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  3. EPREX 8000IU INJECTION 0.8ML

EPREX 8000IU INJECTION 0.8ML, Pack of 1 INJECTION
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
EPREX 8000IU INJECTION 0 is used to treat anaemia in cancer, chronic kidney disease, and HIV. It contains Epoetin alfa which works by stimulating the bone marrow to make more red blood cells. In some cases, this medicine may cause side effects such as diarrhoea, vomiting, fever, feeling sick, stuffy nose and sore throat. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions
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Composition :

EPOETIN ALFA-8000I.U

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About EPREX 8000IU INJECTION 0

EPREX 8000IU INJECTION 0 belongs to the class of medication called 'blood-forming agent'  primarily used to treat anaemia (low red blood cell count) in persons with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells' cancer). Anaemia occurs when the body has a lower amount of red blood cells or haemoglobin. In chronic kidney disease, the kidney gets damaged and doesn't filter the blood, leading to anaemia.

EPREX 8000IU INJECTION 0 contains a human-made protein known as 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells (RBCs). EPREX 8000IU INJECTION 0 helps to reverse anaemia and reduce the need for blood transfusion. EPREX 8000IU INJECTION 0 is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, EPREX 8000IU INJECTION 0 stimulates the production of this protein in the bone marrow. 

EPREX 8000IU INJECTION 0 will be administered by a healthcare professional; do not self-administer. The most common side effects of EPREX 8000IU INJECTION 0 are shortness of breath,  cough, low blood pressure during dialysis, headache, body aches, diarrhoea, injection site pain and abdominal pain. Most of these side effects of EPREX 8000IU INJECTION 0 do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

If you have uncontrolled/untreated high blood pressure or red cell aplasia (a type of anaemia) due to epoetin alfa or darbepoetin alfa, please inform your doctor before taking EPREX 8000IU INJECTION 0 to avoid any complications. Inform your doctor immediately, if you feel weak, lightheaded, tired, or short of breath, or if your skin looks pale as it may be a sign that the body has stopped responding to EPREX 8000IU INJECTION 0. It is not known whether EPREX 8000IU INJECTION 0 will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant and breastfeeding before starting treatment with this medicine. EPREX 8000IU INJECTION 0 is a cold chain medicine, and so it has to be stored in the refrigerator between 2-8 degrees Celsius else its efficiency might be lost. Do not store in the freezer or the fridge.

Uses of EPREX 8000IU INJECTION 0

Treatment of Anemia in cancer, Anemia in chronic kidney disease, Anemia in HIV.

Directions for Use

• Follow your doctor's instructions on the dosage and timing of EPREX 8000IU INJECTION 0. Typically, it is administered 3 times a week.• EPREX 8000IU INJECTION 0 will be administered subcutaneously (under the skin) or intravenously (through the vein) by the doctor or nurse in a medical setting. • Do not self-administer it.

Medicinal Benefits

EPREX 8000IU INJECTION 0 is a human-made form of naturally occurring erythropoiesis-stimulating protein or erythropoietin (a hormone produced by the kidney's specialized cells and is responsible for protecting red blood cells against destruction and also stimulates the cells of bone marrow to produce more amount of red blood cells). Deficiency of erythropoietin happens when a person is suffering from chronic kidney diseases, which in turn causes low red blood cells count causing anemia.  This medicine is primarily indicated for treating anemia (low red blood cell count) in persons with long-term serious (chronic) kidney disease, persons receiving chemotherapy for some types of cancer except for bone marrow or blood cells cancer, and persons taking zidovudine to treat HIV(human immunodeficiency virus). EPREX 8000IU INJECTION 0 is also used to reduce the need for red blood cell transfusions in adults having certain types of surgery. EPREX 8000IU INJECTION 0 contains a protein 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells. 

How EPREX 8000IU INJECTION 0 Works

EPREX 8000IU INJECTION 0 contains a human-made protein known as 'Epoetin alfa' which works by providing signals to the bone marrow to make more red blood cells (RBCs). EPREX 8000IU INJECTION 0 helps to reverse anaemia and reduce the need for blood transfusion. EPREX 8000IU INJECTION 0 is a biologic response modifier and erythropoiesis-stimulating protein. In chronic kidney disease, when the kidney fails to produce sufficient 'erythropoietin protein' which aids in the formation of red blood cells, EPREX 8000IU INJECTION 0 stimulates the production of this protein in the bone marrow.

