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  3. Equisulin M 30 Injection 100 IU/ml

Equisulin M 30 Injection 100 IU/ml, Pack of 1 Injection
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Equisulin M 30 Injection 100 IU/ml is used in the treatment of type 1 and 2 diabetes mellitus. This medicine works by suppressing the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells, thereby maintaining consistent sugar control. Common side effects include low blood sugar, swelling in your hands or feet, weight gain, or thickening of the skin at the injection site.

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Composition :

HUMAN INSULIN-30% + INSULIN ISOPHANE-70%

Manufacturer/Marketer :

Koye Pharmaceuticals Pvt Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Equisulin M 30 Injection 100 IU/ml

Equisulin M 30 Injection 100 IU/ml used for the treatment of both type 1 and type 2 diabetes mellitus. It maintains blood sugar levels in adults and children. In Type 1 Diabetes Mellitus, the body does not produce enough insulin to regulate blood sugar levels. In type 2 diabetes mellitus, either the body stops producing enough insulin (a hormone that helps lower blood sugar levels) or there is resistance to the action of insulin. As a result, insulin is produced in large quantities, but it is unable to function properly on the body's organs.

Equisulin M 30 Injection 100 IU/ml is a combination medicine that works by promoting the recovery of sugar in muscle and fat cells and suppressing sugar production in the liver. Together, Equisulin M 30 Injection 100 IU/ml confirms rapid and stable sugar control.

Not everyone who is taking Equisulin M 30 Injection 100 IU/ml will get these side effects. You may experience rash, injection site allergic reaction, weight gain, edema (tissue swelling or fluid overload), skin thickening at the injection site, low blood glucose levels, and itching. Most of these side effects of Equisulin M 30 Injection 100 IU/ml do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Equisulin M 30 Injection 100 IU/ml should be taken as advised by your doctor. It should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks) only. Your doctor will explain how to inject the medicine by your own. However, if it is difficult to inject the medicine, ask a healthcare professional to administer it. Along with Equisulin M 30 Injection 100 IU/ml, you should take a healthy diet, do regular exercise, and maintain weight as advised by your doctor.

Inform your doctor if you are allergic to Equisulin M 30 Injection 100 IU/ml. Do not take Equisulin M 30 Injection 100 IU/ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs. Try not to stop receiving Equisulin M 30 Injection 100 IU/ml of your own. Let your doctor know about this, as it may cause withdrawal symptoms. Equisulin M 30 Injection 100 IU/ml is a cold chain medicine, and so it must be stored in the refrigerator between 2-8 degrees Celsius, or else its efficiency might get lost. Do not store in the freezer or the fridge.

Uses of Equisulin M 30 Injection 100 IU/ml

Equisulin M 30 Injection 100 IU/ml is used in the treatment of Diabetes (Type 1 diabetes mellitus, Type 2 diabetes mellitus). The detailed uses of Equisulin M 30 Injection 100 IU/ml are as follows:

  • Diabetes Management: Equisulin M 30 Injection 100 IU/ml is primarily used to regulate blood glucose levels in individuals with diabetes mellitus, helping to keep them within a healthy range.
  • Postprandial Blood Sugar Control: Equisulin M 30 Injection 100 IU/ml effectively manages postprandial (after-meal) blood sugar spikes through its combination of intermediate and short-acting insulin.
  • Type 1 and Type 2 Diabetes Treatment: Equisulin M 30 Injection 100 IU/ml is prescribed for patients with Type 1 and Type 2 diabetes who are unable to achieve adequate glycemic control with oral hypoglycemic agents alone.

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Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication, to ensure the safety.
  • Equisulin M 30 Injection 100 IU/ml should be administered subcutaneously (in the upper thigh, abdomen, upper arm, or buttocks).
  • It should never be administered intravenously (into the vein).
  • If you are not well trained to self-administer it, ask your healthcare professional to administer it.

Medicinal Benefits

  • Equisulin M 30 Injection 100 IU/ml is a combination medicine used for the treatment of both type 1 and type 2 diabetes mellitus. 
  • Equisulin M 30 Injection 100 IU/ml suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells; thereby,
  • This medicine ensures rapid and consistent sugar control in your body.
  • Equisulin M 30 Injection 100 IU/ml helps in improving glycaemic control, which in turn decreases the risk of progression of diabetes like damage of the retina, damage to the kidney, damage to nerve cells, delayed wound healing, diabetic foot ulcer and others.
  • The Penfill format facilitates precise and convenient dosing using an insulin pen device, thereby enhancing the ease of use for diabetic patients.

