsafe 5mg/5ml/500mg/5ml Suspension.

Domsafe 5mg/5ml/500mg/5ml Suspension should be used with caution in diabetic patients as it may increase the risk of change in blood sugar levels. However, inform your doctor if you have diabetes before taking have Domsafe 5mg/5ml/500mg/5ml Suspension so that the dose may be adjusted appropriately and regular monitoring of blood sugar levels is recommended while taking Domsafe 5mg/5ml/500mg/5ml Suspension.

Domsafe 5mg/5ml/500mg/5ml Suspension may cause dry mouth as a temporary side effect. It is not necessary for everyone taking Domsafe 5mg/5ml/500mg/5ml Suspension to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.

You are recommended to use Domsafe 5mg/5ml/500mg/5ml Suspension for as long as your doctor has prescribed it. However, avoid taking Domsafe 5mg/5ml/500mg/5ml Suspension for more than 1 week without consulting a doctor.

Domsafe 5mg/5ml/500mg/5ml Suspension should be used with caution in patients suffering from kidney problems. However, inform your doctor if you have any kidney problems before taking have Domsafe 5mg/5ml/500mg/5ml Suspension so that the dose may be adjusted appropriately.

You should take Domsafe 5mg/5ml/500mg/5ml Suspension at the time and dosage prescribed by your doctor. It is typically taken on an empty stomach, either 1 hour before or 2 hours after a meal. For best results, it is important to take it at the same time every day to maintain a consistent level of the medication in your body.

Yes, you can take Domsafe 5mg/5ml/500mg/5ml Suspension with other medications in most cases. However, you should inform your doctor first, especially if you are already taking certain medications, such as antifungals (e.g., fluconazole), antidepressants (e.g., citalopram), anti-allergic drugs (e.g., mizolastine), vitamins (e.g., ascorbic acid), and antibiotics (e.g., clarithromycin, erythromycin). This is not a complete list, and other drugs may interact with Domsafe 5mg/5ml/500mg/5ml Suspension. Your doctor will evaluate your overall health, medication history, and any underlying conditions before recommending Domsafe 5mg/5ml/500mg/5ml Suspension, to avoid possible interactions or side effects. Always follow your doctor's guidance and avoid self-medicating to ensure your safety and well-being.

Yes, Domsafe 5mg/5ml/500mg/5ml Suspension may cause side effects in some individuals, although not everyone will experience them. Common side effects include dry mouth, diarrhoea, constipation, drowsiness, dizziness, and headache. These side effects are generally mild and tend to resolve over time or once the medication is discontinued. However, if any side effects persist or worsen, please consult your doctor for further guidance and management.

If you are pregnant or breastfeeding, it is important to consult your doctor. Domsafe 5mg/5ml/500mg/5ml Suspension may be excreted in small amounts in human milk and could potentially cause adverse effects in the baby. Your doctor will prescribe Domsafe 5mg/5ml/500mg/5ml Suspension only if the benefits outweigh the risks.

You should store Domsafe 5mg/5ml/500mg/5ml Suspension in a cool, dry place, away from direct heat or sunlight. Make sure it is kept out of reach of children. Do not freeze the medication.

Country of origin

India

Manufacturer/Marketer address

Eskag Pharma Pvt. Ltd., Ag-112, Sector-Ii, Suite No.804 & 805, Baishakhi, Salt Lake City, Kolkata-700091
Other Info - DO67639

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:29 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.3188.pdf
  2. https://www.drugs.com/mtm/sucralfate.html
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