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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Doxin-25 Capsule is used to treat depression and anxiety when patients become intolerant to other medicines. In addition, it is also given as a medication to treat insomnia (difficulty in sleeping) in some people. It contains Doxepin, which increases the level of chemicals in the brain responsible for mood changes and causing depression. As a result, your mood is enhanced, and you feel better. If it is prescribed for insomnia, it helps us sleep for more time and treats sleeping difficulty. In some cases, you may experience side effects such as drowsiness, dry mouth, increased heart rate, constipation, weight gain, difficulty in urination, and sudden blood pressure lowering on standing up (orthostatic hypotension). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

DOXEPIN-25MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Doxin-25 Capsule

Doxin-25 Capsule is used to treat depression and anxiety when patients become intolerant to other medicines. In addition, it is also given as a medication to treat insomnia (difficulty in sleeping) in some people. An anxiety disorder is a mental condition characterized by excessive fear or worry affecting an individual's daily activities. High anxiety levels can cause panic attacks, with intense feelings of nervousness, fear, sudden onset of sweating, hyperventilation, fast heartbeat, and skin flushing.

Doxin-25 Capsule contains Doxepin, a tricyclic antidepressant that increases the level of chemicals in the brain known as GABA, responsible for mood changes and causing depression. As a result, your mood is enhanced, and you feel better. If Doxin-25 Capsule is prescribed for insomnia, it helps us sleep for more time and treats sleeping difficulty.

Take Doxin-25 Capsule as prescribed by your doctor. Depending upon your medical condition, you are advised to take Doxin-25 Capsule for as long as your doctor has prescribed it for you. In some cases, you may experience drowsiness, dry mouth, increased heart rate, constipation, weight gain, difficulty in urination, and sudden blood pressure lowering on standing up (orthostatic hypotension). Most of these side effects of Doxin-25 Capsule do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Do not take Doxin-25 Capsule if you have had an allergic reaction to Doxin-25 Capsule or any of its ingredients. Doxin-25 Capsule should not be taken if you have glaucoma (increased eye pressure), severe liver or kidney problems, asthma, difficulty in urination, and have taken monoamine oxidase inhibitors (MAOs) in the last 15 days. If you are breastfeeding or pregnant, please do not take Doxin-25 Capsule as it is a category C pregnancy drug. Doxin-25 Capsule may lead to withdrawal symptoms if stopped abruptly, like suicidal thoughts, irritability, and excessive aggression, which can sometimes be fatal. So, please consult your doctor; the doctor might lower your dose depending on your medical condition.

Uses of Doxin-25 Capsule

Treatment of Depression, Anxiety, Insomnia (sleepiness)

Directions for Use

Swallow the medicine as a whole with water; do not crush, break or chew it.

Medicinal Benefits

Doxin-25 Capsule contains Doxepin, which is a tricyclic anti-depressant. It is primarily used to treat depression and anxiety when patients become intolerant to other medicines. In addition to this, it is also given as a medication to treat insomnia (difficulty in sleeping) in some people. Doxepin works by increasing the level of chemicals in the brain responsible for mood changes and causing depression. As a result, your mood is enhanced, and you feel better. If Doxin-25 Capsule is prescribed for insomnia, it helps us sleep for more time and, hence, treats sleeping difficulty.

How Doxin-25 Capsule Works

Doxin-25 Capsule contains Doxepin, a tricyclic antidepressant that increases the level of chemicals in the brain known as GABA, responsible for mood changes and causing depression. As a result, your mood is enhanced, and you feel better. If Doxin-25 Capsule is prescribed for insomnia, it helps us sleep for more time and treats sleeping difficulty.

Storage

Store in a cool and dry place away from sunlight
Side effects of Doxin-25 Capsule
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Get ample rest; this helps your stomach to settle.
  • Eat soft and easy-to-digest foods like white rice, bananas, crackers and apple sauce.
  • Include probiotics-rich food like yoghurt, kefir, or miso, as they help maintain gut functioning.
  • Wash your hands properly before preparing/eating food and after using the toilet.
  • Drink water, broth or diluted fruit juice to replace electrolytes and lost fluids.
  • Avoid caffeine, alcohol, high-fat, fried and fast foods, as well as sweetened beverages.

What if I have taken an overdose of Doxin-25 Capsule

Do not take more than the prescribed dose of Doxin-25 Capsule as it may cause overdose. The symptoms of overdose include vomiting, nausea, dizziness, tiredness or weakness, dry mouth, mouth sores, increase in pupil size, constipation, indigestion, diarrhoea, difficulty urinating or changes in taste. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Doxin-25 Capsule if you have had an allergic reaction to any ingredient present in Doxin-25 Capsule or if you have glaucoma (increased eye pressure), serious liver or kidney problem, asthma, difficulty in urination, and have taken monoamine oxidase inhibitors  (MAOIs) in the last 15 days. If you are breastfeeding or pregnant, please do not take Doxin-25 Capsule as it is a category C pregnancy drug. Do not take alcohol and Doxin-25 Capsule as it can affect you much more and make you even more depressed. Avoid driving or anything that requires concentration, as Doxin-25 Capsule is known to cause drowsiness. Doxin-25 Capsule may lead to withdrawal symptoms if stopped abruptly, like suicidal thoughts, irritability, and excessive aggression, which can sometimes be fatal. So, please consult your doctor; the doctor might lower your dose depending on your medical condition.