How Equisulin M 30 Injection 100 IU/ml Works

Equisulin M 30 Injection 100 IU/ml is a combination of two drugs: Human insulin (a short-acting type of insulin) and Insulin isophane (intermediate-acting). Equisulin M 30 Injection 100 IU/ml suppresses the production of sugar in the liver and facilitates the reuptake of sugar in the fat and muscle cells; thereby, Equisulin M 30 Injection 100 IU/ml ensures rapid and consistent sugar control.

Storage

• Store in a cool and dry place away from sunlight.• Keep this medicine out of the sight and reach of children.• Cold chain - To be stored in cold places at 2ºC to 8ºC
Side effects of Equisulin M 30 Injection 100 IU/ml
  • If you experience low blood sugar levels, inform your doctor. They will assess the severity and make recommendations for the next actions.
  • Your doctor will assess your symptoms, blood sugar levels, and overall health before recommending the best course of action, which may include treatment, lifestyle modifications, or prescription adjustments.
  • Follow your doctor's instructions carefully to manage the episode and adjust your treatment plan.
  • Make medication adjustments as recommended by your doctor to prevent future episodes.
  • Implement diet and lifestyle modifications as your doctor advises to manage low blood sugar levels.
  • Monitor your blood sugar levels closely for patterns and changes.
  • Track your progress by recording your blood sugar levels, food intake, and physical activity.
  • Seek further guidance from your doctor if symptoms persist or worsen so that your treatment plan can be revised.
Managing Medication-Related Skin Allergies: A Step-by-Step Guide
  • If you experience signs of skin allergies such as redness, itching, or irritation after taking medication, contact your doctor right away.
  • To alleviate skin allergy symptoms, your doctor may change your medication regimen or offer tailored medication management advice.
  • Your doctor may recommend or prescribe drugs to relieve discomfort.
  • Cool compresses or calamine lotion can help relieve redness and itching on the afflicted skin area.
  • Staying hydrated by consuming plenty of water can help relieve discomfort.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

What if I have taken an overdose of Equisulin M 30 Injection 100 IU/ml

Never take more than the prescribed dose. Overdose of Equisulin M 30 Injection 100 IU/ml may cause cold sweats, trembling hands, intense anxiety, and a general sense of confusion. Seek immediate medical help if you suspect that you might have taken an overdose.

Drug Warnings

  • Inform your doctor if you are allergic to Equisulin M 30 Injection 100 IU/ml. 
  • Do not take Equisulin M 30 Injection 100 IU/ml if you have any low blood glucose levels, kidney, liver, or heart problems, or problems with alcohol or other prescription or recreational drugs. 
  • Do not stop taking Equisulin M 30 Injection 100 IU/ml without consulting your doctor, as it may cause withdrawal symptoms. 
  • Equisulin M 30 Injection 100 IU/ml may decrease the level of potassium, leading to a state of hypokalemia that, if left untreated, may lead to respiratory paralysis, irregular heartbeat rhythm, coma, and even death.
  • Equisulin M 30 Injection 100 IU/ml is for subcutaneous (under the skin) use only. If you are switching to a different insulin brand or using a different method of injection, it is recommended that you do so under strict medical supervision. 
  • Cases of heart failure have been reported when pioglitazone was used with insulin, especially in patients at high risk of cardiac heart failure. 
  • The first symptoms of hyperglycemia (high blood sugar levels) may include excessive thirst, dry mouth, increased frequency of urination, nausea, vomiting, drowsiness, flushed dry skin, loss of appetite, and an acetone odour in the breath. You should closely monitor these symptoms.
  • It is advisable not to consume alcohol, as it may either increase or decrease your blood glucose level. 
  • Care should be taken while travelling across more than two time zones. Your doctor may adjust your insulin schedule. 
  • Equisulin M 30 Injection 100 IU/ml is a cold chain medicine, and therefore it must be stored in the refrigerator at a temperature between 2 °C and 8 °C; otherwise, its efficiency may be compromised. Do not store in the freezer or the fridge.
  • Equisulin M 30 Injection 100 IU/ml should not be administered intravenously (into the vein).

