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  3. Doxybenz-50 Injection 1's

Doxybenz-50 Injection 1's, Pack of 1 INJECTION
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Written By Lakshmithulasi Yarragunta ,
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Doxybenz-50 Injection 1's is an anti-cancer medicine used to treat cancer. It contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs; this causes double-helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, it treats cancer.

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Synonym :

DOXORUBICIN HYDROCHLORIDE

Composition :

DOXORUBICIN-50MG

Manufacturer/Marketer :

Admac Lifesciences(Oncology)

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Doxybenz-50 Injection 1's

Doxybenz-50 Injection 1's is an anti-cancer medicine used in the treatment of cancer. Cancer is a disease where the cells grow abnormally and divide uncontrollably. Doxybenz-50 Injection 1's is primarily used as adjuvant chemotherapy in women with axillary lymph nodes with involvement resection of breast cancer (abnormal growth in the cells of the breast). It is also used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children).

Doxybenz-50 Injection 1's contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Doxybenz-50 Injection 1's may cause certain side effects such as nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhea, and pain at the site of injection. Most of these side effects do not require medical attention and gradually resolve over time. However, if the side effects persist, please consult your doctor. A trained healthcare doctor will administer Doxybenz-50 Injection 1's. So, do not self-administer. Your doctor will decide the dose of the medicine based on your health condition.

Doxybenz-50 Injection 1's should be avoided if you are allergic to it or any other components of this medicine. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression, and severe liver disease. Hence, if you have any such conditions, inform your doctor. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause adverse effects. Doxybenz-50 Injection 1's is known to cause embryo-fetal toxicity. Hence, if you are pregnant or breastfeeding, inform your doctor beforehand.

Uses of Doxybenz-50 Injection 1's

Doxybenz-50 Injection 1's is used to treat various types of cancer. The detailed uses of Doxybenz-50 Injection 1's are as follows:<br/>• Treats solid tumors: Doxybenz-50 Injection 1's is used alone or with other medicines to manage bladder, breast, lung, stomach, ovarian, and thyroid cancers, as well as certain soft tissue and bone sarcomas.<br/>• Treats blood cancers: Doxybenz-50 Injection 1's helps treat Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, and certain types of leukemia, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML, ANLL).<br/>• Manages childhood cancers: Doxybenz-50 Injection 1's is also used to treat neuroblastoma and Wilms’ tumor (a kidney cancer in children).<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.• Doxybenz-50 Injection 1's will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Doxybenz-50 Injection 1's contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis. Doxybenz-50 Injection 1's is also used in the treatment of acute lymphoblastic leukaemia, acute myeloblastic leukaemia, Hodgkin lymphoma, Non-Hodgkin lymphoma, metastatic breast cancer, metastatic Wilms’ tumour, metastatic neuroblastoma, metastatic soft tissue sarcoma, metastatic bone sarcomas, metastatic ovarian carcinoma, metastatic transitional cell bladder carcinoma, metastatic thyroid carcinoma, metastatic gastric carcinoma, metastatic bronchogenic carcinoma.

How Doxybenz-50 Injection 1's Works

Doxybenz-50 Injection 1's contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, destroying DNA and RNA synthesis.

Storage

• Store in a cool and dry place away from sunlight.• Keep Doxybenz-50 Injection 1's out of the sight and reach of children. • Cold chain - To be stored in cold places at 2ºC to 8ºC.
Side effects of Doxybenz-50 Injection
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.

What if I have taken an overdose of Doxybenz-50 Injection 1's

Since Doxybenz-50 Injection 1's is given in a controlled medical setting by a healthcare professional, an overdose is not likely to occur. If you think there has been an overdose or experiencing any adverse events, get medical care right away. In a medical setting, an overdose would be treated quickly. Overdose of Doxybenz-50 Injection 1's may cause sores in the mouth and throat, fever, sore throat, chills, or other signs of infection, unusual bleeding or bruising, black and tarry stools, red blood in stools, and bloody vomit or vomited material that looks like coffee grounds.

Drug Warnings

Doxybenz-50 Injection 1's should be avoided if you are allergic to it. It is contraindicated in patients having severe myocardial insufficiency, a recent history of myocardial infarction (MI), severe persistent drug-induced myelosuppression and severe liver disease. Hence avoid using this medicine under such conditions. Inform your doctor if you have any cardiovascular conditions, liver/kidney disease, or taking any CYP3A4 or CYP2D6 inducers medication, as it can cause serious adverse effects. Doxybenz-50 Injection 1's is known to cause embryo-fetal toxicity. Hence it is contraindicated in pregnant or breastfeeding women. Do not stop receiving Doxybenz-50 Injection 1's without a doctor’s advice, as it can cause serious health conditions. Doxybenz-50 Injection 1's is known to cause secondary malignancies, tissue necrosis, cardiomyopathy and septic shock in some patients. Hence careful monitoring of the patient is needed while receiving the medicine.