Drug-Drug Interactions

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DoxepinProcarbazine
Critical
DoxepinPotassium chloride
Critical

Drug-Drug Interactions

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DoxepinProcarbazine
Critical
How does the drug interact with Doxin-25 Capsule:
Combining Procarbazine and Doxin-25 Capsule can increase the risk of a rare but serious condition called the serotonin syndrome(build up high levels of serotonin in the body).

How to manage the interaction:
Taking Doxin-25 Capsule with Procarbazine is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping procarbazine before you start treatment with Doxin-25 Capsule and do not discontinue any medications without consulting your doctor.
DoxepinPotassium chloride
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Doxin-25 Capsule with Potassium chloride is not recommended, as it can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), loss of appetite, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxepinTranylcypromine
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule with Tranylcypromine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Doxin-25 Capsule with Tranylcypromine is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
DoxepinSafinamide
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Safinamide with Amitriptyline can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Doxin-25 Capsule with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DoxepinZiprasidone
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Doxin-25 Capsule with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxepinDronedarone
Critical
How does the drug interact with Doxin-25 Capsule:
Combining Doxin-25 Capsule with Dronedarone can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxin-25 Capsule with Dronedarone is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxepinRasagiline
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Rasagiline with Doxin-25 Capsule can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Doxin-25 Capsule with rasagiline is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms, like confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasms, stomach cramps, nausea, vomiting, and loose stools, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxepinSaquinavir
Critical
How does the drug interact with Doxin-25 Capsule:
Combining Doxin-25 Capsule with Saquinavir can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxin-25 Capsule with Saquinavir is not recommended, as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, diarrhea or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxepinPotassium citrate
Critical
How does the drug interact with Doxin-25 Capsule:
Taking Doxin-25 Capsule and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Doxin-25 Capsule with Potassium citrate is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, consult the doctor immediately if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), loss of appetite, or dark, tarry stools. Do not discontinue any medications without a doctor's advice.
DoxepinPapaverine
Severe
How does the drug interact with Doxin-25 Capsule:
Co-administration of Papaverine with Doxin-25 Capsule can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Papaverine with Doxin-25 Capsule together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Regular exercise can help lower anxiety by releasing endorphins and improving your sleep and self-image.
  • Find humour in your daily life. Try to watch a comedy show to help relieve stress.
  • You can try increasing your mindfulness by including yoga, meditation, cognitive therapy, and mindfulness-based stress reduction.
  • Drink enough water to stay hydrated, and limit or avoid alcohol and caffeine to relieve anxiety.
  • Include a diet rich in whole grains, vegetables, and fruits. This is a healthier option than eating many simple carbohydrates in processed foods.
  • Herbs like turmeric, ginger, and chamomile contain anti-inflammatory properties. Including these in a meal can reduce inflammation caused by anxiety disorders.
  • Reduce your alcohol, caffeine, added sugar, salt, and fat intake. Transfat, especially, may help reduce inflammation.
  • Antioxidants, such as ashwagandha, omega-3 fatty acids, green tea, and lemon balm, can be included in your daily diet.
  • Try to spend time with your friends and family. Having a strong social network may help you lower your risk of anxiety.

Habit Forming

No

Therapeutic Class

ANTIDEPRESSANT

Doxin-25 Capsule Substitute

Substitutes safety advice
  • Spectra 25 Capsule 10's

    by Others

    13.37per tablet
  • Doxbrin 25Mg Capsule 10'S

    by AYUR

    11.34per tablet
  • Dox 25mg Tablet 10's

    by AYUR

    4.95per tablet
  • Galdopin-25 mg Capsule 10's

    by Others

    9.09per tablet
  • Actipin 25mg Tablet

    by Others

    1.82per tablet
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Alcohol

Unsafe

Doxin-25 Capsule should not be taken along with alcohol as it can affect you much more and may make you feel more depressed.

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Pregnancy

Caution

Doxin-25 Capsule is a pregnancy category C drug. It is not known whether it will harm the baby or not. So, it should be only taken when prescribed by a doctor.

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Breast Feeding

Unsafe

Doxin-25 Capsule is not recommended for breastfeeding women.

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Driving

Unsafe

Doxin-25 Capsule may impair your concentration and lead to drowsiness, so do not drive after taking Doxin-25 Capsule .