Drug-Drug Interactions

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INSULIN HUMANGatifloxacin
Critical
INSULIN HUMANCiprofloxacin
Severe

Drug-Drug Interactions

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INSULIN HUMANGatifloxacin
Critical
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Coadministration of Gatifloxacin with Equisulin M 30 Injection 100 IU/ml may sometimes affect blood glucose levels. Both low blood glucose and, less frequently, high blood glucose have been reported.

How to manage the interaction:
Although there is a possible interaction, Equisulin M 30 Injection 100 IU/ml can be taken with Gatifloxacin if prescribed by the doctor. Consult the prescriber if you experience symptoms such as nervousness, confusion, headache, dizziness, drowsiness, tremors, nausea, hunger, weakness, perspiration, palpitation, rapid heartbeat, increased urination, increased thirst, and increased hunger. Maintaining blood glucose levels is advised.
INSULIN HUMANCiprofloxacin
Severe
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Taking Equisulin M 30 Injection 100 IU/ml with ciprofloxacin effects blood glucose levels, which may cause hyperglycemia (high blood sugar) or hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking ciprofloxacin and Equisulin M 30 Injection 100 IU/ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult a doctor if you experience headaches, dizziness, sleepiness, anxiety, disorientation, tremors, nausea, hunger, weakness, increased sweating, and a rapid heartbeat, increased hunger, increased thirst. Do not discontinue any medications without consulting a doctor.
Isophane InsulinNalidixic acid
Severe
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Taking Equisulin M 30 Injection 100 IU/ml with nalidixic acid affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Nalidixic acid and Equisulin M 30 Injection 100 IU/ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinGemifloxacin
Severe
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Taking Equisulin M 30 Injection 100 IU/ml with gemifloxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Gemifloxacin and Equisulin M 30 Injection 100 IU/ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinCiprofloxacin
Severe
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Taking Equisulin M 30 Injection 100 IU/ml with ciprofloxacin effects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently..

How to manage the interaction:
Although taking ciprofloxacin and Equisulin M 30 Injection 100 IU/ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, and rapid heartbeat, increased thirst, increased hunger, and increased urination. Do not stop using any medications without talking to a doctor.
Isophane InsulinCinoxacin
Severe
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Taking Equisulin M 30 Injection 100 IU/ml with cinoxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Cinoxacin and Equisulin M 30 Injection 100 IU/ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinTrovafloxacin
Severe
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Taking Equisulin M 30 Injection 100 IU/ml with trovafloxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking trovafloxacin and Equisulin M 30 Injection 100 IU/ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.
Isophane InsulinEnoxacin
Severe
How does the drug interact with Equisulin M 30 Injection 100 IU/ml:
Taking Equisulin M 30 Injection 100 IU/ml with enoxacin affects blood glucose levels, which may cause hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) less frequently.

How to manage the interaction:
Although taking Enoxacin and Equisulin M 30 Injection 100 IU/ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience hypoglycemia or hyperglycemia. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, shaking, nausea, loss of hunger, weakness, sweating, palpitations, and rapid heartbeat. Symptoms of hyperglycemia may include increased thirst, increased hunger, and increased urination. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Include foods rich in healthy carbohydrates and fiber, fruits, whole grains, and vegetables in your diet.
  • Try eating food at regular intervals. Do not skip meals. Also, try not to overeat.
  • Follow a healthy diet and walk for at least a few minutes to complement treatment with Equisulin M 30 Injection 100 IU/ml.
  • Maintain a healthy weight by exercising regularly.
  • Rest properly, and avoid stress by doing meditation or yoga.

Habit Forming

No

Therapeutic Class

ANTIDIABETICS

Equisulin M 30 Injection 100 IU/ml Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Equisulin M 30 Injection 100 IU/ml to avoid unpleasant side effects. Alcohol may cause increased drowsiness.

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Pregnancy

Consult your doctor

It is safe to use Equisulin M 30 Injection 100 IU/ml during pregnancy if prescribed by the doctor. However, consult your doctor if you have any concerns regarding this.

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Breast Feeding

Consult your doctor

It is safe to use Equisulin M 30 Injection 100 IU/ml by breastfeeding mothers if prescribed by the doctor. However, consult your doctor if you have any concerns regarding this.

bannner image

Driving

Caution

Equisulin M 30 Injection 100 IU/ml may cause drowsiness and hypoglycemia (low blood sugar). Therefore, drive only if you are alert.

bannner image

Liver

Caution

Equisulin M 30 Injection 100 IU/ml should be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Equisulin M 30 Injection 100 IU/ml should be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

bannner image

Children

Safe if prescribed

Equisulin M 30 Injection 100 IU/ml can be given safely to children provided the dose has been prescribed by a child specialist.