Storage

Keep EPREX 8000IU INJECTION 0 out of the sight and reach of children.
Side effects of Eprex 8000iu Injection 0.8ml
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage Joint Pain caused by medication usage:
  • Please inform your doctor about joint pain symptoms, as they may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Your doctor may prescribe common pain relievers if necessary to treat joint discomfort.
  • Maintaining a healthy lifestyle is key to relieving joint discomfort. Regular exercise, such as low-impact sports like walking, cycling, or swimming, should be combined with a well-balanced diet. Aim for 7-8 hours of sleep per night to assist your body in repairing and rebuilding tissue.
  • Applying heat or cold packs to the affected joint can help reduce pain and inflammation.
  • Please track when joint pain occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • If your joint pain is severe or prolonged, consult a doctor to rule out any underlying disorders that may require treatment.
Here are the steps to manage the medication-triggered Cough:
  • Tell your doctor about the cough symptoms you're experiencing, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your cough symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids, such as water, tea, or soup, to help thin out mucus and soothe your throat.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your cough persists or worsens, consult your doctor for further guidance.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of EPREX 8000IU INJECTION 0

Since EPREX 8000IU INJECTION 0 is administered by a healthcare professional, an overdose is unlikely to occur. However, seek medical attention if you experience symptoms of overdose such as a fast or racing heartbeat.

Drug Warnings

EPREX 8000IU INJECTION 0 can enhance the risk of blood clots and serious heart problems including heart attack so tell your doctor immediately if you notice shortness of breath, sudden numbness or weakness, chest pain, or trouble speaking or understanding. This medicine may speed up tumor growth, or shorten remission or survival time in some people with certain types of cancer. Inform your doctor before taking EPREX 8000IU INJECTION 0 if you have heart disease, high blood pressure, kidney disease, stroke, heart attack, blood clot, seizure, or latex allergy. Do not take EPREX 8000IU INJECTION 0 if you are pregnant or breastfeeding unless prescribed by the doctor. EPREX 8000IU INJECTION 0 should not be given to children below 1 month of age, as safety and effectiveness have not been established. Do not use EPREX 8000IU INJECTION 0 from a multi-dose vial when giving medicine to a baby. The multi-dose vial contains an ingredient (benzyl alcohol) that can cause serious side effects or death in very young infants or premature babies. EPREX 8000IU INJECTION 0 may affect a person's ability to drive as it may cause convulsions during the initial days of treatment, so a person taking EPREX 8000IU INJECTION 0 should avoid driving or operating any machine. Avoid consuming alcohol along with EPREX 8000IU INJECTION 0 as it could lead to increased dizziness and sleepiness. 

Drug-Drug Interactions

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ErythropoietinCarfilzomib
Severe
ErythropoietinThalidomide
Severe

Drug-Drug Interactions

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ErythropoietinCarfilzomib
Severe
How does the drug interact with Eprex 8000iu Injection 0.8ml:
Carfilzomib can cause serious blood clots and taking it alongside Eprex 8000iu Injection 0.8ml may enhance the risk.

How to manage the interaction:
Co-administration of Eprex 8000iu Injection 0.8ml with Carfilzomib can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without consulting a doctor.
ErythropoietinThalidomide
Severe
How does the drug interact with Eprex 8000iu Injection 0.8ml:
Taking thalidomide with Eprex 8000iu Injection 0.8ml may increase the risk or severity of thromboembolism(a circulating blood clot that gets stuck and causes an obstruction).

How to manage the interaction:
Although taking Eprex 8000iu Injection 0.8ml and thalidomide together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as chest pain, shortness of breath, difficulty breathing, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body. Do not discontinue any medications without consulting a doctor.
ErythropoietinLenalidomide
Severe
How does the drug interact with Eprex 8000iu Injection 0.8ml:
Combining Eprex 8000iu Injection 0.8ml with Lenalidomide can increase the risk of Thrombosis(formation of a blood clot ).

How to manage the interaction:
Although there is an interaction between Eprex 8000iu Injection 0.8ml and Lenalidomide, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
ErythropoietinPomalidomide
Severe
How does the drug interact with Eprex 8000iu Injection 0.8ml:
Pomalidomide can cause serious blood clots and taking it alongside Eprex 8000iu Injection 0.8ml may enhance the risk.