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Liver

Caution

Inform your doctor before receiving the Doxin-25 Capsule if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

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Kidney

Caution

Inform your doctor before receiving the Doxin-25 Capsule if you have a history of liver diseases/conditions. Your doctor may adjust your dose depending on your current liver conditions.

bannner image

Children

Caution

Doxin-25 Capsule is not recommended for children below the age of 12 years.

Have a query?

FAQs

Doxin-25 Capsule is used to treat depression and anxiety when patients become intolerant to other medicines. In addition, it is also used to treat insomnia (difficulty in sleeping) in some people.

Doxin-25 Capsule contains Doxepin, which is a tricyclic anti-depressant. Doxepin works by increasing the level of chemicals in the brain responsible for mood changes and causing depression. As a result, your mood is enhanced, and you feel better. If Doxin-25 Capsule is prescribed for insomnia, it helps us to sleep for more time and hence treats difficulty in sleeping.

The time of taking the Doxin-25 Capsule depends upon the medical condition for which you are taking it. If you are taking it for insomnia, take it 30 minutes before your bedtime. If you are taking it for anxiety or depression, take it as advised by your doctor for the best results. Also, take medicine at the same time each day.

Doxin-25 Capsule can cause weight gain but in a sporadic case. If you feel you are gaining weight, please inform your doctor and do as advised.

NO, Doxin-25 Capsule should not be stopped abruptly, even if you feel better. It may lead to withdrawal symptoms like suicidal thoughts, irritability, and excessive aggression, which can sometimes be fatal. So, please consult your doctor; the doctor might lower your dose depending on your medical condition.

If you have allergies to any of its ingredients or are pregnant, you are advised to avoid using Doxin-25 Capsule . Do not take the Doxin-25 Capsule if you have glaucoma (increased eye pressure), severe liver or kidney issues, or trouble urinating. Take Doxin-25 Capsule only as recommended by a doctor and with under medical care if you are pregnant or nursing. If you have taken an MAO inhibitor within the last 15 days, avoid taking Doxin-25 Capsule .

Yes, Doxin-25 Capsule can be used to treat insomnia, especially in people who do not fall asleep or have difficulty staying asleep.

Doxin-25 Capsule contains Doxepin, which is a tricyclic antidepressant medication. It works by increasing the levels of certain chemicals in the brain called GABA (Gamma-aminobutyric acid). These chemicals help regulate mood and can reduce feelings of depression. If Doxin-25 Capsule is prescribed for insomnia, it can help you sleep longer and improve sleep quality.

Doxin-25 Capsule may lead to withdrawal symptoms if stopped abruptly, like suicidal thoughts, irritability, and excessive aggression, which can sometimes be fatal. So, please consult your doctor; they may recommend gradually reducing your dose rather than stopping it all at once, depending on your medical condition.

Doxin-25 Capsule should not be taken if you are allergic to any of its ingredients, or if you have used monoamine oxidase inhibitor (MAOI) within the past 15 days (a class of drugs used to treat depression and other neurological disorders). Also, do not take Doxin-25 Capsule if you have glaucoma (increased eye pressure), severe liver or kidney problems, asthma, or difficulty urinating.

No, do not drive while taking Doxin-25 Capsule , as it may cause drowsiness and impair your concentration. If you feel sleepy or dizzy, avoid driving until you are sure it is safe.

Overdose symptoms of Doxin-25 Capsule can include irregular heartbeat, feeling agitated or confused, drowsiness, trouble concentrating, vomiting, seizures, muscle stiffness, increase in pupil size, hallucination (seeing or hearing things that aren't there), fever, low body temperature, and even coma (loss of consciousness for some time). If you suspect an overdose, seek immediate medical help from your doctor.

It usually takes several weeks or longer for you to experience the full effects of Doxin-25 Capsule . Even if you start feeling better, it is important to continue taking Doxin-25 Capsule as prescribed. Do not stop taking Doxin-25 Capsule abruptly without consulting your doctor, the doctor will reduce your dose gradually to prevent withdrawal symptoms.

No, do not drink alcohol while taking Doxin-25 Capsule , as alcohol may increase the side effects of the medication.

No, Doxin-25 Capsule is generally not considered addictive. While it may cause withdrawal symptoms if stopped suddenly, Doxin-25 Capsule has not been found to cause the psychological dependence commonly associated with addictive substances.

Yes, Doxin-25 Capsule , like other antidepressants, may increase the risk of suicidal thoughts or behaviours, particularly in children, adolescents, and young adults. This risk is higher when starting the medication or adjusting the dosage. If you notice any changes in your mental health while using Doxin-25 Capsule , please contact your doctor immediately.

The common side effects of Doxin-25 Capsule include drowsiness, dry mouth, increased heart rate, constipation, weight gain, difficulty urinating, and a sudden drop in blood pressure upon standing (orthostatic hypotension). Most of these side effects may resolve gradually over time, but if they persist or worsen, please consult your doctor.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - DOX0108

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