FAQs

Equisulin M 30 Injection 100 IU/ml is used for the treatment of‚ both type 1 and type 2 diabetes mellitus.

Equisulin M 30 Injection 100 IU/ml suppresses the production of sugar in the liver and‚ facilitates the reuptake of sugar in the fat and muscle cells, thereby Equisulin M 30 Injection 100 IU/ml ensures rapid and consistent sugar control.

Equisulin M 30 Injection 100 IU/ml may sometimes lower the blood glucose levels more than normal, leading to hypoglycaemia. Regularly monitor your blood sugar levels while taking Equisulin M 30 Injection 100 IU/ml. Hypoglycaemia symptoms include headache, drowsiness, cold sweat, feeling sick, unusual tiredness or weakness, and visual disturbances.

Do not stop taking Equisulin M 30 Injection 100 IU/ml without consulting your doctor on your own as it may cause an increase in blood glucose levels. Continue taking Equisulin M 30 Injection 100 IU/ml for as long as your doctor has prescribed it to you. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Equisulin M 30 Injection 100 IU/ml.

Maintain a healthy diet by regular intake of carbohydrates such as bread and products containing starch and sugar. Eat your meals regularly, and do not exercise heavily for longer durations with an empty stomach.

Hypoglycaemia may occur following prolonged or severe exercise, during illness, alcohol consumption, low food intake, or when Equisulin M 30 Injection 100 IU/ml is taken along with other antidiabetic medicines.

Side effects of Equisulin M 30 Injection 100 IU/ml include allergic reaction at the site of injection, hypoglycemia (low blood glucose level), itching, lipodystrophy (skin thickening or pits at the injection site), oedema (swelling), rashes, and weight gain. Most of these side effects may not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Cut back on foods high in sodium, alcohol, fried foods, and high-carb food and drinks like sugary drinks, drinks with added sugar, white rice and starchy vegetables.

The injection site should be changed to prevent skin changes like lumps under the skin. Equisulin M 30 Injection 100 IU/ml may not work well if injected into the lumpy area.

Maintain a healthy diet and exercise regularly. Limit sugar intake and avoid smoking & alcohol consumption. Manage stress by doing meditation or yoga.

Hypoglycaemia (low blood sugar) may occur because you inject too much insulin, miss or delay meals, do not eat enough, eat food containing less carbohydrate than normal, drink alcohol, lose carbohydrates due to vomiting or diarrhoea, do more exercise than usual or a different type of physical activity, are recovering from an injury, illness, operation or stress, or are taking/have stopped taking other medicines.

Symptoms of high blood sugar include feeling thirsty, increased urination, weakness or tiredness, blurred vision and weight loss.

Equisulin M 30 Injection 100 IU/ml is to be injected below the skin (subcutaneously). The best areas to inject Equisulin M 30 Injection 100 IU/ml are on your stomach, upper arm, upper thigh, or buttocks.

Unopened vials are to be refrigerated between 2°C and 8°C. Opened vials (in-use) may be stored not above 25ºC for a maximum of 4 weeks. The used needle should be placed in a puncture-resistant disposable container and disposed of properly as directed by your healthcare provider.

Avoid drinking alcohol while taking Equisulin M 30 Injection 100 IU/ml as it might lower blood sugar levels and cause hypoglycaemia.

Country of origin

India

Manufacturer/Marketer address

A-10, 3rd Floor, Art Guild House, Phoenix Market City Annexe, LBS Marg, Kurla (West), Mumbai - 400070
Other Info - EQU0098

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Keep Refrigerated. Do not freeze.Prepaid payment required.

Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Aug 8, 2025 | 8:16 AM IST

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Reference

  1. https://www.drugs.com/mtm/insulin-isophane.html#:~:text=What%20is%20insulin%20isophane%3F,for%2012%20to%2018%20hours.
  2. https://www.drugs.com/monograph/insulin-human.html
  3. https://biocon.com/docs/prescribing_information/diabetology/insugen505040iu_pi.pdf
  4. https://reference.medscape.com/drug/humulin-70-30-novolin-70-30-insulin-isophane-human-insulin-regular-human-999708

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