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
DoxorubicinSotalol
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Doxybenz-50 Injection:
Coadministration of Doxybenz-50 Injection with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Doxybenz-50 Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinSotalol
Severe
How does the drug interact with Doxybenz-50 Injection:
Using Doxybenz-50 Injection together with sotalol can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although there is a possible interaction between Sotalol and Doxybenz-50 Injection, you can take these medicines together if prescribed by a doctor. If you experience dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations consult a doctor. Do not stop using any medications without talking to a doctor.
DoxorubicinEtanercept
Severe
How does the drug interact with Doxybenz-50 Injection:
When Etanercept is used with Doxybenz-50 Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Doxybenz-50 Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxorubicinBaricitinib
Severe
How does the drug interact with Doxybenz-50 Injection:
Using baricitinib together with Doxybenz-50 Injection may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Doxybenz-50 Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
DoxorubicinHydroxychloroquine
Severe
How does the drug interact with Doxybenz-50 Injection:
The combined use of Doxybenz-50 Injection and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Doxybenz-50 Injection and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DoxorubicinNilotinib
Severe
How does the drug interact with Doxybenz-50 Injection:
Coadministration of Doxybenz-50 Injection and Nilotinib can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Doxybenz-50 Injection and nilotinib together can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without consulting your doctor.
DoxorubicinAmisulpride
Severe
How does the drug interact with Doxybenz-50 Injection:
Using Amisulpride together with Doxybenz-50 Injection can increase the risk of severe irregular heart rhythm.

How to manage the interaction:
Although taking Doxybenz-50 Injection and Amisulpride together can cause an interaction, it can be taken if a doctor has suggested it. If you're having any of these symptoms like an irregular heart rhythm, sudden dizziness, or severe diarrhea, it's important to contact the doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinCladribine
Severe
How does the drug interact with Doxybenz-50 Injection:
The combined use of cladribine with Doxybenz-50 Injection can increase the risk of developing serious infections.

How to manage the interaction:
Co-administration of Doxybenz-50 Injection with Cladribine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
DoxorubicinMifepristone
Severe
How does the drug interact with Doxybenz-50 Injection:
Co-administration of Doxybenz-50 Injection with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Doxybenz-50 Injection with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
DoxorubicinHaloperidol
Severe
How does the drug interact with Doxybenz-50 Injection:
Co-administration of Doxybenz-50 Injection and Haloperidol can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Doxybenz-50 Injection with Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Meditation and yoga have been proven very effective in helping cancer patients maintain a healthy attitude and body.
  • Eat more lean meats, healthy fats, fruits, vegetables, and whole-grain foods to give you more energy. 
  • Stay hydrated by drinking plenty of water, as dehydration is often seen in cancers.
  • Taking a stroll in the garden or spending 30 minutes of your time doing some light physical activity can be very useful. However, do not over-exert yourself if you feel too tired. 
  • Avoid smoking and alcohol consumption.

Habit Forming

No

Therapeutic Class

ANTINEOPLASTIC

Doxybenz-50 Injection 1's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

Doxybenz-50 Injection 1's is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Doxybenz-50 Injection 1's. Use reliable methods of birth control while on treatment with Doxybenz-50 Injection 1's.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Doxybenz-50 Injection 1's. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Doxybenz-50 Injection 1's may cause dizziness and tiredness; therefore, avoid driving vehicles or operating machinery until you return to normal.

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Liver

Caution

Doxybenz-50 Injection 1's should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

bannner image

Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Consult your doctor

Doxybenz-50 Injection 1's is used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children). Your doctor may recommend a suitable dosage based on your child's condition.

Have a query?

FAQs

Doxybenz-50 Injection 1's is used to treat Breast Cancer.

Doxybenz-50 Injection 1's contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs. This causes double helix DNA to be uncoiled, thereby destroying the DNA and RNA synthesis.

Doxybenz-50 Injection 1's can disrupt a woman&amp;#039;s natural menstrual cycle (period) and inhibit sperm production in men. However, you should not presume that you cannot become pregnant or that you cannot make someone else pregnant. It may also harm your foetus. Use reliable methods of birth control while on treatment with Doxybenz-50 Injection 1's.

Yes, Doxybenz-50 Injection 1's is considered a vesicant. This means it may cause tissue blistering and damage if it leaks out of the vein during administration in some individuals. Hence, this medication must be administered by a trained healthcare professional to reduce the risk of this complication.

The common side effects of Doxybenz-50 Injection 1's may include nausea, headache, abdominal pain, loss of appetite, vomiting, dizziness, mouth sores, tiredness, back pain, red discoloration of urine, diarrhoea, and pain at the injection site. Most of these side effects are mild and temporary, and they often resolve on their own over time. However, if you experience persistent, severe, or worsening side effects, it's crucial to consult your doctor.

It is not recommended for use in breastfeeding women as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before prescribing Doxybenz-50 Injection 1's.

Doxybenz-50 Injection 1's is an anti-cancer medication used to treat various types of cancer. It belongs to the class of anthracycline topoisomerase inhibitors.

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended during the treatment.

Country of origin

India

Manufacturer/Marketer address

Sco 84, Sector 5, Panchkula (Haryana) 134112 India.
Other Info - DOX0605

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Author Details

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 7:04 AM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/050467s078,050629s030lbl.pdf
  2. https://medlineplus.gov/druginfo/meds/a682221.html#side-effects
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