How to manage the interaction:
Co-administration of Eprex 8000iu Injection 0.8ml with Pomalidomide can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience chest pain, breathing difficulty, coughing up blood, sudden loss of vision, pain, redness or swelling in an arm or leg, and numbness or weakness on one side of the body, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Limit the consumption of fluids, salt, potassium, phosphorous, and other electrolytes.
  • Eat a low-protein diet, and get enough calories from the foods if you are losing weight.
  • Eat foods that are high in vitamin B12, iron, and folic acid can fulfill the deficiencies of happed in kidney disease.
  • Include a little number of healthy fats in your diet that gives you enough energy to be active during the day; however, try to limit fats that make you fat. Try to include olive oil, peanut oil, and corn oil in your diet.
  • Rest well, and get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Using essential oils for massages can help increase circulation.

Habit Forming

No

Therapeutic Class

ERYTHROPOIESIS STIMULATING AGENTS (ESAs)
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Alcohol

Unsafe

Avoid consumption of alcohol while taking EPREX 8000IU INJECTION 0 as it may increase dizziness and sleepiness.

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Pregnancy

Caution

Avoid taking EPREX 8000IU INJECTION 0 if you are pregnant unless prescribed by a doctor as EPREX 8000IU INJECTION 0 is a pregnancy category B drug. Please consult your doctor if you have any concerns regarding this, your doctor will prescribe only if the benefits outweigh the risks. If prescribed use only single-dose vials (the benzyl alcohol-free formulation) in pregnant women.

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Breast Feeding

Caution

Consult your doctor before taking EPREX 8000IU INJECTION 0; your doctor will decide whether EPREX 8000IU INJECTION 0 can be taken by breastfeeding mothers or not.

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Driving

Caution

EPREX 8000IU INJECTION 0 causes convulsions (seizures), especially during the initial months of treatment. So, it is better not to drive or operate machinery unless you are alert.

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Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

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Children

Caution

EPREX 8000IU INJECTION 0 should not be given to neonates as the safety and efficacy have not been established.

Have a query?

FAQs

EPREX 8000IU INJECTION 0 is used to treat anaemia (low red blood cell count) in people with chronic kidney disease (CKD), patients affected with HIV, and those receiving chemotherapy for cancer (except for bone marrow or blood cells cancer).

EPREX 8000IU INJECTION 0 contains a protein "Epoetin alfa", which works by providing signals to the bone marrow to make more red blood cells. As in chronic kidney disease, the kidney gets damaged and doesn't filter the blood in the way it should be leading to anemia.

A person who is allergic to any chemical compound present in EPREX 8000IU INJECTION 0 or have uncontrolled/untreated high blood pressure, or ever had pure red cell aplasia (a type of anaemia) caused by using darbepoetin alfa, or epoetin alfa is not allowed to take a name.

It is advised to tell your doctor about your medical conditions like heart disease, high blood pressure, kidney disease, a stroke, heart attack, or blood clot, a seizure, a latex allergy to avoid any type of medical condition.

It is suggested to store the EPREX 8000IU INJECTION 0 in the refrigerator between 2 and 8 ℃ and protect it from light. However, a person should not freeze it.

The common side-effects of EPREX 8000IU INJECTION 0 are headache and pain, redness at the injection site. These side-effects are usually mild and temporary. However, inform your doctor immediately if any of these side-effects persist or get worse.

EPREX 8000IU INJECTION 0 will be administered subcutaneously (under the skin) or intravenously (through the vein) by the doctor or nurse based on individual considerations.

Since EPREX 8000IU INJECTION 0 will be administered by the doctor it is unlikely to exceed the recommended dose. However, seek medical attention if you experience symptoms of overdose such as a fast or racing heartbeat.

Yes, EPREX 8000IU INJECTION 0 will be given to children by the doctor if needed. However, it should not be given to children under 1 month of age, as its safety and effectiveness have not been established for this age group. Consult the doctor if you have any concerns.

Yes, EPREX 8000IU INJECTION 0 may cause hypertension (high blood pressure). The doctor will control high blood pressure before and during treatment. However, it is not recommended for people with uncontrolled hypertension. Let the doctor know if you have hypertension before starting treatment with EPREX 8000IU INJECTION 0.

Country of origin

India

Manufacturer/Marketer address

Corporate Communications, Johnson & Johnson Private Limited., 501 Arena Space, Behind Majas Bus Depot, Off Jogeshwari Vikhroli Link Road, Jogeshwari (E), Mumbai 400 060
Other Info - EPR0011

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Keep Refrigerated. Do not freeze.

Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:47 AM IST

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Reference

  1. https://www.drugs.com/mtm/epoetin-alfa.html
  2. https://www.medicines.org.uk/emc/files/pil.1193.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/103234s5363s5366lbl.pdf

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